104 results about "Helicobacter pylori" patented technology

The invention discloses a Pediococcus pentosaceus (Pediococcus pentosaceus, PP) strain, the Pediococcus pentosaceus is preserved in the China General Microbiological Culture Collection Center (CGMCC), and the preservation number is CGMCC No.24884. The Pediococcus pentosaceus has the advantages that the Pediococcus pentosaceus can be used for preparing the Pediococcus pentosaceus; the strain has a good antibacterial effect on helicobacter pylori; the composition is friendly to normal gastric mucosa cells and does not have an inhibition effect; the compound has an obvious inhibiting effect on the growth of gastric cancer and can be used for preventing or treating gastric cancer.

The invention discloses a helicobacter pylori question answering method and system based on retrieval enhancement, and the method comprises the steps: collecting big data related to helicobacter pylori, carrying out the standardization processing of the big data, carrying out the entity recognition and label labeling of the data after the standardization processing, and obtaining an initial data set; performing text embedding processing on the initial data set by utilizing domain self-adaption, and performing vectorization processing on the initial data set after the text embedding processing to obtain a helicobacter pylori knowledge base; an RAG retrieval model is constructed, the RAG retrieval model carries out association matching on the user question and the helicobacter pylori knowledge base, and a plurality of auxiliary knowledge documents related to the user question are obtained; and constructing an RAG generation model, performing professional field fine tuning on the RAG generation model to obtain a helicobacter pylori special disease model, generating a final cue word based on the auxiliary knowledge document, and outputting an answer corresponding to a user question by using the helicobacter pylori special disease model based on the final cue word. According to the invention, accurate answering of helicobacter pylori related medical questions can be realized.

The invention relates to a 14C urea pharmaceutical composition for helicobacter pylori diagnosis and application of the 14C urea pharmaceutical composition. The 14C urea pharmaceutical composition comprises 14C urea, 12C urea, citric acid, malic acid and mannitol. According to the invention, the 12C urea and the 14C urea are added together, so that the radioactivity can be ensured, the stability of the medicine can be improved, and the auto-radiolysis of 14C can be reduced. Besides, citric acid, malic acid and mannitol have a remarkable synergistic effect in the aspect of improving the radioactive activity and radiochemical purity of the composition, the stability of the 14C urea pharmaceutical composition can be improved, meanwhile, the activity of urease generated by helicobacter pylori can be improved, and the detection sensitivity and detection efficiency are further guaranteed.

Disclosed is a composition for eradicating Helicobacter pylori, comprising zastaprazan or a pharmaceutically acceptable salt thereof.

The invention provides a phthalocyanine compound as well as a preparation method and application thereof, and relates to the technical field of medicinal chemistry. The structure of the phthalocyanine compound is A-X-B. In the formula, A is a structure containing phthalocyanine and salts thereof; x is a divalent organic structure which enables A and B to be bonded through a chemical bond; and B contains a first polypeptide structure which specifically binds and / or recognizes urease. The phthalocyanine compound disclosed by the invention combines the effects of a photosensitizer and targeting, and has good targeting and antibacterial activity on helicobacter pylori.

The invention provides a primer combination for detecting helicobacter pylori and application of the primer combination. The primer combination is used for strain identification of the helicobacter pylori and detection of gastric cancer risk sites, antibiotic resistance sites, virulence genotyping and human proton pump inhibitor drug metabolism. On the basis of multiple PCR and targeted high-throughput sequencing technologies, specific targeted amplification primers are designed and mixed, so that the helicobacter pylori identification can be completed, gastric cancer risk sites, antibiotic resistance genes, virulence typing and human proton pump inhibitor drug metabolism genes of the helicobacter pylori can be detected, and finally, the helicobacter pylori can be detected. A quantitative algorithm of approximate concentration of helicobacter pylori is also introduced into the system, so that more sensitive, accurate and comprehensive detection of helicobacter pylori is realized.

The present application relates to the field of biological detection, and in particular, the present application relates to a method for detecting drug-resistant mutations of Helicobacter pylori 23S rRNA gene and application thereof.The present application provides a SHERLOCK primer set for detecting drug-resistant mutations of Helicobacter pylori 23S rRNA gene, and the primer set has good distinguishing ability for different drug-resistant mutations of Helicobacter pylori 23S rRNA gene.In addition, the present application also screens and optimizes the conditions of the SHERLOCK reaction system, and provides a test strip for detecting drug-resistant mutations of Helicobacter pylori 23S rRNA gene, which has good application prospect.

