42226results about How to "Improve immunity" patented technology

The present invention features PD-1 binding proteins, a subset of which inhibits binding of PD-L1 to the PD-1 receptor. These binding proteins can be employed to modulate the immune system through the manipulation of the PD-1 signaling pathway, enhancing host immunity to treat infections and cancer.

The anti-infective medicine, including powder, mixture, aerosol, capsule, injection, suppository, ointment and microcapsule, is characterized by that on the theroretical basis of combining traditional Chinese medicine and modern immunology the immunoglobulin, effective components of Chinese medicinal materials which are extracted according to the compound prescription and auxiliary preparation are combined together organically, and undergone the fine preparation process to obtain a high-efficiency, safe, stable, environment-protecting type anti-infection medicine having no toxic side effect and having no drug resistance.

The present invention features PD-1 binding proteins, a subset of which inhibits binding of PD-L1 to the PD-1 receptor. These binding proteins can be employed to modulate the immune system through the manipulation of the PD-1 signaling pathway, enhancing host immunity to treat infections and cancer.

Disclosed are systems and methods which provide interference mitigation by making alternative resources available within areas served by wireless communication links. Embodiments provide multiple channel availability in establishing wireless communication links to facilitate interference mitigation. Time domain techniques, spatial processing techniques, and / or frequency domain techniques may be implemented for spectrum management. Embodiments provide wireless base station configurations in which all or a plurality of base station sectors use a same frequency channel and / or in which each sector or a plurality of sectors use all frequency channels. Multi-channel strategies may be implemented such as to provide dynamic selection of a “best” frequency channel, to provide transmission of identical data on multiple channels for combining / selection at the receiver, and / or to provide for dividing the data for transmission on multiple channels.

A wireless apparatus and method for the measurement and monitoring of bioelectric signal patterns associated with EEG, EOG and EMG readings is provided. The apparatus is comprised of at least one measurement device employing the use of three bioelectric sensing electrodes, wherein at least one of the electrodes is configured for secure placement within the ear canal of an individual under medical surveillance. Acoustic stimulation may be provided directly into the ear canal of the individual via an auditory stimulus emitted from the measurement device for evoking brain activity and the subsequent measurement of bioelectric signal patterns associated with the evoked activity.

A preparation method of a ferment Chinese Traditional Herbs for feeding belongs to the production field of the feed additives. The technical proposal provided by the present invention is that one or various intestinal probiotics is inoculated on a cultivation matrix containing extracts of Chinese Traditional Herbs, and undergoes ferment cultivation in a proper condition. The probiotics include Lactobacillus acidophilus, Bacillus subtilis, and candida utilis, etc, and the selected Chinese Traditional Herbs include astragalus, atractlylis lancea formalyrata, codonopsis pilosula, pericarpium citri reticulatae, and atractylis atractylis ovata, etc. The ferment Chinese Traditional Herbs for feeding provided by the present invention used to breed the livestock and the poultry is capable of preventing and treating epidemic diseases and improving the growth of the animal. The biological ferment of the water extract of Chinese Traditional Herbs by the probiotics is utilized to produce the elements with higher activities, thereby improving the absorption, transportation, metabolism, activation and medical efficacy of the Chinese Traditional Herbs in human body.

In one aspect, the invention provides methods and compositions for the expression of small RNA molecules within a cell using a retroviral vector. The methods can be used to express double stranded RNA complexes. Small interfering RNA (siRNA) can be expressed using the methods of the invention within a cell, that interfere with a viral life cycle by down regulating either the viral genome, a viral genome transcript, or a host cell that. In another aspect the invention provides methods for treating patients having suffering from infection, particularly infection with HIV.

An intelligent electronic device (IED) configured to supervise a process having a state has at least one of a current, voltage or resistive input configured to monitor the state of the process, a binary status input configured to monitor the state of the process, a binary status input configured to receive a digitally encoded serial communication package for monitoring the state of the process, a control output configured to output a signal to control process protection, control, or automation, or a combination thereof, or a control output configured to output a digitally encoded serial communication package to control protection, control, or automation, or a combination thereof. The IED is also configured to facilitate digital communication between at least two compatible devices by directing communication packets from ports connected to an originating compatible device to ports connected to a destination compatible device.

