39results about How to "Disintegrates quickly" patented technology

The invention provides a quick-release alfacalcidol soft capsule and a preparation method thereof, and relates to the technical field of pharmaceutical preparations, the preparation raw materials comprise a PLGA microsphere content containing vitamin D3 and a capsule shell liquid containing beta-cyclodextrin, the preparation method of the quick-release alfacalcidol soft capsule comprises the following steps: preparing the capsule content and the capsule shell liquid into the soft capsule by using a full-automatic soft capsule machine, shaping in cold air at the temperature of 20 DEG C and the humidity of 45%, washing pills, drying and packaging to obtain the alfacalcidol soft capsule.

The invention provides anti-scattering water-guided laser cutting fluid as well as a preparation method and application thereof. The anti-scattering water-guided laser cutting fluid comprises the following components in parts by weight: 0.1-1 part of an anti-scattering agent; 0.01 to 0.1 part of a foam discharging agent; 1-5 parts of a refractive index regulator; and 80-99 parts of ultrapure water. The anti-scattering agent is a polymer; the foam removing agent is one or more of hydroxymethyl cellulose, hydroxy propyl cellulose, sodium lignin sulfonate, potassium lignin sulfonate and naphthalene sulfonic acid formaldehyde condensate sodium salt; the refractive index regulator is an iodine-containing compound and / or a fluorine-containing compound. According to the anti-scattering water-guided laser cutting fluid, light beam scattering and energy loss in the water-guided laser cutting process can be remarkably reduced, and the cutting precision and efficiency are improved. The anti-scattering water-guided laser cutting fluid has very good application prospects and large-scale industrial popularization potential in the field of water-guided laser cutting.

The invention provides a pharmaceutical composition containing fenerenone, which comprises the following components in percentage by weight: 1.0%-30.0% of fenerenone, 1.0%-5.0% of hydroxypropyl methylcellulose, 0.1%-1.0% of lauryl sodium sulfate, 5.0%-15.0% of polyvinylpolypyrrolidone and 0.5%-5.0% of sodium stearyl fumarate. The filler is microcrystalline cellulose and lactose monohydrate, a wet granulation process is adopted, the pharmaceutical composition has the characteristics of stable and rapid dissolution and rapid disintegration of the fenerenone, the process is simple, the production steps are simplified, the production efficiency is improved, and the cost is reduced.

The invention relates to a pharmaceutical composition containing vitamin D as well as a preparation method and application of the pharmaceutical composition. The pharmaceutical composition contains the following components: (A) 0.0001-0.5 wt% of vitamin D; (B) an emulsifier; (C) an oil solvent; and (D) 0.1-70 wt% of an adhesive, the emulsifier is selected from at least one of starch sodium octenylsuccinate or beta-cyclodextrin, and the pharmaceutical composition contains 0.001-80 wt% of the emulsifier; the ratio of the use amount of the oil solvent to the use amount of the vitamin D is (1.4-1000): 1. According to the invention, the vitamin D pharmaceutical composition with a wide concentration content range is prepared by selecting proper auxiliary materials and dosage thereof, and the vitamin D pharmaceutical composition has good drug dispersibility and stability and proper disintegration performance.

The invention provides a pramipexole oral soluble film composition as well as a preparation method and application thereof. The invention provides a pramipexole oral soluble film composition. The pramipexole oral soluble film composition comprises an active medicine, a film-forming material, a plasticizer and a flavoring agent, the active drug is a hydrochloride of S-2-amino-4, 5, 6, 7-tetrahydro-6-(propylamino)-benzothiazole as shown in a formula I and / or other pharmaceutically acceptable salt forms of the hydrochloride of S-2-amino-4, 5, 6, 7-tetrahydro-6-(propylamino)-benzothiazole as shown in the formula I. The pramipexole oral soluble film composition has the advantages that the pramipexole oral soluble film composition is thin in thickness, fast in disintegration, free of grit feeling after being dissolved in the oral cavity, capable of improving the taste of a medicine and improving the compliance of a patient, capable of being instantly dissolved in the oral cavity without drinking water, fast in oral absorption speed, uniform in film appearance, high in tensile capacity, good in flexibility and long in service life. Meanwhile, the raw materials are easy to obtain, the process is simple, the operation is simple and convenient, the drug loading capacity is high, the drug content uniformity is good, and the preparation method is suitable for industrial production. # imgabs0 #

