50 results about "Nausea" patented technology

This invention provides a novel GABA structure with better efficacy, reduced side effects, and greater safety for clinical use. A This invention relates to receptor agonists, specifically a phenol derivative, its preparation method, and its use in the central nervous system. The phenol derivative provided by this invention offers more and better drug options for inducing or maintaining anesthesia in animals or humans, promoting sedation and hypnosis, and treating and / or preventing anxiety, nausea, vomiting, migraines, seizures, epilepsy, neurodegenerative diseases, and other central nervous system-related disorders.

A traditional Chinese medicine composition for alleviating gastrointestinal toxic side effects caused by chemotherapy, the traditional Chinese medicine composition for daily administration is prepared from the following weight ratio of traditional Chinese medicine formula: Taizishen 20-30g, Fuling 10-15g, Fried Baizhu 10-15g, Zhigancao 5-10g, Jiangbanxia 5-10g, Chenpi 5-15g. The formula can effectively alleviate the gastrointestinal toxic side effects caused by chemotherapy, such as nausea, vomiting, diarrhea, poor appetite, etc.

The invention belongs to the technical field of functional compositions, and discloses a composition for dispelling effects of alcohol and protecting liver as well as a preparation method and application thereof, and the composition comprises the following raw materials in percentage by mass: 13-28% of ginseng, 18-28% of globe artichoke, 10-27% of pueraria peptide, 7-12% of houttuynia cordata, 7-9% of mulberry, 6-9% of gardenia and 10-29% of collagen composite peptide. The composition can reduce alcohol irritation, relieve alcohol absorption and increase the alcohol content; meanwhile, the liver and stomach are protected; meanwhile, alcohol metabolism is rapid, hangover is prevented, headache, dizziness, nausea and other uncomfortable symptoms caused by alcohol are relieved, and the drunkenness degree is relieved. After the medicine is taken for 2-6 months, mild fatty liver and moderate fatty liver can be obviously improved, and severe fatty liver and alcoholic liver can be obviously improved; indexes related to endocrine metabolism, such as blood sugar, blood fat, uric acid, triglyceride, total cholesterol, high-density lipoprotein cholesterol, low-density lipoprotein cholesterol, glutamic oxalacetic transaminase and glutamic-pyruvic transaminase, are obviously improved.

The invention discloses an esophagus medicine applying device for a patient in the digestive system department, and relates to the field of medical equipment, the esophagus medicine applying device comprises a medicine applying pipe, an air pipe is fixedly mounted at the bottom of the outer surface of the medicine applying pipe, and a protective air bag is fixedly mounted on one side of the medicine applying pipe and one side of the air pipe; a pressure sensor is installed on the edge portion of one side of the outer surface of the extending pipe, a dosing mechanism is arranged on the outer surface of the medicine applying pipe and used for adjusting different types of dosing modes, the dosing mechanism comprises a dosing connecting part, the dosing connecting part is fixedly installed on the position, close to the upper portion of the protective air bag, of the outer surface of the medicine applying pipe, and a fixing groove is formed in the middle of one side of the outer surface of the dosing connecting part; the closed administration area is formed by inflating the protective air bag, and by matching with real-time monitoring of the pressure sensor, medicine is effectively prevented from flowing back to the stomach and entering the airway by mistake, discomfort such as nausea and sour regurgitation of a patient is reduced, lung injury is avoided, and the administration safety is improved compared with the prior art.

This invention provides a highly thermally stable enteric-coated DHA microcapsule powder, its preparation method, and its applications. The microcapsule powder utilizes a composite wall material system with a specific ratio of raw materials: carbohydrate film-forming materials, protein film-forming materials, hydrophilic colloids, and dietary fiber materials. The resulting dense wall material not only maintains a supportive interface and film-forming structure under hot water reconstitution conditions, exhibiting high-temperature reconstitution stability, but also features an acid-resistant design, ensuring resistance to acid in aqueous solutions and reducing the nausea / gastric reflux after oral administration of the microcapsule powder. This achieves a balance between high-temperature and acid resistance, overcoming the problems of dispersion and nausea / gastric reflux associated with traditional DHA microcapsules. Furthermore, the microcapsules of this invention, through a synergistic system of "lipid-soluble antioxidants + aqueous antioxidants / reducing agents," reduce accelerated oxidation and off-flavor release during high-temperature reconstitution, thereby improving flavor acceptability.