The invention provides a helicobacter pylori fluorescence image fine tuning detection method and device and a readable storage medium thereof, and belongs to the technical field of medical image processing and computer-aided diagnosis. The method aims at solving the problems that in the prior art, the false positive is high due to the fact that only a fluorescence signal is relied on, and a model is poor in generalization for different data environments. The method comprises the following steps: outputting a detection frame of a suspected target from a fluorescence image block through a detection module; determining a target analysis area containing a detection frame and a surrounding tissue area, and inputting the analysis area into a classification module to judge true and false positive; and when the classification result is confirmed to be wrong, only performing fine tuning training on a classifier in the classification module by utilizing target analysis area data corresponding to the error and combining a group of preset representative sample features. According to the method, the false positive rate is remarkably reduced by using surrounding organization information, and the generalization ability and scene adaptability of the model are improved through an efficient fine adjustment mechanism.

Particle structure of a nutrient composition for reducing colonization by Helicobacter pylori, reducing inflammation of the gastric mucosa and promoting the repair of the esophageal barrier, comprising a core layer, a binder layer and an antioxidant layer, wherein the core layer contains a chocolate paprika extract and piperine, the binder layer consists of a honey complex and envelops the core layer so that the structure of the core layer is stabilized, the honey complex is formed by mixing honey and turmeric extract powder and the antioxidant layer contains sea buckthorn powder and envelops the binder layer.

The present application provides a compound comprising a structure shown in formula (I), and the present application also provides use of the compound for selectively inhibiting or preventing growth of Helicobacter pylori, and / or preparing a medicament.

Disclosed is a composition for removing Helicobacter pylori, comprising zastaprazan or a pharmaceutically acceptable salt thereof.

The invention discloses an antibody pair, a reagent and a method for detecting helicobacter pylori, and relates to the field of immunodiagnosis. The antibody pair for detecting the helicobacter pylori comprises the first antibody and the second antibody, and the reagent and the detection method based on the antibody pair can accurately detect the existence of the helicobacter pylori.

The invention relates to an infectious bronchitis subunit vaccine based on a nano-skeleton technology. Specifically, the invention provides a fusion protein which sequentially comprises an infectious bronchitis virus S protein fragment or a mutant thereof, a connecting peptide and helicobacter pylori ferritin from an N terminal to a C terminal, wherein the infectious bronchitis virus S protein fragment is S1 protein, and the amino acid sequence of the S protein fragment is as shown in SEQ ID NO. 2; the mutant of the chicken infectious bronchitis virus S protein fragment is S1-2 protein or S1-3 protein, the amino acid sequence of the S1-2 protein is shown as SEQ ID NO.4, and the amino acid sequence of the S1-3 protein is shown as SEQ ID NO.5. The invention further discloses a preparation method of the chicken infectious bronchitis virus S protein fragment.

The invention relates to the technical field of helicobacter pylori multi-drug-resistant gene detection, and discloses a paper sensor-based helicobacter pylori multi-drug-resistant gene detection and treatment quantitative monitoring kit, which comprises an isothermal amplification module, which comprises a loop-mediated isothermal amplification reaction system and is used for carrying out isothermal amplification on 23S rRNA gene and rdxA gene of helicobacter pylori; the paper sensor module comprises a nitrocellulose membrane, the nitrocellulose membrane comprises a test area and a control area, a biotin labeled probe aiming at 23S rRNA gene and rdxA gene mutant amplification products is fixed in the test area, and a biotin labeled probe aiming at reference gene cgt amplification products is fixed in the control area; and the color development module is used for performing color development and quantitative analysis on the detection result of the paper sensor module. The kit disclosed by the invention can be used for detecting various helicobacter pylori multi-drug-resistant genes, can be used for quantitatively monitoring, and is rapid and convenient to monitor.

The invention relates to the technical field of microorganisms, and particularly discloses a lactobacillus plantarum R202448 and application thereof in resisting helicobacter pylori, the lactobacillus plantarum R202448 is preserved in China General Microbiological Culture Collection Center on June 27, 2025, and the preservation number is CGMCC NO. The lactobacillus plantarum is located in Institute of Microbiology, Chinese Academy of Sciences, No.3, No.1 Yard, West Beichen Road, Chaoyang District, Beijing, has a preservation number of CGMCCNO: 31101, and is classified and named as lactobacillus plantarum R202448. According to the plant lactobacillus R202448 and the metabolite thereof disclosed by the invention, on the basis of inhibiting an H.pylori biological membrane and reducing the activity of the H.pylori, the damage and apoptosis promoting effects of the H.pylori on gastric mucosa epithelial cells can be effectively inhibited, so that the occurrence of the H.pylori is effectively inhibited, and the functions of the gastric mucosa epithelial cells are protected.

