37 results about "Myricetin" patented technology

The invention relates to the technical field of traditional Chinese medicines, and discloses application of an active ingredient of shiny-leaved yellowhorn leaves in preparation of a medicine for treating hyperuricemia. The xanthoceras sorbifolia leaf active ingredients comprise quercitrin, rutin and myricetin; the content of quercitrin is 0.2508 mg / g to 0.6719 mg / g, the content of rutin is 0.6707 mg / g to 1.5831 mg / g, and the content of myricetin is 0.8002 mg / g to 3.4858 mg / g. According to the invention, myricetin, quercitrin and rutin are determined as core effective substances of shiny-leaved yellowhorn leaves for treating hyperuricemia for the first time; the multi-target and multi-channel action mechanism is disclosed; meanwhile, network pharmacological analysis shows that the three components have high connectivity in a network and jointly act on key targets such as XOD, ACE, AKR1B1 and TNF, it is prompted that the three components do not act singly, but play a treatment role through multi-target and multi-channel cooperation, the traditional'single target-single drug 'thinking is changed into a'multi-component-multi-target-multi-channel' system regulation mode, and the treatment effect is improved. A new thought is provided for comprehensive treatment of the hyperuricemia.

The invention discloses myricetin-loaded bone-targeted magnetic composite nanoparticles and a preparation method thereof. The preparation method comprises the following steps: step 1, preparing nanoparticles taking ferroferric oxide as an inner core; step 2, preparing magnetic mesoporous silica nanoparticles with ferroferric oxide as an inner core according to the nanoparticles prepared in the step 1; step 3, performing amination modification treatment on the surfaces of the magnetic mesoporous silica nanoparticles prepared in the step 2 to obtain magnetic mesoporous silica modified nanoparticles; step 4, preparing a ketal thiol-polyethylene glycol-aspartic acid hexapeptide molecule; and step 5, loading myricetin on the magnetic mesoporous silica modified nanoparticles prepared in the step 3, and blocking myricetin by using the ketal thiol-polyethylene glycol-aspartic acid hexapeptide molecules prepared in the step 4 after loading. The invention further discloses application of the compound in image tracing in osteolysis and treatment drugs.

The invention discloses a Pickering emulsion with stable starch-myricetin composite nanoparticles and a preparation method of the Pickering emulsion, and belongs to the technical field of starch modification and emulsion delivery. Starch and myricetin are combined and compounded, a dynamic high-pressure microjet homogenization technology is introduced, the starch-myricetin composite nano-particles capable of stabilizing Pickering emulsion are obtained through a one-step method, and the application limitation that nano-starch is high in hydrophilicity, high in digestibility and the like is effectively solved; the prepared starch-myricetin composite nanoparticles have the characteristics of high stability and slow digestion function; the Pickering emulsion is prepared by further matching with a compound oil phase of coconut oil and cinnamon essential oil, so that the problem of coconut oil solidification can be effectively solved, and the Pickering emulsion has an antibacterial effect.

The application discloses a three-channel fluorescence sensor array based on sulfur quantum dots and a preparation method and detection application thereof. The sensor array is composed of three kinds of sulfur quantum dots, namely C-SQDs, PSS-SQDs and beta-SQDs. When target objects exist, the three kinds of sensing units generate differentiated fluorescence responses, forming a unique "fingerprint map". By using principal component analysis to analyze the response mode, the array can successfully distinguish between structurally similar baicalein, fiscetin, myricetin, quercetin and rutin in a concentration range of 8.0-56 muM. In addition, the array can also perform semi-quantitative analysis on a single flavone compound in a range of 4.0-56 muM, and the first principal component has a good linear relationship with the logarithm of the concentration of the target object.

The invention relates to the technical field of food processing, in particular to a composition for reducing the content of advanced glycosylation end products of food and application of the composition. The invention provides a composition for reducing the content of advanced glycosylation end products of food. The composition is prepared from the following components: myricetin-3-O-rhamnoside, oleuropein and kaempferol. According to the composition, through the synergistic effect of myricetin-3-O-rhamnoside, oleuropein and kaempferol, the content of advanced glycosylation end products in food is remarkably reduced, the composition is suitable for various high-temperature processed food such as baked, fried and barbecue food, the addition amount is low, the sensory quality and the processing technology of the food are not affected, and the composition is suitable for industrial production. And an innovative health solution is provided for the food industry.

