88 results about "Sea cucumber extract" patented technology

The invention relates to a method for extracting multiple active nutrient contents from sea cucumber processing liquid. The method comprises the following steps: raw material collection, primary filtration, enzymolysis, rough filtration, ultrafiltration, concentration, secondary rough filtration, desalination, fermentation, centrifugation, secondary enzymolysis, secondary centrifugation, third rough filtration, secondary ultrafiltration, secondary concentration and spray drying. The invention further relates to application of the method in orally disintegrating tablets. Compared with the prior art, the method has the advantages that a prepared sea cucumber extract contains multiple nutrient contents, and the total content of sea cucumber polypeptide, small proteins, sea cucumber mucopolysaccharide and sea cucumber glycosides reaches 80%-90%; in the whole technological process, reaction conditions are mild, no organic solvent is used, nutrient contents are hardly damaged, and molecules of the extracted sea cucumber extract are relatively small; after the sea cucumber extract is fermented by using beneficial bacteria, the nutrient contents in the sea cucumber extract are easily absorbed by human bodies, and almost no peculiar smell exists; furthermore, the technological process is very suitable for the industrial expanded production.

The present invention relates to food processing, and is especially the nutrient liquid of abalone, sea cucumber and sea chestnut and its production process. The nutrient liquid consists of abalone extracting liquid, sea cucumber extracting liquid and sea chestnut extracting liquid in the ratio of 1 to 0.010-100 to 0.010-100 and the concentrated mixed liquid has a soluble solid matter content of 0.1-10 %. The production process includes crushing fresh abalone, sea cucumber and sea chestnut material, extraction with alcohol, heating via stirring, centrifugation to eliminate dreg, eliminating alcohol, concentration, filtering and other steps. Similarly, single oral liquid of abalone extracting liquid, sea cucumber extracting liquid or sea chestnut extracting liquid may be also produced. The present invention has no damage to the nutrients of abalone, sea cucumber and sea chestnut and is health food capable of raising immunity and strengthening physique.

The invention relates to a Chinese artichoke and puer tea composition for regulating intestines and stomach, strengthening immunity and resisting senility. The composition comprises the following components in part by weight: 40 to 80 parts of Chinese artichoke powder, 20 to 60 parts of puer tea extract, 0 to 60 parts of sea cucumber extract, 0 to 30 parts of chitosan oligosaccharide, and 0 to 30parts of probiotic. By combining four substances, namely Chinese artichoke, puer tea, sea cucumber and the chitosan oligosaccharide with the probiotic, the composition can better multiply beneficial bacteria in the intestines, purify the internal environment of the intestines, strengthen the immunity of organisms and prevent multiple senile diseases, and has special effect of delaying senility. Starting from the improvement of internal environment of human bodies, the composition ensures that the nutrient absorption condition of the intestines of the human bodies is improved by promoting the multiplication of the probiotics, the organisms reach a balance state through auto-regulation, the immunity of the organisms is enhanced, and the aims of regulating intestines and stomach and delayingsenility are fulfilled finally. The used raw materials are all food-grade raw materials, so the composition has high safety without adverse effect, and is a better product for regulating intestines and stomach, strengthening immunity and resisting senility.

The invention discloses a sea cucumber wine and further discloses a method for preparing the sea cucumber wine. The method is implemented according to the following steps: step one, preparing a sea cucumber extraction solution; step two, deodorizing the sea cucumber extracting solution; step three, preparing a traditional Chinese medicine extraction solution, preparing medicinal and edible traditional Chinese medicine which is composed of the fruit of Chinese wolfberry, sealwort, fructus alpiniae oxyphyllae, arillus longan and Chinese Dates according to a certain mass ratio, dissolving the traditional Chinese medicine, and filtering the mixture, wherein filtered leach liquors of all ingredients and a concentrated solution of traditional Chinese medicine filter residues form the traditional Chinese medicine extraction solution; and steps four, subjecting the deodorized extraction solution and the traditional Chinese medicine extraction solution to mixing, blending, settling and ageing to obtain the sea cucumber wine. According to the sea cucumber wine and the method for preparing the same, active ingredients in sea cucumbers are fully used, the active ingredients in the wine, water and ethanol are compounded, blended skillfully, filtered and aged. The sea cucumber wine has the advantages of no fishy odor, good taste, and strong nutrition and health care effect.

