64 results about "Myricetin" patented technology

The invention discloses establishment and application of a white kidney bean HPLC (High Performance Liquid Chromatography) fingerprint spectrum. The HPLC fingerprint spectrum of 114 batches of white kidney bean methanol extracts from different geographical sources is established, 9 common peaks are identified, and the spectrum-effect relationship between the 9 characteristic peaks of the HPLC fingerprint spectrum and the alpha-amylase inhibition rate is established through grey correlation analysis and partial least squares regression analysis. The invention finds that the myricetin component is highly correlated with the activity index of the alpha-amylase inhibitor and is possibly a key component of the hypoglycemic activity of the white kidney beans, and provides methodological reference for evaluating the hypoglycemic activity and quality control of the white kidney beans and also provides reference for development and utilization of the white kidney beans.

The invention discloses EGCG-myricetin carrier-free nanoparticles based on hydrogen peroxide oxidation crosslinking as well as a preparation method and application of the EGCG-myricetin carrier-free nanoparticles. The preparation method comprises the following steps: mixing amino acid, EGCG and hydrogen peroxide for reaction to prepare a covalent skeleton of an EGCG-amino acid network; and subjecting myricetin and the covalent skeleton of the EGCG-amino acid network to self-assembly so as to obtain the EGCG-myricetin carrier-free nanoparticles based on hydrogen peroxide oxidation crosslinking. According to the EGCG-myricetin carrier-free nano-particles disclosed by the invention, complex molecular design and tedious preparation schemes of a current delivery system and potential harmful effects of excipients are avoided, the prepared carrier-free nano-particles have good loading effect, stability and biological safety, and meanwhile, the EGCG-myricetin carrier-free nano-particles can obviously improve mouse colitis symptoms induced by DSS; technical support is provided for developing carrier-free nano-particles and relieving inflammatory bowel diseases, and the carrier-free nano-particles have huge clinical development prospects.

The invention relates to the technical field of traditional Chinese medicines, and discloses application of an active ingredient of shiny-leaved yellowhorn leaves in preparation of a medicine for treating hyperuricemia. The xanthoceras sorbifolia leaf active ingredients comprise quercitrin, rutin and myricetin; the content of quercitrin is 0.2508 mg / g to 0.6719 mg / g, the content of rutin is 0.6707 mg / g to 1.5831 mg / g, and the content of myricetin is 0.8002 mg / g to 3.4858 mg / g. According to the invention, myricetin, quercitrin and rutin are determined as core effective substances of shiny-leaved yellowhorn leaves for treating hyperuricemia for the first time; the multi-target and multi-channel action mechanism is disclosed; meanwhile, network pharmacological analysis shows that the three components have high connectivity in a network and jointly act on key targets such as XOD, ACE, AKR1B1 and TNF, it is prompted that the three components do not act singly, but play a treatment role through multi-target and multi-channel cooperation, the traditional'single target-single drug 'thinking is changed into a'multi-component-multi-target-multi-channel' system regulation mode, and the treatment effect is improved. A new thought is provided for comprehensive treatment of the hyperuricemia.

The invention discloses myricetin-loaded bone-targeted magnetic composite nanoparticles and a preparation method thereof. The preparation method comprises the following steps: step 1, preparing nanoparticles taking ferroferric oxide as an inner core; step 2, preparing magnetic mesoporous silica nanoparticles with ferroferric oxide as an inner core according to the nanoparticles prepared in the step 1; step 3, performing amination modification treatment on the surfaces of the magnetic mesoporous silica nanoparticles prepared in the step 2 to obtain magnetic mesoporous silica modified nanoparticles; step 4, preparing a ketal thiol-polyethylene glycol-aspartic acid hexapeptide molecule; and step 5, loading myricetin on the magnetic mesoporous silica modified nanoparticles prepared in the step 3, and blocking myricetin by using the ketal thiol-polyethylene glycol-aspartic acid hexapeptide molecules prepared in the step 4 after loading. The invention further discloses application of the compound in image tracing in osteolysis and treatment drugs.

