230 results about "Targeted release" patented technology

The invention relates to hydrogel for treating ischemic brain injury and a preparation method thereof. The hydrogel is prepared from the following raw materials: methylacryloylated hyaluronic acid, methylacryloylated gelatin, curcumin loaded HA-PPS (Hydroxypropyl-Polyphenylene Sulfite) nano-micelles and dendrobium polysaccharide loaded sodium alginate microspheres. Through combination of a nanotechnology and an intelligent response material, HA-PPS is adopted to load curcumin and sodium alginate microspheres are adopted to encapsulate dendrobium polysaccharide, so that the drug activity can be more effectively protected, the drug is protected to penetrate through a blood brain barrier and be accurately delivered to a brain injury area, and targeted release of the drug is realized; the anti-oxidation and anti-inflammatory effects are better under the combined action of the curcumin and the dendrobium polysaccharides, and meanwhile, a slow release function is also achieved.

The invention provides the nano-liposome for embedding the cod bone peptide calcium chelate, so that the digestion stability of the cod bone peptide calcium chelate is enhanced, targeted release of Ca < 2 + > in small intestines is facilitated, and the bioavailability of the cod bone peptide calcium chelate is further improved. The amino acid sequence of the cod bone calcium chelating active peptide is SSGPGGERGPp. The nano-liposome disclosed by the invention can ensure the structural integrity in the stomach to protect the cod bone peptide calcium chelate from being damaged, and can release the peptide calcium chelate in the intestinal digestion process, so that the digestion stability of the cod bone peptide calcium chelate is improved, and the targeted delivery of the cod bone peptide calcium chelate is realized.

The invention belongs to the technical field of inhibitors, and provides a temperature-controlled targeted release composite inhibitor and a preparation method and application thereof. The preparation method comprises the following steps: carrying out a neutralization reaction on an acrylic acid solution, cellulose, acrylamide and water to obtain an intermediate solution, carrying out a polymerization reaction on an initiator, a cross-linking agent and the intermediate solution to obtain water-absorbing gel, and soaking the water-absorbing gel into an aqueous solution of an antioxidant for adsorption. The temperature-controlled targeted release composite stopping agent is composed of water-absorbing gel (a physical stopping agent) and an antioxidant (a chemical stopping agent), the water-absorbing gel is of a three-dimensional network structure, cellulose in the water-absorbing gel contains a large number of water-absorbing groups, a solution containing the antioxidant can be wrapped in the three-dimensional network structure, and the stability of the antioxidant is effectively improved; the water-absorbing gel can play roles in physical cooling and fire extinguishing, and is a biodegradable material; along with the rise of the temperature, the water-absorbing gel slowly releases the antioxidant, so that the effect of continuously inhibiting spontaneous combustion of the coal is exerted.

The invention discloses a preparation method and application of silymarin spray curing nano-carrier powder, and relates to the technical field of medicines and the field of foods. The method comprises the following steps: firstly, constructing a silymarin-carrier compound through a molecular self-assembly technology, and then, carrying out curing treatment on a nano-carrier by adopting a spray drying technology, so as to obtain nano-powder with good flowability. According to the preparation method disclosed by the invention, the silymarin spray curing nano-carrier powder with a core-shell structure is successfully prepared by optimizing a carrier material ratio and spray drying conditions. Experimental results show that the spray-cured nano-carrier powder prepared by the method significantly improves the solubility and stability of silymarin, and enhances the bioavailability and efficacy, so that silymarin can be more efficiently absorbed and released in a targeted manner in vivo, thereby significantly improving the therapeutic effect.

