108 results about "VASCULAR FUNCTIONS" patented technology

A method and system for use in measuring the endothelial dysfunction utilizing flow mediated dilation and determining arterial health of a patient. The system includes a non-invasive blood pressure monitor, an ultrasound system and a pulse oximeter monitor that all communicate with each other to perform the flow mediated dilation. Initially, the ultrasound transducer, blood pressure cuff and pulse oximeter sensor are positioned on an arm of the patient. The blood pressure cuff is inflated to occlude an artery for an occlusion period. Following the occlusion period, the ultrasound system is automatically signaled to begin determining a parameter of the artery, such as diameter, and the flow rate of blood through the artery without any operator intervention. At the same time, the pulse wave velocity PWV is calculated between the ultrasound transducer and the finger probe of the pulse oximeter following the occlusion period. Based upon the detected characteristics of the artery before and after occlusion, as well as the PWV, the system can determine the endothelial dysfunction and arterial health of the patient.

The present invention describes a device and system for simulating normal and disease state cardiovascular functioning, including an anatomically accurate left cardiac simulator for training and medical device testing. The system and device uses pneumatically pressurized chambers to generate ventricle and atrium contractions. In conjunction with the interaction of synthetic valves which simulate mitral and aortic valves, the system is designed to generate pumping action that produces accurate volume fractions and pressure gradients of pulsatile flow, duplicating that of a human heart. Through the use of a control unit and sensors, one or more parameters such as flow rates, fluidic pressure, and heart rate may be automatically controlled, using feedback loop mechanisms to adjust parameters of the hydraulic system simulate a wide variety of cardiovascular conditions including normal heart function, severely diseased or injured heart conditions, and compressed vasculature, such as hardening of the arteries.

Methods and apparatus are provided for identifying and minimizing neurovascular contributions to determinations of endothelial function, including by digital temperature monitoring such that an accurate status of vascular reactivity can be obtained. Methods are also provided for identifying individuals having increased sympathetic nervous system activity impacting peripheral vascular function as well as for determining a status of diabetic foot.

A mobile measurement device comprising a computing device; one or more sensors that are coupled to the computing device using one or more corresponding compatible digital interfaces; and logic encoded with instructions which when executed perform determining and storing vascular function information and one or more of: values of metrics or parameters; physiological analysis of the parameters and the vascular function information; recommendations for actions that an individual or healthcare provider should take in response to the recommendations or parameters. Embodiments further include processes for using vascular function information collected from a mobile measurement device to generate the parameters, analysis, and recommendations.

Compositions of coffee cherry, methods for their use in the treatment of diabetes and diabetes-related complications, and methods for manufacture of the compositions are disclosed. The compositions find use in the treatment of a variety of diabetes-related conditions including disorders relating to impaired vascular function. Methods for the treatment of macroangiopathies and microangiopathies, including diabetic retinopathy, are disclosed.

A method for automatic examination of echographic images of the cardiovascular system, in particular, for computing functionality indexes of a segment of the cardiovascular system. Said method computes a succession of starting images (1), extracts a succession of images (4) synchronized with a cyclical movement (2) of the examined segment and measures cardiovascular functionality indexes (5) in the succession of synchronized images (4). The method, furthermore, describes the process for defining the edges of the examined structure starting from a starting ultrasonographic image in which the geometric features of the cardiovascular structure are known.

The present invention relates to compositions for supplementing the diet of subjects suffering from cardiovascular or peripheral vascular disease or those at risk for such conditions. Ribose is given alone or in combination with one or a combination of vasodilators, nutrients and vitamins. Preferred vitamins include Vitamins C, B6, B12 and folic acid. Preferred nutrients include glutamine and glucose.

A blood vessel function inspecting apparatus including blood flow velocity distribution measuring portion for measuring a blood flow velocity distribution within a blood vessel in a non-invasion manner with ultrasonic waves before releasing of the blood vessel from a blood flow obstruction or after a blood vessel diameter measuring time period; viscosity-shear rate relationship calculating portion; and blood shear stress calculating portion for measuring a blood flow velocity within the blood vessel, concurrently with the measurement of a change ratio of the diameter of the blood vessel within the predetermined blood vessel diameter measuring time period after releasing of the blood vessel from the blood flow obstruction, and calculating a blood shear stress on the basis of a measured blood flow velocity, and according to a viscosity-shear rate relationship.

Dysregulation of vascular function is observed in brain endothelium derived from patients affected by Alzheimer's disease. This may be manifested at the cell or organ level: e.g., abnormal capillary morphogenesis, defective angiogenesis, inappropriate cellular senescence, mitotic catastrophe, or combinations thereof. This observation can be used for diagnosis or treatment of neurodegenerative disorders and other cognitive impairments.

The invention discloses a method for calculating heart and vessel functional parameters based on blood pressure and pulses of four limbs, and belongs to the technical field of biomechanics. The arterial blood pressure and pressure pulse waves of the four limbs are detected through a pulse wave sensor and a blood pressure sensor, and noninvasive synchronous detection on the heart function, the rete arteriosum hardenability and blood flow parameters of the heart and the vascular function is achieved. The method comprises the steps that blood pressure and pulse wave information of the brachial artery and ankle artery of the four limbs are firstly collected, a series of collected pulse waves are subjected to waveform averaging, and average waveforms of the brachial artery and ankle artery of the four limbs are obtained respectively. The relation between the pulse waves of the four limbs, a pressure gradient and blood flow is set up based on the waveform characteristic parameters acquired through waveform analysis and the nonlinear pulse wave theory, and then the heart and vessel functional parameters are calculated on the basis of the blood flow and four limb pulse and blood pressure data. According to the method, a frequent and noninvasive detecting means easy to operate, fast in output and low in price is provided for a heart and vessel system.

