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1394results about How to "Disintegrates quickly" patented technology

Quick-disintegrating tablet in buccal cavity and manufacturing method thereof

The present invention relates to a quick-disintegrating tablet in the buccal cavity comprising a drug, a diluent, and a saccharide with a relatively lower melting point than the drug and the diluent, which is obtained by uniformly mixing the saccharide with a low melting point in the tablet so that a bridge will be formed between said drug and / or said diluent particles by the product of melting and then solidification of this saccharide with a low melting point. Moreover, the present invention relates to a method of manufacturing a quick-disintegrating tablet in the buccal cavity comprising a drug, a diluent and a saccharide with a relatively lower melting point than the drug and the diluent, which comprises (a) the process whereby tablet starting materials including a drug, a diluent, and a saccharide with a relatively lower melting point than the drug and the diluent are molded under the low pressure necessary for retaining the shape of a tablet, (b) the process whereby the molded product obtained in process (a) is heated to at least the temperature at which this saccharide with a low melting point will melt, and (c) the process whereby the molded product obtained in process (b) is cooled to at least the temperature at which the molten saccharide with a low melting point solidifies. The present invention presents a quick-disintegrating tablet in the buccal cavity that can be used for practical purposes in that it has almost the same properties as conventional oral pharmaceutical tablets, that is, it has sufficient tablet strength that it can be used with automatic unit dosing machines, and it is produced by conventional tableting machines, and a manufacturing method thereof. Moreover, the present invention presents a quick-disintegrating tablet in the buccal cavity which, in comparison to conventional quick-disintegrating tablets in the buccal cavity, has increased tablet strength and an improved friability without prolonging the disintegration time in the buccal cavity, and a manufacturing method thereof.
Owner:ASTELLAS PHARMA INC

Alginate hard capsule disintegrable at different positions in gastrointestinal tract

Disclosed is an alginate hard capsule disintegrable at different positions in gastrointestinal tract. Processing steps include preparing glue solution, glue solution dipping, solidifying, drying, drawing out, cutting, fastening, optical testing and sterilizing of glue solution and capsule filling. The glue solution is prepared by dissolving univalent alginate, plasticizer and pore former in water, wherein the pore former is a polymer film-forming material, glycerin and sorbitol serve as the plasticizer; the solidifying is that dipped gel solution is made into alginate gel capsule by means of ionic cross-linking or acidulating, wherein solidifying solution is multivalent metal ion water solution or acid solution; and finally active ingredients and disintegrating accelerator are filled in hard capsule shells to obtain finished products, wherein the disintegrating accelerator is a substance which can be in precipitation reaction or complexation with multivalent metal ions. The alginate hard capsule is widely applied to different disintegrating environments in the gastrointestinal tract and disintegrable in vivo at different speeds to release the active ingredients and has the advantages of high hydrothermal stability, simple preparation method and low cost.
Owner:南京健辉生物科技有限公司

Method for extracting multiple active nutrient contents from sea cucumber processing liquid and application of method

The invention relates to a method for extracting multiple active nutrient contents from sea cucumber processing liquid. The method comprises the following steps: raw material collection, primary filtration, enzymolysis, rough filtration, ultrafiltration, concentration, secondary rough filtration, desalination, fermentation, centrifugation, secondary enzymolysis, secondary centrifugation, third rough filtration, secondary ultrafiltration, secondary concentration and spray drying. The invention further relates to application of the method in orally disintegrating tablets. Compared with the prior art, the method has the advantages that a prepared sea cucumber extract contains multiple nutrient contents, and the total content of sea cucumber polypeptide, small proteins, sea cucumber mucopolysaccharide and sea cucumber glycosides reaches 80%-90%; in the whole technological process, reaction conditions are mild, no organic solvent is used, nutrient contents are hardly damaged, and molecules of the extracted sea cucumber extract are relatively small; after the sea cucumber extract is fermented by using beneficial bacteria, the nutrient contents in the sea cucumber extract are easily absorbed by human bodies, and almost no peculiar smell exists; furthermore, the technological process is very suitable for the industrial expanded production.
Owner:YINGSHANG TIANHAO FOOD
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