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In cellular biology, membrane transport refers to the collection of mechanisms that regulate the passage of solutes such as ions and small molecules through biological membranes, which are lipid bilayers that contain proteins embedded in them. The regulation of passage through the membrane is due to selective membrane permeability - a characteristic of biological membranes which allows them to separate substances of distinct chemical nature. In other words, they can be permeable to certain substances but not to others.
Light-driven molecular machine and its application in transmembrane delivery of trivalent metal drugs
This invention discloses a light-driven molecular machine and its application in transmembrane delivery of trivalent metal drugs. The molecular machine features a light-driven molecular motor based on a tetrasubstituted crowded olefin, which consists of a core unit, a polyethylene glycol chain, and trivalent metal ion coordinating groups. This invention utilizes the directional rotational motion of the molecular motor under light irradiation, embedding it into a phospholipid bilayer membrane, and achieving light-controlled transmembrane transport of trivalent metal ions through a "bind-release" mechanism. This molecular machine can selectively complex trivalent metal ions (such as Bi...) 3+ Ga 3+ Ce 3+ (etc.), and accelerates ion transmembrane transport under light-driven conditions, thereby disrupting the intracellular and extracellular ion balance of bacteria. Experiments have shown that this system has significant light-controlled antibacterial activity against Staphylococcus aureus. This invention has advantages such as controllable structure, precise spatiotemporal targeting, and ease of derivatization, and has promising applications in antibacterial therapy and biomedicine.
Owner:TSINGHUA SHENZHEN INTERNATIONAL GRADUATE SCHOOL