Method for preparing nano magnetic microballoons and anticancer oral preparation prepared using the method

A nano-magnetic and oral preparation technology, which is applied in the direction of antineoplastic drugs, pharmaceutical formulations, organic active ingredients, etc., can solve the problems that the active ingredients cannot be reached quickly, the drug bioavailability is low, and the side effects are large, so as to achieve good biodegradability and Biocompatibility, improving drug bioavailability, and reducing toxic and side effects

Inactive Publication Date: 2009-06-24
黄云清
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0006] Various oral preparations of Chinese herbal medicines prepared by the currently marketed and disclosed technologies for the treatment or adjuvant treatment of various common cancers generally have the following disadvantages: 1. The active ingredients of the medicine cannot quickly reach the designated lesion target of the human body , the drug release is subject to non-selective clearance by the reticuloendothelial system (RES), and the drug is digested and absorbed in the human body while affecting normal healthy tissue cells, especially the side effects on the liver, spleen, kidney, etc. very big
2. The drug is metabolized and degraded by the enzyme system in the severe environment of the digestive tract. At the same time, it is difficult for the macromolecule (active ingredient) of the drug to penetrate the cell membrane and enter the cell to be fully absorbed, and the bioavailability of the drug is very low.

Method used

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  • Method for preparing nano magnetic microballoons and anticancer oral preparation prepared using the method
  • Method for preparing nano magnetic microballoons and anticancer oral preparation prepared using the method
  • Method for preparing nano magnetic microballoons and anticancer oral preparation prepared using the method

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Embodiment approach 1

[0022] Making a novel nano-magnetic microsphere comprises the following steps:

[0023] a. Material preparation: prepare carrier materials, framework materials, drugs and solvents, wherein the carrier materials are nano-magnetic biomaterials, that is, Fe with a particle diameter between 2 and 20 nm 3 o 4 Powder, the skeleton material is β-cyclodextrin, the drug is a hydrophilic modern Chinese medicine compound, and the solvent used is water with a Ph value of 6-7. The weight ratio of carrier material, framework material, drug and solvent is: 0.001-0.01:1:1:1-2.

[0024] b. Preparation: Add β-cyclodextrin and drug into a variable-speed food mixer, stir at a constant speed of 50-200 rpm for 5-15 minutes, and then add Fe 3 o 4After the powder is stirred at a constant speed for 30-90 minutes, change to 50-500 rpm for stirring, and continuously and slowly inject water until the slurry is formed, take it out and pour it into the supramolecular encapsulation compounding machine, s...

Embodiment approach 2

[0028] Making a novel nano-magnetic microsphere comprises the following steps:

[0029] a. Material preparation: prepare carrier materials, framework materials, drugs and solvents, wherein the carrier materials are nano-magnetic biomaterials, that is, Fe with a particle diameter between 2 and 20 nm 3 o 4 In the powder, the frame material is beta-cyclodextrin, the medicine is a hydrophobic alcohol-soluble natural medicine compound, and the used solvent is 50-95% ethanol. The weight ratio of carrier material, framework material, drug and solvent is: 0.001-0.01:1:1:1-2.

[0030] b. Preparation: Add β-cyclodextrin and drug into a variable-speed food mixer, stir at a constant speed of 50-200 rpm for 5-15 minutes, and then add Fe 3 o 4 After the powder is stirred at a constant speed for 30-90 minutes, change to 50-500 rpm for stirring, and continuously and slowly inject 50-95% ethanol until the slurry is formed, take it out and pour it into the supramolecular encapsulation compou...

Embodiment approach 3

[0034] Making a novel nano-magnetic microsphere comprises the following steps:

[0035] a. Material preparation: prepare carrier materials, framework materials, drugs and solvents, wherein the carrier materials are nano-magnetic biomaterials, that is, Fe with a particle diameter between 2 and 20 nm 3 o 4 Powder, the skeleton material is β-cyclodextrin, the drug is oil phase and fat-soluble drug or drug combination, and the solvent is water with a Ph value of 6-7. The weight ratio of carrier material, framework material, drug and solvent is: 0.001-0.01:1:1:2-3.

[0036] b. Preparation: Add β-cyclodextrin and drug into a variable-speed food mixer, stir at a constant speed of 50-200 rpm for 5-15 minutes, and then add Fe 3 o 4 After the powder is stirred at a constant speed for 30-90 minutes, change to 50-500 rpm for stirring, and continuously and slowly inject water until the slurry is formed, take it out and pour it into the supramolecular encapsulation compounding machine, s...

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Abstract

The invention discloses a method for preparing nanometer magnetic microspheres and an anticancer oral preparation prepared by utilizing the method. The method comprises the process steps of: a, material preparation, in which a carrier material, a framework material, a drug and a solvent are prepared; b, the preparation; c, the stability and drying; and d, the crushing and preparation and so on. The method takes beta-cyclodextrin as the framework material and includes the carrier material (a nanometer magnetic biomaterial) and drug combination and so on. The drug-loaded nanometer magnetic microspheres can quickly reach appointed focus target positions, penetrate target cell membranes to enter cells, realize the trans-membrane transport of target macromolecules, achieve the effects of targeted release and slow / controlled release, improve the drug concentration in target cells, and inhibit the gene expression and amplification of the target cells to ensure that the target cells are degenerated to necrotize or apoptosize; at the same time, the microspheres strengthen the killing activity of T cells and NK cells and the phagotrophic ability of macrophages to the target cells, improve the immunity of organisms, and achieve the effects of multiple treatment and multi-drug resistance reverse.

Description

technical field [0001] The invention relates to a preparation method of a novel tumor drug, in particular a preparation method of a novel drug-loaded nano magnetic microsphere, and its application in an oral preparation of a tumor drug. Background technique [0002] Regarding the application of "nano-magnetic biomaterials" in the field of biomedicine, the currently disclosed technologies mainly include: the application research of various drug-loaded magnetic nanoparticles / microcapsules / microspheres in injections, superparamagnetic iron oxide nanoparticles Wide clinical application in magnetic resonance imaging contrast agents, and nano-magnetic biomaterial transdermal preparation technology are applied in OTC series of external dermatology products (including liquid, powder, ointment, etc.). [0003] "Drug-loaded nano-magnetic microspheres" (also known as "drug-loaded nano-magnetic microcapsules", "nano-magnetic biomissiles") have good biodegradability and biocompatibility,...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K9/14A61K47/02A61K47/40A61K36/9066A61K31/675A61K31/704A61P35/00A61K35/56A61K31/337A61K31/513
Inventor 黄云清
Owner 黄云清
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