The invention discloses a compound rosa roxburghii tratt preparation for promoting digestion and a preparation method thereof, the rosa roxburghii tratt preparation is prepared by taking rosa roxburghii tratt normal juice and blueberry normal juice as main raw materials and taking lily, pericarpium citri reticulatae, dandelion, agastache rugosus and green tea extract as auxiliary materials, and the compound rosa roxburghii tratt preparation can effectively promote gastric acid secretion, promote gastrointestinal motility and relieve symptoms such as stomach distension, hiccup and nausea. Belongs to the technical field of health-care food. The product is stable in quality, remarkable in effect and safe to take.

The suppression of the gag reflex response, administered through a training device and associated desensitization method(s), without medical intervention, is desirable for many people who suffer from gag reflex response issues. An oral acclimation training device comprise various thickness(es) and length(s) and may have components to prevent swallowing or choking of the device by the user. Further, the device may be part of a kit having multiple training objects with specific attributes (e.g. thickness, depth, shape, finish, texture) that are designed for a specific stage in the training sequence and tailored for the user's inherent gag reflex sensitivity. Training objects are designed to provide optimal stimulus range to cause desensitization but not cause severe gagging or vomiting. The gag suppression stemming from this device is long-term, meaning that it may last for many weeks or months, depending on the individual. This duration may be extended indefinitely by occasional re-training or similar conditioning.

The present invention relates to a pharmaceutical composition comprising a polypeptide, and more particularly, to a pharmaceutical composition for preventing or treating obesity, diabetes, or non-alcoholic fatty liver disease. The pharmaceutical composition is safe without any side effects such as vomiting or nausea and has the effects of reducing food intake, enhancing insulin secretion, inhibiting gastric emptying, promoting lipolysis and reducing triglyceride levels.

Disclosed are the use of methods for reducing one or more gastrointestinal side effects in a subject receiving glucagon-like peptide-1 (GLP-1) receptor agonist (RA) therapy. The methods include administering to a subject receiving GLP-1 RA therapy an amount of homotaurine-like gastrointestinal distress-relieving (HTL-GIDR) composition effective to reduce gastrointestinal side effects of GLP-1 RA therapy, e.g., nausea, vomiting, and constipation. Generally, the HTL-GIDR composition can be homotaurine or a homotaurine analog such as acamprosate calcium and valiltramiprosate (ALZ-801), or a combination thereof. Furthermore, the HTL-GIDR composition may facilitate tolerance during the GLP-1 RA dose escalation phases and enable administration of higher GLP-1 RA doses, thereby enhancing therapeutic outcomes in conditions including diabetes, obesity, and neurodegenerative diseases.

The invention discloses a traditional Chinese medicine composition for treating chemotherapy-related nausea and vomiting, an acupoint patch and a preparation method, and belongs to the technical field of traditional Chinese medicine research. According to a fine-tuning external application formula, acupoint external application is achieved, medicine transdermal absorption is matched with acupoints to stimulate channel and qi combination, and the effect is special and strong; the medication route is changed, oral administration is avoided, and the gastrointestinal burden is relieved. Aromatic traditional Chinese medicines are used for guiding channels, promoting qi circulation, dredging collaterals and promoting transdermal absorption; and the aromatic traditional Chinese medicines enter spleen and stomach channels, enlivene spleen and please stomach, and are helpful for improving gastrointestinal reactions such as nausea and vomiting. The acupoint patch is simple and easy to operate and learn, has a high degree of recognition by the masses, and is easy to popularize in western medicine hospitals and primary hospitals.

The invention discloses a traditional Chinese medicine composition for treating a warm disease clinically belonging to the same disease of defensive qi and a preparation method and application thereof.The traditional Chinese medicine composition is prepared from, by weight, 5-35 parts of bupleurum chinense, 9-50 parts of scutellaria baicalensis, 9-50 parts of artemisia apiacea, 5-35 parts of radix paeoniae rubra, 5-35 parts of moutan bark and 4-26 parts of folia perillae acutae. According to the traditional Chinese medicine composition, the effects of all the medicines are utilized to generate a synergistic effect, and the effects of relieving fever, eliminating evil and detoxifying are achieved together. The traditional Chinese medicine composition is used for treating fever or hyperpyrexia, slight aversion to wind-cold, headache, sweating, thirst, cough and pharyngalgia caused by cold, viral cold and upper respiratory tract infection febrile disease defensive qi, and can be accompanied by nausea, vomiting, neck stiffness, rash appearance, red eye swelling and pain and the like, so that the febrile disease is effectively treated.

