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Method for preparing Tengchasu dispersibletablet and its use

A technology for dispersible tablets and rattan tea, which is applied to medical preparations containing active ingredients, pharmaceutical formulations, organic active ingredients, etc., can solve the problems of poor clinical effect, low water solubility, low oral bioavailability, etc. The solubility of the main drug, the convenience of taking, and the effect of easy oral administration

Inactive Publication Date: 2006-10-25
广西中医学院
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  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

We have used the total flavonoids extract of vine tea to make vine tea capsules for preliminary clinical trials, but found that the water solubility of the total flavonoids of vine tea and its main active ingredients dihydromyricetin and myricetin Small, low oral bioavailability, poor clinical effect; and chewable dispersible tablets have the characteristics of convenient taking, fast absorption, high bioavailability, less adverse reactions, and can be quickly dissolved and dispersed after oral administration, which can overcome the above shortcoming

Method used

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  • Method for preparing Tengchasu dispersibletablet and its use

Examples

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Effect test

Embodiment 1

[0046] Example 1: Preparation of vine tea dispersible tablets for treating or preventing hyperlipidemia and hyperglycemia.

[0047] Take 3000g of processed vine tea, add 12 times the amount of 50% ethanol aqueous solution, reflux extraction for 3 times, filter, combine the extracts, boil, concentrate at pH 6-8 to a volume equivalent to 5 times the amount of medicinal materials, place and crystallize, The crystallization is carried out through ethanol-water recrystallization to obtain the total flavonoid extract of vine tea containing 70-95% of dihydromyricetin and 5-30% of myricetin.

[0048] According to the calculation of preparing 1000 tablets, weigh 230g of the above extract, 75g of microcrystalline cellulose, 48g of cross-linked polyvinylpyrrolidone, 18g of povidone K30, 6g of micropowdered silica gel, 40g of xylitol, 11g of mannitol, and pregelatinized starch 105g, sodium lauryl sulfate 5g, essence 2g. Combine the extract with 90-10% cross-linked polyvinylpyrrolidone, 9...

Embodiment 2

[0052] Example 2: Preparation of vine tea dispersible tablets for treating or preventing thromboembolic cardiovascular and cerebrovascular diseases.

[0053] Take 3000g of processed vine tea, add 8 times the amount of water, decoct twice, combine the extracts, boil, concentrate at pH 6-8 to a volume equivalent to 4 times the amount of medicinal materials, place for crystallization, and crystallize through ethanol-water The recrystallization can obtain the total flavonoid extract of rattan tea containing 5-70% of dihydromyricetin and 30-95% of myricetin.

[0054] According to the calculation of preparing 1000 tablets, weigh 230g of the above extract, 27g of sodium carboxymethyl starch, 28g of low-substituted hydroxypropyl cellulose, 72g of microcrystalline cellulose, 41g of sorbitol, 9g of mannitol, and 17g of povidone K30 , 110g of pregelatinized starch, 6g of micropowdered silica gel, 8g of sodium lauryl sulfate, and 2g of essence. Combine the extract with 90-10% sodium carb...

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Abstract

The present invention relates to a preparation method of tengchasu dispersion tablet and its application. Said tengchasu dispersion tablet can be used for making health-care food and medicine for preventing and curing the diseases of hyperglycemia, hyperlipemia, angiocardiopathy and cerebrovascular diseases. Its main effective component includes dihydromyricetin 5-95% and myricetin 95-5%. Besides, said invention also provides the concrete steps of its preparation method.

Description

technical field [0001] The present invention relates to a kind of health food or pharmaceutical preparation for treating or preventing hyperlipidemia, hyperglycemia and thromboembolic cardiovascular and cerebrovascular diseases made from Chinese herbal medicinal extracts, in particular to a kind of Preparation method and application of chewable dispersible tablet of flavonoid extract. Background technique [0002] The main active ingredients in vine tea are flavonoid alcohols, mainly dihydromyricetin and myricetin. Pharmacodynamic studies have proved that the total flavonoids of vine tea and dihydromyricetin and Myricetin has a significant hypoglycemic effect on four experimental diabetic animal models, and has various biological activities such as hypolipidemic, antithrombotic, antioxidative, and liver protection. Toxicological studies have proved that the total flavonoids of vine tea are very toxic. Small. We have used the total flavonoids extract of vine tea to make vin...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K31/352A61K9/20A61P3/06A61P3/10A61P7/02A61P9/10
Inventor 覃洁萍王乃平陈卫卫蔡毅谭建宁
Owner 广西中医学院
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