A drivable drug-release and sampling integrated capsule, which falls within the technical field of medical instruments, and can achieve targeted release of a drug of an exact dose and nearly non-invasive tissue sampling at a precise position in the human intestinal tract. The capsule comprises a shell (1), wherein the shell (1) is provided with a first external thread (11) and an internal thread (12) having the same rotation direction, and is provided with a first drug outlet at the tail and a sampling needle (4) at the head; a sleeve (2) and a plunger (3) are provided in the shell (1); the sleeve (2) is a cylinder having an opening at one end; the plunger (3) comprises a threaded section (31) and a plain shaft section (32), the threaded section (31) being provided with a second external thread (33) adapted to the internal thread (12), the plain shaft section (32) extending into the sleeve (2) and capable of axially sliding in the sleeve (2), and the bottom surface of the plain shaft section (32), the bottom surface of the sleeve (2) and the inner side wall of the sleeve (2) enclosing a drug storage cavity (5); a second drug outlet is provided in a side wall of the drug storage cavity (5); the plunger (3) can push the sleeve (2) to move in the axial direction of the shell (1); when the sleeve (2) moves to the bottom of the shell (1), the first drug outlet is in communication with the second drug outlet; and both the first external thread (11) and the second external thread (33) have magnetic properties.

The invention relates to a drug delivery system for treating osteoporosis caused by cell aging as well as a preparation method and application of the drug delivery system. The drug delivery system comprises a bone targeting ligand modified drug carrier and an anti-bone cell aging drug entrapped in the drug carrier, the bone targeting ligand is selected from any one of alendronate sodium, bisphosphate and analogues thereof, tetracycline, tartrate-resistant acid phosphatase TRAP binding peptide, pregnancy region protein or e-selectin; the anti-osteocyte senescence medicine comprises any one or a combination of at least two of dasatinib, quercetin, metformin, L-ascorbic acid, aspirin or fisetin. According to the prepared drug delivery system, the bioavailability of the drug can be effectively improved, targeted release of the drug in bone tissue is achieved, senescent cell enrichment is reduced, and the bone microenvironment is improved, so that a new strategy is provided for treating osteoporosis caused by cell senescence.

The invention discloses a targeted drug delivery capsule robot based on a soluble film. The targeted drug delivery capsule robot comprises a soft capsule shell, a magnetic control module, a camera module, a drug storage cavity, a release channel and the soluble film covering an outlet of the release channel. The capsule robot has the advantages that by means of the transparent design of the soft capsule shell, the intuition and safety of the drug delivery process are guaranteed, the targeted drug delivery mechanism is located at one end of the capsule robot, drug release is controlled by a soluble film, accurate response can be conducted according to the environmental conditions (such as pH value, temperature or enzyme concentration) of different parts of the digestive tract, and the targeted drug delivery mechanism is suitable for being applied to the digestive tract. Therefore, targeted release of the drug is realized. Due to the linkage design of the magnetic control system and the oscillation module, the capsule robot can be rapidly positioned to a target area in a complex alimentary canal environment, and the accuracy and reliability of targeted drug delivery are improved. Compared with a traditional medicine release mode, the structure remarkably reduces medicine waste and systemic side effects, and meanwhile the efficient treatment requirement of minimally invasive medical treatment is met.

The invention discloses a nano-drug delivery method for enhancing LGP kidney targeted release and application of the nano-drug delivery method, and relates to the technical field of nano-drugs. According to the nano-drug delivery method for enhancing LGP kidney targeted release and the application thereof, a hydrophobic modified chitosan polymer is synthesized; preparing HCS nanoparticles; and constructing a drug loaded nanoparticle, namely, HCS-LGP NPs. According to the invention, the solubility of the medicine is increased, the distribution of the medicine in vivo is changed, and the targeting of the medicine is improved, so that the treatment effect is improved, and adverse reactions are reduced. Due to good biocompatibility and modifiability, chitosan is widely used as a nano delivery carrier of anti-tumor and antibacterial drugs.

The invention belongs to the technical field of composite gel and application thereof, and relates to colon-targeted composite gel and a preparation method and application thereof.The preparation method of the colon-targeted composite gel comprises the following steps that S1, polysaccharide and protein are dissolved in water with the same volume, and a polysaccharide solution and a protein solution are correspondingly obtained; s2, mixing the protein solution and the polysaccharide solution, adding succinic acid and calcium chloride, and finally staying overnight at 4 DEG C to obtain the colon-targeted composite gel. Polysaccharide, protein, succinic acid and calcium chloride are adopted to form the colon-targeted composite gel, the colon-targeted composite gel has a compact and stable structure, the encapsulation efficiency of succinic acid is greatly improved, the targeted release rate of succinic acid in colon is facilitated, and precise targeted delivery of succinic acid in colon is realized.

