72 results about "Targeted release" patented technology

The invention relates to the technical field of alimentary canal diagnosis and treatment, in particular to an alimentary canal detection drug delivery system which comprises an alimentary canal sensing unit for collecting an image, a pH value, a temperature and pathological tissue pathological characteristic data in an alimentary canal cavity; the lesion positioning analysis unit identifies a lesion area through an image segmentation algorithm, constructs a lesion three-dimensional coordinate model according to physiological parameters, prejudges a lesion displacement trend in combination with an alimentary canal peristalsis rule, analyzes a lesion state in stages, and outputs lesion severity; the response type drug delivery module controls the micro drug delivery device to perform targeted release and adjust the drug release rate based on the lesion coordinates and the intracavity environment parameters; the data collaboration platform shares a detection result and a drug administration record through a real-time interaction interface; the curative effect feedback unit is used for collecting physiological index change and patient symptom improvement data after drug administration, judging the drug onset period and possible adverse reactions, and optimizing drug administration parameters and detection frequency. Therefore, the problems of low targeting precision, poor diagnosis and treatment efficiency and the like in the prior art are solved.

An iRGD-LAMP2B-EGFP fusion protein mediated exosome surface engineering strategy is adopted, through specific recognition of iRGD peptide and integrin alpha v beta 3, corneal neovascularization core lesion cells are actively targeted, the limitation of off-target toxicity of a traditional delivery system is broken through, and a'accurate focus recognition-efficient homing 'targeted delivery normal form is established. Meanwhile, the screened circular RNA with anti-inflammatory and anti-angiogenesis dual activities is used as a core effector molecule, and in combination with an in-situ loading technology of the circular RNA molecule in an exosome parent cell, stable entrapment and targeted release of a nucleic acid drug in an exosome cavity are realized, and the problems that the nucleic acid drug is easy to degrade and poor in targeting property are solved; and dual guarantee of function specificity and delivery stability is formed. And a synergistic treatment system of a targeting exosome carrier and bifunctional circular RNA is further constructed, active molecules are accurately delivered to focus cells, and an inflammation microenvironment and an angiogenesis pathway are synchronously regulated and controlled.

The invention relates to the technical field of biological scaffolds, in particular to a silk fibroin-based biological 3D intelligent response scaffold and a preparation method and application thereof.The silk fibroin-based biological 3D intelligent response scaffold adopts a three-layer bionic gradient structure of an oriented fiber membrane, a porous sponge layer and an interface layer, simulates natural tissues, and has the advantages that the bionic gradient structure is improved; mechanical guidance, cell inhabitation and biological activity interfaces are provided respectively, and high-quality regeneration of blood vessels, nerves and skin is promoted synergistically. According to the present invention, the pH / enzyme / temperature triple response unit is provided, such that the lesion microenvironment can be perceived, the targeted release can be triggered, the problem of high burst release rate of the traditional physical drug loading can be solved, and the on-demand accurate drug delivery can be achieved. The SF / HPMC gel is adopted for 3D printing, the printing precision is high, and the porosity difference is 1t; the product performance is stable, and the pore structure can be precisely designed and customized according to the regeneration requirements of different tissues (such as blood vessels, nerves and skin).

The invention belongs to the technical field of biological medicine, and relates to an oral peptide drug delivery system based on a soybean trypsin inhibitor and core-shell hydrogel, the oral peptide drug delivery system comprises therapeutic polypeptide, KTI and a core-shell structure gel matrix, and the problems that an existing oral peptide delivery system is passively protected and drug burst release is remarkable are solved. A chitosan / sodium tripolyphosphate ionic cross-linked network forms an inner core, a sodium alginate / calcium ion'egg box 'structure cross-linked network forms a shell, and therapeutic polypeptides such as liraglutide and KTI are jointly embedded. Through the pH response characteristic and sequential release design of the core-shell structure, KTI is preferentially and rapidly released in the intestinal environment to inhibit local protease activity, then therapeutic polypeptide is slowly released, and active protection and synergistic interaction are achieved. The invention further provides a specific preparation method and parameters. The polypeptide has the advantages of stable structure in a gastric acid environment, targeted release in intestinal tracts, high encapsulation efficiency, capability of avoiding burst release and the like, and provides a new strategy for efficient delivery of oral polypeptide drugs.