The bagged mangosteen tea may be pure mangosteen powder or the mixture of mangosteen powder and supplementary material, which may be tea, health food material, probiotics, sea weed, dry fruit and / or flower. The bagged mangosteen tea has the functions of relieving cough, eliminating phlegm, strengthening immunity, nourishing stomach, invigorating spleen, invigorating kidney, promoting blood circulation, etc.

A memory device configurable for independent double gate cells, storing multiple bits per cell includes multilayer stacks of conductive strips configured as word lines. Active pillars are disposed between pairs of first and second stacks, each active pillar comprising a vertical channel structure, a charge storage layer and an insulating layer. The insulating layer in a frustum of an active pillar contacts a first arcuate edge of a first conductive strip in a layer of the first stack and a second arcuate edge of a second conductive strip in a same layer of the second stack. A plurality of insulating columns serve, with the active pillars, to divide the stacks of word lines into even and odd lines contacting opposing even and odd sides of each active pillar. The active pillar can be generally elliptical with a major axis parallel with the first and second conductive strips.

Clock alignment circuits and techniques for reducing power dissipation, increasing power supply noise immunity, decreasing process and temperature variation sensitivity, and providing a wide operating range. A power supply generator generates an isolated supply voltage for a delay line used in a clock alignment circuit. The delay line generates a delayed clock from a reference clock. A comparator detects a correction information (i.e., delay or phase error) between the delayed clock and the reference clock and generates error information representative of the correction information. A charge pump circuit converts the error information into a voltage signal, wherein the voltage signal is a scaled representation of the error information. The power supply generator includes an amplifier having a first input coupled to the voltage signal and an output to provide the supply voltage and a capacitor coupled between the supply voltage and a ground voltage, wherein the amplifier tracks the voltage signal level to regulate the supply voltage.

An MPC adaptation and tuning technique integrates feedback control performance better than methods commonly used today in MPC type controllers, resulting in an MPC adaptation / tuning technique that performs better than traditional MPC techniques in the presence of process model mismatch. The MPC controller performance is enhanced by adding a controller adaptation / tuning unit to an MPC controller, which adaptation / tuning unit implements an optimization routine to determine the best or most optimal set of controller design and / or tuning parameters to use within the MPC controller during on-line process control in the presence of a specific amount of model mismatch or a range of model mismatch. The adaptation / tuning unit determines one or more MPC controller tuning and design parameters, including for example, an MPC form, penalty factors for either or both of an MPC controller and an observer and a controller model for use in the MPC controller, based on a previously determined process model and either a known or an expected process model mismatch or process model mismatch range. A closed loop adaptation cycle may be implemented by performing an autocorrelation analysis on the prediction error or the control error to determine when significant process model mismatch exists or to determine an increase or a decrease in process model mismatch over time.

Vaccines that target one or more antigens to a cell surface receptor improve the antigen-specific humoral and cellular immune response. Antigen(s) linked to a domain that binds to a cell surface receptor are internalized, carrying antigen(s) into an intracellular compartment where the antigen(s) are digested into peptides and loaded onto MHC molecules. T cells specific for the peptide antigens are activated, leading to an enhanced immune response. The vaccine may comprise antigen(s) linked to a domain that binds at least one receptor or a DNA plasmid encoding antigen(s) linked to a domain that binds at least one receptor. A preferred embodiment of the invention targets HIV-1 env antigen to the CD40 receptor, resulting in delivery of antigen to CD40 positive cells, and selective activation of the CD40 receptor on cells presenting HIV-1 env antigens to T cells.

An internetworking device that provides improved immunity to Denial of Service attacks, and in general, improved Quality of Service (QoS). An internetworking element or other route processor is composed of two main parts, including a data forwarding plane and a control plane; the control plane runs routing, signaling and control protocols that are responsible for determining the packet forwarding behavior by the data plane. Independent control plane processes may be provided; however, they are considered to be a single network entity that is a uniquely addressable port. Packets thus intended for the control plane always pass through a designated point. As a result, a set of port services unique to the control plane may be applied to the control plane port. These control plane port services thus can be utilized to control all packet traffic entering and exiting the control plane processes as a whole.