The invention provides a boron drug with tumor targeted release capability for boron neutron capture therapy and a preparation method thereof, relates to the technical field of tumor therapy, and provides a boron drug which can be activated through high-concentration NAD (P) H at a tumor site and can release a B-10 drug in a targeted manner for boron neutron capture therapy. A boron-10-containing compound in the boron medicine is connected with 3-aldehyde quinoline salt through a self-elimination reactive group, the 3-aldehyde quinoline salt can be specifically reduced by NAD (P) H rich in tumor cells to trigger chain reaction, and the effective boron-10 compound is released for boron neutron capture therapy. The damage to normal cells in the BNCT process can be effectively reduced by a method for targeted aggregation of the boron drug in the tumor cells. The boron drug synthesis method is simple, mild in condition and high in yield, has the advantages of stable chemical property, good light stability, small toxicity and the like, and provides a good application prospect for the field of boron neutron capture therapy.

The invention relates to the technical field of vehicles, and discloses a vehicle fragrance release control method and device, electronic equipment and a storage medium, the method is applied to a vehicle end, and the method comprises the steps that in response to a fragrance release instruction, fragrance parameters of specified fragrance are determined, and according to the current in-vehicle total pressure, the current in-vehicle temperature and the current in-vehicle humidity, the fragrance parameters of the specified fragrance are determined; calculating to obtain a target release concentration of a specified fragrance in the fragrance release instruction; according to the target release concentration, the fragrance release rate constant and the fragrance release amount, the release duration of the specified fragrance is calculated; according to the perceptual fragrance intensity, the in-vehicle space volume, the perceptual fragrance release rate constant, the perceptual fragrance release amount and the perceptual intensity correction coefficient, the release air volume of the specified perceptual fragrance is obtained through calculation; and controlling the release of the specified fragrance based on the release air volume and the release duration. According to the method, the release parameters of the specified fragrance can be determined in real time, so that the requirement of a driver on the concentration of the fragrance in the vehicle is met, and the experience feeling of the driver is provided.

The invention firstly provides an intestinal tract targeted pH-ROS double-response hydrogel packaging system, the hydrogel packaging system is sodium alginate (SA)-based hydrogel modified by ketothioacetal (tK) and calcium ions, and the hydrogel is used for intestinal tract probiotics lactobacillus rhamnosus GG (LGG). Wherein the hydrogel in unit volume contains 10 < 8 >-10 < 9 > CFU of LGG (Ligusticum Glycol Glycol); the LGG is the LGG modified by EGCG-Mn nano particles, namely LGG (at) EGCG-Mn. The hydrogel matrix adopted in the packaging system not only provides enough gastric acid resistance for the LGG, but also promotes colon targeting and enhances intestinal retention. More importantly, the modification of the EGCG-Mn nanoparticles endows the LGG with a cell protection capability in an excessive ROS environment, so that targeted release, stable survival and colonization of the LGG after the LGG reaches the colon are realized. The technical problems that the LGG cannot reach the colon sufficiently and is difficult to survive stably in the prior art are solved, and an unexpected technical effect is generated; and the method is simple to operate, quick in reaction and mild in reaction condition, and has important practical application prospects.

The invention discloses a composition for preventing and treating eggplant root rot, and relates to the technical field of biological prevention and treatment. The composition consists of three parts, namely a double-stranded RNA (Ribonucleic Acid) delivery body controlled by a kaolinite nanotube-metal polyphenol network-boric acid ester, a nitric oxide / hydrogen sulfide double-pulse microcapsule and volatile organic compound particles of beta-cyclodextrin cross-linked aerogel, wherein the three parts are matched according to the total mass ratio of 1: (0.8-1.5): (0.8-1.2). Through structural design, time sequence release of non-overlapping peak values is realized, and a prevention and control mode for inhibiting environment enhancement host precise silencing is formed. The deliverer can be selectively disintegrated under the condition of pathogen-induced organic acid, iron chelating agent and hydrogen peroxide, so that the targeted release of the double-stranded RNA is realized; the double-pulse microcapsule respectively releases nitric oxide and hydrogen sulfide in a transplanting stress stage and an early disease stage, and induces host defensive gene expression; the aerogel particles continuously release 2, 3-butanediol and aromatic aldehyde to inhibit germination of pathogenic bacteria and serve as rhizosphere signals to enhance host resistance.