The present invention discloses a recombinant antigen protein SecG of Helicobacter pylori and its preparation method and application. The amino acid sequence of the recombinant antigen protein SecG is shown in SEQ ID NO: 1, and the nucleotide sequence of the recombinant antigen protein SecG encoding gene is shown in SEQ ID NO: 2. The present invention obtains a high-purity antigen protein through the steps of plasmid construction, induced expression, affinity chromatography and exchange chromatography purification. The purification process is simple, low in cost, and highly operable. The antigen prepared after purification has high immunogenicity and immune titer and can be used as a genetically engineered subunit vaccine. As an important component protein in the membrane transport protein of Helicobacter pylori, the antigen protein SceG will become one of the most promising candidate antigens in the development of Helicobacter pylori genetically engineered vaccines.

The invention belongs to the technical field of biological medicine, and discloses lactococcus lactis HX9302 for expressing foreign protein and application, the lactococcus lactis HX9302 is preserved in China General Microbiological Culture Collection Center on January 20, 2025, and the preservation number is CGMCC NO.33477. The lactococcus lactis HX9302 is preserved in China General Microbiological Culture Collection Center on January 20, 2025; the lactococcus lactis has good acid resistance and digestive enzyme tolerance, can be used as an oral delivery live carrier of helicobacter pylori vaccines, and promotes research, development and application of oral vaccines.

This invention relates to the field of biomedical technology, specifically to a subspecies of Bifidobacterium animalis B189 and its applications. The classification name of this strain is... Bifidobacterium animalum subsp . animal The accession number is CGMCC No. 37052. Bifidobacterium animalis B189 not only exhibits significant antibacterial effects against Helicobacter pylori, but also possesses extremely strong acid and bile resistance, making it valuable for the development of microbial agents to inhibit Helicobacter pylori.

Provided in the present invention are a detection reagent for detecting coccoid forms and spiral forms of Helicobacter pylori under a gastroscope and the use thereof, which belong to the technical field of biomedicine. A detection reagent for detecting coccoid forms of Helicobacter pylori, which takes anthocyanin as a pH value indicator, and further comprises hydrogen peroxide. Given that the coccoid forms of Helicobacter pylori have catalase activity, the pH value is increased by means of acting on the substrate hydrogen peroxide, and then the distribution of the coccoid forms of Helicobacter pylori on gastric mucosa is displayed on the basis of a change in color of the anthocyanin.

The invention discloses compound plant essential oil for eradicating helicobacter pylori and a preparation method thereof, and belongs to the technical field of traditional Chinese medicines. The plant essential oil comprises an active component and base oil, wherein the content of the active component is 15-20wt%; the active ingredients comprise the following components in parts by weight: 2-4 parts of sandalwood essential oil, 2-3 parts of patchouli oil, 1-3 parts of frankincense essential oil, 2-3 parts of ginger essential oil, 1-1.5 parts of liquorice essential oil, 2-3 parts of thyme essential oil and 1-2 parts of rhizoma bletillae essential oil. The compound plant essential oil provided by the invention can eradicate helicobacter pylori, and has the advantages of quick response, good curative effect and convenience in use.

The preparation method comprises the following steps: respectively preparing a plant active extract and a zinc carnosine homogeneous solution; adding a plant active extract into the zinc carnosine homogeneous solution, adding a buffering agent and a coupling agent to obtain an external phase solution, dropwise adding the external phase solution into the internal phase solution, and cross-linking to form gas-producing coagulation beads; the preparation method comprises the following steps: placing aerogenic beads at an ambient temperature of-40 DEG C, carrying out pre-freezing for 3-4 h, carrying out vacuum heating to-10 DEG C, drying for 24 h to obtain aerogel particles, spraying freeze-dried Ackermania muciniphila on an enteric-coated film to obtain enteric-coated pellets, and mixing the enteric-coated pellets and the aerogel particles to obtain the composition with the functions of nourishing the stomach and resisting the helicobacter pylori. The problems that the composition cannot be delivered at a fixed point and the activity is attenuated are solved.