The invention discloses a Pickering emulsion with stable starch-myricetin composite nanoparticles and a preparation method of the Pickering emulsion, and belongs to the technical field of starch modification and emulsion delivery. Starch and myricetin are combined and compounded, a dynamic high-pressure microjet homogenization technology is introduced, the starch-myricetin composite nano-particles capable of stabilizing Pickering emulsion are obtained through a one-step method, and the application limitation that nano-starch is high in hydrophilicity, high in digestibility and the like is effectively solved; the prepared starch-myricetin composite nanoparticles have the characteristics of high stability and slow digestion function; the Pickering emulsion is prepared by further matching with a compound oil phase of coconut oil and cinnamon essential oil, so that the problem of coconut oil solidification can be effectively solved, and the Pickering emulsion has an antibacterial effect.

The invention belongs to the technical field of traditional Chinese medicine extraction, and particularly relates to hovenia dulcis thunb powder with a hangover alleviating effect and a preparation method thereof. Comprising the following steps: (1) mixing hovenia dulcis thunb powder and water to obtain a mixed solution; (2) adding a compound enzyme into the mixed solution for enzymolysis to obtain an enzymatic hydrolysate A; (3) adding laccase into the enzymatic hydrolysate A for enzymolysis to obtain enzymatic hydrolysate B; (4) adding tannase into the enzymatic hydrolysate B for enzymolysis to obtain enzymatic hydrolysate C; (5) adding an alcohol solvent into the enzymatic hydrolysate C for extraction, carrying out solid-liquid separation, and concentrating and drying supernate to obtain hovenia dulcis thunb powder; wherein the compound enzyme comprises cellulase, pectinase and hemicellulose. According to the method, the contents of quercetin, myricetin, dihydromyricetin and spinosin in the hovenia dulcis thunb powder can be remarkably increased.

The application discloses a three-channel fluorescence sensor array based on sulfur quantum dots and a preparation method and detection application thereof. The sensor array is composed of three kinds of sulfur quantum dots, namely C-SQDs, PSS-SQDs and beta-SQDs. When target objects exist, the three kinds of sensing units generate differentiated fluorescence responses, forming a unique "fingerprint map". By using principal component analysis to analyze the response mode, the array can successfully distinguish between structurally similar baicalein, fiscetin, myricetin, quercetin and rutin in a concentration range of 8.0-56 muM. In addition, the array can also perform semi-quantitative analysis on a single flavone compound in a range of 4.0-56 muM, and the first principal component has a good linear relationship with the logarithm of the concentration of the target object.

The invention relates to the technical field of food processing, in particular to a composition for reducing the content of advanced glycosylation end products of food and application of the composition. The invention provides a composition for reducing the content of advanced glycosylation end products of food. The composition is prepared from the following components: myricetin-3-O-rhamnoside, oleuropein and kaempferol. According to the composition, through the synergistic effect of myricetin-3-O-rhamnoside, oleuropein and kaempferol, the content of advanced glycosylation end products in food is remarkably reduced, the composition is suitable for various high-temperature processed food such as baked, fried and barbecue food, the addition amount is low, the sensory quality and the processing technology of the food are not affected, and the composition is suitable for industrial production. And an innovative health solution is provided for the food industry.

The invention discloses an intestinal tract hemostatic composition as well as a preparation method and application thereof, and relates to the field of hemostatic drugs. Wherein the catechin, the hyperoside, the isoquercitrin, the quercetin-3-O-glucuronide, the gallocatechin, the myricetin-3-O-galactoside, the proanthocyanidin B1, the proanthocyanidin B3, the syringe-3-O-glucoside and the astragalus smicus glycoside are flavonoid compounds; nuciferine, higenamine, N-methyl-higenamine and N-trans-feruloyl tyramine are taken as alkaloid compounds, and the compound is selected from the group consisting of higenamine, nuciferine, higenamine The composition has the advantages of simple preparation process, good hemostatic effect and the like, and provides a new raw material choice for the development of intestinal bleeding treatment medicines.

This invention provides the application of glucose-responsive nanohydrogels in the preparation of drugs for treating skin injuries. The method includes the following steps: mixing hyaluronic acid with a phenylboronic acid compound, adding 3-aminophenylboronic acid, 1-ethyl-3-(3-dimethylaminopropyl)carbodiimide hydrochloride and N-hydroxysuccinimide, and performing a grafting reaction to obtain boric acid-modified hyaluronic acid; adding myricetin-3-O-galactoside, phospholipids, and cholesterol to an organic solvent, followed by thin-film hydration and ultrasonic treatment to obtain nanoliposomes; mixing the boric acid-modified hyaluronic acid with a polyvinyl alcohol solution, then adding the nanoliposome solution, and finally mixing to obtain the resulting nanohydrogel. The glucose-responsive nanohydrogel of this invention achieves adaptive drug release in the high glucose environment of diabetic wounds and regulates local metabolic homeostasis of the wound, especially the lysine degradation pathway in amino acid metabolism.