The invention provides a brexpiprazole tablet and a preparation method thereof, and belongs to the technical field of medicines. According to the preparation method disclosed by the invention, firstly, the brexpiprazole raw material medicine and the excipient are pretreated, then premixed, and then mixed with other components for total mixing, tabletting and coating, all the components are mixed more uniformly, and meanwhile, the variety of the filler is controlled, so that the brexpiprazole tablet is relatively low in friability, high in dissolution speed of a finished product and short in disintegration time.

This invention discloses a method for producing crop cultivation substrate using sugarcane filter mud and sugarcane pith as main raw materials, comprising the following steps: (1) dissolving and diluting 4,5-dihydro-4,5-dioxo-1H-pyrrolo[2,3-f]quinoline-2,7,9-tricarboxylic acid in water to obtain a solution; (2) mixing sugarcane slurry, sugarcane pith, the 4,5-dihydro-4,5-dioxo-1H-pyrrolo[2,3-f]quinoline-2,7,9-tricarboxylic acid solution, fermentation agent, and improver, adjusting the moisture content, and then composting and fermenting. The compost is turned over every few days and continuously composted and fermented for several days to obtain the crop cultivation substrate. The crop cultivation substrate produced by this invention is of excellent quality, allowing direct planting of plants without root burn. Therefore, this invention, using sugarcane filter mud and sugarcane pith as main raw materials to prepare and produce crop cultivation substrate, can effectively solve the problem of comprehensive utilization of sugarcane filter mud and improve product sales.

The invention discloses a valsartan-silicon dioxide micro-capsule orally disintegrating tablet and a preparation method thereof, and relates to the technical field of medicines. The invention relates to a preparation method of a valsartan-silicon dioxide micro-capsule orally disintegrating tablet. The preparation method comprises the following steps: S11, preparing an aqueous solution of a cationic surface active agent; s12, valsartan is added and stirred, so that the surface of valsartan is positively charged; s13, continuing to add silicon dioxide and stirring to enable a silicon dioxide monomer to be adsorbed on the surface of valsartan; and S14, continuously adding the cationic polymer and carrying out high-speed shearing, so that the cationic polymer is encapsulated on the surface of the silicon dioxide. The valsartan-silicon dioxide micro-capsule orally disintegrating tablet prepared by the invention has a medicine taste masking effect, and the taste masking effect is excellent; meanwhile, the problems of poor compressibility and flowability of materials caused by hygroscopicity and viscosity of valsartan are solved; a sweetening agent and a flavoring agent are not needed in the formula, so that the formula is simplified, impurities are prevented from being introduced into the essence, and the stability is effectively improved.

The invention discloses a levonorgestrel tablet and a preparation method thereof. The levonorgestrel tablet is prepared from the following components: 0.75 part of levonorgestrel, 20 to 30 parts of lactose, 20 to 25 parts of corn starch, 0.8 to 1.0 part of corn starch slurry, 1 to 2 parts of colloidal silicon dioxide, 1 to 2 parts of talcum powder and 1 to 2 parts of magnesium stearate. The colloidal silicon dioxide provided by the invention can cooperate with the corn starch to help the tablet to be disintegrated more quickly in vivo, so that the release rate of the medicine is accelerated. The dissolution rate of the prepared levonorgestrel tablet reaches 65.6%-70.7% in 30 minutes, and the dissolution rate of the prepared levonorgestrel tablet reaches up to 86.0% in 60 minutes.

