13 results about "Membrane transport" patented technology

The application discloses a single-particle layer metal organic framework mixed matrix nanometer porous membrane and a preparation method thereof, and belongs to the field of functional materials and membrane separation technology. The preparation method comprises the following steps: firstly, synthesizing MOF nanoparticles; then, self-assembling the MOF particles and polystyrene balls on the water surface; after treatment, obtaining a MOF single-particle layer; finally, adding a proper amount of a polymer binder to fill the gaps between the MOF particles, so that a single-particle layer MOF mixed matrix nanometer porous membrane is obtained. The single-particle layer MOF mixed matrix nanometer porous membrane prepared by the preparation method is composed of a single-particle layer, has an ultrathin thickness and high strength, and the transmembrane transport of substances in the membrane only needs to pass through a single MOF particle, so that the nanometer porous structure of the MOF particle can be used to the maximum extent, the negative influence of polymer blockage and grain boundary between particles on the substance transport of the nanometer porous membrane is avoided, and the single-particle layer MOF mixed matrix nanometer porous membrane has high selectivity and high permeability.

This invention provides the preparation and application of a class of artificial peptide transporters for promoting transmembrane delivery of peptide drugs. The general structural formula is as follows: The compound involved in this invention consists of three parts: (1) a diamide structure as an anion-binding unit, which binds to the carboxyl anion of the peptide molecule; (2) a crown ether as a cation-binding unit, which binds to the amino cation of the peptide molecule; and (3) a hydrophobic side chain: connecting the anion-binding unit and the cation-binding unit, so that the whole molecule can act as molecular tweezers to form a stable complex with the peptide drug and encapsulate it in a hydrophobic environment to promote its transmembrane transport. The compound obtained in this application has inexpensive raw materials, is easy to synthesize, and significantly improves the bioavailability of peptide drugs. It has shown significant synergistic anticancer activity in both in vitro and in vivo experiments, and therefore has great potential as a pharmaceutical excipient.

Nonaqueous redox flow batteries are one economically promising solution for meeting grid-scale energy storage needs at discharge durations of 10 h or more. However, membrane transport properties in nonaqueous systems are not as well understood as in water. Solvent-specific effects complicate efforts to understand transport in nonaqueous. In one aspect, the disclosure relates to blended cross-linked membranes compositions, methods of making same, and devices, products, and systems comprising same. In one aspect, the disclosed blended cross-linked membranes compositions comprise a cross-linked first polymer and a second polymer. The disclosed blends have desired permeabilities for selected cations and rejected undesired materials from the redox reaction mixture. This abstract is intended as a scanning tool for purposes of searching in the particular art and is not intended to be limiting of the present disclosure.

According to the present invention, in the prior art, staphylococcus aureus infection and antibiotic resistance (AMR) are two important factors threatening public health, such that persistent pain and even death may be caused, and the common health can be threatened by the staphylococcus aureus infection and the antibiotic resistance (AMR), such that the common health can be threatened by the staphylococcus aureus infection and the antibiotic resistance (AMR), and the common health can be threatened by the staphylococcus aureus infection and the antibiotic resistance (AMR); therefore, it is urgent to develop alternative antibacterial materials. In the invention, a biocompatible nano system (ZIF-67 HS) based on a hollow spherical zeolite imidazate skeleton is successfully developed, and the biocompatible nano system has a remarkable bactericidal effect on gram-positive staphylococcus aureus in vitro and in vivo. Importantly, the research result shows that S. aureus does not generate secondary drug resistance like traditional antibiotics when being exposed to ZIF-67 HS with sub-minimum inhibitory concentration for a long time; on the contrary, it maintains continuous sensitivity to antibiotic resistant strains. Multi-omics analysis (including transcriptomics, metabonomics and metallomics) is combined with bioassays to prove that ZIF-67 HS destroys a plurality of necessary pathways in S.aures, including amino acid metabolism, iron metabolism, membrane transport, ROS and S.aures infection pathways. According to the invention, a new insight is provided for the potential of nano biological medicines in the aspect of removing bacteria, and a related molecular mechanism is clarified.

The invention provides application of esketamine in preparation of hyperalgesia drugs, and relates to the technical field of clinical medicine. Clinical tests and animal experiments are combined, it is systematically proved that sub-anesthetic dose esketamine can effectively relieve diabetic hyperalgesia, and a novel molecular action mechanism of esketamine is disclosed. Preliminary tests and animal experiments show that the scheme can significantly improve the mechanical pain threshold and reduce the pain score, and the effect is exact. In mechanism, it is clarified for the first time that esketamine regulates and controls downstream PI3K / Akt / GSK-3beta signal channels by inhibiting excessive activation of an NMDA receptor, and abnormal expression and membrane transport of a GLuR1 receptor are reduced, so that central sensitization is reversed. The scheme has the advantages of quick response, no opioid drug dependence, clear mechanism and the like, provides a new safe, effective and clear-target analgesic strategy for clinical treatment of diabetes-related neuropathic pain, and has good transformation and application prospects.

The utility model provides a film cutting and transporting device, wherein the film cutting and transporting device comprises an adhesive film adsorption turntable, an adhesive film transverse cutting mechanism and an adhesive film transporting platform, the adhesive film adsorption turntable is provided with an adhesive film adsorption rotating column with a polygonal cross section, the adhesive film transverse cutting mechanism is provided with a first cutting knife, and the adhesive film transporting platform is provided with a second cutting knife. The first cutting knife can cut off the adhesive film corresponding to the gap position between the two adjacent adsorption faces of the adhesive film adsorption rotating column, and the adhesive film conveying platform is located below the adhesive film adsorption rotating column so as to bear and convey the adhesive film section released by the adsorption face, located on the lower side, of the adhesive film adsorption rotating column. According to the utility model, the phenomenon that the rotary adhesive tape pasting mechanism in the prior art is directly adhered to the surface of the battery piece after the adhesive film section is prepared, so that the battery piece is damaged due to stress concentration can be avoided, the bunching qualification rate of the battery piece is improved, and the quality and the performance of the battery piece are further improved.

