70results about How to "Achieve targeted release" patented technology

The invention relates to consumer products, including detergents or cleaning agents which comprise capsules that are low in formaldehydes and / or free from formaldehyde, are storage stable and thus prevent a contamination of the detergent or cleaning agent with formaldehyde, comprising microcapsules, the capsule wall of which contains a resin which is obtained by reacting at least one aromatic alcohol or ether or derivative thereof and at least one aldehydic component which comprises at least two c-atoms per molecule, and optionally at least one (meth)acrylate polymer, and builders and / or surfactants. Said detergent or cleaning agents enable, during application, a targeted and durable release of liquid active substances, such as, in particular scents, to the treated objects.

The invention relates to a double-sensitive disintegrating nano-sized vesica medicine carrier preparation and a preparation method thereof. The carrier preparation is a hollow nano-sized spherical vesica with a hydrophobic bimolecular membrane and an inner hydrophilic cavity, wherein the hydrophobic bimolecular membrane loads a hydrophobic medicine; and the inner hydrophilic cavity loads a hydrophilic medicine. The carrier preparation is formed by self-assembling a double-sensitive amphiphilic block copolymer through the hydrophobic effect by a solvent exchange method, wherein the double-sensitive amphiphilic block copolymer is formed by bridging reducing-sensitive disulfide bond and pH-sensitive carbon-nitrogen double bonds with polylysine protected by hydrophilic polyethylene glycol and hydrophobic carbobenzoxyl group. The carrier preparation can effectively utilize reduce environment and acidic environment of tumor cells, so that the carrier preparation is disintegrated to release medicines to realize targeted medicine release, and the bioavailability of the medicines is improved. Compared with the prior art, the carrier preparation has high stability and good biocompatibility and can reverse the medicine tolerance of chemotherapy to a certain degree.

The invention provides an information publishment method and device, which relate to a communication field, and are capable of publishing different information based on different WLAN hotspots. The information publishment method comprises: an information publishment server receives information content request massage transmitted by a terminal device, and the information content request massage carries a MAC address of AP; the information publishment server acquires information content corresponding to the MAC address of AP based on the MAC address of AP; and the information publishment server transmits the information content to the terminal device. The method, the device and the network system are used for information publishment.

The invention belongs to the technical field of drug synthesis, relates to modified synthesis of drug molecules, and specifically relates to a novel disulfide bond-containing polymerizable taxol monomer and a synthetic method thereof. by virtue of esterification or amidation reactions, the disulfide bond-containing polymerizable taxol monomer can be obtained by reacting carboxyl groups at one end of a dithio-dicarboxylic acid compound with acrylic acid monomer containing carboxyl groups or amino groups, and reacting carboxyl groups at the other end to esterification with hydroxyl groups on taxol chemotherapeutic drug. The method provided by the invention is simple; raw materials are cheap; the disulfide bonds in the monomer allow the monomer having reducing and responsive drug controlled release properties, and the polymerizable acyclic acid structure makes the monomer generate polymerization easily or prepare a drug controlled release system by copolymerization with other monomers.

The invention discloses chitosan-containing curcumin slow-release aggregate and a preparation method thereof; the chitosan-containing curcumin slow-release aggregate comprises transparent immobile liquid crystal; the liquid crystal comprises a surfactant, ethyl oleate and water at a mass ratio of (34-56):(1-14):(38-57), wherein the surfactant is a mixture of tween-80 and water-soluble chitosan, and the mass ratio of the tween-80 to the water-soluble chitosan is (4-9):1; the liquid crystal is coated with curcumin; the curcumin has a concentration of 0.7-2.5 mg / g in the liquid crystal. The chitosan-containing curcumin slow-release aggregate has good structural stability, has improved curcumin slow-release effect and allows the curcumin to be present and released continuously and stably.

The invention discloses a method for preparing nanometer magnetic microspheres and an anticancer oral preparation prepared by utilizing the method. The method comprises the process steps of: a, material preparation, in which a carrier material, a framework material, a drug and a solvent are prepared; b, the preparation; c, the stability and drying; and d, the crushing and preparation and so on. The method takes beta-cyclodextrin as the framework material and includes the carrier material (a nanometer magnetic biomaterial) and drug combination and so on. The drug-loaded nanometer magnetic microspheres can quickly reach appointed focus target positions, penetrate target cell membranes to enter cells, realize the trans-membrane transport of target macromolecules, achieve the effects of targeted release and slow / controlled release, improve the drug concentration in target cells, and inhibit the gene expression and amplification of the target cells to ensure that the target cells are degenerated to necrotize or apoptosize; at the same time, the microspheres strengthen the killing activity of T cells and NK cells and the phagotrophic ability of macrophages to the target cells, improve the immunity of organisms, and achieve the effects of multiple treatment and multi-drug resistance reverse.

