203 results about "Total cholesterol" patented technology

The invention relates to the technical field of food, in particular to diglyceride for reducing triglyceride, cholesterol and uric acid as well as a biological enzyme preparation method and application of the diglyceride. The preparation method comprises the following steps: (1) adding water and glycerol into vegetable oil, and then adding immobilized lipase to react to obtain a reactant; (2) centrifuging reactants, collecting a light-phase product, carrying out molecular distillation, and collecting a heavy-phase product to obtain diglyceride; the immobilized lipase comprises lipase and a carrier, the carrier comprises loofah sponge, soybean meal and bentonite, and the mass ratio of the loofah sponge to the soybean meal to the bentonite is 1: (2-4): (3-6). The method has the advantages that the effects of reducing triglyceride, total cholesterol and uric acid are relatively good, and the yield and the purity are relatively high.

The invention discloses application of an overexpressed carp lpla gene in regulation and control of expression of cyprinid fish tissue-related genes, and relates to the field of gene engineering, in particular to application of the overexpressed carp lpla gene in regulation and control of cyprinid fish tissue-related genes. The overexpressed carp lpla gene is applied to regulation and control of contents of lipid indexes of total cholesterol TC and triglyceride TG of different tissues of cyprinid fishes. The invention further discloses application of the overexpressed carp lpla gene in regulation and control of fat marker genes lpla, ppar gamma, Fabp3, fast and acaca of livers and muscle tissues of cyprinid fishes. The invention further discloses application of the overexpressed carp lpla gene in regulating and controlling the relative expression quantity of carp liver cell fat metabolism related genes lpla, ppar gamma, Fabp3, fast, acaca, hsl and pnpla2. The overexpressed carp lpla gene can regulate and control lipid deposition in different tissues in zebra fish, and a research model is provided for lpla to regulate and control fat deposition and differentiation. According to the overexpressed carp lpla gene disclosed by the invention, lpla high-expression carp hepatocytes are obtained through a liposome transfection technology, so that fat key gene expression in the carp hepatocytes is changed.

The invention relates to a preparation method and application of a medicine-food homologous compound with weight-losing and lipid-lowering effects. According to the present invention, the weight of the obese mouse can be reduced by 23.23% at most, the serum total cholesterol is reduced, the leptin secretion is reduced, AST (aspartate transaminase) and ALT (alanine transaminase) have no significant difference compared to the model mouse, the volume of epididymal fat and inguinal fat cells is reduced, the number of cells in unit area is significantly increased, the fatty liver sample is relieved, the TMEM26 gene expression in the epididymal fat is significantly increased, and the weight of the obese mouse can be significantly reduced; the expression quantity of the UCP1 gene in brown fat is obviously increased. The traditional Chinese medicine composition adopts medicinal and edible substances as raw materials, is widely applicable to people, is more suitable for prevention and treatment of chronic diseases, is safe and effective, and causes little damage to liver and kidney after long-term use.

The invention relates to the technical field of intelligent health management, in particular to an intelligent nutrition intervention method based on underlying logic, which comprises the following steps: acquiring serum triglyceride, atherophilic lipoprotein cholesterol, anti-arterial lipoprotein cholesterol and total cholesterol concentration, collecting exhaled carbon dioxide release amount, and monitoring fatty acid oxidation rate. According to the method, through blood fat metabolism monitoring data, extraction of blood fat fluctuation characteristics, recognition of key abnormal time points, combination of fatty acid oxidation rate change, quantification of individual metabolic capability, adjustment of dietary fat composition, dietary fiber proportion and protein collocation, optimization of blood fat metabolism states and calculation of fat oxidation rate fluctuation, the fat oxidation rate fluctuation is calculated. According to the method, the influence of the feeding time on the blood fat change is evaluated, the optimal feeding time interval is matched, the dietary intake and the metabolic rhythm are coordinated, a personalized dietary adjustment scheme and the optimal feeding time are synthesized, the individual metabolic demand is matched, the pertinence and the adaptation degree of nutrition intervention are improved, and errors caused by intervention scheme generalization are avoided.

The invention relates to the field of medicines, and particularly discloses a fusion protein with a GIP and GLP-1 dual receptor agonist function and application of the fusion protein. A specifically designed GLP-1 / GIP targeting polypeptide is fused with the N end of an IgG4 heavy chain constant region and the N end of a light chain constant region or the N end of Fc to obtain the GLP-1 / GIP targeting polypeptide. A research result shows that the fusion protein with the GIP and GLP-1 dual receptor agonist function has an obvious effect of reducing the weight of a mouse, the weight of the liver of the mouse is also reduced, the blood sugar of the mouse is also remarkably reduced, and the total cholesterol in serum is reduced to a certain extent. Therefore, the compound can be applied to medicines or products for slimming, reducing blood sugar and treating fatty liver.

The present application provides a polypeptide composition with anti-obesity effect, which is composed of capsaicin and polypeptides, and the amino acid sequence of the polypeptides comprises any one or more of SEQ ID NO. 1 to SEQ ID NO. 8. The polypeptides of sequences 1-8 are mixed uniformly at a mass ratio of 1-20:1-4:1-2:1-4:1:1:1:1, and the capsaicin is mixed with the mixed polypeptides at a ratio of 2-12:100 (w / w). The polypeptide composition proposed in the present application, in combination with capsaicin, not only promotes the weight loss effect of capsaicin, but also significantly reduces the fat index of the test mice after use, and can significantly reduce the total cholesterol concentration in the liver and the liver triglyceride concentration under a high-fat diet.