1. The name of this design product: Tartar Detection Kit. 2. Purpose of the product of this design: Used for in vitro qualitative and quantitative detection of Helicobacter pylori in human dental plaque. 3. The key design point of this design product lies in the combination of shape and pattern. 4. The picture or photo that best illustrates the design points: Stereoscopic drawing 1.

The invention relates to a pharmaceutical composition for efficiently eradicating helicobacter pylori, which is prepared from the following components in parts by weight: 830 to 1150 parts of chicken yolk immunoglobulin, 230 to 360 parts of whey protein, 230 to 360 parts of barley seedling extract, 8 to 100 parts of probiotics, 30 to 700 parts of amino acid, 50 to 100 parts of turmeric extract and a pharmaceutically acceptable carrier, the viable count of the probiotics in unit dose of the composition is greater than or equal to 1 * 10 < 8 > CFU / g. The traditional Chinese medicine composition can effectively eradicate helicobacter pylori, remarkably improve gastrointestinal functions, remarkably reduce secondary infection of helicobacter pylori on subjects and remarkably reduce the recurrence rate, and has the advantages of being safe, effective, free of side effects and the like.

This application relates to the field of biological fermentation technology, and specifically discloses a probiotic composition and a preparation method thereof. The probiotic composition provided by this application comprises the following components in parts by weight: Bifidobacterium longum 5 - 15 parts, Saccharopolyspora sp. 3 - 10 parts, longan seed powder 5 - 15 parts, and small molecule peptides 2 - 6 parts; further, the probiotic composition comprises the following components in parts by weight: Bifidobacterium longum 5 - 15 parts, Saccharopolyspora sp. 2 - 4 parts, longan seed powder 8 - 13 parts, and small molecule peptides 2 - 6 parts. The probiotic composition provided by this application can effectively inhibit the growth of Helicobacter pylori and improve gastrointestinal discomfort.

1. The name of the product of this design: Helicobacter pylori test strips (3). 2. Purpose of this design product: used for detecting Helicobacter pylori. 3. The key point of the design of this product lies in its shape. 4. The picture or photo that best illustrates the key points of the design: Design 1 3D drawing. 5. Designate Design 1 as the base design.

The present application relates to a fusion protein and its application in detection of Helicobacter pylori CagA antibody, and belongs to the technical field of biology.The present application provides a fusion protein, wherein the fusion protein comprises a polypeptide with an amino acid sequence as shown in SEQ ID NO.1, or a derivative polypeptide with more than 80% homology with the amino acid sequence as shown in SEQ ID NO.1 and capable of being specifically combined with Helicobacter pylori CagA antibody; the fusion protein is capable of being specifically combined with Helicobacter pylori CagA antibody, and has a very high application prospect in detection of Helicobacter pylori CagA antibody.

1. The name of the design product: Helicobacter pylori tester. 2. The use of the design product: for detecting Helicobacter pylori. 3. The design points of the design product: in shape. 4. The picture or photo that best shows the design points: perspective view.

The application discloses application of selenized chitosan CS-Se in preparation of a drug for increasing gastric residence time of Bi-MOF, and simultaneously discloses a selenized chitosan functionalized bismuth-based metal compound, belonging to the technical field of Helicobacter pylori treatment, and the compound is Bi-MOF@CS-Se; the application synthesizes a bismuth-based metal framework Bi-MOF and selenized chitosan CS-Se respectively, and prepares a Bi-MOF solution with a concentration of 2 mg / mL; then, Se-CS is added into a 1% glacial acetic acid solution, and is ultrasonically dissolved until completely dissolved; then, the above solution is added into the Bi-MOF solution prepared in step 1), and is ultrasonically dispersed for 30 min; the solution is centrifuged and washed with ultrapure water for three times, and is freeze-dried to obtain Bi-MOF@CS-Se.

This invention belongs to the field of biodetection technology, specifically disclosing a primer-probe composition and kit for detecting drug-resistant gene mutations in Helicobacter pylori. The composition comprises two sets of primers and probes, using the probe melting curve method as its principle. The composition and universal PCR reagents are used to detect multiple drug resistance mutations in the quinolone resistance gene gyrA and the clarithromycin resistance gene 23S rRNA of Helicobacter pylori in biological samples. This overcomes the limitation of existing methods that only detect single mutation sites in a single tube for Helicobacter pylori drug resistance genes, providing a new, rapid, and efficient method for detecting Helicobacter pylori drug resistance genes.