The invention belongs to the field of food, and relates to a new application of myricetin-3-O-galactoside. The invention provides an application of myricetin-3-O-galactoside in preparation of a food for improving urinary tract infection. The invention also provides a food for improving urinary tract infection, and the food comprises myricetin-3-O-galactoside. The myricetin-3-O-galactoside is proved to have the effect of inhibiting the adhesion activity of urinary tract pathogenic escherichia coli for the first time, and the myricetin-3-O-galactoside can be used as an adhesion inhibiting active agent for urinary tract infection pathogen urinary tract pathogenic escherichia coli and can be used for preparing food for effectively improving urinary tract infection.

The invention discloses bifidobacterium adolescentis for producing various active small molecules by fermenting white truffle, promoting collagen synthesis of skin cells and resisting aging, and belongs to the technical field of microorganisms. According to the present invention, the Bifidobacterium adolescentis CCFM1492 obtained through screening can degrade eriodictyol and cyanidin-3-O-glucoside chloride in the white truffle, and can produce a variety of active small molecules such as hesperetin, phloretin, ganoderenic acid D, gallic acid, myricetin and the like through fermentation of the white truffle, such that the active small molecules can be used for degrading the white truffle and the cyanidin-3-O-glucoside chloride in the white truffle; according to the present invention, with the application of the Bifidobacterium adolescentis CCFM1492 fermented white truffle fermentation broth, the promotion effect of the white truffle on the skin cell collagen synthesis and the anti-aging can be improved so as to improve the skin quality, such that the Bifidobacterium adolescentis CCFM1492 fermented white truffle fermentation broth has the huge application prospect in the preparation of the product for preventing or treating the skin quality.

The application discloses a research method of a potential protein target point of Guangxi Yaoshan sweet tea against diabetic nephropathy based on proteomics, relates to the technical field of biological medicine, and solves the problem of lacking research on the target point of the action of Yaoshan sweet tea on the prevention and treatment of diabetic nephropathy from the perspective of proteomics. The method comprises the following steps: determining a characteristic active ingredient, namely myricetin, of Yaoshan sweet tea for intervention on diabetic nephropathy, obtaining a PPI network of network pharmacology of the intersection target point of the characteristic active ingredient of Yaoshan sweet tea and diabetic nephropathy; preparing a myricetin solution, preparing a cell disease model and grouping intervention, collecting and pre-treating a cell protein sample, performing mass spectrometry, pre-processing proteomic mass spectrometry data, screening a potential protein target point, identifying and analyzing an expression change trend of the potential protein target point, and analyzing a core protein target point and a key signal path. The application directly locates the key protein target point of Guangxi Yaoshan sweet tea on diabetic nephropathy from a protein expression level, which is more intuitive and more accurate.

The invention discloses a plant lactobacillus for producing various active small molecules by fermenting truffles and resisting skin cell aging in multiple mechanisms, and belongs to the technical field of microorganisms. The lactobacillus plantarum CCFM1494 obtained by screening can be used for fermenting the white truffle, degrading cyanidin-3-O-glucoside chloride, and generating a plurality of active small molecules such as hesperetin, phloretin, ganoderenic acid D, gallic acid, myricetin, protocatechuic acid and the like; meanwhile, after the white truffle is fermented by the plant lactobacillus CCFM1494, the promotion effect of the white truffle on the synthesis of skin collagen and the improvement effect on cell senescence can be improved. Therefore, the lactobacillus plantarum CCFM1494 has a huge application prospect in preparation of products for improving skin quality.