The invention relates to the field of gastrointestinal surgical nursing, and discloses a gastrointestinal fluid decompression device for gastrointestinal surgical nursing, which comprises a tank body, a negative pressure bottle body is arranged in the tank body, a pressure supplementing assembly is arranged on one side of the tank body, and a partition assembly is arranged above the pressure supplementing assembly. Through the deformation linkage design of the negative-pressure self-adaptive pressure supplementing assembly and the elastic negative-pressure bottle, real-time monitoring and dynamic compensation of the negative pressure in the negative-pressure bottle are achieved, the pressure supplementing strength can be automatically adjusted according to the springback unfolding degree of the negative-pressure bottle, the problems that the negative pressure of a traditional negative-pressure bottle is continuously attenuated, and pressure fluctuation is large are fundamentally solved, and the service life of the negative-pressure bottle is prolonged. And the whole gastrointestinal drainage process is kept in a stable, uniform and effective negative pressure state. The stable drainage pressure can avoid stimulation to gastrointestinal tracts of patients caused by sudden strong and weak suction, uncomfortable symptoms such as abdominal distension, nausea and reflux are remarkably reduced, drainage sufficiency of gastrointestinal fluid is improved, hydrops retention and related complication risks are reduced, and safer and more comfortable decompression guarantee is provided for postoperative recovery of the patients.

The invention provides a nicotine osmotic pump tablet and a preparation method thereof, the nicotine osmotic pump tablet is suitable for the oral cavity, the nicotine osmotic pump tablet comprises a tablet core, the tablet core comprises a drug-containing layer and a boosting layer, the drug-containing layer contains nicotine, and the ratio of the viscosity of the drug-containing layer to the viscosity of the boosting layer is 1: 1.5-1: 2; the tablet core is coated with the semi-permeable membrane; and the release hole can release nicotine after the semipermeable membrane permeates into the liquid. By adopting the nicotine osmotic pump tablet, nicotine is released at an approximately constant rate, the problems that oral mucosa and even stomach are stimulated to cause nausea and the like due to too fast release of nicotine are avoided, and meanwhile, sticky feeling or foreign body sensation is avoided during oral administration.

The invention relates to cannabidiol-based (CBD) formulations, and to their use in treating, preventing or alleviating pain, inflammation, an autoimmune disease, a neurological disease, neoplasm, or nausea in a subject. The invention also concerns low-dose CBD compositions, and extends to their use in methods of treatment.

The present application belongs to the technical field of traditional Chinese medicine, and particularly relates to a traditional Chinese medicine composition with an antiemetic effect and a preparation method thereof. The traditional Chinese medicine composition contains perilla leaf, Coptis chinensis, Amomum villosum, Saussurea lappa, Pinellia ternata, ginger, Chinese yam and honey. The traditional Chinese medicine composition has a good relieving and treating effect on pregnancy vomiting through pharmacological experiments and clinical use verification. The clinical treatment rate of pregnancy vomiting reaches 92.86%, and the traditional Chinese medicine composition can effectively relieve the clinical symptoms of patients, such as nausea and vomiting, dizziness, anorexia, food entering the stomach and then vomiting, and the like. The preparation process is simple, the traditional Chinese medicine composition can be further produced, and has a wide market prospect.

