The invention discloses a high-sensitivity pH value
biosensor chip, which can realize low-cost and rapid
food safety detection. At the same time, the sensor
chip is conducive to the integration of large-scale sensing arrays, which can be used for fast, low-cost, high-
throughput gene sequencing. The
chip includes a row / column decoder, a large sensing unit array, a sub-threshold region pH-
time domain-
voltage conversion reading circuit group, a 10-bit analog-to-
digital conversion circuit group, a static random register reading circuit group, etc. The chip can detect the change of pH value in the solution and convert it into a
voltage signal, and finally convert the
voltage into a
digital signal through the on-chip analog-to-
digital conversion circuit, and send it to the computer for data reception, storage and analysis. The reading amplification circuit of the present invention can effectively improve the sensitivity of the sensor, and the minimum resolution reaches 0.01pH, which can solve the compatibility problem between the chip and the standard complementary
metal oxide semiconductor (
CMOS) process and the problem of low sensitivity in the process of process
miniaturization .