172results about How to "Improve immunity" patented technology

The invention relates to selenium-rich health-care rice dumplings. The selenium-rich health-care rice dumplings are prepared from the following raw materials of selenium-rich glutinous rice, rose petals, haw tree parasitism, plum tree parasitism, radix rehmanniae, dendrobium candidum, vegetable oil, pork, mung beans, ground cinnamon and table salt. The selenium-rich glutinous rice is used as a main raw material, so that selenium elements in human bodies are complemented, and collective antioxidation is strengthened; besides, the glutinous rice and the mung beans are soaked in a traditional Chinese medicine extracting solution, and medical components in traditional Chinese medicines are absorbed, so that the selenium-rich health-care rice dumplings have the efficacies of clearing heat, promoting salivation, relieving restlessness, resolving stagnation, reducing blood lipid, promoting digestion and enhancing the immunity of organisms.

The invention relates to the technical field of biological medicines, in particular to a soluble skin-adhering microneedle for delivering an inactivated enterovirus vaccine as well as a preparation method and application of the soluble skin-adhering microneedle. Sodium hyaluronate is adopted as a film forming material to wrap an enterovirus 71 type (EV71)-coxsackie virus A16 (CA16) type bivalent inactivated vaccine antigen, and a needle body layer of the soluble microneedle is formed; the substrate layer is prepared from a pullulan material, so that the microneedle patch with a stable overall structure is formed. The technology provided by the invention is completed in a clean environment, and the vaccine patch which is qualified through sterility detection is obtained. The soluble microneedle disclosed by the invention has good antigen stability under the condition of 2-8 DEG C. In animal experiments, the microneedle is attached to the skin surface of a mouse for skin-adhering immunization, a strong immune response reaction can be induced, good immunogenicity is shown, and a novel, safe and effective vaccine delivery way is provided for prevention and control of the infantile hand-foot-and-mouth disease.

The invention relates to the field of control, in particular to a flight attitude control method and system for an unmanned aerial vehicle, and the method comprises the steps: obtaining an expected attitude angle instruction and actual attitude angle feedback of the unmanned aerial vehicle, calculating an attitude angle error, employing a tracking differentiator to calculate a transition process for the expected attitude angle instruction, and enabling a tracking rate factor to achieve the control of the flight attitude of the unmanned aerial vehicle when the instruction is subjected to step change. Based on initial attitude angle error setting, instruction smooth transition is ensured, based on a transition signal output by a tracking differentiator and an estimated value of an expansion state observer, a basic control quantity is generated through nonlinear state error feedback, and control gain is adjusted on line according to a lumped disturbance amplitude. And predicting the lumped disturbance historical sequence by using a grey prediction model, calculating a predicted value at a future moment, and carrying out algebraic summation on the basic control quantity, a compensation component of the lumped disturbance predicted value and a gyroscopic moment decoupling component to generate an attitude control moment signal so as to realize stable flight of the unmanned aerial vehicle.

This invention provides a highly pathogenic feline calicivirus strain, its vaccine, and its applications. The highly pathogenic feline calicivirus was isolated from pathogenic material and identified as a highly pathogenic strain, named FCV CC475, with its cDNA sequence shown in SEQ ID NO.1. This strain exhibits strong pathogenicity, causing infected animals to develop symptoms such as fever, paw pad ulcers, and dehydration by day 3 post-infection; the viral load after 5 generations is 10. 9.80 TCID 50 / ml. This strain produces high antibody titers after immunization of cats and rabbits, demonstrating good immunogenicity. Therefore, this highly pathogenic feline calicivirus has broad application prospects in the preparation of feline calicivirus infection vaccines, diagnostic reagents, or therapeutic drugs.

A robustness measurement method for LeNet-5 networks based on adversarial boundary constraints is presented, relating to the field of deep learning model testing. The main steps include: for each training sample, dynamically generating adversarial examples based on the model's current state during training iterations; constructing a composite loss function based on standard cross-entropy loss and dynamic boundary constraint loss; performing end-to-end training on all parameters of the LeNet-5 network; and using the overall approximate robustness boundary as a measure of model robustness after training. This method effectively improves the resistance of the LeNet-5 model to fast gradient sign-based adversarial attacks without altering the basic structure of the LeNet-5 network by designing a new loss function.