The invention relates to the technical field of non-uniformly distributed oil and gas reservoir transformation, and particularly discloses a soluble bridge plug for a casing deformation well, which comprises a limiting joint, a connecting pull rod, a rubber sleeve, a slip assembly, a central pipe, a locking ring and an expansion component, and the expansion component comprises a first cone expansion piece and a second cone expansion piece; the first cone expansion piece is arranged on the central pipe in a sleeving mode and located between the rubber sleeve and the slip assembly, one end of the first cone expansion piece is used for limiting the other end of the rubber sleeve, the other end of the first cone expansion piece is used for expanding one end of the slip assembly, and the first cone expansion piece is connected to the other end of the connecting pull rod; the second cone expansion part is used for expanding the other end of the slip assembly, and the locking ring is connected into the second cone expansion part and slidably connected to the connecting pull rod. The soluble bridge plug can achieve effective packing in an ultra-large annular gap after passing through a casing change point, it is guaranteed that the casing change well passing through the casing change point transformation process is smoothly implemented, section loss is reduced, and the reservoir transformation efficiency is improved.

The utility model discloses an environmental simulation device for soft rock mass disintegration rate test, including the box for simulating environment, the box top is equipped with the box cover that can open, and the bottom surface of box cover is fixed with the sprinkling tray to the box, and the sprinkling tray is connected with the water source outside through the pipeline fixed on the box cover, and the rotatable sample stage of containing rock sample is equipped in the box, and the water wave manufacturing mechanism of simulating water wave impact rock mass is still provided in the box. The environmental simulation of the utility model is closer to the actual situation, and the comprehensiveness and accuracy of soft rock mass disintegration rate test are improved.

The invention relates to the field of health food, in particular to a preparation method of milk-derived exosome buccal sugar, which comprises the following steps: mixing milk-derived exosome with a skeleton agent and auxiliary materials to prepare a dispersion solution; and placing the dispersion solution in an environment of-30 DEG C for vacuumizing, and then performing freeze drying according to freeze-drying program setting to obtain the milk-derived exosome buccal sugar. Through the preparation method, the activity of mEV in the product can be maintained to the maximum extent; the use amount of the freeze-drying protective agent is reduced, the mEV biological activity can be maintained, the mEV can be quickly released in the oral cavity, the taste is obviously improved, and the onset time is obviously prolonged.

The present application belongs to the field of pharmaceutical preparation technology, and specifically discloses a lanthanum polystyrene sulfonate tablet and a preparation method thereof. Lanthanum polystyrene sulfonate tablet coating and powder, the powder comprising the following raw materials in parts by weight: 30-50 parts of lanthanum polystyrene sulfonate micropowder, 10-20 parts of filler, 15-25 parts of microcrystalline cellulose, 8-15 parts of hydroxypropyl methylcellulose, 0.1-0.6 parts of flavoring agent, 0.3-0.8 parts of lubricant and 0.5-0.9 parts of vitamin C. The lanthanum polystyrene sulfonate tablets prepared in this application can be dispersed in the oral cavity, and patients with chronic renal failure who have no chewing ability can swallow directly or take it with water, which is convenient for patients to take, so that the lanthanum polystyrene sulfonate micropowder can exert its medicinal effect.

The invention discloses a pharmaceutical composition for treating or preventing ovarian cancer, the pharmaceutical composition comprises a PARP inhibitor, a VEGF inhibitor, an excipient, a disintegrating agent, a lubricant and a latent solvent, various raw materials are combined and mixed through a proper process to obtain the pharmaceutical composition for treating ovarian cancer, the PARP inhibitor and the VEGF inhibitor are matched for pharmaceutical production, the formula is novel, and the pharmaceutical composition is suitable for clinical application. The preparation method is simple, the process is ingenious, the growth of the ovarian tumor is synergistically inhibited through multiple mechanisms by utilizing the matched multi-target effect of various inhibitors, the treatment and inhibition effect on the ovarian tumor is improved, the selection and proportioning of auxiliary materials are adopted, the adverse reaction of the medicine is reduced, the workability of medicine granulation is improved, the production is convenient, and the quality of a finished product is ensured; meanwhile, by adopting an oral tablet mode, the traditional Chinese medicine composition has good oral property, the compliance of a patient is improved, and the traditional Chinese medicine composition has a good application prospect.