The invention provides a nano medicinal preparation for tumor treatment as well as a preparation method and application thereof, and relates to the technical field of medicinal preparations. The preparation method of the nano medicinal preparation comprises the following steps: S1, adding metal salt and oxidase into water, uniformly stirring and mixing to form a compound, then adding antibiotics, and continuously stirring and uniformly mixing for reaction to obtain a mixed solution; and S2, centrifuging the mixed solution, collecting the precipitate, washing, and dispersing into water for storage to obtain the nano-drug preparation. The nano medicinal preparation disclosed by the invention can intelligently respond to a tumor microenvironment, efficiently remove fusobacterium nucleatum in tumors and kill tumor cells through synergistic antibacterial and anticancer effects, so that tumor development is inhibited. Moreover, the complex prepared by the invention can enhance the stability of a medicinal preparation, can realize targeted release of the medicine in a tumor microenvironment, and improves the action effect.

This invention discloses a meglumine-luteolin complex, its preparation method, and its applications, belonging to the interdisciplinary field of microbiome and drug delivery. Using luteolin as the main material, this invention employs a dual inclusion technique with hydroxypropyl-β-cyclodextrin and meglumine to synergistically prepare a meglumine-luteolin complex with colon-targeted delivery capabilities. This invention significantly improves the delivery efficiency and drug loading of luteolin in the colon through the dual inclusion technique. The preparation process is simple, and it exhibits excellent hypoglycemic effects and colon-targeted release characteristics in the treatment of diabetes and its complications.

The invention relates to a drug-loading material containing modified sodium alginate and application of the drug-loading material in pesticide preparations, and belongs to the technical field of pesticide pharmacy, the drug-loading material containing modified sodium alginate contains an N-vinyl caprolactam chain segment, the volume phase transition temperature of the drug-loading material can be regulated and controlled through the concentration of metal ions, and the temperature-sensitive chain segment collapses at high temperature, so that the drug-loading material containing modified sodium alginate has good stability. At low temperature, the network is loose to promote release, at low temperature, the network is compact, ineffective release is inhibited, temperature fluctuation in the field is adapted, metal ions, carboxyl of modified sodium alginate, carboxyl of dehydroabietic acid and acylamino of N-vinylcaprolactam form a dynamic coordination network, accurate gradient release is presented in weak-acid, neutral and alkaline environments, and the metal ion-modified hydrogel has good biocompatibility. Amino and carboxyl of the chitosan quaternary ammonium salt form an acid-base buffer pair, the pH response interval is further refined, release disorder caused by small fluctuation of soil acidity and alkalinity is avoided, the drug-loading material has a temperature and pH dual response function, and targeted release in a pest and disease damage high-incidence environment (high temperature and specific pH) is achieved.

The invention discloses a redox sensitive cationic polymer gene vector as well as preparation and application thereof. According to the invention, hydrophobic small molecules with oxidation / reduction responsive S-S bonds are adopted to carry out side chain modification on polyglycidyl amine, and the cationic polymer gene delivery carrier material with specific tumor microenvironment response capability is prepared. The material has good biocompatibility, and can effectively load siRNA molecules and form siRNA compound nanoparticles with good stability and excellent gene transfection capacity. The compound nanoparticles can be effectively absorbed by cells, and can effectively respond to an oxidation / reduction tumor microenvironment to realize targeted release of siRNA. The oxidation / reduction response cationic polymer gene vector provided by the invention has a relatively great clinical application prospect.