The invention discloses a traditional Chinese medicine tea drink for preventing and treating oral mucosa diseases and a preparation method of the traditional Chinese medicine tea drink. The traditional Chinese medicine tea drink is prepared from 10-15 parts of radix astragali, 8-12 parts of radix codonopsis, 6-10 parts of radix salviae miltiorrhizae, 5-9 parts of radix angelicae sinensis, 3-6 parts of fructus psoraleae, 6-9 parts of rhizoma polygonati, 6-9 parts of radix adenophorae, 6-10 parts of rhizoma atractylodis macrocephalae, 5-9 parts of radix ophiopogonis, 3-5 parts of radix glycyrrhizae, 4-6 parts of pericarpium citri reticulatae and 5-8 parts of herba taraxaci. Aiming at the core pathogenesis of low immunity, long-term deficiency, long-term deficiency and kidney-yang insufficiency of patients suffering from oral mucosa diseases, qi tonifying, blood activating and kidney-qi strengthening are taken as a core treatment method, the formula is scientific and reasonable, all the medicinal materials act synergistically, the overall immune function of the body is adjusted, T lymphocyte subpopulation imbalance and cell factor network disorder are improved, and the curative effect is good. The oral mucosa microcirculation is improved, local inflammation is relieved, the immunity of a patient is improved fundamentally, the recurrence rate of oral mucosa diseases is reduced, and the problems that an existing tea drink is not high in pertinence and limited in curative effect are solved. The tea drink is appropriate in taste, good in compliance, high in safety and suitable for people with various oral mucosa diseases and low immunity.

The invention provides composite haw jelly and a preparation method thereof. The composite haw jelly comprises the following raw materials in parts by weight: 90-100 parts of haw pulp, 1.8-2.0 parts of russule, 27-30 parts of white granulated sugar and 1.8-2.0 parts of composite gel. The prepared haw jelly has the advantages of being low in heat and sugar, high in nutrient content, good in health care effect and the like, and has a wide range of audiences.

The present invention belongs to the fields of medicine, health care and food, and specifically relates to use of a composition of alcohol and a cooling agent in regulating sexual functions, protecting cardiovascular and cerebrovascular systems, promoting regeneration of liver cells, preventing and / or treating tumors, and improving immunity and sleep quality. The technical problem to be resolved by the present invention is to provide the use of a composition of alcohol and a cooling agent in regulating sexual functions, protecting cardiovascular and cerebrovascular systems, promoting regeneration of liver cells, preventing and / or treating tumors, and improving immunity and sleep quality. The composition of the present invention includes the alcohol and the cooling agent. Further, the composition includes an organic acid. The alcohol in the composition is 1%vol-99%vol, and the cooling agent therein is 0.05ppm-500ppm. The composition provided according to the present invention can play the role of regulating sexual functions, protecting cardiovascular and cerebrovascular systems, promoting regeneration of liver cells, preventing and / or treating tumors, and improving immunity and sleep quality in a short period.

This invention provides an oyster peptide and its application in enhancing immunity. The oyster peptide has a novel amino acid structure. The oyster peptide can enhance the activity of immune cells, promote the proliferation of immune cells, promote the development and maturation of immune organs, regulate the in vivo immune environment, promote the secretion of immunoglobulins, and improve humoral immunity.

The invention relates to the field of food, and particularly discloses a kudzuvine root, rape pollen and bean composition and a preparation method thereof, and the kudzuvine root, rape pollen and bean composition comprises the following raw materials in parts by weight: 40-60 parts of rape pollen, 20-40 parts of kudzuvine root powder, 1-10 parts of rhizoma polygonati powder, 1-10 parts of smoked plum powder, 1-10 parts of Chinese yam powder and 1-10 parts of maltodextrin. The preparation method comprises the following steps: S1, preparing materials, namely crushing and sieving the raw materials, and weighing the prepared materials; and S2, mixing the raw materials, granulating, drying, tabletting, and packaging to obtain the kudzuvine root, rape and pollen bean composition. The pollen nutritional supplement has the characteristic that the functionality and the absorptivity of the pollen nutritional supplement can be enhanced.