The invention relates to the technical field of alimentary canal diagnosis and treatment, in particular to an alimentary canal detection drug delivery system which comprises an alimentary canal sensing unit for collecting an image, a pH value, a temperature and pathological tissue pathological characteristic data in an alimentary canal cavity; the lesion positioning analysis unit identifies a lesion area through an image segmentation algorithm, constructs a lesion three-dimensional coordinate model according to physiological parameters, prejudges a lesion displacement trend in combination with an alimentary canal peristalsis rule, analyzes a lesion state in stages, and outputs lesion severity; the response type drug delivery module controls the micro drug delivery device to perform targeted release and adjust the drug release rate based on the lesion coordinates and the intracavity environment parameters; the data collaboration platform shares a detection result and a drug administration record through a real-time interaction interface; the curative effect feedback unit is used for collecting physiological index change and patient symptom improvement data after drug administration, judging the drug onset period and possible adverse reactions, and optimizing drug administration parameters and detection frequency. Therefore, the problems of low targeting precision, poor diagnosis and treatment efficiency and the like in the prior art are solved.

The invention provides a high-definition vascular structure reconstruction and blood flow function evaluation method and system, and the method comprises the steps: constructing a high-dimensional feature manifold space based on an ultrasound contrast image, carrying out the recognition to obtain a vascular subgroup with different blood flow function modes, and finally obtaining a high-definition rainbow vascular structure video and a vascular heterogeneity index in an ultrasound scanning region. A powerful tool can be provided for evaluating tumor microvascular structures, blood flow functions and time-space heterogeneous characteristics, abundant parameters for quantitatively describing tumor complex vascular systems are provided for early evaluation of drug curative effects, and a target blood flow perfusion area can be specifically recognized according to functional characteristics; and a target prompt and feedback intervention basis is provided for drug targeted release.

An iRGD-LAMP2B-EGFP fusion protein mediated exosome surface engineering strategy is adopted, through specific recognition of iRGD peptide and integrin alpha v beta 3, corneal neovascularization core lesion cells are actively targeted, the limitation of off-target toxicity of a traditional delivery system is broken through, and a'accurate focus recognition-efficient homing 'targeted delivery normal form is established. Meanwhile, the screened circular RNA with anti-inflammatory and anti-angiogenesis dual activities is used as a core effector molecule, and in combination with an in-situ loading technology of the circular RNA molecule in an exosome parent cell, stable entrapment and targeted release of a nucleic acid drug in an exosome cavity are realized, and the problems that the nucleic acid drug is easy to degrade and poor in targeting property are solved; and dual guarantee of function specificity and delivery stability is formed. And a synergistic treatment system of a targeting exosome carrier and bifunctional circular RNA is further constructed, active molecules are accurately delivered to focus cells, and an inflammation microenvironment and an angiogenesis pathway are synchronously regulated and controlled.

The present invention discloses a puerarin microcapsule for intestinal targeted release and its preparation method and application in the field of puerarin microcapsule embedding technology. The preparation method is as follows: using yeast β-glucan as an embedding carrier, in a solution environment, puerarin is embedded in yeast β-glucan under ultrasound to form a core material to obtain a first mixed solution; then sodium alginate powder is added to the first mixed solution under stirring to coat the surface of the core material with sodium alginate to form a layer of wall material to obtain a second mixed solution; using a sharp hole method, the second mixed solution is added dropwise to a coagulation bath for solidification, washed, and freeze-dried after solid-liquid separation to obtain puerarin microcapsules. The preparation method of the present invention is simple and easy to operate, selects medicine and food homologous substances as raw materials, does not introduce toxic and harmful chemical preparations such as cross-linking agents, avoids chemical pollution and potential health risks, and the puerarin microcapsules of the present invention have good intestinal sustained release and antioxidant properties.