The invention belongs to the field of targeted drug slow-release carrier materials, and particularly relates to a biological responsiveness targeted double-drug slow-release carrier material and a preparation method thereof. The biological responsiveness targeted double-drug slow-release carrier material is prepared from double-shell biological responsiveness nanometer microspheres; an inner shell of the material is prepared from nanometer microspheres formed by aggregating amphiphilic polymers; an outer shell of the material is mesoporous silica; the diameter of the inner shell is 160nm to 800nm; the mesoporous diameter of the mesoporous silica of the outer shell is 2 to 4nm. The amphiphilic polymer nanometer microspheres of the inner shell can provide load loci for a hydrophobic drug, and the mesoporous silica of the outer shell can provide load loci for a hydrophilic drug; hence, the biological responsiveness targeted double-drug slow-release carrier material can load two different drugs and realize slow release of the double drugs, so as to achieve the aim of double-drug synergy therapy.

Belonging to the field of medical materials, the invention in particular relates to a super-paramagnetic targeting dual-drug sustained-release carrier material and a preparation method thereof. The inner shell of the carrier material is super-paramagnetic Fe3O4 hollow microspheres, and the outer shell is mesoporous silica, the inner shell is accumulated by Fe3O4 nanoparticles and has a thickness of 5-50nm, and the accumulation holes formed between the Fe3O4 nanoparticles are mesopores. The outer shell is formed by hydrolysis of a silicon source, and the mesoporous aperture of the mesoporous silica is 2-4nm. The super-paramagnetic Fe3O4 hollow microspheres of the inner shell involved in the invention can load hydrophobic drug, and the outer shell mesoporous silica can load hydrophilic drugs, and the drugs are released through the mesopores of the inner shell and the outer shell. Therefore, the super-paramagnetic targeting dual-drug sustained-release carrier material provided by the invention can load two different drugs, and under the orientation action of a magnetic field, can realize targeted sustained-release of dual drugs so as to achieve the purpose of synergy therapy of dual drugs.

The invention provides an antibacterial peptoid and a vesicle and a preparation method and application thereof. A hydrophilic part of the antibacterial peptoid is a lysine residue, and a hydrophobic part of the antibacterial peptoid is a diisocyanate unit, and the lysine residue links with the diisocyanate unit by means of a covalent bond. The antibacterial drug-loading vesicle is formed by self-assembling of the antibacterial peptoid and a drug in a mixture of an organic solvent and water. The antibacterial peptoid of the invention has a similar structure to that of a natural cationic anti-microbial peptide, and thus has a similar antibacterial mechanism; the antibacterial peptoid has broad-spectrum antibacterial properties, and cause the bacteria to be hard to produce drug resistance thereto; the antibacterial drug-loading vesicle has both antibacterial effect and dug-loading function, and can achieve sustained drug release.

The invention discloses a PEG modified PHPMA material and a preparation method thereof. The PEG modified PHPMA material which is provided by the invention is N-(2'-hydroxyl) propyl methyl acrylamide (HPMA) and / or a copolymer of the derivative of the N-(2'-hydroxyl) propyl methyl acrylamide and polyethylene glycol (PEG). The PEG modified PHPMA material of the invention is a polymer which is formed by the copolymerization of the polyethylene glycol (PEG), poly-N-(2'-hydroxyl) propyl methyl acrylamide (PHPMA) and the derivative of the PHPMA, the copolymer can be obtained by adopting the reversible addition-fragmentation chain transfer (RAFT), the composition and the molecular weight are controllable, and the molecular weight distribution is narrow (the molecular weight distribution d is less than 1, 4). Such polymers can be applied in the targeting drug delivery, which can not only have high targeting property and good biocompatibility, but can also have the function of preventing the protein non-specific absorption after the PEG modification, so the PEG modified PHPMA material is a good drug targeting carrier with the good performance, in particular to the drug targeting carrier of an anti-tumor drug.

