Apparatus and methods for performing
charge detection mass spectrometry for measurement of the
mass of a
single ion of interest are disclosed. The
ion of interest is caused to undergo
harmonic oscillatory movement in the
trapping field of an electrostatic trap, such that an image current
detector generates a time-varying
signal representative of the
ion's oscillatory movement. This time-varying
signal (transient) is processed (e.g., via a
Fourier transform) to derive the
ion's frequency and consequently determine the ion's
mass-to-charge ratio (m / z).
Ion charge is determined by construction of a Selective Temporal Overview of Resonant
Ion (STORI) plot, which tracks the temporal evolution of signals attributable to the ion of interest, and where the slope of the STORI plot is related to the charge. The STORI plot may also be employed to identify ion decay events during transient acquisition and / or the presence of multiple ions of the same mass or non-resolvable ions.