The invention relates to the field of composite soft plastic packaging, in particular to a dynamic self-repairing type high-toughness bio-based degradable film and a preparation method and application thereof. The film is composed of a lactic acid high polymer, a copolymer of butylene adipate and butylene terephthalate, a compatibilizer, a nucleating agent, a catalyst, an auxiliary agent and an antibacterial agent, the catalyst is formed by mixing a main catalyst and a co-catalyst, the main catalyst comprises any one of zinc acetylacetonate, ferric acetylacetonate, antimony trioxide and zinc oxide, and the co-catalyst comprises any one of zinc acetylacetonate, ferric acetylacetonate, antimony trioxide and zinc oxide. The cocatalyst is selected from any one of triethylamine, triphenylphosphine and aluminum acetylacetonate. The invention provides an effective scheme for solving the core contradiction that the strength, toughness, repairability and controllable degradability of a bio-based material are difficult to consider at the same time, is expected to replace traditional plastics in the fields of high-end environment-friendly packaging, intelligent agricultural mulching films and the like, and has great environmental benefits and industrialization prospects.

The utility model discloses a device of on -the -spot red sandstone quick determination disintegration coefficient, including test device main part, be equipped with the base on test device main part, install the soaking cylinder and drying cylinder on the base, the utility model through setting up soaking area and drying area, respectively to red sandstone sample carries out soaking and drying treatment, through the lifting rod and the rotating motor drive sample moves between drying cylinder and soaking cylinder, spares the manual operation of operator, through setting up multiple test area, simultaneously, the same condition carries out multiple group disintegration test, and tries to exclude accidental error, in the soaking process, through the magnetic capsule rotation, drive the clear water in the soaking area rotation, utilize the flow to accelerate the disintegration of red sandstone, and the flow speed is limited, not to produce bigger external force, seriously influence red sandstone disintegration rate, in the drying process, through the fan acceleration drying, and remove the loose particle on the sample surface when drying, after drying, through the fan acceleration sample cooling.

The invention discloses a preparation method of a composition containing uridine and application thereof in treating developmental epileptic encephalopathy type 50, belonging to the technical field of pharmaceutical compositions. The preparation method comprises the following steps: preparing a disintegrant, preparing a uridine complex, preparing a tablet core, preparing a coating liquid, and coating; the preparation of the disintegrant comprises the following steps: preparing an aqueous phase, preparing an oil phase, cross-linking, primary modification, and secondary modification; the preparation of the uridine complex comprises the following steps: surface treatment and loading; the preparation of the tablet core comprises uniformly mixing the uridine complex, the disintegrant, hydroxypropyl methylcellulose, and magnesium stearate, and then tabletting to obtain the tablet core; the uridine-containing composition prepared by the invention has small weight difference and high hardness, is not easy to peel off the coating during preparation, storage, and transportation, is not easy to break and deform during preparation and transportation, and has a fast disintegration speed.

An orally disintegrating nicotine tablet for nicotine craving relief is disclosed, the tablet comprising a pressed powder formulation, the tablet being designed to disintegrate within a period of less than 60 seconds upon oral administration, the powder formulation comprising an amount of nicotine, a pH regulating agent, at least one polyol, and a disintegrant, wherein the polyol comprises more than 40% by weight of the tablet, and wherein the pH regulating agent is an alkaline pH regulating agent.

The present invention discloses a retinal filling hydrogel and a preparation method and application thereof, wherein the method comprises the following steps: mixing an arginine-modified amino-containing polymer and a aldehyde-modified polysaccharide for reaction to obtain the retinal filling hydrogel. The raw material source of the hydrogel of the present invention is natural and non-toxic, the hydrogel has good adhesion ability and mechanical strength, the modulus is adjustable at 1 kPa-3 kPa, the modulus of the hydrogel matches the intraocular pressure of the human body, and it has good elasticity and deformation recovery ability, which is beneficial to the patient's postoperative recovery. The degradation cycle of the hydrogel matches the postoperative recovery cycle of retinal surgery patients, it degrades stably and slowly during the recovery cycle, and disintegrates rapidly after recovery, and can be absorbed by the human body, so there is no need to remove it after surgery, thereby reducing the patient's pain. The retinal filling hydrogel of the present invention is used to prepare a cushion for recovery surgery after retinal detachment.

