6results about How to "Achieve targeted release" patented technology

The application provides a preparation method of astaxanthin cordyceps militaris fine tablets, comprising the following steps: subjecting cordyceps militaris fruiting bodies to supercritical CO2 extraction treatment to separate a cordyceps militaris terpene component; mixing Haematococcus pluvialis powder and edible vegetable oil, adding the cordyceps militaris terpene component and rosemary extract, and cooling and forming to obtain an astaxanthin-cordyceps militaris terpene blend; crushing the residue after extraction, adding purified water and a composite enzyme preparation to perform enzymolysis to obtain an enzymolysis liquid; adding a chitosan quaternary ammonium salt solution, centrifuging after flocculation, vacuum drying, and crushing to obtain cordyceps militaris active powder; mixing and granulating raw materials to obtain granulation particles; uniformly mixing the granulation particles with xylitol and microcrystalline cellulose, and pressing into tablets; and placing the tablets in a coating machine for coating. The application realizes efficient retention of active ingredients, improvement of safety and stability of product quality through the cooperation of multiple technologies such as supercritical CO2 extraction, enzymolysis flocculation, low-temperature fluidized bed granulation and hot melt coating.

The application discloses a special feed for fattening pigs rich in functional amino acids, which comprises the following components in parts by weight: a core functional amino acid composition 3-5 parts, a low-soybean meal multi-protein matrix 60-70 parts, a nutrition synergistic component 20-25 parts, an anti-nutritional factor degradation agent 1-2 parts, and a micro-ecological and plant extract component 1-2 parts. A preparation method comprises the following steps: obtaining the low-soybean meal multi-protein matrix by pretreating raw materials; preparing the core functional amino acid microcapsule; mixing the basic materials and then performing low-temperature section granulation; after cooling, mixing the micro-ecological and plant extract component at low temperature; and finally screening and removing impurities and unqualified particles to obtain the finished product. The application optimizes the amino acid ratio and the preparation process, protects the activity of the amino acids, adapts to different growth stages of the fattening pigs, improves the growth performance and carcass quality, improves the raw material digestion rate, reduces nitrogen emission, and has strong applicability.

This invention belongs to the technical field of additive manufacturing technology and discloses an in-situ oxygen-controlled composite scraper and a laser selective melting device equipped with the in-situ oxygen-controlled composite scraper. The bottom of the composite scraper includes a second scraper (16), an air jet unit, and a first scraper (18) arranged sequentially along the powder spreading direction. It has an internal gas storage chamber (15) and a powder drop chamber (19). The first scraper is used to evenly spread the powder raw material to form an initial powder layer. The air jet unit performs in-situ oxidation treatment on the surface of the initial powder layer by spraying oxygen-containing gas. The second scraper is used to level and compact the powder layer after the in-situ oxidation treatment. This invention improves the composition and structure of the composite scraper and utilizes the overall cooperation of the first scraper, the air jet unit, and the second scraper to generate a synergistic mechanism of powder spreading, in-situ oxidation, and secondary compaction, breaking through the process limitation that it is difficult to construct oxide dispersion-strengthened structures in-situ during additive manufacturing.

The application discloses a feline panleukopenia virus, feline herpes virus and feline calicivirus yolk antibody preparation and a preparation method and application thereof. The feline triple yolk antibody preparation comprises a core material, and the core material comprises feline calicivirus yolk antibody, feline panleukopenia virus yolk antibody, feline herpes virus type 1 yolk antibody and probiotics. The application can produce specific neutralization to feline calicivirus, feline panleukopenia virus and feline herpes virus type 1, significantly reduces the infection rate and the severity of clinical symptoms, is stably released in the gastrointestinal tract after oral administration, the antibody activity retention rate is more than 90%, the probiotics synergistically regulate intestinal microecology, enhance the immune response of the body and improve the overall protection efficiency.

This invention relates to the synergistic anticancer application of redox-responsive condensates (FFSSFF) for delivering jujube extract and 3-methyladenine. Specifically, this invention relates to the application of redox-responsive condensates in the preparation of targeted drug delivery products, wherein the targeted drug delivery products release drugs in response to glutathione. The active ingredients in the targeted drug delivery products are jujube extract and 3-methyladenine. This invention utilizes an FFSSFF carrier designed based on the LLPS principle, integrating redox-sensitive disulfide bond linkage modules to achieve spatiotemporally controlled drug delivery within a tumor tissue-specific microenvironment with high glutathione concentrations.

This invention discloses a method for preparing soft-particle starter feed based on low-temperature curing and microencapsulation, belonging to the field of livestock and poultry feed preparation technology. The method includes basic raw material pretreatment, low-temperature curing, mixing and blending, soft-particle molding, drying and cooling, and screening and packaging steps. The core lies in employing a process of "low-temperature curing + double-layer microencapsulation + soft-particle molding," combined with an excipient system composed of modified chitosan, sodium alginate, and attapulgite solution. Low-temperature curing preserves heat-sensitive nutrients and kills harmful microorganisms; double-layer microencapsulation enables targeted release of core functional components, ensuring their activity; soft-particle molding balances palatability and intestinal protection; and the various components of the excipients synergistically improve feed stability, probiotic colonization rate, and digestibility.