A continuous or distributed resonator geometry is defined such that the fabrication process used to form a spring mechanism also forms an effective mass of the resonator structure. Proportional design of the spring mechanism and / or mass element geometries in relation to the fabrication process allows for compensation of process-tolerance-induced fabrication variances. As a result, a resonator having increased frequency accuracy is achieved.

A capacitive sensing-based electronic switch, which incorporates an integrated circuit with processing capability, which can only be activated by user action in a dedicated area, whereby switch activation occurs only if, at least, a touch is capacitively sensed and criteria based on timing plus sequential touches on capacitive sensors are satisfied.

The invention discloses a special biological fish fertilizer and a preparation method for the fertilizer used in aquiculture; wherein, the biological fish fertilizer mainly comprises raw materials as follows: microbiological preparation, inorganic fertilizers, fermentation organics, micro-mineral amino acid chelate, mineral composites, and water quality improver. The preparation method for the special biological fish fertilizer in aquiculture comprises steps as follows: microbiological preparation is produced; fermentation organics is then produced, and the micro-mineral amino acid chelate is produced, eventually the finished products are made. The special biological fish fertilizer has the advantages of limiting the growth and reproduction of the harmful algae, promoting the large-scale growth and reproduction of the suitable food for fish, effectively improving the water quality and purifying the water environment, strengthening the fish immunity, reducing the diseases, reducing cost due to the small use level, convenient use, mild odor, no pollution to the water, and environment protection. By combining the modern bioengineering technique, low-temperature drying technique, spray-drying technique, and super-fine crushing techniques, the preparation method has the advantages of stable quality for the fish fertilizers and lower overall cost.

A memory device configurable for independent double gate cells, storing multiple bits per cell, includes multilayer stacks of conductive strips configured as word lines. Active pillars are disposed between pairs of first and second stacks, each active pillar comprising a vertical channel structure extending from an underlying bounded conductive layer, a charge storage layer and an insulating layer. The insulating layer in a frustum of an active pillar contacts a first arcuate edge of a first conductive strip in a layer of the first stack and a second arcuate edge of a second conductive strip in a same layer of the second stack. The conductive strips can comprise a metal. The active pillar can be generally elliptical with a major axis parallel with the first and second conductive strips.

The power strip of the present disclosure includes an arc fault circuit interrupter (AFCI) to interrupt power to electrical devices plugged into the power strip when arcing is detected and, when combined with a transient voltage surge suppressor (TVSS) device and / or a ground fault circuit interrupter (GFCI) also can provide transient voltage surge suppression and ground fault protection. The power strip here disclosed can include an AFCI by itself or an ACFI in combination with a GFCI.

The invention provides a Chinese herbal medicinal feed additive for preventing and controlling swine infectious disease. The swine feed additive consists of 37 Chinese medicinal herbs, namely, gypsum, rehmannia root, rhinoceros horn, golden thread, cape jasmine fruit, tree peony bark, baical skullcap root, red paeony root, figwort root, common anemarrhena rhizome, forsythia suspensa , platycodon root, liquorice root, common lophatherum herb, amur corktree bark, honeysuckle flower, Chinese pulsatilla root, indigowoad root, heartleaf houttuynia herb, astragalus, szechwon tangshan root, hawkthorn fruit, medicated leaven, barley sprout, radish seed, chicken's gizzard -membrane, Chinese thorowax root, common andrographis herb, philippine violet herb, tuber fleeceflower root, massa medicata fermentata fujianensis, cyrtomium rhizome, tung leaf, tangerine peel, white paeony root, pine needle and indigowoad leaf through scientific compatibility. The feed additive is added into swine feed in the proportion; under the condition of not using any vaccine, the feed additive can effectively prevent and cure severe mixed flu symptoms, infection and other syndromes caused by swine respiratory disease, asthma, contagious pleuropneumonia, swine virus mixed flu, high swine fever, porcine circovirus, swine fever, flu, pseudorabies, salmonellosis, bacillosis, streptococcus, erysipelas, paratyphoid, eperythrozoon, toxoplasm and other multi-pathogeny and provides genuine green food for the market.