The invention discloses a nitrate-free smoked ginseng sausage and a preparation method thereof, and belongs to the technical field of meat product processing. The method comprises the following steps: adding different addition amounts of ginseng powder into a nitrate-free smoked sausage to prepare the nitrate-free smoked ginseng sausage, mincing pork serving as a main raw material, adding water, plasma activated water, beet root powder, celery powder, ginseng powder and nisin, and uniformly stirring to prepare the nitrate-free smoked ginseng sausage. The preparation method comprises the following steps: uniformly stirring other ingredients including table salt, white granulated sugar, monosodium glutamate, potato starch, soybean protein isolate, pepper powder and ginger powder, pickling, filling, cooking, drying to be mature, cooling, and packaging in vacuum to obtain the nitrate-free ginseng smoked sausage. According to the method, the flavor quality and functional characteristics of the nitrate-free smoked sausage are optimized, the defects of a single nitrate-free smoked process in flavor level and nutritional added value are overcome, and the flavor and texture of the sausage are remarkably improved.

The application discloses a kind of fermented feed fermented by three strains of probiotics of Bacillus YA ( Bacillus sp ), yeast Y ( Saccharomyces cerevisiae ) and capsular red bacteria R3 ( Rhodobacter capsulatus ), and preparation method and application in aquaculture thereof, and viable count is not less than 1×10 7 CFU / g.The fermented feed is replaced ordinary feed according to certain proportion, and feeding result shows that aquaculture water quality is significantly improved after adding fermented feed, and fish growth performance, digestive enzyme activity, immunity, and muscle quality are also obviously improved.Using the feed in suitable range can shorten growth cycle, reduce cost, improve aquaculture environment, reduce antibiotic use, and improve muscle quality of farmed animals, with good economic and ecological benefits, simple fermentation process, low cost, and suitable for industrial large-scale production.

The invention provides a traditional Chinese medicine additive for improving the survival rate of piglets and a preparation method and application thereof, and belongs to the technical field of feed additives. The traditional Chinese medicine additive provided by the invention is Qibai tonifying powder and comprises the following raw materials in parts by weight: 20-30 parts of radix astragali, 15-25 parts of rhizoma atractylodis macrocephalae, 10-20 parts of pericarpium citri reticulatae, 10-15 parts of radix saposhnikoviae, 15-25 parts of folium cortex eucommiae, 10-15 parts of malt, 10-15 parts of cortex magnoliae officinalis, 5-10 parts of poria cocos, 5-10 parts of rhizoma dioscoreae and 5-10 parts of folium perillae. The Qibai tonifying powder provided by the invention improves the immunity of piglet organisms, promotes digestion and absorption, enhances the anti-stress ability of piglets and reduces piglet diarrhea through the synergistic effect of invigorating spleen and tonifying qi, strengthening superficies and resisting evil and strengthening tendons and bones, thereby achieving the purpose of increasing the survival rate of piglets.

This invention relates to anti-PD-1 antibodies and methods of using them in treating diseases and conditions related to PD-1activity, e.g., cancer.

The invention discloses a medicinal and edible traditional Chinese medicine composition for postoperative rehabilitation as well as a preparation method and application of the medicinal and edible traditional Chinese medicine composition. The traditional Chinese medicine composition is prepared from the following raw materials in parts by weight: 12 to 27 parts of radix astragali seu hedysari, 2 to 10 parts of radix ginseng, 2 to 10 parts of colla corii asini, 5 to 18 parts of radix angelicae sinensis, 8 to 25 parts of cortex eucommiae, 5 to 18 parts of semen persicae, 23 to 37 parts of small red beans, 8 to 25 parts of pericarpium citri reticulatae, 23 to 37 parts of fructus ziziphi jujubae, 2 to 10 parts of rhizoma zingiberis recens and 8 to 25 parts of semen ziziphi spinosae. The traditional Chinese medicine composition has the effects of tonifying qi and nourishing blood, promoting blood circulation to remove blood stasis and strengthening the spleen and stomach, integrates the effects of tonifying qi and nourishing blood, warming and dredging to remove blood stasis and strengthening the spleen and soothing the nerves in one formula, can cover common deficiency syndrome types, and breaks through the limitation of traditional Chinese medicine individualized dialectical treatment in popularization.