This invention provides the application of glucose-responsive nanohydrogels in the preparation of drugs for treating skin injuries. The method includes the following steps: mixing hyaluronic acid with a phenylboronic acid compound, adding 3-aminophenylboronic acid, 1-ethyl-3-(3-dimethylaminopropyl)carbodiimide hydrochloride and N-hydroxysuccinimide, and performing a grafting reaction to obtain boric acid-modified hyaluronic acid; adding myricetin-3-O-galactoside, phospholipids, and cholesterol to an organic solvent, followed by thin-film hydration and ultrasonic treatment to obtain nanoliposomes; mixing the boric acid-modified hyaluronic acid with a polyvinyl alcohol solution, then adding the nanoliposome solution, and finally mixing to obtain the resulting nanohydrogel. The glucose-responsive nanohydrogel of this invention achieves adaptive drug release in the high glucose environment of diabetic wounds and regulates local metabolic homeostasis of the wound, especially the lysine degradation pathway in amino acid metabolism.

The invention discloses bifidobacterium adolescentis for producing various active small molecules by fermenting white truffle, promoting collagen synthesis of skin cells and resisting aging, and belongs to the technical field of microorganisms. According to the present invention, the Bifidobacterium adolescentis CCFM1492 obtained through screening can degrade eriodictyol and cyanidin-3-O-glucoside chloride in the white truffle, and can produce a variety of active small molecules such as hesperetin, phloretin, ganoderenic acid D, gallic acid, myricetin and the like through fermentation of the white truffle, such that the active small molecules can be used for degrading the white truffle and the cyanidin-3-O-glucoside chloride in the white truffle; according to the present invention, with the application of the Bifidobacterium adolescentis CCFM1492 fermented white truffle fermentation broth, the promotion effect of the white truffle on the skin cell collagen synthesis and the anti-aging can be improved so as to improve the skin quality, such that the Bifidobacterium adolescentis CCFM1492 fermented white truffle fermentation broth has the huge application prospect in the preparation of the product for preventing or treating the skin quality.

The application discloses a research method of a potential protein target point of Guangxi Yaoshan sweet tea against diabetic nephropathy based on proteomics, relates to the technical field of biological medicine, and solves the problem of lacking research on the target point of the action of Yaoshan sweet tea on the prevention and treatment of diabetic nephropathy from the perspective of proteomics. The method comprises the following steps: determining a characteristic active ingredient, namely myricetin, of Yaoshan sweet tea for intervention on diabetic nephropathy, obtaining a PPI network of network pharmacology of the intersection target point of the characteristic active ingredient of Yaoshan sweet tea and diabetic nephropathy; preparing a myricetin solution, preparing a cell disease model and grouping intervention, collecting and pre-treating a cell protein sample, performing mass spectrometry, pre-processing proteomic mass spectrometry data, screening a potential protein target point, identifying and analyzing an expression change trend of the potential protein target point, and analyzing a core protein target point and a key signal path. The application directly locates the key protein target point of Guangxi Yaoshan sweet tea on diabetic nephropathy from a protein expression level, which is more intuitive and more accurate.

The invention discloses a plant lactobacillus for producing various active small molecules by fermenting truffles and resisting skin cell aging in multiple mechanisms, and belongs to the technical field of microorganisms. The lactobacillus plantarum CCFM1494 obtained by screening can be used for fermenting the white truffle, degrading cyanidin-3-O-glucoside chloride, and generating a plurality of active small molecules such as hesperetin, phloretin, ganoderenic acid D, gallic acid, myricetin, protocatechuic acid and the like; meanwhile, after the white truffle is fermented by the plant lactobacillus CCFM1494, the promotion effect of the white truffle on the synthesis of skin collagen and the improvement effect on cell senescence can be improved. Therefore, the lactobacillus plantarum CCFM1494 has a huge application prospect in preparation of products for improving skin quality.

The application provides a high-efficiency and green synthesis method of dihydromyricetin, which takes myricetin and a Pd-PEG2000 catalyst as main raw materials, and finally obtains a dihydromyricetin product with high purity and high content through chemical reduction and hydrogenation reactions.The method is not only simple in operation, but also mild in reaction conditions; meanwhile, the prepared Pd-PEG2000 catalyst can be recycled and recovered easily, and is suitable for industrial production of dihydromyricetin.