The invention discloses a making method of seafood health-care food with the blood pressure reducing function. Sea cucumbers serve as main raw materials, after the sea cucumber are boiled in water and subjected to desalination, and hydrolysate is obtained; boiled liquid obtained by boiling the sea cucumbers in boiling water is subjected to desalination, and desalinated boiled liquid is obtained; the hydrolysate and the desalinated boiled liquid are mixed into a sea cucumber extracting solution; the sea cucumber extracting solution is compounded with other auxiliary materials so that a sea cucumber oral administration stock solution and sea cucumber buccal tablets can be prepared. Compared with the prior art, original active components in the oral administration stock solution and the buccal tablets are reserved to the maximum extent, collagen low in nutritional value is converted into pesticide with blood pressure reducing activity by means of enzymolysis, the raw material utilizing rate is greatly increased, the ACE inhibiting rate of the prepared sea cucumber oral administration solution is 60-65%, the content of active pesticides is 900-1000 micrograms / mL, the polysaccharide content is 900-1000 micrograms / mL, and the prepared sea cucumber buccal tablets contain 18.0-21.0% sea cucumber powder.

The invention relates to a trepang boiling solution and application of products made thereof in cosmetics, washing products and daily necessities. The trepang boiling solution and the products made thereof are at least one of a trepang boiling solution, a trepang water extract, a trepang alcohol extract, a trepang extract obtained through a drying method, a trepang extract obtained through an alcohol precipitation method and a trepang extract obtained through an acetone precipitation method. According to various substances and content differences thereof in different trepang boiling solutions and the products made thereof, cosmetics, washing products and daily necessities with different performances are prepared.

The invention relates to a sea cucumber extract and a preparation method thereof. The sea cucumber extract prepared from sea cucumber infusion as a raw material by precipitation method or drying method has no connective tissues under microscopic examination; has the content of lipids or lipoproteins less than 5% and the content of free amino acids less than 10%; and contains proteins, peptides, glycoproteins, saponins and other trace substances in balancing amount. Before the precipitation or drying process, the sea cucumber infusion can be concentrated and filtered or entrapped according to classification by using ultrafiltration. The inventive method prepares the sea cucumber extract from the waste sea cucumber infusion by precipitation method with ethanol, Chinese liquor or acetone or drying method. The sea cucumber extract has high contents of saponins and low contents of arsenicum (As), mercury (Hg) and chromium (Cr), and the contained proteins and peptides are small molecular weight water-soluble substances which are very suitable for being absorbed by human body.

The invention discloses a sea cucumber extract and a preparation method thereof, which is characterized in that: the sea cucumber extract is obtained by swelling dried sea cucumber in water, washing, crushing, incubating, hydrolyzing with compound enzymes, inactivating enzymes, ultra-filtering, making a natural odor-masking liquid, blending, filling and sterilizing. The preparation method adopts the biological enzymes with special function to extract the active components of sea cucumber, and produces the sea cucumber extract with anticancer activity by the biological enzyme-cleavage modification technique. The sea cucumber extract has remarkable immunomodulating effect and has high tumor-inhibition rate up to 80%.

The invention belongs to the field of nutrition and health care and relates to a preparation with a fatigue relieving function. The preparation consists of a ginseng extract, an American ginseng extract, chicken hydrolyzed protein, cordyceps militaris, a maca extract, eucommia male flower, a saussurea involucrata tissue culture, a sea cucumber extract, herba cistanches, L-arginine, zinc gluconate, vitamin B1, vitamin B2, vitamin B6, taurine, starch, isomaltitol and maltodextrin. The particles are scientific in compatibility, and the traditional Chinese homologous raw materials are combined with the vitamins, minerals and amino acid, so that the preparation can relieve physical and mental fatigue, and also can achieve a health improvement function after being taken for a long time.

The invention relates to the technical field of medicines, in particular to a Holothuria nobilis Selenka saponin compound extracted from Holothuria nobilis Selenka. The invention also provides a preparation method for Holothuria nobilis Selenka saponins and application of the Holothuria nobilis Selenka saponins. The invention has the advantages that a Holothuria nobilis Selenka extract has low cost, strong controllability and stable quality.