The application discloses Metrnl-a gene and application thereof in preparation of a DNA vaccine molecular adjuvant for grass carp hemorrhagic disease, and relates to the technical field of aquatic immunology and biological agents. The molecular adjuvant is that a grass carp Metrnl-a gene is constructed into a eukaryotic expression vector pcDNA3.1 to obtain a recombinant eukaryotic expression vector pcDNA3.1-Metrnl-a of the grass carp Metrnl-a. The pcDNA3.1-Metrnl-a plasmid and the pcDNA3.1-VP35 DNA vaccine can be stably expressed in the grass carp through muscle injection, significantly enhance the expression of immune-related genes and the antibody titer, significantly reduce the VP56 virus titer in the grass carp after challenge, and increase the survival rate of the grass carp after infection with grass carp reovirus by about 13.3%. The molecular adjuvant can effectively enhance the immune effect of the DNA vaccine of the grass carp and has a good application prospect.

The application relates to the technical field of semiconductor bridge electrostatic discharge protection and current protection, and discloses an electrostatic discharge and current protection circuit of a semiconductor bridge, which comprises an ESD protection circuit, a current protection circuit and an NMOS connected in parallel, the ESD protection circuit comprises a bidirectional transient suppression diode and a capacitor connected in parallel, the bidirectional transient suppression diode clamps a transient high voltage by breakdown conduction, the voltage is limited in a safe range, the capacitor reduces a voltage rising rate and suppresses overshoot by shunting and absorbing a transient current, the NMOS provides a low-resistance discharge path, and the voltage and current impact applied to the semiconductor bridge are reduced; the current protection circuit comprises a bidirectional rectifier circuit and a detection circuit; and the NMOS is connected between the detection circuits. The application can realize ESD protection and current protection of the semiconductor bridge, prevents current from damaging the structure, and guarantees the safety of the semiconductor bridge working in an electromagnetic and ESD environment.

The present application relates to the field of feed additive, and discloses a feed additive, a preparation method and application thereof.The feed additive contains astaxanthin, curcumin, vitamin C palmitate, vitamin E, vitamin D3, piperine and a carrier.The preparation method comprises the following steps: mixing astaxanthin, curcumin, vitamin C palmitate, vitamin E, vitamin D3, piperine and the carrier.The feed additive can significantly improve the stress resistance, immunity, antioxidant capacity and disease resistance of aquatic animals, and has significant economic benefits.

This invention relates to a lipid-lowering synbiotic, its preparation method, and its application, belonging to the field of egg-laying hen farming technology. The lipid-lowering synbiotic of this invention comprises the following components in parts by weight: 3-85 parts of traditional Chinese medicine extract, 1-25 parts of probiotics, 3-30 parts of prebiotics, 1-16 parts of enzyme preparation, and 4-55 parts of dietary therapy components. This synbiotic not only significantly improves the lipid metabolism of laying hens but also significantly prolongs the peak egg-laying period, increases the egg production rate, reduces cholesterol content in egg yolks, promotes calcium and phosphorus absorption, and reduces the paralysis rate in laying hens. It comprehensively improves the economic benefits of egg-laying hen farming.

The invention discloses brown cattle bone marrow collagen polypeptide with an immunoregulation effect as well as a preparation method and application of the brown cattle bone marrow collagen polypeptide, and belongs to the technical field of animal-derived food processing. The preparation method comprises the following steps: pretreating brown cattle bone marrow; the method comprises the following steps: dissolving pretreated brown cattle bone marrow in water, firstly adding alkaline protease to carry out enzymolysis, then simultaneously adding collagenase U and basophilic protease into a system, carrying out coupled enzymolysis under the protection of nitrogen, then cooling the system to 0-4 DEG C, regulating the pH value to 3-4, then carrying out autolysis for 10-30 minutes, and finally carrying out enzyme deactivation; centrifuging an enzyme deactivation product, taking supernatant, adjusting the pH value to be neutral, concentrating, dialyzing and freeze-drying to obtain crude collagen peptide; and carrying out primary purification and secondary refining on the crude collagen peptide to obtain the collagen peptide. The preparation process is simple, the molecular weight of the prepared polypeptide is 366-1514 Da, and the polypeptide has immunoregulation and antioxidant activity, can be used for preparing food, health care products or medicines for improving immunity and resisting oxidation, and realizes high-value utilization of livestock and poultry byproducts.

