70results about How to "Achieve targeted release" patented technology

The invention relates to a double-sensitive disintegrating nano-sized vesica medicine carrier preparation and a preparation method thereof. The carrier preparation is a hollow nano-sized spherical vesica with a hydrophobic bimolecular membrane and an inner hydrophilic cavity, wherein the hydrophobic bimolecular membrane loads a hydrophobic medicine; and the inner hydrophilic cavity loads a hydrophilic medicine. The carrier preparation is formed by self-assembling a double-sensitive amphiphilic block copolymer through the hydrophobic effect by a solvent exchange method, wherein the double-sensitive amphiphilic block copolymer is formed by bridging reducing-sensitive disulfide bond and pH-sensitive carbon-nitrogen double bonds with polylysine protected by hydrophilic polyethylene glycol and hydrophobic carbobenzoxyl group. The carrier preparation can effectively utilize reduce environment and acidic environment of tumor cells, so that the carrier preparation is disintegrated to release medicines to realize targeted medicine release, and the bioavailability of the medicines is improved. Compared with the prior art, the carrier preparation has high stability and good biocompatibility and can reverse the medicine tolerance of chemotherapy to a certain degree.

The invention provides an information publishment method and device, which relate to a communication field, and are capable of publishing different information based on different WLAN hotspots. The information publishment method comprises: an information publishment server receives information content request massage transmitted by a terminal device, and the information content request massage carries a MAC address of AP; the information publishment server acquires information content corresponding to the MAC address of AP based on the MAC address of AP; and the information publishment server transmits the information content to the terminal device. The method, the device and the network system are used for information publishment.

The invention belongs to the technical field of drug synthesis, relates to modified synthesis of drug molecules, and specifically relates to a novel disulfide bond-containing polymerizable taxol monomer and a synthetic method thereof. by virtue of esterification or amidation reactions, the disulfide bond-containing polymerizable taxol monomer can be obtained by reacting carboxyl groups at one end of a dithio-dicarboxylic acid compound with acrylic acid monomer containing carboxyl groups or amino groups, and reacting carboxyl groups at the other end to esterification with hydroxyl groups on taxol chemotherapeutic drug. The method provided by the invention is simple; raw materials are cheap; the disulfide bonds in the monomer allow the monomer having reducing and responsive drug controlled release properties, and the polymerizable acyclic acid structure makes the monomer generate polymerization easily or prepare a drug controlled release system by copolymerization with other monomers.

Belonging to the field of medical materials, the invention in particular relates to a super-paramagnetic targeting dual-drug sustained-release carrier material and a preparation method thereof. The inner shell of the carrier material is super-paramagnetic Fe3O4 hollow microspheres, and the outer shell is mesoporous silica, the inner shell is accumulated by Fe3O4 nanoparticles and has a thickness of 5-50nm, and the accumulation holes formed between the Fe3O4 nanoparticles are mesopores. The outer shell is formed by hydrolysis of a silicon source, and the mesoporous aperture of the mesoporous silica is 2-4nm. The super-paramagnetic Fe3O4 hollow microspheres of the inner shell involved in the invention can load hydrophobic drug, and the outer shell mesoporous silica can load hydrophilic drugs, and the drugs are released through the mesopores of the inner shell and the outer shell. Therefore, the super-paramagnetic targeting dual-drug sustained-release carrier material provided by the invention can load two different drugs, and under the orientation action of a magnetic field, can realize targeted sustained-release of dual drugs so as to achieve the purpose of synergy therapy of dual drugs.