A switching power converter and method of controlling an output voltage thereof using predictive sensing of magnetic flux provides a low-cost switching power converter via primary-side control using a primary-side winding. The power converter has improved immunity to parasitic phenomena and other variations within the power converter components. An integrator is used to generate a voltage analog that represents magnetic flux within a power magnetic element via an integration of a voltage on a primary-side winding of the power magnetic element. A detection circuit detects the end of a half-cycle of post-conduction resonance that occurs in the power magnetic element subsequent to the energy level in the power magnetic element reaching zero. The voltage of the integrator is stored at the end of the post-conduction resonance half-cycle and is used to determine a sampling point prior to or equal to the start of post-conduction resonance in a subsequent switching cycle of the power converter (which is the predicted zero-energy storage point of the power magnetic element). The primary-side winding voltage is then sampled at the sampling point, providing an indication of the output voltage of the power converter. By predicting the zero-magnetic-energy storage point, the output voltage of a power converter operating in discontinuous or boundary conduction mode can be accurately controlled without being affected by parasitic phenomena or variations in circuit performance over time, input voltage and temperature.

The present invention provides a method for contactless programming of a memory element of an electronic device having a wireless short range communications interface. The method comprises performing an interrogation for detecting the presence of said wireless short range communications interface, receiving, responsive to said interrogation, data from said wireless interface, said data indicating a hardware configuration of said electronic device, selecting programming data for programming said memory element based on said hardware configuration, and transmitting said selected programming data to be received by said wireless short range communications interface. The method further comprises detecting an interrogation, transmitting, responsive to said interrogation, data via said wireless interface, said data indicating a hardware configuration of said electronic device, receiving programming data at said wireless short range communications interface, and programming said memory element according to said programming data. The invention also provides devices for performing the inventive method.

ESR microscope systems and methods for examining specimens using both continuous wave and pulsed modes in the 9 to 60 GHz range. The ESR microscope uses an image probe comprising gradient coils in addition to conventional modulation coils (in continuous wave mode) or magnetic field bias coils (in pulse mode), and a resonator constructed from high permittivity material. The systems and methods also involves the use of sample containers that permit the precise placement of samples in relation to the image probe. The microscope uses a microstrip or thin coaxial or dielectric antenna to obtain a high coupling coefficient to the specimen being imaged. The microscope systems provide resolution at the single micron level, and permit the observation of images comprising tens to hundreds of pixels for each of two or three dimensions in a few minutes. Novel stable radicals used as the imaging media are also described.

The present invention relates to methods and compositions for use in mediating an immunosuppressive reaction. The compositions of the invention comprise exosomes having immunosuppressive activity. Such exosomes may be derived from a variety of different cell types, including antigen presenting cells such as dendritic cells and macrophages. Prior to isolation of exosomes, the cells may be genetically engineered to express molecules capable of enhancing the immunosuppressive activity of said exosomes and / or may be exposed to one or more agents, such as cytokines or cytokine inhibitors, which are also capable of enhancing the immunosuppressive activity of exosomes. The present invention also relates to the use of such exosomes for the treatment of diseases and disorders associated with undesirable activation of the immune system. The present invention also includes exosomes isolated directly from serum that have been shown to be immunosuppressive.

The invention provides a micro-ecological traditional Chinese medicine preparation for enhancing the immunity of livestock and poultry, and a preparation method thereof. The invention is characterized in that traditional Chinese medicines are combined with the modern microbial fermentation technology to develop a novel feed additive, i.e. traditional Chinese medicines such as astragalus root, eucommia, licorice, bupleurum and the like are directly fermented by two or more of sporeformer, microzyme, lactobacillus to obtain the product. The micro-ecological traditional Chinese medicine preparation provided by the invention has the efficacies of enhancing the body immunity of livestock and poultry, maintaining the gastrointestinal microbial flora balance of animals, preventing and treating alimentary and respiratory diseases of livestock and poultry, promoting healthy and quick growth of the animals, and improving the qualities of meat, egg and milk; the micro-ecological traditional Chinese medicine preparation has no toxic side effect, no pollution and no residue, can not generate drug resistance, and is suitable for use at each growth stage of the livestock and poultry; and the effect is stable and reliable and can meet the requirements of people for safety in production of livestock and poultry products. The micro-ecological traditional Chinese medicine preparation for enhancing the immunity of livestock and poultry can be increased in dose to be used as a veterinary medicine for application.