The invention relates to a preparation method of a galactose vinyl ester / isopropyl acrylamide copolymer nanofiber membrane. The preparation method comprises the following steps of: dissolving divinyl azelate ester and galactose in anhydrous pyridine, adding alkaline protease, reacting, and separating and purifying to obtain galactose vinyl ester; adding the galactose vinyl ester into N-isopropyl acrylamide, an initiator and a solvent and then, and stirring to perform reaction under the protection of nitrogen, wherein after copolymerization reaction, the galactose vinyl ester / isopropyl acrylamide copolymer is obtained; adding the copolymer and PLCL [poly(L-lactide-co-epsilon-caprolactone)], stirring to obtain spinning liquid, and then, statically spinning and drying to obtain the galactose vinyl ester / isopropyl acrylamide copolymer nanofiber membrane. The method is simple to operate, the products are easy to treat and the method is economical and environment-friendly. The membrane with galactose fixed on the surface is used for separating and purifying proteins, and has thermosensitive property and more potential applications.

The invention relates to the technical field of biomedical materials. The method comprises the steps of firstly synthesizing a yellow gelatinous compound thiocinamide from lipoic acid and ethylenediamine under an N,N'-carbonyl diimidazole catalyst; carrying out polymerization by using thiocinamide, ethylene glycol diglycidyl ether and lysine through a nucleophilic addition mechanism to prepare a poly(lysine-co-ethylene glycol diglycidyl ether-co-thiocinamide) terpolymer, and then forming a zwitter-ion nano micelle in a selective solvent through self-assembly. The micelle can be endowed with excellent anti-protein nonspecific adsorption and enhanced cell uptake property through protonation / deprotonation action under different pH conditions; a disulfide bond in lipoyl can form a linear polydisulfide structure under the action of 1,4-dithiothreitol, so that a micelle core is crosslinked and a cross-linked structure is destroyed in the cell, and controlled release of a drug can be achieved. The nano micelle is expected to be a drug carrier for treating cancers.

The invention provides an ultrasonic contrast agent and a preparation method and a pharmaceutical preparation thereof. The ultrasonic contrast agent is of a hollow microbubble structure. The shell ofthe hollow microbubble structure comprises a biodegradable polymer and lipids, wherein the lipids modify the biodegradable polymer. The ultrasonic contrast agent is prepared by taking the biodegradable polymer and lipids as an oil phase, preparing an oil-in-water-in-oil compound emulsion and finally removing a solvent out of the compound emulsion. The pharmaceutical preparation takes the ultrasonic contrast agent as a drug carrier. The shell of the hollow microbubble structure of the ultrasonic contrast agent has good flexibility and elasticity, so that the ultrasonic contrast agent is endowedwith good ultrasonic responsiveness and ultrasonic contrast effect, is stable in structure, can carry out ultrasonic detonation, and is safe and non-toxic and good in safety. The preparation method of the ultrasonic contrast agent is easy to control process condition and mild in condition, and can ensure that the prepared ultrasonic contrast agent is stable in structure and performance, preparation efficiency is high, and the production cost is lowered.

The invention provides a hypoxia sensitive response type chitosan-nitroimidazole graft, and a preparation method and an application thereof. The weight average molecular weight of chitosan is 2000-20000 Da, and the grafting ratio of nitroimidazole is 1-20%. The hypoxia sensitive response type chitosan-nitroimidazole graft is synthesized by adopting chitosan with a good biocompatibility as a hydrophilic material, N-Boc-bromoalkylamine as a bridging group and nitroimidazole as an anoxic sensitive group. The graft material self-aggregates in water to form polymer micelles, and has a low criticalmicelle concentration; and the chitosan-nitroimidazole graft can be used as a drug carrier, and drug-loaded nanoparticles formed by combining the graft with a drug can rapidly release the drug under the action of nitroreductase highly expressed in hypoxia cells, realizes the targeted release of the drug in the environment of hypoxic lesions such as tumors and stroke, and improves the drug effects.The structural formula of the chitosan-nitroimidazole graft of the present invention is shown in the description.

The invention discloses a clathrate compound of camptothecin and acid-sensitive open-loop cucurbituril. The clathrate compound comprises camptothecin and acid-sensitive open-loop cucurbituril, and themolar ratio of camptothecin to acid-sensitive open-loop cucurbituril is 1:1 to 5:1. According to the clathrate compound, open-loop cucurbituril has a C-shaped cavity and can wrap the drug camptothecinv to form the clathrate compound, due to the fact that open-loop cucurbituril belongs to flexible molecules, the size of the cavity can be changed according to the size of the drug, and therefore open-loop cucurbituril and the drug form good cavity matching, and then the water solubility of camptothecin is enhanced to improve the bioavailability of camptothecin. The clathrate compound can fast release the drug in the cavity fast in the exterior tumor environment (weak acid condition), and therefore targeted release of the drug is achieved. The prepared clathrate compound is good in water solubility and high in stability and has potential value on development of clinical application of camptothecin.