The invention discloses a cardiospermum halicacabum extract, which is prepared by the following steps: (1) taking cardiospermum halicacabum powder, adding 70-90% ethanol aqueous solution, heating and refluxing for 40-50 minutes under the condition of 65-71 DEG C, and filtering to obtain filtrate and decoction dregs; (2) flushing the medicine residues with a 70-90% ethanol aqueous solution to obtain a flushing solution, combining the flushing solution with the filtrate obtained in the step (1) to obtain a combined filtrate, adding the 70-90% ethanol aqueous solution into the combined filtrate to complement the weight lost due to ethanol volatilization, shaking uniformly, and filtering to obtain a supernatant; and (3) enabling the supernate obtained in the step (2) to pass through a microfiltration membrane with the size of 0.45 mu m. The preparation method of the cardiospermum halicacabum extract is simple, and the content of myricetin, luteolin and apigenin in the cardiospermum halicacabum extract is high. The invention further discloses application of the cardiospermum halicacabum extract in preparation of cosmetics or medicines for relieving light aging damage.

The application provides a high-efficiency and green synthesis method of dihydromyricetin, which takes myricetin and a Pd-PEG2000 catalyst as main raw materials, and finally obtains a dihydromyricetin product with high purity and high content through chemical reduction and hydrogenation reactions.The method is not only simple in operation, but also mild in reaction conditions; meanwhile, the prepared Pd-PEG2000 catalyst can be recycled and recovered easily, and is suitable for industrial production of dihydromyricetin.

The present invention relates to a composition for alleviating skin damage caused by particulate matter (PM), the composition comprising myricetin as an active ingredient. Myricetin, which is an active ingredient of the composition for alleviating skin damage according to the present invention, can effectively reduce oxidative stress caused by PM2.5, endoplasmic reticulum stress and mitochondrial dysfunction, and apoptosis caused by cell exposure to PM2.5. Therefore, the composition comprising myricetin as an active ingredient according to the present invention shows great potential as a therapeutic candidate for treating skin damage caused by PM2.5.

The invention discloses a method for reducing sensitization of beta-lactoglobulin and a hypoallergenic milk product, the hypoallergenic milk product is prepared through interaction reaction of beta-lactoglobulin and a natural anti-allergic active substance, and the natural anti-allergic active substance is myricetin. The method has the beneficial effects that the allergenicity of beta-Lg can be effectively reduced, a theoretical basis is provided for mechanism research of infant food allergy, and a data support is provided for development of functional infant food; the histamine release rate of KU812 and the expression quantity of IL-4, IL-6 and the like can be remarkably reduced, the food anaphylaxis is regulated and controlled on the gene expression level, and a feasible way is provided for achieving the anti-allergic effect to a certain degree.

The invention relates to medical application of myricetin in preparation of a Listeria monocytogenes sortase A inhibitor. A sortase activity inhibition test, a growth curve, a biofilm formation inhibition test, a bacterial internalization analysis test and the like verify that myricetin can effectively inhibit the activity of sortase A under the condition of not inhibiting bacterial growth, and has a certain inhibition effect on the pathogenicity of Listeria monocytogenes. Myricetin is a main chemical component of bark and leaves of myricaceae plant waxberry, belongs to a flavonoid compound, and has multiple effects of diminishing inflammation, resisting oxidation and the like. Therefore, myricetin can provide a new selection thought for prevention and treatment of Listeria monocytogenes infection, and has important significance for development of new drugs.

The invention provides a construction method of the UPLC specific chromatogram of sword bean and preparation thereof, which comprises the following steps: A) dissolving a test raw material with a solvent, and extracting to obtain a to-be-detected solution; b) determining the liquid to be detected by adopting a high performance liquid chromatography to obtain the UPLC characteristic chromatogram of the sword bean and the preparation thereof; chromatographic conditions of the high performance liquid chromatography are as follows: a chromatographic column is a C18 column; a mobile phase A is an acetonitrile solution, a mobile phase B is a 0.1% phosphoric acid aqueous solution, and gradient elution is carried out. According to the method, a high performance liquid chromatography is adopted, an acetonitrile-0. 1% phosphoric acid solution is selected as a mobile phase for gradient elution, quercetin-3-O-glucose-7-O-rhamnoside, myricetin-3-O-galactoside, lysimachin, rutin and isoquercitrin are taken as reference substances, and the UPLC characteristic spectrum method of the sword beans and the preparation thereof is established. And more scientific technical means are provided for controlling the medicinal quality of the sword beans and the preparation thereof.

