High-sensitivity pH value biosensor chip

A sensor chip and high-sensitivity technology, applied in biochemical equipment and methods, microbial measurement/inspection, instruments, etc., can solve the problems of complicated testing process, large testing equipment, long testing time, etc., to ensure the shrinkable characteristics, Reduce inspection time and achieve low-cost results

Inactive Publication Date: 2016-12-21
严媚
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Problems solved by technology

The chip (128) can be used to detect the concentration of Escherichia coli in food hygiene, and solves the following two key technical problems: i) problems such as long testing time, complicated testing process,

Method used

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  • High-sensitivity pH value biosensor chip
  • High-sensitivity pH value biosensor chip
  • High-sensitivity pH value biosensor chip

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[0055] The present invention will be described in further detail below in conjunction with the accompanying drawings.

[0056] Figure 4 based on silicon nitride (Si 4 N 3 ) structure diagram of the ion sensitive field effect transistor (105) of the passivation layer (106), its structure is the same as that of the metal-oxide semiconductor field effect transistor (MOSFET), but the gate (108) of the ion sensitive field effect transistor (105) in a floating state. The electrode (103) (Ag / AgCl) in the solution (104) provides bias voltage (V ref ), so that the ion sensitive field effect transistor (105) works in the sub-threshold region. Since silicon nitride (Si 4 N 3 ) passivation layer (106) contains chemical molecules SiOH and SiNH 2 Can react with the hydrogen ion in the solution (104), the chemical reaction formula is as follows:

[0057]

[0058]

[0059]

[0060] where H S + represents hydrogen ions on the surface of the passivation layer (106). Passiva...

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Abstract

The invention discloses a high-sensitivity pH value biosensor chip, which can realize low-cost and rapid food safety detection. At the same time, the sensor chip is conducive to the integration of large-scale sensing arrays, which can be used for fast, low-cost, high-throughput gene sequencing. The chip includes a row/column decoder, a large sensing unit array, a sub-threshold region pH-time domain-voltage conversion reading circuit group, a 10-bit analog-to-digital conversion circuit group, a static random register reading circuit group, etc. The chip can detect the change of pH value in the solution and convert it into a voltage signal, and finally convert the voltage into a digital signal through the on-chip analog-to-digital conversion circuit, and send it to the computer for data reception, storage and analysis. The reading amplification circuit of the present invention can effectively improve the sensitivity of the sensor, and the minimum resolution reaches 0.01pH, which can solve the compatibility problem between the chip and the standard complementary metal oxide semiconductor (CMOS) process and the problem of low sensitivity in the process of process miniaturization .

Description

technical field [0001] The invention relates to a food safety detection technology, in particular to an acid-base detection sensor chip for Escherichia coli concentration detection. Based on its high sensitivity and large array characteristics, the biochip can also be applied to the field of gene sequencing. Background technique [0002] Food safety is closely related to public health and sanitation. Food poisoning and viral infections caused by foodborne pathogens can cause various diseases, such as nausea and vomiting easily caused by Staphylococcus aureus enterotoxin, pathogenic Escherichia coli O157 :H7 can easily cause diarrhea and dehydration, and Listeria can even cause sepsis, meningitis, and even death. In addition to these dangerous pathogenic bacteria, non-pathogenic bacteria have also attracted the attention of the industry. For example, harmless Escherichia coli, which is widely present in the intestinal tract of humans and animals, is used as an indicator of f...

Claims

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Application Information

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IPC IPC(8): G01N27/414C12Q1/68
CPCG01N27/4148C12Q1/6869
Inventor 姜钰刘旭严媚余浩
Owner 严媚
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