The application discloses a coating composition, a coating material and an anti-fouling coating, and the coating composition comprises: pentaerythritol tetra-3-mercapto propionate (PETMP), hexamethylene diisocyanate (HDI), an indole derivative containing a carbon-carbon double bond and an initiator. The indole derivative containing the carbon-carbon double bond is a Friedel-Crafts alkylation product of N-hydroxymethyl acrylamide and the indole derivative. The anti-fouling coating obtained after curing of the coating composition provided by the application has excellent mechanical properties, high anti-biofouling adhesion and strong adhesion between the coating and a substrate. The indole derivative can act on transmembrane transport of calcium ions in cells, trigger Ca 2+ efflux in the intracellular environment, destroy the homeostasis of Ca 2+ in the cells, and have an adverse effect on the growth and development of the cells, thereby inhibiting the adhesion and growth and reproduction of biofouling organisms such as microalgae.

The invention discloses a modified sulfonated polyethersulfone membrane as well as a preparation method and application thereof, and the preparation method of the membrane comprises the following steps: preparing a membrane from a sulfonated polyethersulfone solution by adopting a tape casting method, drying, immersing the formed membrane into an acrylic acid solution, initiating a grafting reaction by ultraviolet light, and then washing and drying to obtain the modified sulfonated polyethersulfone membrane. The carboxyl is grafted to the surface of the membrane through ultraviolet initiation, so that the physical and chemical properties such as hydrophilicity and hydroxyl conductivity of the membrane are remarkably improved, and efficient transmembrane transportation of carriers is realized.

The invention discloses an electronic tomato hydroponic device and a cultivation method thereof, and relates to the field of hydroponic cultivation. The control module obtains a preset reference parameter and outputs a control instruction; the direct-current stabilized power supply outputs low-voltage direct current according to the control instruction; the electrode module forms an electric field at the root system of the tomato plant according to the low-voltage direct current and penetrates through a root system-stem pathway to activate a cell membrane ion channel, so that the permeability of a cell membrane of the root system is changed based on electrical stimulation, and transmembrane transportation of anions and cations in a nutrient solution is promoted; the control module also compares the acquired data with a preset reference parameter and outputs an adjustment instruction; the circulation module drives the nutrient solution in the water culture container to flow according to the circulation triggering instruction. The absorption efficiency of the tomato root system on the nutrient solution can be improved, so that efficient and accurate regulation and control of water culture are realized.

This invention discloses a light-driven molecular machine and its application in transmembrane delivery of trivalent metal drugs. The molecular machine features a light-driven molecular motor based on a tetrasubstituted crowded olefin, which consists of a core unit, a polyethylene glycol chain, and trivalent metal ion coordinating groups. This invention utilizes the directional rotational motion of the molecular motor under light irradiation, embedding it into a phospholipid bilayer membrane, and achieving light-controlled transmembrane transport of trivalent metal ions through a "bind-release" mechanism. This molecular machine can selectively complex trivalent metal ions (such as Bi...) 3+ Ga 3+ Ce 3+ (etc.), and accelerates ion transmembrane transport under light-driven conditions, thereby disrupting the intracellular and extracellular ion balance of bacteria. Experiments have shown that this system has significant light-controlled antibacterial activity against Staphylococcus aureus. This invention has advantages such as controllable structure, precise spatiotemporal targeting, and ease of derivatization, and has promising applications in antibacterial therapy and biomedicine.

Disclosed herein are methods of delivering biomolecules to the cytosol of a cell using a substituted tertiary amine (STA) moiety.

The invention discloses an efficient synthesis method of corynebacterium glutamicum gamma-aminobutyric acid based on membrane transport engineering, and belongs to the technical field of genetic engineering. GABA transporters are screened, firstly, a transporter library is constructed, a series of effective GABA transporters which are genes cg2139, cg2568, cg2339, cg11006 and cg1281 are obtained through screening of a flow cytometry, the transporters obtained through screening are integrated to a genome for fermentation verification, so that corynebacterium glutamicum can produce GABA more efficiently, and the GABA production efficiency is improved. And compared with a control strain FF10, the yield reaches 10.73 g / L and is improved by 34%.

The invention belongs to the technical field of bioengineering, and relates to a recombinant engineering bacterium and application thereof in preparation of mannitol, and the recombinant engineering bacterium is a plasmid-free strain for producing a cofactor NAD < + > by using cheap xylose and nicotinamide. The following genes are knocked out from the strain: a gene ptsG for coding protein EIICBGlc in a glucose PTS system, mtlA for coding EIICA protein in D-mannitol transmembrane transport, a D-mannitol 1-phosphate dehydrogenase gene mtlD in a D-mannitol utilization path, purine de novo synthesis regulation protein purR, and srlAE in a sorbitol utilization gene cluster. The following genes are integrated in a genome of the strain: glucose transport assisting protein glf, glucokinase glcK, xylose utilization gene cluster xylose isomerase xlyA and xylulose phosphorylase xlyB, phosphoribose pyrophosphate synthetase prs, polyphosphate kinase ppk2, nicotinamide phosphoribose transferase nadV and nicotinamide mononucleotide adenylate transferase nadM. The strain is fermented by using glucose and xylose, and provides chassis bacteria for reaction needing cofactor circulation.