The invention belongs to the technical field of preparation of tumor targeted drug carriers, and particularly discloses a reduction response type photopolymerizable supramolecular monomer as well as a preparation method and application thereof. According to the reduction response type photopolymerizable supramolecular monomer disclosed by the invention, a disulfide bond of cystamine dihydrochloride is taken as a molecular skeleton center, one end of the disulfide bond is substituted by hydrophilic element dendritic alkoxy ether, and hydrophobic element triphenylamine or tetraphenylethylene with an aggregation-induced emission (AIE) effect is introduced into the other end of the disulfide bond. The prepared supramolecular monomer can be self-assembled in a solution to form a supramolecular polymer, disulfide bonds can be broken under the action of a reducing compound, and targeted release of a loaded drug in a tumor microenvironment is achieved. Under the irradiation of ultraviolet light, partial crosslinking can be realized, so that the stability of the polymer is improved.

The invention relates to the technical field of biological scaffolds, in particular to a silk fibroin-based biological 3D intelligent response scaffold and a preparation method and application thereof.The silk fibroin-based biological 3D intelligent response scaffold adopts a three-layer bionic gradient structure of an oriented fiber membrane, a porous sponge layer and an interface layer, simulates natural tissues, and has the advantages that the bionic gradient structure is improved; mechanical guidance, cell inhabitation and biological activity interfaces are provided respectively, and high-quality regeneration of blood vessels, nerves and skin is promoted synergistically. According to the present invention, the pH / enzyme / temperature triple response unit is provided, such that the lesion microenvironment can be perceived, the targeted release can be triggered, the problem of high burst release rate of the traditional physical drug loading can be solved, and the on-demand accurate drug delivery can be achieved. The SF / HPMC gel is adopted for 3D printing, the printing precision is high, and the porosity difference is 1t; the product performance is stable, and the pore structure can be precisely designed and customized according to the regeneration requirements of different tissues (such as blood vessels, nerves and skin).

The invention discloses a control method, device and equipment for intelligently releasing fragrance of an automobile machine and a medium, and the method comprises the following steps: if a fragrance opening instruction is received, obtaining state information of a safety belt in each area of an automobile cabin; according to the state information of the safety belt, whether the safety belt in each area is in a working state or not is judged; if the safety belt in any area is in a working state, determining that the fragrance release device in the current area is a target release device; and sending a fragrance release control instruction to each target release device so as to control the corresponding target release device to release fragrance. According to the method, after the user shows the use requirement of the fragrance, the working state of the safety belt in each area is identified to judge which area the user sits, so that the fragrance is released to the area where the user sits, and the problems that in the prior art, the fragrance is released in the whole range in the vehicle, and the fragrance is wasted are solved.

The invention provides a double-layer wound dressing with gradient adhesive power and a preparation process thereof, the dressing comprises a wound contact layer A and a functional support layer B, the layer A is a chitosan / epsilon-polylysine nanofiber membrane prepared by electrostatic spinning, a composite antibacterial agent is loaded, and mild antibacterial and histocompatibility are realized; the layer B is oxidized sodium carboxymethyl cellulose-polyvinyl alcohol cross-linked hydrogel, the pore diameter is in gradient distribution, pH response type microcapsules are embedded, and repair factors can be directionally released according to wound microenvironment alkalinity. The gradient adhesive force constructed by the dressing gives consideration to wound fitness and external fixity. The preparation technology comprises the steps of electrostatic spinning film forming, gradient aperture construction through three-stage freeze drying, plasma activation interface and pulsed electric field auxiliary lamination compounding, and precise regulation and control of the material structure and function are achieved. According to the dressing, through gradient adhesive force design, targeted release and an antibacterial system, the hemostatic efficiency is remarkably improved, wound healing is promoted, secondary injury is reduced, and the dressing has outstanding clinical application value.

The invention belongs to the technical field of biological medicines, and discloses a fish collagen and rose double-effect anti-aging composition, and the core active ingredients of the fish collagen and rose double-effect anti-aging composition comprise fish collagen peptide, red roses with double petals, dried cranberries, Chinese wolfberry fruits, roxburgh rose puree and saffron. According to the preparation method, specific degradation of intestinal flora is realized by virtue of the targeting effect of the xylooligosaccharide on bifidobacteria through the compound polysaccharide microcapsules, so that collagen peptide and antioxidant components are accurately released in colon, gastric acid damage is effectively avoided, and meanwhile, the piperine nanoparticles inhibit the activity of UGT enzyme, so that the anti-oxidation effect of the collagen peptide on the colon is improved, and the anti-oxidation effect of the collagen peptide on the colon is improved. The bioavailability of crocin is increased to 45% or above from 2%, the absorption rate of rose polyphenol is increased by 3 times, the intestinal absorption efficiency of collagen peptide reaches 95%, a remarkable breakthrough is achieved compared with 60-80% of a traditional process, and an efficient delivery mode of targeted release-absorption enhancement is constructed.