The invention discloses a PEG modified PHPMA material and a preparation method thereof. The PEG modified PHPMA material which is provided by the invention is N-(2'-hydroxyl) propyl methyl acrylamide (HPMA) and/or a copolymer of the derivative of the N-(2'-hydroxyl) propyl methyl acrylamide and polyethylene glycol (PEG). The PEG modified PHPMA material of the invention is a polymer which is formed by the copolymerization of the polyethylene glycol (PEG), poly-N-(2'-hydroxyl) propyl methyl acrylamide (PHPMA) and the derivative of the PHPMA, the copolymer can be obtained by adopting the reversible addition-fragmentation chain transfer (RAFT), the composition and the molecular weight are controllable, and the molecular weight distribution is narrow (the molecular weight distribution d is less than 1, 4). Such polymers can be applied in the targeting drug delivery, which can not only have high targeting property and good biocompatibility, but can also have the function of preventing the protein non-specific absorption after the PEG modification, so the PEG modified PHPMA material is a good drug targeting carrier with the good performance, in particular to the drug targeting carrier of an anti-tumor drug.

The invention relates to a preparation method of a galactose vinyl ester/isopropyl acrylamide copolymer nanofiber membrane. The preparation method comprises the following steps of: dissolving divinyl azelate ester and galactose in anhydrous pyridine, adding alkaline protease, reacting, and separating and purifying to obtain galactose vinyl ester; adding the galactose vinyl ester into N-isopropyl acrylamide, an initiator and a solvent and then, and stirring to perform reaction under the protection of nitrogen, wherein after copolymerization reaction, the galactose vinyl ester/isopropyl acrylamide copolymer is obtained; adding the copolymer and PLCL [poly(L-lactide-co-epsilon-caprolactone)], stirring to obtain spinning liquid, and then, statically spinning and drying to obtain the galactose vinyl ester/isopropyl acrylamide copolymer nanofiber membrane. The method is simple to operate, the products are easy to treat and the method is economical and environment-friendly. The membrane with galactose fixed on the surface is used for separating and purifying proteins, and has thermosensitive property and more potential applications.

The invention provides an ultrasonic contrast agent and a preparation method and a pharmaceutical preparation thereof. The ultrasonic contrast agent is of a hollow microbubble structure. The shell ofthe hollow microbubble structure comprises a biodegradable polymer and lipids, wherein the lipids modify the biodegradable polymer. The ultrasonic contrast agent is prepared by taking the biodegradable polymer and lipids as an oil phase, preparing an oil-in-water-in-oil compound emulsion and finally removing a solvent out of the compound emulsion. The pharmaceutical preparation takes the ultrasonic contrast agent as a drug carrier. The shell of the hollow microbubble structure of the ultrasonic contrast agent has good flexibility and elasticity, so that the ultrasonic contrast agent is endowedwith good ultrasonic responsiveness and ultrasonic contrast effect, is stable in structure, can carry out ultrasonic detonation, and is safe and non-toxic and good in safety. The preparation method of the ultrasonic contrast agent is easy to control process condition and mild in condition, and can ensure that the prepared ultrasonic contrast agent is stable in structure and performance, preparation efficiency is high, and the production cost is lowered.

The invention discloses a compound micelle-based nano-vector, and a preparation method and application thereof. The nano-vector comprises a compound micelle which is mainly formed by glucan, an active component combined with glucan through a reduction-sensitive bond, and water-soluble vitamin E (such as TPGS, namely tocopherol polyethylene glycol succinate), wherein the casing of the compound micelle is mainly formed by glucan and the hydrophyllic terminal of the water soluble vitamin E, and the core is mainly formed by the active component and the hydrophobic terminal of the water soluble vitamin E; the reduction-sensitive bond is preferably disulfide bond, and the active component can be adriamycin. The preparation method comprises the step of dialyzing the glucan-active component micelle and the water soluble vitamin E to form the compound micelle. The nano-vector can effectively realize targeted release of anti-tumor antibiotics and other active components in a physiological environment, and reduces the side effect and drug resistance; the preparation method is simple and feasible, low in cost and convenient to popularize, and is applicable to application of targeted drug vectors, genetic vectors or bio-probe vectors.