The present application provides the use of a nanocomposite with a core-shell structure. Specifically, the present application provides the use of a nanocomposite with a core-shell structure in the preparation of a drug for preventing and / or treating Clostridium difficile infection and recurrent diseases caused thereby, wherein the nanocomposite comprises: ZnO nanoparticles as a core; mesoporous silica as a shell coated on the surface of the ZnO nanoparticles; an antibiotic loaded in the pore channel of the mesoporous silica; hyperbranched polylysine modified on the surface of the mesoporous silica; and a pH-responsive coating material as the outermost layer. The nanocomposite provided by the present application can achieve precise targeted release of the drug in the colon, and through the sequential and synergistic mechanism of "membrane breaking-sterilization-spore inhibition-repair", it can simultaneously solve multiple factors leading to CDI recurrence such as biofilm protection, spore storage, bacterial population destruction, mucosal damage, etc., and improve the treatment effect.

The invention discloses a galanthamine hydrobromide enteric-coated tablet and a preparation method thereof. The tablet is composed of a tablet core, an isolation layer and an enteric layer, the tablet core contains 5.0%-16.0% of galanthamine hydrobromide, and auxiliary materials such as mannitol, a mixture of magnesium stearate and sodium stearyl fumarate in a specific proportion, colloidal silicon dioxide and the like are matched; the isolating layer adopts an opadry II type film coating, and the enteric-coated layer adopts an opadry Acryl-EZE II type enteric-coated coating. The dissolution rate of the tablet in an acidic medium with the pH value of 1.2 for 2 hours is less than 5%, the release rate of the tablet in a medium with the pH value of 5.5 or 6.8 for 45 minutes is more than or equal to 80%, the tablet is sealed and placed at 40 DEG C + / -2 DEG C / 75% + / -5% RH for 6 months, the stability is good, and the pharmacokinetic parameters are excellent. The preparation method comprises the steps of raw and auxiliary material pretreatment, graded premixing, total mixing and lubricating, tabletting, two-step coating and the like, and the process is stable and controllable. The enteric-coated tablet disclosed by the invention is strong in targeted release property, high in stability and good in bioavailability, and can guarantee the effectiveness and safety of medication.

The invention discloses an EVOH packaging material with long-acting antibacterial and antioxidant functions and a preparation method of the EVOH packaging material, wherein the EVOH packaging material is obtained on the basis of a dynamic molecular switch and a microcapsule targeted release technology. The material comprises an EVOH matrix (A), an environmental response type molecular switch polymer (B) and an intelligent microcapsule (C) sensitive to at least one putrefying biomarker, and a compatibilizer (D). In a normal state, the molecular switch is turned off, and the release of the active agent is inhibited; when the environment humidity is increased or the concentration of the putrefying biomarker is changed, the molecular switch is turned on, and the microcapsule is disintegrated in a targeted manner, so that the efficient and intelligent release of active substances is realized. The material can prolong the effective period of an active agent by more than 300%, realizes accurate intervention on food spoilage, and is suitable for the field of high-end intelligent packaging.

The invention discloses oral composite microspheres for treating ulcerative colitis based on intestinal ROS storm pathological axis regulation as well as a preparation method and application of the oral composite microspheres, and aims to solve the problems that an existing ulcerative colitis treatment means is difficult to reverse core pathological circulation, oral antioxidant drugs and nano-enzymes are easily inactivated by gastric acid, the targeting property is poor, and the treatment effect is poor. And when the probiotics are independently used, the oxidation resistance is insufficient. The oral composite microsphere is prepared by taking clostridium butyricum spores as a biological carrier, firstly loading Ir10-KB nano-enzyme with peroxidase, superoxide dismutase and catalase like activities, and then carrying out sodium alginate-calcium ion cross-linking embedding. Anti-gastric acid protection and colon targeted release are achieved through the pH response gel characteristic of the sodium alginate, the flora regulation and mucous membrane repair effects of clostridium butyricum spores and the efficient ROS removal, mitochondrial protection and PANoptosis inhibition functions of the Ir10-KB nano-enzyme are synergistically exerted, and the synergistic treatment purpose of precise delivery-efficient oxidation resistance-micro-ecological regulation is achieved.