The application provides a molecular marker related to immune traits of Lake sheep, a detection method and application thereof. Through PCR amplification and sequence analysis of a PD-L1 gene of the Lake sheep, a G / A polymorphic site at the 135th position of the amplified fragment is found, further detection of the polymorphic site of 898 Lake sheep is carried out by using KASPar primers, a least square model is established, and correlation analysis of the genotype and growth traits is carried out, and finally it is determined that the amplified PD-L1 gene fragment can be used as a molecular marker of immune traits related to the total number of red blood cells and the average concentration of hemoglobin of red blood cells of the Lake sheep. Through detection of the molecular marker, the application can be used for disease-resistant breeding of the Lake sheep, so as to guarantee the health of the Lake sheep and help to increase economic benefits.

The present application belongs to the technical field of aquaculture, and particularly relates to a segmented type of pompano breeding method. The segmented type of breeding method provided by the present application supplies nutrition accurately according to the requirements of different growth stages of pompano, and significantly improves the growth speed. Through the optimization of water temperature and light conditions in different stages, the growth speed of pompano is significantly accelerated, thereby shortening the breeding cycle. The addition of licorice powder and melatonin in the feed further enhances the immunity of pompano and reduces the use of drugs. Through the segmented type of breeding, the present application improves the unit yield and survival rate of pompano, and significantly improves the economic benefits.

This invention discloses a forest-grown Panax notoginseng extract, an oral liquid, its preparation method, and its application, belonging to the field of Panax notoginseng processing technology. The preparation method includes the following steps: (1) fresh forest-grown Panax notoginseng is crushed with water to obtain a Panax notoginseng suspension; (2) a complex enzyme is added to the Panax notoginseng suspension for enzymatic hydrolysis to obtain an enzymatic hydrolysate; (3) the enzyme inactivation of the hydrolysate, solid-liquid separation, and concentration of the clear liquid are obtained; the complex enzyme is cellulase, xylanase, and flavor protease, and the mass ratio of cellulase, xylanase, and flavor protease is 10-20:3-7:2-6. The Panax notoginseng extract prepared by enzymatic hydrolysis using forest-grown Panax notoginseng as raw material has the effects of assisting in lowering blood pressure and enhancing immunity. Compared with conventional Panax notoginseng extracts, this invention has a better effect in assisting in lowering blood pressure.

The application discloses a kind of rice wine production methods with multicolor rice as raw material, it is related to rice wine production technical field.Worker first selects red rice, black rice, yellow rice, green rice and purple rice five kinds of color rice, then five kinds of color rice are screened, full grain of five kinds of color rice is screened as the raw material of multicolor rice for standby, then multicolor rice is sequentially cleaned, soaked, steamed rice, temperature reduction, saccharification fermentation, squeezing, sterilization and aging process, so that multicolor rice wine is obtained, multicolor rice wine after finished product will present rich color and level, five kinds of color rice in multicolor rice wine is rich in protein, mineral, trace element and vitamin and various nutritional components, while saccharification fermentation and aging process, multiple amino acids and phenolic substances are produced in wine, these substances have certain antioxidant and anti-inflammatory health care effect, can improve the immunity and disease resistance of human body to a certain extent.

The invention provides radix astragali homogeneous polysaccharide as well as a preparation method and application thereof, and belongs to the field of separation and purification of natural products. The radix astragali homogeneous polysaccharide is composed of glucose and galactose, and the molecular weight of the radix astragali homogeneous polysaccharide is 1900-2200 Da. The preparation method comprises the following steps: performing water extraction and alcohol precipitation on astragalus membranaceus to obtain astragalus membranaceus crude polysaccharide, and performing column chromatography elution on the astragalus membranaceus crude polysaccharide to obtain the homogeneous astragalus membranaceus polysaccharide with the molecular weight of 1900-2200Da. The radix astragali homogeneous polysaccharide has excellent effects of resisting inflammation, regulating intestinal flora, regulating intestinal absorption function, scavenging free radicals, regulating immunity, improving prebiotic activity and resisting pulmonary fibrosis.