The invention discloses a nourishing health-care buccal tablet. The buccal tablet is characterized by comprising the following components in parts by weight: 20 to 30 parts of sea cucumber extract, 24 to 50 parts of cooked rice flour, 2 to 5 parts of honey, 6 to 10 parts of cane sugar, 5 to 9 parts of mannitol, 0.5 to 2 parts of soybean lecithin, 7 to 12 parts sodium alginate, 5 to 9 parts of magnesium stearate, and 0.2 to 0.5 part of peppermint essence. The nourishing health-care buccal tablet has the advantages of convenience in administration, easiness in storage and convenient portability, the bioavailability is remarkably improved compared with a conventional preparation, and a novel and more convenient administration method is provided to treatment and prevention of sub-health.

The invention discloses a sea cucumber extract containing alkaloids active ingredients as well as an extracting method and an application thereof. The sea cucumber extract is extracted by comprising the following steps of: weighing sea cucumber powder, and adding distilled water of 56 DEG C into the sea cucumber powder for stirring; centrifuging a lixivium and discarding sediments; filtering a supernate with a filtering membrane, and ultra-filtering a filtrate through an ultrafiltration membrane; concentrating an external ultrafiltrate through a nanofiltration membrane to obtain an internal nanofiltration concentrated solution; carrying out rotary evaporation and concentrating the concentrated solution again; enabling the concentrated solution to pass through a macroporous resin column; eluting the concentrated solution with distilled water and discarding an elution peak; eluting the concentrated solution with 30% ethanol and adopting the elution peak; and after evaporation and concentration, enabling the elution peak to pass through DA25 anion chromatography, adopting an active ingredient peak and freeze-drying the active ingredient peaks to obtain freeze-dried powder of five alkaloids active ingredients including H1a, H2b, H2c, H2d and H2e. Experiments prove that the sea cucumber extract and an alkaloid compound containing the same have potential uses for treating anemia, immunocom promise, wound and fatigue recovery and chemoradiotherapy-induced immune repairing.

This invention is directed to a composition and method for the buccal delivery of sea cucumber extract. The composition for the buccal delivery of sea cucumber extract comprises a substantially uniform mixture of an effective amount of sea cucumber extract and sugar. In one embodiment of the invention, the sea cucumber extract is approximately 5% to approximately 35% by weight of the sea cucumber tablet formulation. In another embodiment of the invention, the composition for the buccal delivery of sea cucumber tablets comprises a substantially uniform mixture of an effective amount of sea cucumber extract and a sugar and an artificial sweetener. The compression process for the production of the buccal tablets uses lower pressure than conventional tableting pressures. The above dosage units dissolve quickly in the buccal cavity allowing rapid absorption of the sea cucumber tablets through the buccal mucus membrane into the systemic bloodstream.

The invention relates to a product for improving a male sexual function and a preparation method thereof. The product comprises the following components in part by weight: 10 to 20 parts of cordyceps extract, 10 to 20 parts of puncturevine caltrop fruit extract, 20 to 30 parts of grape extract, 5 to 15 parts of watermelon extract, 8 to 15 parts of sea cucumber extract, 5 to 15 parts of integripetal rhodiola herb extract and 10 to 20 parts of epimedium. Compared with the prior art, the invention has the advantages that: the product is studied on the basis of improving a hypothalamus-hypophysis-gonadal axis function by combining the theory of Chinese and western medicines, so that a function of an excitatory conditioning center is enhanced, internal secretion is adjusted, vitality is tonified, a physiological function is improved, immunity is regulated, fatigue and the delayed time of aging are resisted, a gonadal function is enhanced, norepinephrine is resisted, and cavernous bodies are expanded; and the aim of improving the male sexual function effectively, comprehensively and scientifically is fulfilled under the combined action of the multiple links.

The invention provides a sea cucumber extract Western ham and a production method thereof, which can solve the defect that sea cucumber ham does not exist in the prior product. The technical scheme is as follows: the weight percentage of sea cucumber is 2 percent to 20 percent, the weight percentage of livestock meat is 30 percent to 85 percent, the weight percentage of condiment is 5 percent to 20 percent, and the rest is water. While maintaining the original flavor and textural characteristics of the traditional ham, the invention increases the nutritive value of the sea cucumber extract Western ham, so that the sea cucumber extract Western ham has the functional nutritive properties of the sea cucumber and can meet the current requirement of consumers on healthy nutritive diet.