The invention belongs to the technical field of traditional Chinese medicine preparations, and provides a traditional Chinese medicine granule composition based on rhizoma polygonati and a preparation method and application thereof. A three-layer intelligent response structure design is adopted, a 80-300 nm rhizoma polygonati nano core is prepared through an anti-solvent precipitation technology, a calcium alginate gel buffer layer containing probiotic nutritional factors is constructed through an ionic crosslinking technology, a pH response shell layer is prepared through a fluidized bed coating technology, and the release rate lt in gastric juice is achieved; the cumulative release rate gt in intestinal juice is 10%; according to the invention, the rhizoma polygonati polysaccharide and probiotic nutritional factors are added into the preparation, the precise intestinal targeted release performance is 80%, the drug loading capacity is 15-35%, the coating efficiency is 85-95%, and the technical problems that a traditional rhizoma polygonati preparation is poor in stability, effective components are damaged by gastric acid, and the bioavailability is low are solved; the traditional Chinese medicine composition can be used for treating diseases such as weakness of the spleen and the stomach, functional dyspepsia and dysbacteriosis of intestinal flora, and has wide application value.

The invention belongs to the technical field of biological medicine, and relates to an oral peptide drug delivery system based on a soybean trypsin inhibitor and core-shell hydrogel, the oral peptide drug delivery system comprises therapeutic polypeptide, KTI and a core-shell structure gel matrix, and the problems that an existing oral peptide delivery system is passively protected and drug burst release is remarkable are solved. A chitosan / sodium tripolyphosphate ionic cross-linked network forms an inner core, a sodium alginate / calcium ion'egg box 'structure cross-linked network forms a shell, and therapeutic polypeptides such as liraglutide and KTI are jointly embedded. Through the pH response characteristic and sequential release design of the core-shell structure, KTI is preferentially and rapidly released in the intestinal environment to inhibit local protease activity, then therapeutic polypeptide is slowly released, and active protection and synergistic interaction are achieved. The invention further provides a specific preparation method and parameters. The polypeptide has the advantages of stable structure in a gastric acid environment, targeted release in intestinal tracts, high encapsulation efficiency, capability of avoiding burst release and the like, and provides a new strategy for efficient delivery of oral polypeptide drugs.

The present invention relates to the technical field of tumor therapeutic drugs, and in particular to a composition of albumin and mercaptododecaborane and its application in the preparation of tumor therapeutic drugs. Its technical solution includes albumin, which is covalently coupled with mercaptododecaborane through the cysteine thiol group at position 34 to construct a nucleation site, and further point-loaded with mercaptododecaborane on the protein through the nucleation effect; the thiol group of the mercaptododecaborane is bound to the thiol group at position 34 of albumin cysteine through a disulfide bond. The present invention forms a nucleus by covalently coupling the free thiol group of albumin with mercaptododecaborane, and utilizes the nucleation effect to point-coat mercaptododecaborane, thereby avoiding the toxicity risks brought by organic solvents or chemical modifications in traditional solubilization methods, and effectively preventing oxidative degradation and free boron ion release, achieving pH-responsive targeted release, and significantly increasing the boron accumulation in tumor tissues, with both high stability, precise drug release, and low systemic toxicity.

The invention provides a nano medicinal preparation for tumor treatment as well as a preparation method and application thereof, and relates to the technical field of medicinal preparations. The preparation method of the nano medicinal preparation comprises the following steps: S1, adding metal salt and oxidase into water, uniformly stirring and mixing to form a compound, then adding antibiotics, and continuously stirring and uniformly mixing for reaction to obtain a mixed solution; and S2, centrifuging the mixed solution, collecting the precipitate, washing, and dispersing into water for storage to obtain the nano-drug preparation. The nano medicinal preparation disclosed by the invention can intelligently respond to a tumor microenvironment, efficiently remove fusobacterium nucleatum in tumors and kill tumor cells through synergistic antibacterial and anticancer effects, so that tumor development is inhibited. Moreover, the complex prepared by the invention can enhance the stability of a medicinal preparation, can realize targeted release of the medicine in a tumor microenvironment, and improves the action effect.