The invention discloses a drug conveying device, comprising a feeding rod, a balloon, an internal tube, a developing mark, a stress diffusion tube and a connection device, wherein a groove is arranged on the surface of the balloon, and a plurality of micropores internally communicated with the interior of the balloon are arranged in the groove. The drug conveying device can be used for directly treating stenosis in a stent or be used for conveying drug to vessels, which are subjected to balloon dilation operation or stent implantation operation. Oriented release of the drug to vascular walls can be realized without the help of any drug coating, so as to repair vascular endothelial injury and restrain hyperplasia of vascular smooth muscle cell. Furthermore, the drug conveying device can be dismounted from a human body after the operation, so as to avoid blood cohesion at vascular pathological change. Therefore, the possibility of vascular restenosis is reduced.

The invention provides a vincristine-PEG-PLGA segmented copolymer nanoparticle for incorporating vincristine into PEG-PLGA segmented copolymer, also provides a method for preparing the nanoparticle by emulsification-solvent evaporation method and other methods, and use of the nanoparticle in preparing anticancer drug. The nanoparticle provided by the invention can improve the solubility of drugs effectively; can avoid dose dumping and incomplete release to allow the drug to release slowly; can reduce the abilities of RES to identificate and phagocytose nanoparticle, so as to realize the targeted release of the drug in tissues and organs out of the reticuloendothelial system; can reduce toxic and side effect, increase biocompatibility, prolong the circulation time of the drug in the blood; and can increase the compliance of the patients.

The invention provides a hydrogel. The hydrogel is prepared from the following components: medicine-loading particles, modified chitosan with a structure shown in a formula II, a poly-gamma-glutamic acid star-type block copolymer containing blocks with structures shown in a formula III and a formula IV, a poly-L-lysine star-type block copolymer containing blocks with structures shown in a formula V and a formula VI, and a solvent, wherein the medicine-loading particles are prepared from modified glucan with a structure shown in a formula I and medicines. The hydrogel provided by the invention is a hydrogel based on electrostatic action and Schiff base bond crosslinking; by virtue of the combination of physical electrostatic action and Schiff base bond chemical crosslinking, the hydrogel provided by the invention has relatively high strength and good stability, and ensures that the requirements of clinical injection can be met; and moreover, the medicine-loading particles are taken as a chemical crosslinking agent so as to ensure that medicines in the hydrogel can be released slowly, the targeted release and enrichment of the medicines at focus locations can be achieved, and thus the treatment effects of the medicines can be improved. The invention also provides a preparation method of the hydrogel.

The invention discloses an anaerobic granular sludge conditioning agent and a preparation method and application thereof, the anaerobic granular sludge conditioning agent comprises citric acid or citrate as raw materials, humic acid, a surfactant, trace elements and a biological factor supplement. The method has the effects that 1, inorganic mineral deposition is regulated and controlled, the density of anaerobic granular sludge is regulated, the fluidization mass transfer characteristic of an anaerobic granular sludge bed is maintained, and the activity of an anaerobic granular sludge reactoris ensured, and 2, the growth of anaerobic microorganisms is promoted, and the activity of granular sludge is maintained, and the method effectively solves the problem of inactivation of the anaerobic granular sludge reactor caused by biologically induced carbonate deposition, and has remarkable application value.

The invention relates to a preparation method and application of a nanoparticle microsphere for improving oral bioavailability of poorly soluble drugs, and the microsphere is capable of effectively solving the problems of existing drugs which have low oral bioavailability, poor efficacy, high toxic and side effects and discomfort in stomach due to the burst release of the drugs. The method comprises the following steps: mixing and melting glyceryl monostearate and glyceryl behenate, so that an oil phase is obtained; dissolving 2-ME and polyethylene glycol-polycaprolactone in absolute ethyl alcohol, and adding to the oil phase, so that a mixture oil phase is obtained; dissolving soybean lecithin and Tween-80 in water, so that an aqueous phase is obtained, dropping the aqueous phase to the mixture oil phase so as to obtain a primary emulsion, and filtering by virtue of a microfiltration membrane, so that a solid lipid nanoparticle suspension of the 2-ME is obtained; adding polyacrylic resin to a PBS solution, and adding hydroxypropyl methyl cellulose, so that a microsphere material solution is obtained; and stirring and uniformly mixing the microsphere material solution with the solid lipid nanoparticle suspension of the 2-ME, and spray-drying, so that the nanoparticle microsphere is obtained. According to the invention, the oral bioavailability of the drugs is improved and oral effective rate is increased.