The invention provides a sea cucumber mask and a preparation method thereof, and belongs to the technical field of cosmetics, wherein the raw materials comprise, by weight, 18-25 parts of a sea cucumber extract, 0.1-0.5 part of hyaluronic acid, 0.5-1.2 parts of xanthan gum, 8-12 parts of an aloe extract, 5-8 parts of glycerin, 0.3-0.6 part of vitamin E, 0.3-0.5 part of rose essential oil, 4-6 parts of 1,2-pentanediol, and 50-65 parts of water. According the present invention, the production is simple, the nutrients of sea cucumber are completely utilized, and the obtained mask can smooth and compact skin and supplement moisture and nutrition, and further is non-irritating to the skin.

The invention relates to a compound traditional Chinese medicine formula for treating cardio-cerebral vessel embolism and belongs to the technical field of traditional Chinese medicine formulas.The compound traditional Chinese medicine formula for treating cardio-cerebral vessel embolism comprises, by mass, 4-6 g of tempeh extract, 8-12 g of sea cucumber extract, 4-6 g of hirudo extract, 3-8 g of Urechis unicinctus extract, 3-8 g of Radix Salviae Miltiorrhizae extract, 8-13 g of Radix Astragali extract, 90-110 mg of coenzyme Q10, 180-220 mg of procyanidine, 70-110 mg of sodium selenite, 1800-2200 IU of vitamin A, 28-32 mg of vitamin B2, 25-35 mg of folic acid, 5-7 g of lecithin and 800-1100 mg of carnitine.The compound traditional Chinese medicine formula for treating cardio-cerebral vessel embolism is reasonable in design, good in treating effect by combining traditional Chinese medicines with dietetic invigoration, low in price and free of side effect.

The invention discloses an oral solid preparation for treating hypertension and a preparation method thereof. The oral solid preparation for treating hypertension is composed of the following components: 12-26 parts of active ingredients of traditional Chinese medicine, 4-7 parts of mushroom polysaccharide, soybean peptide 3-5 parts, purple corn extract 2.2-3.5 parts, gallic acid 0.5-0.8 parts, citric acid 0.4-0.6 parts, taurine 0.3-0.5 parts, lutein 0.1-0.3 parts, lycopene 0.1-0.3 parts parts, 0.1-0.2 parts of genistein; the active ingredient of the traditional Chinese medicine is composed of the following components: 3-6 parts of betulin alcohol, 2-3 parts of Sanbai grass extract, 2-3 parts of mulberry leaf baking powder, red 1-3 parts of sea cucumber extract, 1-3 parts of Humulus japonicus extract, 1-3 parts of wax gourd extract, 1-3 parts of weed extract, 1-2 parts of creeper extract. The present invention can enhance immunity, relieve fatigue, invigorate the kidney, invigorate qi, activate blood, inhibit the rise of blood sugar and blood pressure, reduce the burden on the kidney, also have anti-oxidation, maintain vascular permeability and elasticity, effectively prevent and treat high blood pressure, and has a remarkable curative effect. And safe without side effects.

The invention discloses a fermentation culture medium and a culture method for a cordyceps sinensis mycelium. The fermentation culture medium for the cordyceps sinensis mycelium further contains sorbose, sea cucumber extract, radix angelicae sinensis extract and soybean meal on the basis of the traditional culture media. As compared with natural cordyceps sinensis, the fermentation culture mediumand the culture method have the advantages that the contents of cordyceps polysaccharides can be increased by the fermentation culture medium and can reach 7.5% by weight, the content of cordycepic acid can reach 8.0%, and the dry weight of the cordyceps sinensis mycelium can be obviously increased and can reach 25 g / L; indexes of amino acid, adenosine, heavy metal and the like in mycelium powderare superior to indexes of amino acid, adenosine, heavy metal and the like in the natural cordyceps sinensis.

The invention relates to a health food containing sea cucumber extract and earthworm protein powder and a preparation method of the food. The invention relates to the health food and the preparation method of the food. The invention aims to solve the problems that health products in the prior art are added with various traditional Chinese medicine components, wherein the traditional Chinese medicine components are complex, and include beneficial components for human beings and adverse components for human health. The traditional Chinese medicine components can play certain health-care effect of improving certain functions, but long-term consumption of the traditional Chinese medicine components is generally not suitable. The health food consists of the sea cucumber extract and the earthworm protein powder. The preparation method comprises the following steps: 1, preparation of the sea cucumber extract; 2, preparation of the earthworm protein powder; and 3, mixing. The invention can beapplied to the health food containing sea cucumber extract and earthworm protein powder and the preparation method of the food.