Stabilized oils including an edible oil and an antioxidant composition comprising α-lipoic acid and least one of ascorbic acid, ascorbyl palmitate, green tea extract, lecithin, and rosemary extract or at least one of 1,2,4-benzenetriol, carnosic acid, dihydromyricetin, dihydrorobinetin, epigallocatechin, gallic acid, 3-hydroxytyrosol, myricetin, and nepodin, and methods of preparing such stabilized edible oils. The stabilized oils may have an Oxidative Stability Index (“OSI”) at 110° C. of at least 30 hours.

A nanomaterial is gold or silver nanoparticle having a nanoparticle surface that consists of one or more of the following extracts from sweet gum leaves: shikimic acid, sweet gum leaf family of Catechins, sweet gum leaf family of Quercetin, Sweroside, Afzelechin, p-Coumaric Acid, Epiafzelechin Trimethyl Ether, Myricetin, Naringenin, Phloretin, Procyanidin B1 and related polyphenols, flavonoids and alkaloids. An antiviral / antibacterial agent includes sweet gum mediated silver nanoparticles having a core size and in a concentration having efficacy as an antiviral / antibacterial exceeding a 3 log 10 reduction in viral titer.

The invention relates to the field of biological medicines, in particular to a nano-drug for treating eye diseases and a preparation method and application thereof. According to the invention, myricetin is wrapped by a polymer PLGA-PEG-HA, so that the prepared nano-drug prolongs the residence time of the drug in eyes, the release cycle and bioavailability of the drug are obviously improved, and the nano-drug has a long-acting protective effect on optic nerve injury and retinal inflammation and is remarkable in curative effect; the hyaluronic acid modified nanoparticles can improve the biocompatibility and inflammation targeting ability of the drug. A suspension obtained after the nano-drug is redissolved can be injected into a vitreous body through a microsyringe, and a long-acting protection or treatment strategy is provided for treatment of optic nerve injury and retinal inflammation.

The invention relates to the technical field of material preparation and separation, and discloses a preparation method and application of a boron affinity adsorbent for separating myricetin in a weak acid environment, a deep eutectic solvent is used as a drive, and a large specific surface area matrix material HOF-101 and a deep eutectic solvent DES are combined to improve the synthesis of a molecularly imprinted polymer MIP. The multi-functionality of the eutectic solvent is exerted, the dominant effect of boric acid groups is combined with the hydrogen-bond effect to construct an imprinting cavity with a high recognition effect, the imprinting cavity is also used as a green pore-foaming agent, and the dependence of the imprinting cavity on an alkaline environment is broken while the high recognition capability of a traditional boric acid material is reserved through a team boric acid affinity effect. The boron affinity molecularly imprinted polymer composite adsorbent provided by the invention is low in cost, reduces the use of toxic chemical solvents, solves the limitation of traditional boron affinity, is beneficial to industrial production and application, and has a wide application prospect in separation and purification of myricetin in fruit juice.

There are described compositions comprising an effective amount of a combination of two or more components, said components selected from acacetin, ACTI peptide, alpha-lipolic acid, alprostadil, anisomycin, apigenin, ascorbic acid, astragalus, berberine, β-lapachone, β-hydroxy-beta-methyl-butyrate, Bacopa monnieri, catechin, catechol, chamomile, chrysin, coumestrol, curcumin, dinitrophenol, dinoprost, ellagic acid, (−)-epigallocatechin gallate, green tea extract, fisetin, genistein, ginsenoside RE, glabridin, 18-α-glycyrrhetinic acid, 18-β-glycyrrhetinic acid, glycyrrhizin, hydroquinone, isoquercitrin (EMIQ), kaempferol, kuromanin, leucine, lithium, luteolin, luteolin, luteolinidin, melatonin, menadione, 1-methylnicotinamide (MNA), methyl salicylate, myricetin, nadide, niacin (vitamin B3), nicotinamide (NAM), nicotinamide mononucleotide (NMN), nicotinamide riboside (NR), nicotinic acid adenine dinucleotide (NaAD), nicotinic acid mononucleotide (NaMN), parsley (Petroselinium crispum), phenylephrine, pokeweed mitogen, 15-Δ prostaglandin J2, puromycin, quercetin, quinolinic acid, retinoic acid, trichostatin A, troxrutin, rutin, tryptophan, vitamin D3, withaferin A, wortmannin and zinc (including salts thereof).