The invention discloses sober-up tea and a preparation method thereof.The sober-up tea is prepared from, by weight, 5-20 parts of flos puerariae, 3-10 parts of pericarpium citri reticulatae, 3-10 parts of flos chrysanthemi, 2-8 parts of radix astragali and 20-50 parts of dark tea, the preparation method of the sober-up tea comprises the following steps that 1, raw material pretreatment is conducted, specifically, the flos puerariae, the pericarpium citri reticulatae, the flos chrysanthemi and the radix astragali which are free of mildew and impurities are selected, and the selected raw materials are mixed evenly; the kudzuvine flowers, the pericarpium citri reticulatae, the chrysanthemums, the astragalus membranaceus and the dark green tea are respectively cleaned and then dried in a drying oven at 50-60 DEG C. The alcohol effect dispelling tea is prepared by matching the kudzuvine flowers, the pericarpium citri reticulatae, the chrysanthemums, the astragalus membranaceus and the dark green tea, has the core effects of dispelling alcohol effects, enlivening the spleen, regulating qi, harmonizing the stomach, clearing heat, tonifying qi, relieving discomfort after drinking and protecting the spleen and the stomach, and is a composite tea drink capable of dispelling alcohol effects and conditioning. The flos puerariae is a core alcohol effect dispelling component of the formula, and can directly dispel alcohol toxins, enlivene the spleen, harmonize the stomach and relieve headache, dizziness, nausea and vomiting, abdominal fullness and distention and other symptoms caused by excessive drinking; by matching with the digestion-promoting and greasy-cleansing effects of the dark tea, greasy food retention in the stomach and intestine after drinking can be further relieved, and the problem of poor appetite after drinking is solved.

This invention discloses a cold-relieving bubble tea, belonging to the field of food technology. The bubble tea uses perilla leaves, agastache, honeysuckle, atractylodes, and licorice as medicinal and edible ingredients, compounded in specific weight proportions, and then dried at low temperature, pulverized, mixed, and packaged into tea bags. This product has a scientifically formulated, safe, and mild recipe, and is convenient to brew. It can relieve exterior symptoms, protect the skin, and resolve dampness. It has a relieving and auxiliary conditioning effect on early-stage cold symptoms such as nasal congestion, runny nose, sore throat, chills, fatigue, cough, nausea, loose stools, and recurrent colds. It is suitable for daily prevention and consumption during colds.

GIP receptor agonists of the present disclosure have anti-emetic properties and therefore can be used to reduce or inhibit the frequency or severity of episodes of nausea or emesis in a patient in need thereof.

The invention relates to the field of medicines, in particular to a traditional Chinese medicine composition for treating pancreatitis and a preparation process thereof. The traditional Chinese medicine composition is prepared from more than 30 traditional Chinese medicines such as rheum officinale, codonopsis pilosula, astragalus membranaceus, cape jasmine, radix curcumae, polygonum cuspidatum and rhodiola rosea. Animal experiments prove that the traditional Chinese medicine composition disclosed by the invention can be used for remarkably reducing the ascites amount of rats with severe acute pancreatitis and expression of inflammatory factors such as amylase, serum lipase, IL-1beta and IL-18, and remarkably reducing the incidence rate of pancreatic pseudocyst and abscess. Observed from clinical curative effects, the traditional Chinese medicine composition disclosed by the invention has a relatively good treatment effect on severe acute pancreatitis, acute light pancreatitis and chronic pancreatitis, the symptoms of abdominal pain, diarrhea, nausea and abdominal distension of patients in the treatment process are obviously relieved, and the symptoms are obviously advanced and improved through gastrointestinal tract eating. And further popularization and application are facilitated.

Described herein are methods, compositions, products, and processes that utilize bioceramics in traditional agricultural and hydroponic systems. The bioceramics are utilized in powder form, as films, as aerosols, as water based treatment systems, or in solid forms. The methods and bioceramic compositions described here are also used for growing a Cannabis plant. One or more cannabinoids within the plant can be used in therapeutic compositions for the treatment of glaucoma, AIDS wasting syndrome, neuropathic pain, cancer, multiple sclerosis, chemotherapy-induced nausea, and certain seizure disorders.

The invention provides a spleen-tonifying and detoxifying traditional Chinese medicine composition as well as a preparation method and application thereof, and belongs to the technical field of traditional Chinese medicines. The traditional Chinese medicine composition comprises a formula A and a formula B. The traditional Chinese medicine composition has a comprehensive conditioning effect and can relieve chemotherapy side effects, improve intestinal flora distribution, promote intestinal health, enhance the chemotherapy effect and improve the disease control rate. Wherein the formula A focuses on tonifying spleen and regulating qi, and improving nausea, vomiting and other symptoms at the initial stage of chemotherapy, and the formula B is added with medicines for clearing away heat and toxic materials and promoting blood circulation to remove blood stasis on the basis, is suitable for patients with myelosuppression with cancer toxicity residue, and strengthens the effects of clearing away heat and toxic materials and removing stasis; the composition has a multi-target action mechanism, and through the combined action of multiple ways, the treatment effect is enhanced, and the side effect is reduced.