The present invention relates to a composition for alleviating skin damage caused by particulate matter (PM), the composition comprising myricetin as an active ingredient. Myricetin, which is an active ingredient of the composition for alleviating skin damage according to the present invention, can effectively reduce oxidative stress caused by PM2.5, endoplasmic reticulum stress and mitochondrial dysfunction, and apoptosis caused by cell exposure to PM2.5. Therefore, the composition comprising myricetin as an active ingredient according to the present invention shows great potential as a therapeutic candidate for treating skin damage caused by PM2.5.

Stabilized oils including an edible oil and an antioxidant composition comprising α-lipoic acid and least one of ascorbic acid, ascorbyl palmitate, green tea extract, lecithin, and rosemary extract or at least one of 1,2,4-benzenetriol, carnosic acid, dihydromyricetin, dihydrorobinetin, epigallocatechin, gallic acid, 3-hydroxytyrosol, myricetin, and nepodin, and methods of preparing such stabilized edible oils. The stabilized oils may have an Oxidative Stability Index (“OSI”) at 110° C. of at least 30 hours.

A nanomaterial is gold or silver nanoparticle having a nanoparticle surface that consists of one or more of the following extracts from sweet gum leaves: shikimic acid, sweet gum leaf family of Catechins, sweet gum leaf family of Quercetin, Sweroside, Afzelechin, p-Coumaric Acid, Epiafzelechin Trimethyl Ether, Myricetin, Naringenin, Phloretin, Procyanidin B1 and related polyphenols, flavonoids and alkaloids. An antiviral / antibacterial agent includes sweet gum mediated silver nanoparticles having a core size and in a concentration having efficacy as an antiviral / antibacterial exceeding a 3 log 10 reduction in viral titer.

The invention relates to the technical field of material preparation and separation, and discloses a preparation method and application of a boron affinity adsorbent for separating myricetin in a weak acid environment, a deep eutectic solvent is used as a drive, and a large specific surface area matrix material HOF-101 and a deep eutectic solvent DES are combined to improve the synthesis of a molecularly imprinted polymer MIP. The multi-functionality of the eutectic solvent is exerted, the dominant effect of boric acid groups is combined with the hydrogen-bond effect to construct an imprinting cavity with a high recognition effect, the imprinting cavity is also used as a green pore-foaming agent, and the dependence of the imprinting cavity on an alkaline environment is broken while the high recognition capability of a traditional boric acid material is reserved through a team boric acid affinity effect. The boron affinity molecularly imprinted polymer composite adsorbent provided by the invention is low in cost, reduces the use of toxic chemical solvents, solves the limitation of traditional boron affinity, is beneficial to industrial production and application, and has a wide application prospect in separation and purification of myricetin in fruit juice.

There are described compositions comprising an effective amount of a combination of two or more components, said components selected from acacetin, ACTI peptide, alpha-lipolic acid, alprostadil, anisomycin, apigenin, ascorbic acid, astragalus, berberine, β-lapachone, β-hydroxy-beta-methyl-butyrate, Bacopa monnieri, catechin, catechol, chamomile, chrysin, coumestrol, curcumin, dinitrophenol, dinoprost, ellagic acid, (−)-epigallocatechin gallate, green tea extract, fisetin, genistein, ginsenoside RE, glabridin, 18-α-glycyrrhetinic acid, 18-β-glycyrrhetinic acid, glycyrrhizin, hydroquinone, isoquercitrin (EMIQ), kaempferol, kuromanin, leucine, lithium, luteolin, luteolin, luteolinidin, melatonin, menadione, 1-methylnicotinamide (MNA), methyl salicylate, myricetin, nadide, niacin (vitamin B3), nicotinamide (NAM), nicotinamide mononucleotide (NMN), nicotinamide riboside (NR), nicotinic acid adenine dinucleotide (NaAD), nicotinic acid mononucleotide (NaMN), parsley (Petroselinium crispum), phenylephrine, pokeweed mitogen, 15-Δ prostaglandin J2, puromycin, quercetin, quinolinic acid, retinoic acid, trichostatin A, troxrutin, rutin, tryptophan, vitamin D3, withaferin A, wortmannin and zinc (including salts thereof).