The invention discloses a voglibose tablet which comprises voglibose, a disintegrating agent, magnesium stearate and a coating material, the voglibose content is 5-20%, the disintegrating agent accounts for 5-20% of the mass of the voglibose, the magnesium stearate accounts for 1-5% of the mass of the voglibose, and the coating material accounts for 1-5% of the mass of the voglibose. The dosage of the coating material is 5-20% of the mass of the voglibose; the invention relates to a voglibose tablet processing technology. The voglibose tablet processing technology comprises the following steps: 1, preparing voglibose powder; step 2, drying treatment; step 3, preparing a tablet core; step 4, coating; and step 5, quality inspection. The improved preparation process can also increase the stability of the medicine, reduce the influence of external factors on the release rate of the medicine, ensure that the medicine keeps stable medicine effect release within the period of validity, and improve the life quality of a patient.

The application belongs to the technical field of pharmaceutical preparations, and particularly relates to a compound pharmaceutical preparation based on spray lactose and a preparation method thereof. The compound pharmaceutical preparation comprises the following components in parts by weight: active drug 10-15 parts, spray lactose 27-33 parts, mannitol 30-35 parts, modified microcrystalline cellulose 13-16 parts, disintegrating agent 3-5 parts, lubricant 1-2 parts, and flavoring agent 1-3 parts. The compound pharmaceutical preparation has the characteristics of high hardness, low friability, rapid disintegration, good content uniformity, excellent taste masking effect and good taste.

The invention discloses a dapoxetine hydrochloride tablet pharmaceutical composition and a preparation method thereof, and belongs to the technical field of pharmaceutical preparations. The composition comprises dapoxetine hydrochloride, sodium bicarbonate, a filler, a disintegrating agent and a lubricant. Aiming at the problems of low dissolution rate, poor stability, complex preparation process and the like of dapoxetine hydrochloride tablets in the prior art, sodium bicarbonate is introduced as a key auxiliary material, a raw material pretreatment process is optimized, a traditional adhesive is omitted, and the dissolution rate and the preparation stability are remarkably improved. The preparation method comprises the following steps: pre-drying the filling agent (microcrystalline cellulose) until the water content is less than or equal to 2.0%, sieving sodium bicarbonate with a sieve of more than 100 meshes, mixing the sodium bicarbonate with dapoxetine hydrochloride and the lubricant, directly tabletting, and then coating. The preparation method is simple in process, low in cost and suitable for industrial production, and the obtained tablet is high in dissolution rate and excellent in stability under the conditions of high temperature, high humidity and illumination.

Disclosed is a nicotine disintegrating tablet for rapidly relieving nicotine craving, the tablet comprising nicotine, a disintegrating agent and at least one sugar alcohol wherein the tablet comprises an amount of a dissolution modifier wherein the amount of the dissolution modifier does not exceed 2% by weight of the tablet.

The present application relates to the technical field of traditional Chinese medicine preparation, in particular to a Huangbai eight flavor tablet and a preparation process thereof. The Huangbai eight flavor tablet is a film-coated tablet, comprising a tablet core and a double-layer film coating. The tablet core is composed of Huangbai, Xiangmo, Zhizi, Gancao, Honghua, Baidu, Niudan powder and Huangbai enrichment and re-addition granules. The total mass fraction of the eight medicinal materials is 89.0-97.8 wt%. The Huangbai enrichment and re-addition granules are prepared by adsorbing Huangbai alkaloid enrichment solution on self-supporting porous adsorption granules. The double-layer film coating comprises a carboxymethyl cellulose sodium-glycerol inner layer and a hydroxypropyl methyl cellulose-glycerol outer layer. The present application realizes high-concentration alkaloid enrichment and uniform re-addition through self-supporting porous adsorption technology, solves the contradiction between high loading and formability, realizes moisture-proof barrier and rapid disintegration balance through the double-layer film coating structure, significantly improves the tablet formability, stability and bioavailability, and is suitable for industrialized production of heat-clearing and dampness-drying traditional Chinese medicine.