The invention relates to the technical field of medical apparatus and instruments, discloses an antibacterial photodynamic therapy light-operated catheter system based on targeted delivery, and solves the technical problems of insufficient light penetration depth and active oxygen non-targeted tissue damage when traditional aPDT is used for treating deep tissue infection. Comprises: a sterile flexible catheter body including at least an inflow lumen and an outflow lumen; the light source module is integrated in the catheter body and is used for providing excitation illumination in vitro or in a specific cavity; the photosensitive medicine storage and delivery module is communicated with the inflow cavity; the reaction cavity is arranged in the catheter body / at the near end, the photosensitive medicine is activated by the light source when flowing through the area, and a photochemical product with bactericidal activity is generated. Through a working mode of in-vivo targeted release of the photoactivated antibacterial solution, generation and delivery of antibacterial active substances in a deep infection focus are realized, non-targeted damage caused by direct irradiation of high-energy light to in-vivo tissues is avoided, and safety, effectiveness and clinical application range of aPDT in deep infection treatment are remarkably improved.

This invention discloses an environmentally friendly curcumin nanocrystal and its preparation method, relating to the field of nanoparticle technology. The nanocrystal has a core-shell structure, with a core of curcumin crystals and a shell of hepatin peptide molecules bonded together by intermolecular forces. The average particle size of the nanocrystal is 50-200 nanometers, and it is completely dispersed and stable in an aqueous phase, containing no organic solvents or synthetic surfactants. This invention utilizes a pectin-chitosan complex to microencapsulate the nanocrystal, enabling it to resist gastric acid degradation and target release to the colon, thus precisely acting on the gut-hepatic axis and significantly improving bioavailability and hepatoprotective efficacy. While completely avoiding organic solvents and synthetic stabilizers, it simultaneously solves four major industry challenges related to curcumin: solubility, stability, targeted delivery, and synergistic efficacy, providing a new technical path for developing high-end, naturally derived hepatoprotective products.

This application provides a multi-environment release control method, electronic device, and storage medium, applicable to the field of software release control technology. The method includes: capturing snapshots of each managed object in the production environment to obtain source production snapshots and a list of source production snapshots; reconstructing the test environment based on the source production snapshots, and archiving and packaging each managed object in the test environment to generate candidate release versions and a candidate release list; performing difference analysis on the source production snapshot list, the candidate release list, and the current production snapshot list to determine the production promotion access control result; determining the target release version based on the production promotion access control result and the candidate release versions; and releasing the target release version in the target environment. This application establishes the association between the source production snapshot list, the candidate release list, and the current production snapshot list, and performs three-way verification on the managed objects, which can accurately identify the source of production drift and improve the accuracy of promotion judgment.

The invention relates to the field of cosmetics, in particular to natural foundation cream with a soothing effect and a preparation method of the natural foundation cream. Comprising 10-30% of modified toner, 3-15% of a natural active matter system and 30-40% of a silicone oil-free oil phase, and the balance of water phase; the modified toner is obtained by compositely wrapping toner with coconut oil and an aloe leaf extract, and the aloe leaf extract is obtained by extracting coconut oil as a solvent; the natural active matter system comprises the following components in percentage by weight: 2.0 to 5.0 percent of beta-glucan and 0.25 to 1.0 percent of phaeodactylum tricornutum extract; and 1.0-3.0% of a plant composite extract composed of a coptis root extract, a common vladimiria root extract and a mangnolia officinalis bark extract. The modified toner releases a basic soothing component when being in contact with the skin through a coconut oil aloe leaf extract wrapping layer, and the toner is converted into an efficient delivery carrier of an active soothing component from an inert pigment; the active substance and the modified toner have synergistic interaction; therefore, makeup covering is accompanied by targeted release of the soothing component.