This invention discloses a detachable hydroponic leek cultivation device for turtle ponds, belonging to the field of hydroponic devices. It includes several freely detachable and combinable floating boards, with detachable protective plates installed on the outer sides of the floating boards. The floating boards can be disassembled and reassembled, offering flexible use. The detachable protective plates at the outer edges of the floating boards prevent turtles from climbing in and eating the leeks. The leeks can absorb high levels of nitrogen, phosphorus, and other nutrients from the turtle farming water, removing eutrophic substances. The leek roots release oxalic acid and other organic acids, sulfides, and flavonoids, inhibiting pathogenic microorganisms in the aquatic environment and reducing the incidence of turtle diseases. This invention can not only be used for hydroponic leeks but also for cultivating other suitable hydroponic medicinal herbs and vegetables, and can be reused repeatedly.

The application belongs to the technical field of biological gene engineering, and discloses a lactococcus lactis carrier oral vaccine for producing enterotoxigenic escherichia coli F18 pilus type and application. Four lactococcus lactis antigen surface display strains are prepared, and are mixed to perform oral immunization. The oral immunization mode is convenient to operate, avoids the stress reaction caused by injection immunization on animals, and greatly improves the immunization effect, so that the diarrhea caused by enterotoxigenic escherichia coli on piglets can be effectively prevented. 50 The application is an oral escherichia coli vaccine, and mouse immunization challenge experiment shows that all the mice can survive under the challenge dose of LD , and piglet immunization challenge experiment shows that the piglets can be 100% protected from diarrhea, which shows that the immunization group has effective mucosal immune protection ability.

The invention belongs to the crossing field of an automobile active safety system and a high-precision gas sensing technology, and provides a vehicle-mounted alcohol system and method which can avoid interference of other ethanol-containing substances and only detect gas exhaled by a driver. The system defects of an existing vehicle-mounted alcohol detection system in the aspects of reliability, anti-interference performance and integration are overcome. On the basis of traditional alcohol detection and photoacoustic spectrum detection, the detection sensitivity, reliability and accuracy are improved, meanwhile, the device can be integrally applied to a vehicle-mounted alcohol detection system, and the requirement for rapidly and accurately detecting whether a driver drinks alcohol or not in a vehicle in real time is met.

The invention relates to the technical field of veterinary drugs, and particularly provides a polynucleotide molecule composition for preventing cat infectious peritonitis, a chimeric polynucleotide molecule and an mRNA vaccine. In order to overcome the ADE effect caused by S protein full-length antigen in the prior art, FIPV N protein without ADE risk is adopted and is combined with screened S protein specific T cell and B cell epitopes. Core schemes include two classes: one is a separate polynucleotide composition comprising epitope peptides encoding N and S proteins; and 2, a single chimeric polynucleotide encoding N protein and S protein epitope peptides. The polynucleotides are optimized by codons and encapsulated in lipid nanoparticles (LNP) to prepare vaccines. Experiments prove that the vaccine can synergistically stimulate powerful immune response, the survival rate of immune cats is remarkably increased to 80%-100% from standard 40% on the premise that ADE is not caused, and FIP is effectively prevented.

The present application relates to the technical field of feed premix, especially to a baiting and immunity double-effect premix containing yeast extract and a preparation method thereof, which comprises the following raw materials: yeast extract, compound plant extract, garlic extract, compound vitamin and compound trace element; the yeast extract is prepared by secondary enzymolysis, concentration and spray drying; the compound plant extract is prepared by reflux extraction and spray drying with camellia sinensis shell, Chinese chervil, kaffir lily and dark plum pulp as raw materials; the yeast extract is compounded with the camellia sinensis shell, Chinese chervil and kaffir lily in the compound plant extract, so that the prepared premix has excellent immunity effect; in addition, the yeast extract, dark plum pulp and garlic extract are used to synergistically significantly improve the baiting effect of the feed on aquatic animals and accelerate the feeding speed and feeding amount of the aquatic animals.