This invention provides a traditional Chinese medicine composition for hiccups, acid reflux, and / or bloating, its application, and a drug with the traditional Chinese medicine composition as an active ingredient and its preparation method. The traditional Chinese medicine composition of this invention comprises the following medicinal materials in parts by weight: 3-9 parts agarwood, 3-10 parts processed Evodia rutaecarpa, 10-20 parts cuttlebone, 6-12 parts patchouli, 3-10 parts perilla leaf, 6-12 parts Elsholtzia ciliata, 6-12 parts tangerine peel, 6-10 parts Magnolia officinalis, 6-12 parts Amomum villosum, 6-12 parts stir-fried white hyacinth bean, 6-20 parts stir-fried hawthorn, 3-6 parts Coptis chinensis, 6-12 parts stir-fried malt, 6-15 parts Poria cocos, 3-6 parts licorice root, 6-12 parts talc, 6-15 parts green plum blossom, 3-6 parts cinnamon, and 3-9 parts stir-fried fennel. The traditional Chinese medicine composition of the present invention, when used together, has the combined effects of regulating qi and stomach, relieving nausea and hiccups, neutralizing acid and relieving bloating, strengthening spleen and promoting digestion, and warming the middle and removing dampness. It treats both the symptoms and the root cause, and has a definite and lasting curative effect.

The invention belongs to the technical field of traditional Chinese medicines, and provides a traditional Chinese medicine composition for treating insomnia and a preparation method and application thereof. The traditional Chinese medicine composition comprises the following components in parts by weight: radix bupleuri, rhizoma pinelliae preparata, red ginseng, scutellaria baicalensis, dragon bone, oyster, poria with hostwood, polygala tenuifolia, tuber fleeceflower stem, amethyst and honey-fried licorice root. According to the treatment principle of quieting heart and benefiting gallbladder, radix bupleuri, scutellaria baicalensis, pinellia ternate, red ginseng, dragon bone, oyster, poria with hostwood and amethyst, polygala tenuifolia, tuber fleeceflower stem and honey-fried licorice root are used for harmonizing heart and benefiting gallbladder. The traditional Chinese medicine composition disclosed by the invention is remarkable in effect of improving insomnia symptoms, exact in curative effect, free of toxic and side effects and remarkable in market prospect.

The present invention belongs to the field of polypeptide pharmaceuticals, and provides a dual agonist polypeptide compound and the pharmaceutical use thereof. An amino acid sequence of a GIP-R and GLP-1R dual agonist polypeptide compound is: Y1-X1-EGTFTSDYSI-X2-LDKI-X3-Q-Bn-X4-X5-VQWLI-X6-GGPSSG-X7-PPPS, and the C-terminal amino acid is amidated. The GIP-R and GLP-1R dual agonist polypeptide compound has a more significant dual agonistic effect on human glucose-dependent insulinotropic polypeptide (GIP) and human glucagon-like peptide-1 (GLP-1) receptors. The compound not only has the effects of lowering blood sugar and reducing weight, but also has a longer half-life and a higher bioavailability. The compound can avoid adverse reactions such as nausea and vomiting caused by the long-term use of existing drugs, and thus can be used as an effective raw material for the preparation of a drug for treating or preventing diabetes or an anti-obesity drug.

The invention discloses an anti-alcoholism agent based on a polymer composite material and a preparation method of the anti-alcoholism agent, and belongs to the technical field of biomedical materials and functional foods. In order to overcome the defects that an existing hangover alleviating agent depends on metabolic enzymes, is large in individual difference and is prone to injuring the stomach and intestine, a cyclodextrin-polyacrylic acid compound and hyaluronic acid dynamic cross-linked hydrogel serve as a core, a cleanup promoting agent, natural active ingredients and functional additives are matched, and the microspheres are prepared through the processes of graft polymerization, spray drying and impregnation loading. The core mechanism is physical inclusion and adsorption of ethanol and synergy of rapid excretion promotion and liver protection in intestines, the ethanol adsorption rate is greater than 90%, the blood alcohol concentration is reduced by more than 40% in 30 minutes, and the 28-day biodegradation rate is greater than 95%. The product can be prepared into tablets, granules and other dosage forms, is suitable for social social engagement, auxiliary protection of liver functions and relieving of dizziness, nausea and other uncomfortable symptoms after alcohol intake, and has the advantages of quick action, high safety and no individual difference.