The invention discloses a method for increasing extraction yield of dried sea cucumber proteins and polysaccharides. In the method, dried Cucumaria frondosa is used as a representative raw material and is subjected to low temperature soaking, high temperature boiling and high temperature soaking, ginger homogenate is added, and two-stage enzymolysis is used to extract sea cucumber extracts, so as to extract proteins and polysaccharides from sea cucumber. The sea cucumber extracts obtained by the method of the invention contain more than 72% of proteins, more than 16% of polysaccharides, less than 4% of salts, and less than 4% of water, and the obtained sea cucumber extracts have no fishy smell. The yield of sea cucumber extracts of the method is more than 50%, the protein extraction yield is more than 85%, and the polysaccharide extraction yield is more than 90%.

The present invention relates to food and medicine, and is especially stomach strengthening sea cucumber composition comprising effective components and supplementary material. The effective componens are mixture of sea cucumber extract capable of raising immunity, protecting gastric mucosa and inhibiting gastric acid secretion; chitosan as the unique natural basic polysaccharide and capable of protecting gastric mucosa and inhibiting gastric acid secretion; and xylose oligomer with obvious effect of proliferating bifid bacterium and capable of improving microecological intestinal tract environment and loosening the bowels to relieve constipation. The effective components produce synergistic effect, and the composition of the present invention is suitable for being prepared into health food and medicine.

The invention relates to a sea cucumber extract used for skin care cosmetics. Living sea cucumber is made into supernatant and precipitate, the supernatant is used for preparing skin care cosmetics, and the precipitate is used for preparing soaps. The process comprises the following steps of: putting the living sea cucumber into water to be boiled, frozen and naturally thawed in normal temperature; putting the sea cucumber into cold water to be stirred; drying the sea cucumber in the sun, and putting the sea cucumber into a normal-temperature drier for drying; drying small sea cucumber fragments by a vacuum drier, and then sieving after smashing to obtain fine sea cucumber powder; filtering distilled water, putting the sea cucumber powder into heated distilled water to be soaked until thesea cucumber powder becomes pasty; adding a good amount of 75percent ethanol, stirring, dissolving out sea cucumber components and sterilizing at the same time; standing after stirring; after precipitating, obtaining the supernatant used as an addition material of skin care cream; and the precipitate at the lower part of a container is used for making an addition material of the face washing soaps. The sea cucumber extract is directly used as the addition material of the skin care cosmetics, the sea cucumber extract is beneficial to infiltrating and can be fully absorbed by skin, and the sea cucumber extract plays roles of water retention and senility delaying.

The invention discloses a preparation method and application of sea cucumber extract, and belongs to the technical field of sea cucumber processing methods. The sea cucumber extract is prepared from dried beche-de-mer without spike through the processes of rehydration, enzymolysis, dipping and concentration. The process of dipping comprises the following steps: pulping the sea cucumber subjected to enzymolysis, then putting the obtained pulp into an autoclave, adding deionized water according to the condition that the adding ratio of the sea cucumber to the deionized water is (1:2.5)-(1:6), controlling the temperature to be 90-120 DEG C, controlling the pressure to be 0.15-0.25MPa, and carrying out intermittent microwave assisted extraction for 3h, wherein the microwave power is 1000W, the frequency is 8000MHz, and the microwave period frequency is 10s / 5min. The preparation method of the sea cucumber extract, disclosed by the invention, is capable of reducing the loss of nutrients in a foaming process, keeping most of nutritional and functional components in the sea cucumber and removing harmful components, such as heavy metals, in a manufacturing process, so that the nutrients of sea cucumbers are maximized, and high value utilization of low-value sea cucumbers is achieved.

The present invention relates to green tea and sea cucumber extracts, compositions thereof, and methods of treating or preventing a cardiovascular disease, a peripheral vascular disease, or an aneurysm in a subject, the methods comprising administering to the subject an effective amount of a green tea extract, a sea cucumber extract, or a compound derived from a green tea extract or a sea cucumber extract.