The invention discloses an intestinal micro-emulsified targeted release type xanthoceras sorbifolia bunge oil soft capsule and a preparation method thereof, and belongs to the technical field of functional food and health-care product preparations. The soft capsule is composed of a content containing low-temperature squeezed xanthoceras sorbifolia bunge oil and a self-microemulsion delivery system, and a gastrointestinal fluid response type capsule shell. The preparation method comprises the steps of delivery system preparation, capsule shell preparation, capsule forming, quality detection and the like. Intestinal targeted delivery, controllable disintegration and intestinal in-situ emulsification core technologies are integrated to form a synergistic effect, so that active ingredients such as nervonic acid safely pass through the stomach and are accurately released in the intestinal tract to form a nano-scale microemulsion, the bioavailability is improved from less than 20% to more than or equal to 60%, and the nano-scale microemulsion is high in compatibility with an existing production line, controllable in quality, low in industrialization cost and suitable for industrial production. The xanthoceras sorbifolia bunge oil can be promoted to be upgraded to a high-valued functional preparation.

The present invention relates to the treatment of diseases associated with inflammation including solid cancers. More particularly, certain methods relate to the administration (e.g., intravenously) of polyhedrin protein (PODS) crystals for the delivery of one or more therapeutic proteins. This enables targeted release of low doses of the therapeutic protein at sites of the disease.

The invention discloses a targeted drug release type cardiovascular stent system for preventing vascular restenosis, and belongs to the technical field of interventional medical instruments. Comprising a stent skeleton matched with a coronary artery lumen, a micro-fluidic drug storage bin assembly integrally embedded in the stent skeleton, an intelligent driving assembly correspondingly assembled in a micro-fluidic channel and a targeted release mechanism arranged in the stent skeleton, the micro-fluidic drug storage bin assembly comprises a plurality of independently sealed drug storage bins and corresponding micro-fluidic channels, and the intelligent driving assembly achieves sequential unlocking according to the vascular repair stage through a Venturi tube, a body temperature response type diameter adjusting piece, a sequential degradation sealing piece and an elastic self-reset blocking sealing piece, dynamically adjusts the drug release amount along with the body temperature gradient, and achieves the purpose of repairing the blood vessel. And the liquid medicine is directionally released to a diseased region through the array microtube. The full-period staged precise drug delivery can be realized, the unbalance and unexpected release of the drug are avoided, and the effect and clinical reliability of the stent for preventing the vascular restenosis are improved.

The invention discloses a control system and method for an intelligent fragrance deodorizing refrigerator and a storage medium, and the system comprises a fragrance slow release module arranged at an air duct of a refrigerating chamber, a temperature sensor arranged in the refrigerating chamber of the refrigerator, and a smell sensor arranged at an air return port of the refrigerating chamber, and the controller is electrically connected with the smell sensor, the temperature sensor and the fragrance slow-release module. The controller is configured to obtain peculiar smell concentration data detected by the smell sensor, determine a preset release parameter of the fragrance slow-release module according to the peculiar smell concentration data, obtain temperature data detected by the temperature sensor, and perform temperature compensation on the preset release parameter based on the temperature data to generate a target release parameter of the fragrance slow-release module; and generating a control instruction according to the target release parameter to control the fragrance slow-release module to execute a release operation according to the target release parameter. According to the application, on-demand release and temperature compensation are realized, the consistent release effect at different temperatures is ensured, and the deodorization accuracy and the user experience are improved.

This invention relates to the field of nanomedicine formulation technology, and discloses a ROS-responsive astaxanthin nanoparticle, its preparation method, and its application. The preparation method includes: catalyzing the transketalization reaction of 3-mercaptopropionic acid with 2,2-dimethoxypropane using an alcohol-water tolerant Lewis acid catalyst (preferably scandium trifluoromethanesulfonate) to prepare a thioketal monomer containing dual-terminated carboxyl groups; coupling the thioketal monomer with stearyl alcohol and methoxy polyethylene glycol using a stepwise sequential coupling strategy to construct an amphiphilic polymer with thioketal bonds as ROS-responsive connecting units; co-dissolving the polymer, astaxanthin, and tocotrienols in tetrahydrofuran, and preparing the nanoparticles using a multi-inlet micro-collision flow nanoprecipitation process. The resulting nanoparticles have a particle size of 100 nm to 200 nm, an astaxanthin encapsulation rate of 90% to 99%, and achieve targeted release in response to reactive oxygen species in the pathological microenvironment. Astaxanthin and tocotrienols synergistically exert antioxidant effects.