The invention discloses a compound micelle-based nano-vector, and a preparation method and application thereof. The nano-vector comprises a compound micelle which is mainly formed by glucan, an active component combined with glucan through a reduction-sensitive bond, and water-soluble vitamin E (such as TPGS, namely tocopherol polyethylene glycol succinate), wherein the casing of the compound micelle is mainly formed by glucan and the hydrophyllic terminal of the water soluble vitamin E, and the core is mainly formed by the active component and the hydrophobic terminal of the water soluble vitamin E; the reduction-sensitive bond is preferably disulfide bond, and the active component can be adriamycin. The preparation method comprises the step of dialyzing the glucan-active component micelle and the water soluble vitamin E to form the compound micelle. The nano-vector can effectively realize targeted release of anti-tumor antibiotics and other active components in a physiological environment, and reduces the side effect and drug resistance; the preparation method is simple and feasible, low in cost and convenient to popularize, and is applicable to application of targeted drug vectors, genetic vectors or bio-probe vectors.

The invention discloses a drug conveying device, comprising a feeding rod, a balloon, an internal tube, a developing mark, a stress diffusion tube and a connection device, wherein a groove is arranged on the surface of the balloon, and a plurality of micropores internally communicated with the interior of the balloon are arranged in the groove. The drug conveying device can be used for directly treating stenosis in a stent or be used for conveying drug to vessels, which are subjected to balloon dilation operation or stent implantation operation. Oriented release of the drug to vascular walls can be realized without the help of any drug coating, so as to repair vascular endothelial injury and restrain hyperplasia of vascular smooth muscle cell. Furthermore, the drug conveying device can be dismounted from a human body after the operation, so as to avoid blood cohesion at vascular pathological change. Therefore, the possibility of vascular restenosis is reduced.

The invention provides a vincristine-PEG-PLGA segmented copolymer nanoparticle for incorporating vincristine into PEG-PLGA segmented copolymer, also provides a method for preparing the nanoparticle by emulsification-solvent evaporation method and other methods, and use of the nanoparticle in preparing anticancer drug. The nanoparticle provided by the invention can improve the solubility of drugs effectively; can avoid dose dumping and incomplete release to allow the drug to release slowly; can reduce the abilities of RES to identificate and phagocytose nanoparticle, so as to realize the targeted release of the drug in tissues and organs out of the reticuloendothelial system; can reduce toxic and side effect, increase biocompatibility, prolong the circulation time of the drug in the blood; and can increase the compliance of the patients.

The invention provides a hydrogel. The hydrogel is prepared from the following components: medicine-loading particles, modified chitosan with a structure shown in a formula II, a poly-gamma-glutamic acid star-type block copolymer containing blocks with structures shown in a formula III and a formula IV, a poly-L-lysine star-type block copolymer containing blocks with structures shown in a formula V and a formula VI, and a solvent, wherein the medicine-loading particles are prepared from modified glucan with a structure shown in a formula I and medicines. The hydrogel provided by the invention is a hydrogel based on electrostatic action and Schiff base bond crosslinking; by virtue of the combination of physical electrostatic action and Schiff base bond chemical crosslinking, the hydrogel provided by the invention has relatively high strength and good stability, and ensures that the requirements of clinical injection can be met; and moreover, the medicine-loading particles are taken as a chemical crosslinking agent so as to ensure that medicines in the hydrogel can be released slowly, the targeted release and enrichment of the medicines at focus locations can be achieved, and thus the treatment effects of the medicines can be improved. The invention also provides a preparation method of the hydrogel.

The invention discloses an anaerobic granular sludge conditioning agent and a preparation method and application thereof, the anaerobic granular sludge conditioning agent comprises citric acid or citrate as raw materials, humic acid, a surfactant, trace elements and a biological factor supplement. The method has the effects that 1, inorganic mineral deposition is regulated and controlled, the density of anaerobic granular sludge is regulated, the fluidization mass transfer characteristic of an anaerobic granular sludge bed is maintained, and the activity of an anaerobic granular sludge reactoris ensured, and 2, the growth of anaerobic microorganisms is promoted, and the activity of granular sludge is maintained, and the method effectively solves the problem of inactivation of the anaerobic granular sludge reactor caused by biologically induced carbonate deposition, and has remarkable application value.