The invention provides an application of a sea cucumber extract in preparation of products for treating and preventing neurodegenerative diseases such as senile dementia, and provides a novel active substance which is used for improving the neurodegenerative diseases such as the senile dementia, the sea cucumber extract and the application of the sea cucumber extract can sufficiently improve the neurodegenerative diseases such as the senile dementia without causing any toxic and side effect. The sea cucumber extract and a purification product of the sea cucumber extract can improve the learning and memory ability of a senescence-accelerated mouse SAMP8, can reduce malondialdehyde content in the brain tissue of the mouse SAMP8, and reduce lipid peroxidation. The result shows that the sea cucumber extract has the utilization potential in preparing the products for treating and preventing the neurodegenerative diseases.

The invention discloses a sea cucumber extract production process. According to the process, sea cucumber is mixed and fermented after being subjected to pretreatment, so that beneficial components of sea cucumber can be effectively extracted, macromolecule polysaccharide substances which are not easy to absorb by human bodies can be degraded into components which can be easily absorbed by human bodies, and the process is applicable to healthcare product preparation.

The invention discloses a sea cucumber facial mask and a processing method thereof, and relates to the technical field of cosmetics. The sea cucumber facial mask is mainly prepared from the followingcomponents in parts by weight: 90-105 parts of water, 0.5-4 parts of a sea cucumber extract, 0.5-3 parts of a scutellaria root extract, 0.5-4.5 parts of a glycyrrhiza glabra root extract, 0.5-3.5 parts of an aloe extract, 0.5-3 parts of a chamomilla recutita flower extract, 1-5 parts of glycerinum, 0.1-1 part of carbomer, 0.2-0.4 part of hydroxyethyl cellulose, 0.02-0.15 part of sodium hyaluronate, 0.4-0.6 part of a vitamin E, 0.2-0.6 part of dipotassium glycyrrhizinate, 0.04-0.06 part of triethanolamine, 0.01-0.1 part of lavender oil, 0.05-0.1 part of methyl hydroxybenzoate, and 0.005-0.01 part of methylisothiazolinone. According to the sea cucumber facial mask, through enzymolysis after cell disruption, various nutrient substances contained in sea cucumber are extracted and utilized, thevarious nutrient substances are matched with pure natural Chinese herbal medicine and essences extracted from plants, facial mask liquid is prepared, nutrient components are rich, the moisturizing function is realized, the facial mask liquid is easy to absorb and utilize, the effects of skin protection, deep purification and senescence delaying are achieved more effectively, and the effect of promoting the metabolizing capacity of the skin is achieved.

The invention provides a marine bioactive composition and a pharmaceutical preparation. The marine bioactive composition is prepared from the following components in parts by weight: 10 to 30 parts of oyster extract, 2 to 6 parts of kelp extract, 4 to 8 parts of seaweed extract, 5 to 10 parts of gloiopeltis furcata extract, 10 to 16 parts of hippocampus enzymolysis extract, 10 to 16 parts of sea cucumber extract, 4 to 8 parts of marine sponge extract, 2 to 6 parts of shark extract, and 15 to 25 parts of marine actinomycete fermentation liquor. The pharmaceutical preparation is a capsule, granules, an oral solution, a pill or medicinal granules prepared through mixing the composition, a pharmaceutical carrier and an additive. The composition has high pertinency, a good curative effect, little toxic or side effect, and a good antitumous effect.

The invention discloses a sea cucumber extract for increasing bone mineral density, and belongs to the technical field of health food. The method comprises the following steps: crushing sea cucumbers, carrying out enzymolysis, and carrying out enzyme deactivation, centrifugation, filtration and drying on enzymatic hydrolysate to obtain the sea cucumber extract. The sea cucumber extract with the function of increasing the bone mineral density contains various beneficial components such as sea cucumber polypeptide and sea cucumber polysaccharide, has various action mechanisms, can balance bone metabolism conditions from multiple aspects and promote absorption of substances such as calcium by an organism, and has a synergistic effect. The traditional Chinese medicine composition has the effects of promoting absorption and deposition of mineral elements, inhibiting inflammation in bones, balancing bone metabolism and repairing and promoting bones and bone joints, so that the bone health of a human body is maintained. In addition, after the sea cucumber extract and the calcium ions are compounded, the sea cucumber extract and the calcium ions have a synergistic effect in the aspect of improving the bone mineral density in the rat body.