This invention discloses a machine learning-based method for monitoring the quality of compound fertilizers, belonging to the field of fertilizer quality monitoring technology. The method includes: collecting surface images, water absorption responses, thermal responses, and process parameters of controlled-release compound fertilizer coated granules; preprocessing these parameters to form standardized characterization records; combining the nutrient release curve with the target release curve to construct the overall release deviation and the initial excessive release amount, and calculating the release runaway degree index; inputting the standardized characterization records into a machine learning model, outputting the predicted mean and variance of the release runaway degree, and calculating the release runaway risk probability accordingly to complete granule quality grading and batch release determination. This invention achieves quantitative characterization of nutrient release anomalies and quantitative prediction of release runaway risk, improving the accuracy of quality determination, monitoring reliability, and production quality control efficiency.

The application discloses a drug delivery system for remodeling intestinal uric acid homeostasis and a preparation method, a pharmaceutical composition and an application thereof, and belongs to the field of biomedical technology. The drug delivery system comprises a probiotic active biological carrier with autonomous movement capability, the surface of the probiotic active biological carrier is loaded with uricase and peroxidase-like active nanoscale enzyme through electrostatic interaction, and the probiotic active biological carrier is externally coated with a pH-responsive protective shell. The uricase catalytically degrades intestinal uric acid, the nanoscale enzyme synchronously removes hydrogen peroxide byproducts to maintain catalytic stability, and the shell protects the active ingredients in gastric acid and realizes targeted release and long-term retention in the intestine by responding to dissociation. Moreover, the drug delivery system has high targeting property, high safety and can efficiently remodel intestinal uric acid homeostasis.

This invention provides a stress-triggered selective targeting hydrogel microsphere, its preparation method, and its application, belonging to the field of biomedical technology. The core of this invention is the "stress-triggered charge reversal" mechanism. It utilizes the interaction between weakly cross-linked disulfide bonds broken under stress and "charge reversal" messenger molecules to achieve "charge reversal" of nanoparticles under stress. A dual-network hydrogel microsphere system is prepared using microfluidic technology to achieve bearing lubrication and stress relaxation within the joint cavity. Stress-triggered charge reversal is achieved at stress-overloaded cartilage lesions, imparting a positive charge to the drug-loaded nanoparticles within the hydrogel microspheres. This significantly enhances the ability of the drug-loaded nanoparticles to penetrate deep into the cartilage matrix and target chondrocytes for drug release under the guidance of the charge. This enables the selective and targeted release of appropriate drug concentrations to deep-seated chondrocytes in pathological microenvironments induced by different stress intensities, achieving highly effective and low-toxicity treatment of osteoarthritis.

The invention belongs to the technical field of biology, and particularly relates to an exosome co-delivery composition as well as a preparation method and application thereof. According to the exosome co-delivery composition provided by the invention, a system A utilizes mannitol-chitosan oligosaccharide to embed an active component exosome and probiotics to construct a chitosan oligosaccharide-mannitol nano-coating system, so that the survival rate and the structural stability of the active component can be improved; chitosan oligosaccharide in the system B forms a three-dimensional nanogel network through ionic cross-linking, butyrate and glutathione are embedded, a stable nanogel matrix is formed, a chitosan oligosaccharide-glutathione-butyrate nanogel system is constructed, multi-path protection, targeted release and synergistic interaction of probiotics, exosome, butyrate and glutathione are achieved through synergism of the three-dimensional nanogel network and the butyrate and the glutathione, and the chitosan oligosaccharide-glutathione-butyrate nanogel system has the advantages of being good in biocompatibility, good in biocompatibility and good in biocompatibility. And therefore, a remarkable comprehensive promotion effect is generated in the aspects of intestinal barrier repair, flora reconstruction, anti-inflammation, anti-oxidation and energy supply.