The invention relates to a preparation method and application of a nanoparticle microsphere for improving oral bioavailability of poorly soluble drugs, and the microsphere is capable of effectively solving the problems of existing drugs which have low oral bioavailability, poor efficacy, high toxic and side effects and discomfort in stomach due to the burst release of the drugs. The method comprises the following steps: mixing and melting glyceryl monostearate and glyceryl behenate, so that an oil phase is obtained; dissolving 2-ME and polyethylene glycol-polycaprolactone in absolute ethyl alcohol, and adding to the oil phase, so that a mixture oil phase is obtained; dissolving soybean lecithin and Tween-80 in water, so that an aqueous phase is obtained, dropping the aqueous phase to the mixture oil phase so as to obtain a primary emulsion, and filtering by virtue of a microfiltration membrane, so that a solid lipid nanoparticle suspension of the 2-ME is obtained; adding polyacrylic resin to a PBS solution, and adding hydroxypropyl methyl cellulose, so that a microsphere material solution is obtained; and stirring and uniformly mixing the microsphere material solution with the solid lipid nanoparticle suspension of the 2-ME, and spray-drying, so that the nanoparticle microsphere is obtained. According to the invention, the oral bioavailability of the drugs is improved and oral effective rate is increased.

The invention discloses a monoclonal antibody drug oral nanogel preparation and a preparation method thereof. The monoclonal antibody drug oral nanogel is prepared by cross-linking a monoclonal antibody drug by using a disulfide bond cross-linking agent (2-[(2-{[(4-nitrophenoxy)carbonyl]oxy}ethyl)disulfide]ethyl 4-nitrobenzene carbonate) or a homologue thereof to form a nano cross-linked substance, and then connecting hyaluronic acid to the surface of the nano cross-linked substance through chemical synthesis. The monoclonal antibody drug oral nanogel can adopt an oral administration means to directly transfer an antibody drug to an inflammation site, so that adverse reaction caused by systemic administration of the drug can be avoided, and the compliance of a patient is improved. The nanogel prepared by the method disclosed by the invention can be gathered at the intestinal inflammation part through a targeting effect, and meanwhile, the antibody cross-linked S-S bonds can be responsively degraded in the intestinal environment to release the drug, so that the targeted positioning release of the drug at the intestinal inflammation part is realized.

The invention relates to a preparation process of a moisture absorption and sweat releasing fabric, and belongs to the technical field of fabric preparation processes. The preparation process specifically comprises the following process steps: S1, spinning, namely, spinning a fiber A into a first yarn, and spinning a fiber B into a second yarn; S2, weaving, namely, by taking the first yarn obtained in the step S1 as a raw material of inner-layer cloth and the second yarn obtained in the step S1 as a raw material of outer-layer cloth, carrying out weaving to obtain double-layer gray fabric; andS3, dyeing and finishing, specifically comprising alkali deweighting, dyeing, soaping and shaping, so that the finished product fabric is obtained, wherein the fiber A is a hydrophilic fiber, and thefiber B is a hydrophobic fiber. The moisture absorption and sweat releasing fabric has the effect of being higher in moisture absorption and sweat releasing capacity.

The invention provides a microecological preparation with viable bacteria and relates to the technical field of the microecological preparation. The microecological preparation comprises a core material, a hydrophobic layer and an outer wall layer, wherein the hydrophobic layer and the outer wall layer are coated on the core material in sequence; the core material consists of a porous adsorbing material adsorbed with microorganisms and a polysaccharide layer coated on the surface of the porous adsorbing material; and the parts between pores of the porous adsorbing material and the polysaccharide layer are hollow. The microecological preparation provided by the invention has the advantages that the viable-bacteria microorganisms are put into the hollow pores of the core material, and then with the hydrophobic layer and the outer wall layer coated on the core material in sequence, hot steam and the like are not easy to enter the core material and contact with the microorganisms through outer-layer coatings, and the influences of external bad environments with high temperature, high humidity and high pressure and the like on the activity of the microorganisms can be effectively avoided, so that the stability of the microecological preparation with the viable bacteria is improved and the loss of the microecological preparation with the viable-bacteria microorganisms in the process of after processing is reduced.