The invention discloses an anti-atherosclerosis myricetin glycoside and a preparation method and application thereof, and the preparation method comprises the following steps: by taking sucrose as a glycosyl donor and myricetin as a glycosyl receptor, carrying out enzymatic reaction under the catalysis of sucrose phosphorylase, and transferring glucosyl generated by decomposition of the sucrose to C4-site hydroxyl of myricetin to obtain the myricetin glycoside, the sucrose phosphorylase is derived from leuconostoc mesenteroides. According to the method, oriented synthesis of myricetin glucoside can be realized, the product is single and does not have redundant byproducts, and the subsequent separation and purification process is greatly simplified. The myricetin glucoside is prepared through enzymatic catalysis, the reaction can be efficiently carried out under mild conditions, high temperature, high pressure and other harsh processes are not needed, energy consumption and equipment cost are reduced, impurity generation in the reaction process is reduced, and the production cost is reduced from the source.

This invention discloses a fusion peptide with synergistic anti-allergic effects, an anti-LTB4 monoclonal antibody, and an anti-allergic drug composition thereof. The fusion peptide is composed of peptide A, which inhibits histamine release, and peptide B, which blocks mast cell activation signals, covalently linked by a linker peptide, which can synergistically inhibit mast cell activation. The anti-LTB4 monoclonal antibody can specifically bind to LTB4, blocking its mediated inflammatory response. Combining the fusion peptide, the anti-LTB4 monoclonal antibody, and myricetin, which has antioxidant activity, forms a multi-target drug composition that can synergistically inhibit allergic reactions from multiple aspects, such as inhibiting mast cell degranulation, blocking the action of inflammatory mediators, and clearing oxidative stress products. In vitro cell experiments and OVA-induced allergic asthma mouse models have demonstrated that the anti-allergic effect of this composition is significantly better than that of a single component, and it has no obvious toxicity, providing a new candidate drug for the efficient treatment of allergic diseases.

The invention discloses a method for cooperatively reducing sensitization of beta-lactoglobulin by ultrasound and myricetin, which comprises the following steps: uniformly mixing beta-lactoglobulin with pure water, dissolving myricetin with methanol, mixing the beta-lactoglobulin and the myricetin in proportion, carrying out ultrasonic treatment together, and finally freeze-drying the beta-lactoglobulin-myricetin mixed solution subjected to ultrasonic treatment to obtain the beta-lactoglobulin-myricetin. Therefore, the hypoallergenic beta-lactoglobulin-myricetin powder is obtained, and the allergenicity of beta-lactoglobulin is reduced by more than 40%. According to the method disclosed by the invention, the sensitization of the beta-lactoglobulin can be effectively reduced under the condition that the primary structure of the beta-lactoglobulin is not changed, and the oxidation resistance of the product is improved.

The invention discloses a building wall thermal insulation integrated structure and a preparation method thereof, and belongs to the technical field of building wall preparation. The building wall heat preservation integrated structure comprises a wall base layer, a heat preservation layer, a decoration layer and a durable layer which are sequentially arranged from inside to outside, and the heat preservation layer is made of myricetin, 1, 2-propylene glycol, 1, 2-propylene glycol, 1, 2-propylene glycol, 1, 2-propylene glycol and 1, 2-propylene glycol. The material of the durable layer is prepared from 1, 3-dibromopropane, 1-t-butyloxycarbonyl piperazine, 5-methyl-2-aminothiazole, polyether polyol and toluene diisocyanate, and the material of the durable layer is prepared from diphenyl sulfone, diphenol propane, 2, 4 '-difluorobenzophenone, 4, 4'-dihydroxybenzophenone and epoxy resin. The integrated structure prepared by the method has excellent thermal insulation property, flame retardant property and durability.

The application provides a composition containing myricetin and quercetin, a cypress leaf extract containing the composition and application of the cypress leaf extract in promoting hair growth and preventing hair loss, relates to the technical field of daily chemicals, is composed of myricetin and quercetin, and adopts liquid quality and network pharmacology methods to analyze the main acting components and proportions of the cypress leaf extract, finds that myricetin and quercetin are the main components for preventing hair loss and promoting hair growth, and explores the hair loss prevention / hair growth promotion potential of different compositions of myricetin and quercetin through a 5alpha-reductase inhibition rate experiment, so as to provide a theoretical basis for the application of the myricetin and quercetin composition.