The invention discloses a monoclonal antibody drug oral nanogel preparation and a preparation method thereof. The monoclonal antibody drug oral nanogel is prepared by cross-linking a monoclonal antibody drug by using a disulfide bond cross-linking agent (2-[(2-{[(4-nitrophenoxy)carbonyl]oxy}ethyl)disulfide]ethyl 4-nitrobenzene carbonate) or a homologue thereof to form a nano cross-linked substance, and then connecting hyaluronic acid to the surface of the nano cross-linked substance through chemical synthesis. The monoclonal antibody drug oral nanogel can adopt an oral administration means to directly transfer an antibody drug to an inflammation site, so that adverse reaction caused by systemic administration of the drug can be avoided, and the compliance of a patient is improved. The nanogel prepared by the method disclosed by the invention can be gathered at the intestinal inflammation part through a targeting effect, and meanwhile, the antibody cross-linked S-S bonds can be responsively degraded in the intestinal environment to release the drug, so that the targeted positioning release of the drug at the intestinal inflammation part is realized.

The invention relates to a preparation process of a moisture absorption and sweat releasing fabric, and belongs to the technical field of fabric preparation processes. The preparation process specifically comprises the following process steps: S1, spinning, namely, spinning a fiber A into a first yarn, and spinning a fiber B into a second yarn; S2, weaving, namely, by taking the first yarn obtained in the step S1 as a raw material of inner-layer cloth and the second yarn obtained in the step S1 as a raw material of outer-layer cloth, carrying out weaving to obtain double-layer gray fabric; andS3, dyeing and finishing, specifically comprising alkali deweighting, dyeing, soaping and shaping, so that the finished product fabric is obtained, wherein the fiber A is a hydrophilic fiber, and thefiber B is a hydrophobic fiber. The moisture absorption and sweat releasing fabric has the effect of being higher in moisture absorption and sweat releasing capacity.

The invention belongs to the technical field of drug carrier materials, and particularly relates to a bioadhesive nanoparticle for treating gastrointestinal diseases and a preparation method of the bioadhesive nanoparticle. A non-bioadhesive degradable nanoparticle drug/NNPs is prepared from drugs for treating gastrointestinal diseases and biodegradable PLA and HPG; and the drug/NNPs is oxidized and reduced by sodium periodate to become a biodegradable nanoparticle drug/BNPs with biological viscosity, and the prepared bioadhesive nanoparticle BNPs can be connected with proteins of a gastrointestinal tract system, so that the bioadhesive nanoparticle BNPs can be adhered to tissue, slowly release the drug, realize targeted release of the drug in the esophagus, further play a better treatment effect, and reduces side effects.

The invention discloses a safe and efficient blasting construction method for a vertical shaft well wall beam socket. The method comprises the following steps that a plurality of blast holes distributed in an i x j matrix are formed in a main explosion zone in the center of the beam socket, wherein i and j are both an odd number and greater than or equal to 3; the blast holes in the most center serves as a first set of blast holes, a circle of blast holes which are closest to the periphery of the first set of blast holes are used as second set of blast holes, a circle of blast holes which areclosest to the periphery of the second set of blast holes are used as a third set of blast holes, and so on; the explosive charging mode of each set of blast holes is a detonation mode that a detonator is placed at the top low section, the detonator is placed at the high section of the bottom, and the section of the bottom high-section placement detonator in each group of blast holes is the same as the section of the top low-section placement detonator in the adjacent group of blast holes in the periphery of each group of blast holes. According to the blasting construction method, a pluralityof sets of blast holes are specially arranged in the main explosion zone of the beam nest, each blast hole adopts a detonator detonation mode with different top bottom sections, so that a multi-section gradient blasting mode is formed; each set of blast holes is connected to form a multi-order blasting net path; safe and efficient construction of the vertical shaft well wall beam socket is realized.