This invention belongs to the field of medical auxiliary device technology and discloses a chemotherapy support device for oncology. It includes a seat body, a respiratory status detection device, and a controller. The seat body is connected to armrests, a Neiguan acupoint massage component, a Zusanli acupoint massage component, an abdominal heat therapy component, a headrest, and a speaker. The Neiguan acupoint massage component includes a base, a motor, a fixed gear ring, a sun gear, planetary gears, and massage balls. The Zusanli acupoint massage component includes an air pump and an airbag. The abdominal heat therapy component includes a strap, a medicine storage box, a heat therapy bag, and an electric heating wire. The respiratory status detection device includes a pressure sensor. This invention utilizes the Neiguan acupoint massage component to stimulate and massage the Neiguan acupoint, the Zusanli acupoint massage component to compress the Zusanli acupoint, and the abdominal heat therapy component to provide heat therapy to the abdomen, effectively relieving symptoms such as nausea and vomiting, numbness in the hands and feet, and abdominal cold pain after chemotherapy.

The invention belongs to the technical field of medical instruments, and particularly relates to an auxiliary device suitable for paranasal sinus negative pressure replacement and a using method.The auxiliary device comprises two clamping handles and a controller, an elastic bent strip is arranged between the two clamping handles, and the two ends of the elastic bent strip are fixedly connected with the inner walls of the two clamping handles correspondingly; the inner side wall of the tail end of the clamping handle is fixedly connected with a first induction piece, the tail end of the clamping handle is fixedly connected with an expansion air bag, and the clamping handle is of a cavity structure. An air pump is further included, the output end of the air pump is fixedly communicated with a catheter, the outer end of the catheter is fixedly communicated with a three-way pipe, and the other two ends of the three-way pipe are communicated with the two clamping handle cavities respectively. Compared with a traditional method, the requirement for the body position of a patient is not very strict, the matching degree of the patient is greatly increased, the possibility that medicine flows into the throat and the lower respiratory tract is limited through the expansion air bag of the rear nostril, the reaction degree of nausea and vomiting of the patient is greatly reduced, and complications are also reduced.

This invention discloses an automatic antiemetic massage relief device for tumor chemotherapy, comprising: a contact box, a fixing belt, and a motor; multiple contact boxes are provided and connected to each other via connecting parts; multiple motors are mounted on the contact boxes, and massage heads are fixedly mounted on the output shafts of the motors, extending to the other side of the contact boxes; massage stimulation is provided by the massage heads; the massage heads can effectively massage and simultaneously promote the release of medication, thereby enhancing the antiemetic effect; in addition, this invention places appropriate aromatic drugs or drugs to help relieve nausea in the drug storage chamber; and the friction heat generated by the metal in the drug storage chamber and the friction rod on the motor accelerates the volatilization of the drug, achieving the effect of relieving nausea through respiration.

The invention discloses a sectional type gastric bypass stent conveying and releasing system, and relates to the technical field of medical instruments. The sectional type gastric bypass stent conveying and releasing system comprises a sectional type stent and a conveying and releasing mechanism, the sectional bracket comprises an upper bracket, a lower bracket, a connecting rope and a membrane tube, the upper bracket and the lower bracket are connected through the connecting rope, and one end, far away from the upper bracket, of the lower bracket is connected with the membrane tube; the lower support and the membrane pipe are both contained in a containing pipe of the conveying and releasing mechanism, the membrane pipe is connected with the releasing small ball, the lower support makes contact with the support pushing block, the connecting rope is led out of the rope passing groove, and the upper support is contained in a gap between a conveying pipe of the conveying and releasing mechanism and an outer sleeve. The sectional stent provided by the invention reduces the incidence rate of gastrointestinal tract events (vomiting, nausea, stomachache and the like) and stent displacement, reduces the occurrence rate of gastric retention or obstruction, and is not easy to form pressure ulcer. The sectional type support and the conveying and releasing mechanism are high in matching performance, and the conveying and releasing effects are better.