The invention relates to the technical field of traditional Chinese medicines, in particular to a composition with a uric acid reducing effect and application thereof. The natural adinandra nitida and the natural ampelopsis grossedentata are used as main raw materials, and at least one of the shrimp and crab shell extract, the chitosan, the chitosan oligosaccharide, the celery seed extract and the black cherry extract is used as auxiliary materials, so that the obtained composition is rich in active ingredients such as metoplanin, camelliin, myricetin, dihydromyricetin, apigenin and anthocyanin; the compound has the pharmacological activities of reducing uric acid, resisting inflammation, resisting oxidation, enhancing the vitality of the pineal body and the like. In-vivo and in-vitro experiments show that the composition can effectively reduce the uric acid level in vivo and relieve acute-stage inflammatory response of hyperuricemia, and has the effects of diminishing inflammation, easing pain, dispelling wind, eliminating swelling, clearing heat from throat and the like. In addition, the compound tea does not contain caffeine, does not influence sleep, is free of addiction, is suitable for a wide range of people, and has wide application and development prospects.

The invention discloses a method for evaluating, regulating and controlling ultraviolet B-band (ultraviolet B, UV-B) irradiation enrichment of grape secondary metabolites on the basis of a microtubulin array. The material is used for evaluating a microtubulin array and preparing a sample solution for determining secondary metabolites by applying a high performance liquid chromatography, and by detecting the enrichment degrees of the cell metabolites of rutin, kaempferol, myricetin and resveratrol before and after irradiation, the microtubulin array can be used for evaluating the microtubulin array and preparing the sample solution for determining the secondary metabolites. The raw materials for preparing food and cosmetics with anti-inflammatory and anti-oxidation effects are obtained. The invention creates a complete method from treatment time and treatment steps of UV-B irradiation of the American sandy grape cell suspension, monitoring of dynamic changes of tubulin and cell morphology indexes, and detection of changes of cell metabolites such as rutin, kaempferol, myricetin and resveratrol before and after irradiation. And a new way is provided for applying the enriched grape natural secondary metabolites to production of food and cosmetics with anti-inflammatory and anti-oxidation effects.

The invention discloses combined polyphenol nanocapsule powder with an effect of efficiently regulating lipid metabolism and a preparation method of the combined polyphenol nanocapsule powder, and belongs to the technical field of polyphenol processing and fat-reducing health. The preparation method of the combined polyphenol nanocapsule powder comprises the following steps: dissolving sodium caseinate and pectin in water to obtain a first mixed solution; adjusting the pH value of the first mixed solution to be alkaline, and adding a polyphenol solution into the first mixed solution to obtain a second mixed solution; adjusting the pH value of the second mixed solution to be acidic, and centrifuging to obtain supernate; mixing the supernate with a saccharide drying aid, and performing spray drying to obtain the combined polyphenol nanocapsule powder, the polyphenol solution is prepared by dissolving myricetin and chlorogenic acid in a solvent. The preparation method disclosed by the invention has the advantages of excellent fat reducing effect and high stability, and is suitable for preparation of polyphenol synergistic fat reducing products in industrial mass production.

The invention relates to the field of bio-based hydrogel, and discloses a composition for bio-based hydrogel, the bio-based hydrogel as well as a preparation method and application of the bio-based hydrogel. The composition contains myricetin, glucan, polyvinyl alcohol and a buffer solution, the content mass ratio of the myricetin to the glucan to the polyvinyl alcohol is 1: (2-20): (200-300); the alcoholysis degree of the polyvinyl alcohol is greater than or equal to 90%; the pH (Potential of Hydrogen) of the buffer solution is 6.0 to 8.5. The bio-based hydrogel prepared from the composition for the bio-based hydrogel provided by the invention not only can meet the rheological property requirements of remarkable shear thinning characteristic, rapid thixotropic recovery and the like, but also has excellent biocompatibility, and can avoid the problem of biotoxicity possibly caused in traditional chemical modification; the preparation method has an excellent application prospect in the fields of 3D printing bio-ink and antibiosis.