The invention discloses a fruit and vegetable jam and a preparation method thereof. The fruit and vegetable jam is characterized by being prepared from the following components: 50-99.8% of fruit and vegetable concentrated pulps, 0.01-0.5% of Sodium D-isoascorbate or vitamin C, 0.01-0.5% of citric acid and 0-49.8% of syrup or substitute sugar. The preparation method comprises the following steps:pulping or juicing fruits and vegetables, and then concentrating the pulped or juiced fruits and vegetables 0-10 times; evenly stirring the components in proportion, and sterilizing the components atthe temperature of 75-132 DEG C for 2 seconds-50 minutes; and cooling the sterilized fruit and vegetable pulp to 20-45 DEG C, inoculating lactic acid bacteria into the sterilized and cooled fruit andvegetable pulp at a ratio of 103-109 cfu / mL, and fermenting the pulp at the temperature of 25-45 DEG C for 6-96 hours until the pH value is 2.5-5.0. The method has the following characteristics: (1) obtaining natural tender tart flavor is obtained, the astringent flavor of the fruits and the wild artemisia flavor of the vegetables are effectively removed; (2) by means of lactic acid bacteria fermentation, the content of amino acid in the fruits and vegetables can be improved by more than 20%, the contents of substances with special flavor are improved by more than 30%, and the flavor and taste of products are effectively improved; (3) nutrient components in the fruits and vegetables, such as vitamins, dietary fibers and the like, in the fruits and vegetables are fully maintained; and (4) the quality guarantee period of food is prolonged, and corruption is avoided.

The invention relates to a beverage of fruits, plant perfume materials and edible flowers through combination match and a preparation method thereof. The preparation method comprises the following steps of: taking the fruits, the plant perfume materials and the edible flowers as main materials; respectively preparing fruit juice through zymohydrolysis, plant perfume martial extracts and edible flower extracts through digestion, and then mixing; then adding bee honey or white sugar to adjust the sugar content; adding citric acid to adjust the degree of acidity; and preparing the beverage after sterilization, yeast inoculation and fermentation. On the basis of an aromatic dietary therapy health preserving theory, the fruits, the plant perfume materials and the edible flowers are taken as the main materials, and are rich in various natural nutritional ingredients; through the ingredients in the edible medicine of the materials, the beverage has health effects and medicinal values on promoting blood circulation to remove blood stasis, promoting qi to activate blood, nourishing and preserving health, improving immunity and the like; and through the unique match of the three main materials, the beverage has unique fragrance and mouth feel of being aroma, sweet after taste and the like.

The invention provides a weight losing and meal replacement protein type solid beverage, which comprises ingredients including concentrated whey protein powder, soy isolate protein powder, dried skim milk, soluble dietary fiber, maltitol or erythritol, maltodextrin, fructo-oligose or fructose, soya bean lecithin, nutrose, low-fat pectin and the like. The protein in the body is effectively supplemented, the satiety is effectively prolonged, the appetite and the caloric intake are more strictly controlled, and further, the goal of losing the weight is reached. The product has the advantages that the nutrition is balanced, the mouth feeling is smooth, savoury and mellow, the carrying is convenient, the process is simple and feasible, and the solid beverage is suitable for mass production.

The invention provides an mVSV virus vector, i.e., attenuated mVSV obtained after multiple modification mutations occur to an M protein amino acid site of a wild Indiana strain VSV, and an optimized heterologous antigen gene is preferentially integrated to a double cloning site area of an mVSV packaging core plasmid pmVSV-Core at the same time. The mVSV virus vector vaccine comprises a heterologous antigen gene which fuses or embeds a target virus between G and L genes of an mVSV vector envelope, wherein the antigen gene comprises an enveloped and embedded antigen gene encoding the target virus, an embedded combination antigen gene or a fused antigen gene; the mVSV virus vector is embedded or fused with a dominant antigen of spike protein S of an SARS-CoV-2 pathogen; the dominant antigen is preferably selected from a receptor binding domain of spike protein S, namely RBD; and a COVID-19 vaccine based on mVSV mediation is formed. The vaccine has good prevention or treatment effect on COVID-19 infected people.