The present invention relates to a polybrominated myricetin derivative and a preparation method and application thereof, belonging to the field of chemical drugs. The polybrominated myricetin derivative is prepared by using myricetin as a raw material and performing bromination modification. The compound is tested for its hypoglycemic activity, and the results show that the compound has strong inhibitory activity against protein tyrosine phosphatase 1B (PTP1B) and α-glucosidase, but weak inhibitory effect on human normal liver cell L-02. The compound can be used in drugs for preventing and treating diabetes, and has the potential to be developed into a hypoglycemic drug.

The invention discloses an anti-atherosclerosis myricetin glycoside and a preparation method and application thereof, and the preparation method comprises the following steps: by taking sucrose as a glycosyl donor and myricetin as a glycosyl receptor, carrying out enzymatic reaction under the catalysis of sucrose phosphorylase, and transferring glucosyl generated by decomposition of the sucrose to C4-site hydroxyl of myricetin to obtain the myricetin glycoside, the sucrose phosphorylase is derived from leuconostoc mesenteroides. According to the method, oriented synthesis of myricetin glucoside can be realized, the product is single and does not have redundant byproducts, and the subsequent separation and purification process is greatly simplified. The myricetin glucoside is prepared through enzymatic catalysis, the reaction can be efficiently carried out under mild conditions, high temperature, high pressure and other harsh processes are not needed, energy consumption and equipment cost are reduced, impurity generation in the reaction process is reduced, and the production cost is reduced from the source.

The invention relates to the technical field of lipid-lowering drugs, in particular to application of myricanol as a lipid-lowering drug, and myricanol is applied to the lipid-lowering drug and comes from diaryl heptane compounds. The diaryl heptane compound is prepared by a method comprising the following steps: S1, drying and crushing waxberry barks for later use; s2, percolating and extracting with an ethanol solution, combining extracting solutions, concentrating with a rotary evaporator, and drying to obtain an extract; s3, dissolving the extract with water, sequentially extracting with petroleum ether and ethyl acetate, centrifuging, and concentrating the ethyl acetate part to obtain extract; s4, carrying out silica gel column fractionation on the ethyl acetate extract, carrying out gradient elution by using a petroleum ether-ethyl acetate mixed solvent, collecting eluted fractions, and enriching to obtain the diaryl heptane compound. Myricanol reduces synthesis of lipid and generation of cholesterol by inhibiting expression of HMGCR and ACC in the liver, and has a lipid-lowering effect. The action mechanism of myricanol for reducing blood fat is unique, and a new scheme is provided for treatment of hyperlipidemia diseases.

This invention discloses a fusion peptide with synergistic anti-allergic effects, an anti-LTB4 monoclonal antibody, and an anti-allergic drug composition thereof. The fusion peptide is composed of peptide A, which inhibits histamine release, and peptide B, which blocks mast cell activation signals, covalently linked by a linker peptide, which can synergistically inhibit mast cell activation. The anti-LTB4 monoclonal antibody can specifically bind to LTB4, blocking its mediated inflammatory response. Combining the fusion peptide, the anti-LTB4 monoclonal antibody, and myricetin, which has antioxidant activity, forms a multi-target drug composition that can synergistically inhibit allergic reactions from multiple aspects, such as inhibiting mast cell degranulation, blocking the action of inflammatory mediators, and clearing oxidative stress products. In vitro cell experiments and OVA-induced allergic asthma mouse models have demonstrated that the anti-allergic effect of this composition is significantly better than that of a single component, and it has no obvious toxicity, providing a new candidate drug for the efficient treatment of allergic diseases.

The invention discloses a method for cooperatively reducing sensitization of beta-lactoglobulin by ultrasound and myricetin, which comprises the following steps: uniformly mixing beta-lactoglobulin with pure water, dissolving myricetin with methanol, mixing the beta-lactoglobulin and the myricetin in proportion, carrying out ultrasonic treatment together, and finally freeze-drying the beta-lactoglobulin-myricetin mixed solution subjected to ultrasonic treatment to obtain the beta-lactoglobulin-myricetin. Therefore, the hypoallergenic beta-lactoglobulin-myricetin powder is obtained, and the allergenicity of beta-lactoglobulin is reduced by more than 40%. According to the method disclosed by the invention, the sensitization of the beta-lactoglobulin can be effectively reduced under the condition that the primary structure of the beta-lactoglobulin is not changed, and the oxidation resistance of the product is improved.