This invention belongs to the field of functional probiotic screening and application technology, specifically involving a novel strain of *Lactobacillus plantarum* (…). Lactiplantibacillus plantarum The *Lactobacillus plantarum* strain was deposited on January 15, 2026, at the China Center for Type Culture Collection (CCTCC), Wuhan University, Wuhan, China, with accession number CCTCC NO: M202026133. This strain exhibits strong antioxidant capacity, significant inhibitory and flocculating effects against hemolytic streptococci, and can significantly reduce the levels of pro-inflammatory cytokines IL-6 and IL-1β induced by hemolytic streptococci while increasing the level of the anti-inflammatory cytokine IL-22. It has no toxic effects on the body, good safety profile, and can be used to prevent colonic polyps and colon cancer caused by hemolytic streptococci, showing broad application prospects.

The application discloses a paper cup and coffee residue synergic utilization convertible seedling cup and a preparation method thereof, and belongs to the field of solid waste resource utilization. In view of the pain point of traditional paper cup recycling, the application innovatively constructs a whole life cycle function conversion mechanism of "drinks containing-transplanting ventilation-planting degradation". Through the synergy of a special double-effect barrier coating and an external force activation structure, perfect balance between drinks-level barrier and intelligent root guidance during the seedling period can be achieved with only a very low coating amount, which significantly improves resource utilization and reduces material consumption compared with traditional single-function solutions. In combination with a standardized coffee residue substrate, in-situ closed-loop utilization of store solid waste is realized. The scheme provides an efficient carbon reduction solution with ecological benefits and commercial value for the industry.

The invention belongs to the technical field of blasting, and particularly relates to a blasting oxygenation device and method adaptive to a plateau low-oxygen environment, the device aims at solving the problem that explosive blasting reaction is incomplete in the plateau hypoxia environment, the device comprises a charging bag placed in a blasting hole, an oxygenation device, a partition device and a sealing plug, the oxygenation device is provided with a shell and a liner bag, and the liner bag is provided with an opening. The inner container bag stores oxygen, the partition device is composed of an upper cover plate and an annular air bag, the oxygen increasing device and the partition device are arranged between every two vertically adjacent charging bags, the sealing plug is located at the top of the blast hole, and when the charging bags are detonated, generated shock waves can enable the inner container bag of the oxygen increasing device to be broken to release oxygen, and meanwhile the annular air bag of the partition device is pushed to expand to seal the hole wall. According to the device, oxygen release and sealing are triggered by means of explosion energy, oxygen is supplemented for a reaction area at the moment of explosion, oxygen is prevented from overflowing, and the plateau explosion effect can be improved.

The invention discloses a slow-release fertilizer for enhancing crop stress resistance and a preparation method and application thereof. The slow-release fertilizer disclosed by the invention not only has the advantages of improving the nutrient utilization rate and reducing the nutrient loss, but also saves the labor cost while reducing the environmental pollution, and has a remarkable synergistic effect on improving the stress resistance of crops. The product can meet the long-term nutrition and disease and pest resistance requirements of total crops through one-time application, meanwhile, the release efficiency of nutrients is matched with the requirements of the crops, fertilizer supply is stable, soil hardening and salinization are avoided to a great extent through co-application and a synergistic effect, soil microorganism breeding is promoted, the comprehensive fertility of soil is improved, and the yield of the crops is increased. Diseases, weeds and weeds are effectively prevented and treated, the stress resistance of crops is improved, and stable yield, high yield and income increase are ensured.

The invention discloses a degradable material for a digestive tract and a preparation method and application thereof, and the degradable material for the digestive tract provided by the invention comprises the main component of a polymer containing a glycolide component. The polymer containing the glycolide component has good biodegradability and can be gradually degraded in vivo, the digestive tract implantation intervention medical device made of the degradable material has high initial mechanical strength after being placed into the intestinal tract, can be completely disintegrated within one week, has the characteristics of high strength and fast disintegration, and can be used for preparing the digestive tract implantation intervention medical device. Therefore, the risks of intestinal stenosis and obstruction are greatly reduced.