The invention relates to health-care rice vinegar and a preparation process thereof. The invention belongs to the technical field of processing of condiments and particularly relates to health-care rice vinegar prepared from millet serving as a main raw material and traditional Chinese medicinal materials. The health-care rice vinegar is prepared from the main raw material comprising millet, traditional Chinese medicinal materials comprising hawthorn, dark plum fruit, semen cassia, lotus leaf, oriental wormwood, oolong, lucid ganoderma, immature bitter orange, aloe, peach kernel, ginger and yam, and auxiliary materials comprising wheat koji, bran, cavings and salt. The health-care rice vinegar has the advantages of 1, comprehensively adjusting lipid metabolism, obviously reducing hyperlipaemia, reducing serum total cholesterol, triglyceride and low-density lipoprotein, obviously increasing high-density lipoprotein and degrading atherosclerotic plaques; 2, reducing blood viscosity, obviously inhibiting platelet abnormal coagulation, improving hemodynamic indexes, promoting blood circulation, avoiding thrombus and effectively preventing apoplexia; and 3, dredging blood vessels, improving blood supply microcirculation, improving brain and heart blood supply insufficiency, inhibiting atherosclerosis and effectively preventing coronary heart disease.