This invention belongs to the field of coking wastewater concentrate treatment, and discloses a coking wastewater membrane concentrate treatment agent and its preparation method. The treatment agent comprises the following raw materials in parts by weight: 5-15 parts ethylenediaminetetraacetic acid, 10-30 parts sodium persulfate, 20-50 parts modified cellulose, and 10-25 parts lime; wherein the modified cellulose is a composite material obtained by reacting cellulose with sulfonated myricetin at a mass ratio of 1:(2-3). The treatment agent of this invention uses modified cellulose obtained by combining cellulose and sulfonated myricetin, which can significantly improve its adsorption performance and complexing ability in wastewater treatment, and enhance its ability to remove organic matter. Through the synergistic effect of multiple components, the treatment agent of this invention can simultaneously and efficiently remove high concentrations of organic matter, high salinity, and high color from coking wastewater membrane concentrate.

The invention discloses lactobacillus gasseri capable of metabolizing various components of dendrobium officinale to generate rich active small molecules to promote collagen synthesis of skin cells, and belongs to the technical field of microorganisms. The lactobacillus gasseri (Lactobacillus gasseri) CCFM1481 obtained by screening can be used for fermenting the dendrobium officinale to generate a plurality of active substances, such as quercetin, isoquercetin, p-coumaric acid, kaempferol, isorhamnetin and myricetin. The fermentation liquor obtained by fermenting dendrobium officinale with lactobacillus gasseri CCFM1481 can improve the oxidative stress state of HSF cells, promote the expression of collagen in the HSF cells and regulate cell senescence. Therefore, the lactobacillus gasseri CCFM1481 fermented dendrobium officinale fermentation liquor has a huge application prospect in preparation of products for preventing or treating skin quality.

A myricetin-loaded, phytosome-based emulgel drug delivery system consisting of an encapsulation unit, an emulgel matrix integration unit, and a process control module for the production of a stable, antioxidant topical formulation.

The application relates to the fields of biological analysis and biological medicine and functional food technology, and particularly relates to a food source product affinity screening method for reducing blood pressure, a composition and application, the screening method injects a sample of a food source product to be detected into an ACE / ET-1 composite affinity chromatographic column for chromatographic separation, and adopts ELSD to detect the peak time of the food source product to be detected; the food source product is divided into different binding classification according to the peak time difference between the food source product and a negative control group, and the food source product combination of different binding classification is selected to obtain a food source product composition for reducing blood pressure. The application also specifically discloses the screened composition or monomer compound for reducing blood pressure, PCR / WB and HE pathology prove that the composition can down-regulate ACE / ET-1 path-related indexes, and the monomer compounds of myricetin and myricitrin can also down-regulate ACE / ET-1 related mRNA and protein expression.

The invention relates to the technical field of medicines for women, and discloses a bacteriostatic lotion for women and a preparation method thereof. The bacteriostatic lotion for women prepared by the invention takes dandelion, coptis chinensis, honeysuckle, purslane and plantain herb as traditional Chinese medicines, the traditional Chinese medicines are treated to obtain a traditional Chinese medicine extracting solution, and meanwhile, glycerol, potassium sorbate, allantoin and myricetin derivative nanoparticles are added to comprehensively improve the bacteriostatic performance of the lotion; wherein the myricetin derivative nanoparticles take myricetin as a substrate, and the myricetin derivative nanoparticles are modified to be dissolved in water, so that the antibacterial performance of the lotion is further improved.

The application discloses a method for rapidly detecting 30 compounds in tea, such as catechins, flavonoids, anthocyanins, phenolic acids and amino acids, wherein the 30 compounds are gallic acid, theobromine, GC, protocatechuic acid, theophylline, EGC, theanine, chlorogenic acid, caffeine, catechin, syringic acid, caffeic acid, vanillic acid, epicatechin, EGCG, delphinidin, salicylic acid, GCG, p-coumaric acid, cyanidin, ferulic acid, sinapic acid, rutin, ECG, pelargonidin, myricetin, theaflavin, quercetin, apigenin and kaempferol. The application can realize simultaneous rapid qualitative and quantitative detection of the 30 compounds, and provides technical support for development of active substances in tea.