The invention belongs to the technical field of drug carrier materials, and particularly relates to a bioadhesive nanoparticle for treating gastrointestinal diseases and a preparation method of the bioadhesive nanoparticle. A non-bioadhesive degradable nanoparticle drug / NNPs is prepared from drugs for treating gastrointestinal diseases and biodegradable PLA and HPG; and the drug / NNPs is oxidized and reduced by sodium periodate to become a biodegradable nanoparticle drug / BNPs with biological viscosity, and the prepared bioadhesive nanoparticle BNPs can be connected with proteins of a gastrointestinal tract system, so that the bioadhesive nanoparticle BNPs can be adhered to tissue, slowly release the drug, realize targeted release of the drug in the esophagus, further play a better treatment effect, and reduces side effects.

The invention discloses a body lumen drug-carrying bracket and a preparation method thereof. The body lumen drug-carrying bracket comprises a bracket body. A plurality of holes are uniformly distributed on the outer circumferential surface of the bracket body. Drugs are carried in the plurality of holes. The inside surface of the bracket body is a smooth surface. After the body lumen drug-carrying bracket provided by the embodiment of the invention is implanted in a human body, the problems resulted from polymer drug-carrying can be avoided; furthermore, the body lumen drug-carrying bracket only releases drugs on vascular walls contacted with micro-holes on the outer circumferential surface, therefore, the targeted release drugs can be realized; and the controlled release ability and the effective utilization rate of drugs can be increased.

The invention discloses a safe and efficient blasting construction method for a vertical shaft well wall beam socket. The method comprises the following steps that a plurality of blast holes distributed in an i x j matrix are formed in a main explosion zone in the center of the beam socket, wherein i and j are both an odd number and greater than or equal to 3; the blast holes in the most center serves as a first set of blast holes, a circle of blast holes which are closest to the periphery of the first set of blast holes are used as second set of blast holes, a circle of blast holes which areclosest to the periphery of the second set of blast holes are used as a third set of blast holes, and so on; the explosive charging mode of each set of blast holes is a detonation mode that a detonator is placed at the top low section, the detonator is placed at the high section of the bottom, and the section of the bottom high-section placement detonator in each group of blast holes is the same as the section of the top low-section placement detonator in the adjacent group of blast holes in the periphery of each group of blast holes. According to the blasting construction method, a pluralityof sets of blast holes are specially arranged in the main explosion zone of the beam nest, each blast hole adopts a detonator detonation mode with different top bottom sections, so that a multi-section gradient blasting mode is formed; each set of blast holes is connected to form a multi-order blasting net path; safe and efficient construction of the vertical shaft well wall beam socket is realized.

The invention belongs to the field of macromolecules and relates to a thermo-sensitive polymer-based hollow fiber and hollow microspheres as well as a preparation method and application thereof. The preparation method of the thermo-sensitive polymer-based hollow fiber and or hollow microspheres comprises the following steps: preparing a homogeneous solution as an external spinning liquid from a water-soluble poly N-isopropyl acrylamide polymer, preparing a homogeneous solution as an internal spinning liquid from an anti-cancer medicine, and preparing the thermo-sensitive polymer-based hollow fiber and or hollow microspheres with the thermo-sensitive polymer as a shell layer and the anti-cancer medicine as a core layer from the external spinning liquid and the internal spinning liquid by using a coaxial electrostatic spinning method. The thermo-sensitive polymer-based hollow fiber and or hollow microspheres provided by the invention can be used as a cancer medicine carrier, medicines can be completely wrapped by the carrier, and the purpose of zero medicine release in transportation can be achieved; when reaching an affected part, medicines inside cavities can be released by virtueof volume shrinkage of the thermo-sensitive material at a high temperature, then a targeting release effect can be achieved, and the defects of medicine chemotherapy treatment on cancer can be overcome.

The invention provides an enzymic preparation as well as a preparation method and application thereof, which belongs to the technical field of enzymic preparations. The enzymic preparation comprises acore material as well as a hydrophobic layer and an outer wall layer covering the core material; the core material comprises enzyme molecules, a porous absorption material and a polysaccharide layer,the enzyme molecules are absorbed inside the porous absorption material, and the polysaccharide layer is absorbed on the surface of the porous absorption material; the hydrophobic layer material is selected from one or more of sodium stearate, cetyl trimethyl ammonium bromide, alpha-cyclodextrin and polylactic acid; the outer wall layer is selected from one or more of gelatin, glycerinum, sodiumalginate and polysaccharide; and the weight ratio of the core material to the hydrophobic layer and the outer wall layer is (80 to 110): (0.3 to 0.7): (2.00 to 4.00). The enzymic preparation is good in heat stability and good in processing resistance.