The utility model discloses a breast milk source probiotic and breast milk oligosaccharide co-sealed nozzle, and relates to the technical field of packaging. The pipe comprises a core pipe, a middle pipe and an outer pipe which are concentrically arranged from inside to outside, the top end of the middle pipe is provided with an upper flaring section, the middle pipe is connected with the core pipe through the upper flaring section, the top end of the outer pipe is provided with a lower flaring section, the outer pipe is connected with the middle pipe through the lower flaring section, and the outer sides of the upper flaring section and the lower flaring section are integrally provided with obliquely-arranged access ends. And a mixing channel, a gel channel and a coating channel are respectively formed in the core tube, between the core tube and the middle tube and between the middle tube and the outer tube. According to the utility model, the nozzle structure with the three-stage coaxial flow channel design is adopted, the diameter ratio is 1: 2: 4, the laminar flow stability can be ensured, the conical end on the outer tube is matched, the fluid turbulence problem is reduced, the microsphere monodispersity is improved, the nozzle can realize single-step forming of co-sealing of breast milk source probiotics and breast milk oligosaccharide, and high encapsulation efficiency and targeted release are ensured.

The invention discloses a preparation method and application of esterase sensitive gambogic acid self-assembled micelle nanoparticles. Gambogic acid and poloxamer 188 are used as raw materials of the self-assembled micelle nanoparticle, and GA and P188 form an ester bond through esterification reaction, so that a gambogic acid self-assembled micelle nanoparticle precursor is formed. The gambogic acid micelle nanoparticles can be formed through self-assembly in an aqueous solution, the particle size is uniform, the average particle size is about 58 nm, the polydispersity index is 0.203, and it is indicated that the micelle nanoparticles have good monodispersity. In-vitro release studies show that the prepared gambogic acid self-assembled micelle nanoparticles have esterase responsiveness and are expected to realize targeted release of gambogic acid at tumor sites, and the anti-tumor effect is improved. The preparation method of the gambogic acid self-assembled micelle nanoparticle GA-P188 provided by the invention is simple in operation steps, relatively low in cost and good in tumor inhibition effect, and can have relatively high industrialization prospects.

The invention discloses an oral vaccine as well as a preparation method and application thereof, and relates to the technical field of pharmaceutical preparations. The oral vaccine comprises a core, and a permeation enhancing layer, an active molecular layer and an enteric coating layer which are sequentially coated on the surface of the core, the core is a biodegradable polymer nano particle; the permeation enhancing layer is a polydopamine layer loaded with a permeation enhancer; the active molecular layer is a chitosan layer loaded with an antigen and a targeting substance. The oral vaccine provided by the embodiment of the invention is good in stability, can ensure that the antigen is stable in gastrointestinal tracts and keeps activity, realizes targeted release of intestinal tracts, can activate far-end mucous membrane tissues at the same time, realizes broad-spectrum IgA and IgG immunization, and is suitable for delivery of various oral antigens.

The invention belongs to the technical field of medical treatment, and particularly relates to a pulse and ultrasonic energy time sequence synergistic drug delivery method and system. The pulse and ultrasonic energy time sequence synergistic administration method is characterized by comprising the following steps: (1) suspending medicament injection, and only washing with cooling liquid for 2-4 seconds; (2) the conveying of the cooling liquid is suspended, the medicament is sprayed for 0.5-1.5 seconds, and meanwhile, the ultrasound continuously works; (3) suspending injection of the medicament, re-inputting the cooling liquid, and continuing for 2-4 seconds; and (4) repeating the steps (1), (2) and (3) until completion. The system has the advantages that through pulse type drug delivery and time sequence cooperative control, periodic targeted release of high-concentration drugs is achieved, the drug utilization rate and the thrombolysis effect are remarkably improved, drug permeation is enhanced through the ultrasonic cavitation effect, and meanwhile the heat dissipation requirement of the system is met.