The invention relates to a perampanel coated tablet pharmaceutical composition, in particular to a pharmaceutical composition in the form of tablets. The pharmaceutical composition comprises perampanel, an excipient, a disintegrating agent, a binder and a lubricant, wherein the excipient is selected from lactose, sucrose, glucose, corn starch, mannitol, sorbitol, starch, calcium hydrogen phosphate and the like, the disintegrating agent is selected from agar, calcium citrate, dextrin, low-substituted hydroxypropyl cellulose, carboxymethyl cellulose, calcium carboxymethyl cellulose, croscarmellose sodium, carboxymethyl starch, carboxymethyl starch sodium and the like, the binder is selected from polyvinyl alcohol, methyl cellulose, ethyl cellulose, hydroxypropyl methyl cellulose, hydroxy propyl cellulose, sodium carboxymethyl cellulose, polyvinylpyrrolidone, polyethylene glycol and the like, and the lubricant is selected from magnesium stearate, calcium stearate, talcum powder, polyethylene glycol, colloidal silicon dioxide and the like. The invention further relates to a preparation method and application of the composition. The pharmaceutical composition has excellent properties as described in the description.