The invention provides an off-site radiation dose evaluation method and device based on nuclide migration joint simulation, and the method comprises the steps: obtaining the working condition data and meteorological data of a nuclear power plant; based on the working condition data and the working condition judgment condition, identifying a target release working condition to which the nuclear accident belongs; determining key radionuclides based on the target release working condition; based on the working condition data, the meteorological data and the environmental data of the emergency planning area corresponding to the nuclear power plant, obtaining the total irradiation dose of the key radionuclide through an airborne radionuclide migration dose model, a water radionuclide external irradiation dose model and a soil deposition external irradiation dose model, the technical problems in the prior art are solved.

The invention particularly relates to oral cavity anti-inflammatory toothpaste and a preparation method thereof. Comprising the following components in parts by weight: 20-30 parts of a friction agent, 1-2 parts of a surfactant, 1-2 parts of a thickening agent, 20-30 parts of a humectant, 0.1-0.55 part of a sweetening agent, 0.1-0.3 part of a preservative, 3-5 parts of an anti-inflammatory nano-composite, 0.3-0.35 part of lysozyme, a pH regulator for maintaining the pH value of the toothpaste to be 6.5-7.4, and the balance of water added to 100 parts. The anti-inflammatory nano compound is a nano compound formed by encapsulating patchouli alcohol, magnolol and a Zn-chlorogenic acid complex by using Eudragit E100 / chitosan. The intelligent pH response core-shell structure Eudragit E100 / chitosan is adopted, anti-inflammatory active ingredients can be accurately released at the oral inflammation part, the targeted delivery effect of efficient release of the inflammation part is achieved, a lysozyme pH response nano system is combined, the antibacterial spectrum is enhanced while targeted release is achieved, and the anti-inflammatory effect is achieved. The patchouli alcohol (antibacterial), the magnolol (anti-inflammatory) and the Zn-chlorogenic acid complex (repair promoting) form a composite efficacy system, and experiments prove that the inhibition rate on inflammatory factors such as TNF-alpha and IL-6 is about 70%.

This invention discloses a meglumine-luteolin complex, its preparation method, and its applications, belonging to the interdisciplinary field of microbiome and drug delivery. Using luteolin as the main material, this invention employs a dual inclusion technique with hydroxypropyl-β-cyclodextrin and meglumine to synergistically prepare a meglumine-luteolin complex with colon-targeted delivery capabilities. This invention significantly improves the delivery efficiency and drug loading of luteolin in the colon through the dual inclusion technique. The preparation process is simple, and it exhibits excellent hypoglycemic effects and colon-targeted release characteristics in the treatment of diabetes and its complications.

The invention relates to a drug-loading material containing modified sodium alginate and application of the drug-loading material in pesticide preparations, and belongs to the technical field of pesticide pharmacy, the drug-loading material containing modified sodium alginate contains an N-vinyl caprolactam chain segment, the volume phase transition temperature of the drug-loading material can be regulated and controlled through the concentration of metal ions, and the temperature-sensitive chain segment collapses at high temperature, so that the drug-loading material containing modified sodium alginate has good stability. At low temperature, the network is loose to promote release, at low temperature, the network is compact, ineffective release is inhibited, temperature fluctuation in the field is adapted, metal ions, carboxyl of modified sodium alginate, carboxyl of dehydroabietic acid and acylamino of N-vinylcaprolactam form a dynamic coordination network, accurate gradient release is presented in weak-acid, neutral and alkaline environments, and the metal ion-modified hydrogel has good biocompatibility. Amino and carboxyl of the chitosan quaternary ammonium salt form an acid-base buffer pair, the pH response interval is further refined, release disorder caused by small fluctuation of soil acidity and alkalinity is avoided, the drug-loading material has a temperature and pH dual response function, and targeted release in a pest and disease damage high-incidence environment (high temperature and specific pH) is achieved.