In an embodiment, a data processing method comprises receiving, from a portable physiological measuring device configured for temporary attachment to a human body, data representing one or more physiological metrics or parameters of the body; receiving, from one or more Doppler vascular sensors configured for temporary attachment to peripheral artery locations of the body and a portable Doppler vascular signal measuring device coupled to the Doppler vascular sensors, vascular function information for the body; determining medical condition data indicating one or more medical conditions of the patient based on analysis and correlations of the vascular function information and the patient physiological metrics; generating and providing output records specifying one or more of: recommendations for actions that an individual or healthcare provider should take in response to the recommendations or parameters; or one or more reports, animations or figures; wherein the method is performed by one or more computing devices.

The present invention relates to a gastrodine powder injection preparation. It is made up by using gastrodine as main component, its content is 30-99.9%, and water soluble medicinal auxiliary or water or their mixture. Said powder injection is good in stability, less in toxic side effect and extensive application range, and possesses the function of sedation, analgesia, hypnotic action, resisting vertigo, resisting convulsion, resisting epilepsy, improving cardio-carebral vascular function and resisting senility, etc.

The invention provides an apparatus (10) and method (24) for determining vascular characteristics for early detection of cardiovascular disease comprising: an ultrasonic signal source (32) directing ultrasound signals (30) at an artery (27); an ultrasonic signal receiver (34) receiving ultrasound signals (36) reflected from or transmitted through the artery (27); means for analysing signals (40) received by ultrasonic signal receiver (34) to extract arterial displacement data (42); means for acquiring blood pressure data (48); signal processing means (44) for adjusting said arterial displacement data (46) using the blood pressure data (48); and means for analysing the adjusted arterial displacement data (51) to characterise vascular function (28).

A method for digital thermal monitoring assessment of vascular function comprising a temporary arterial occlusion using a pneumatic cuff positioned on a subject's upper limb, monitoring skin temperature at the fingertip of the occluded limb for a period of time before, during, and after the occlusion, calculating a Zero Reactivity Curve based on variables including start temperature, room temperature, and the slope of temperature decline during the occlusion, and assessing vascular function based on comparing the Zero Reactivity Curve and the observed temperature rebound after the occlusion is removed. A vascular reactivity monitoring apparatus for measuring skin surface temperature comprising an inflatable cuff for placement around a subject's limb, a digital thermal measuring device and photoplethysmography measuring device for placement on a finger of the subject's limb wearing the cuff and a second digital monitoring device and photoplethysmography measuring device for placement on a finger of the subject's contralateral limb.

A scanning line immediately above a blood vessel is detected using a received signal of a reflected wave of an ultrasonic wave transmitted to the blood vessel, and candidates for front and rear walls of the blood vessel are detected based on the received signal of the scanning line. Then, vascular front and rear walls pairs of front and rear walls are narrowed down from the candidates, and the narrowed-down vascular front and rear walls pair is regarded as one blood vessel and artery/vein identification is performed for each blood vessel. Measurement of vascular function information is performed for the blood vessel determined to be an artery. Determination of an artery/vein is performed based on the relative relationship between the contraction time and the expansion time of the blood vessel.

Biomedical images of both anatomical structure and real-time changes in neuronal, metabolic, positional, and vascular function in humans and animals is described. Ultra-wideband (UWB) pulse or square wave generators and electrical samplers, implemented using integrated circuits are used to make arrays of miniaturized microwave modules that are placed around the portion of interest in the body or head, allowing images to be made through either time-domain transmission of these pulsed waves through the body, or time domain reflectivity of the waves from internal structures, or their combination. Signal processing separate and extract the time-varying functional information from the static structural image data. The time-varying functional information from certain brain regions can be interpreted in order to control prosthetics, Brain-Machine-Interfaces and the like.

The invention relates to diagnostic and therapeutic tools and applications, particularly useful in diseases that affect vascular health and in inflammatory diseases. In particular, said diagnostic and therapeutic tools employ suitable detection or modulation of endothelial glycocalyx.

The invention provides a traditional Chinese medicine preparation for regulating borderline hypertension. The preparation has the characteristics that the raw materials of black bean, Chinese yam, polygonatum kingianum, raw hawthorn, mulberry leaf and ilex latifolia thunb are matched, and the effects of the medicinal materials are synergic to play roles in removing toxicity, clearing heat, dispelling wind, nourishing yin and eliminating toxin, so that cardiovascular functions can be effectively balanced, blood circulation can be improved, blood pressure can be balanced and regulated, and the state of borderline hypertension can be regulated and relieved. Clinical information indicates that the traditional Chinese medicine preparation has a good regulating effect on the borderline hypertension, so that the borderline hypertension even hypertension state can be effectively reversed by taking the preparation for a long time, unstable blood glucose can be adjusted, and relatively high blood fat and blood uric acid can be relieved to a certain extent.

Provided are novel binding molecules of human origin, particularly human antibodies as well as fragments, derivatives and variants thereof that recognize antigens such as native endogenous proteins associated with, e.g., immune response, autoimmune disorders, inflammatory diseases, metabolic disorders, vascular function, neurodegenerative diseases or tumors. More particularly, a human Auto-Immunosome and corresponding monoclonal antibody reservoir are provided. In addition, pharmaceutical compositions, kits and methods for use in diagnosis and therapy of are described.

The invention discloses a nutritious health caring food with blood pressure adjusting function, belonging to the nutritious food technology field. The nutritious health caring food of the present invention is made from the following materials: celery, dried laver powder, bucket wheat flour, wheat flour, root of kudzu vine, pseudo-ginseng and red sage root. The food of the invention is made from homologous natural plants having with medicinal food which is composed according to traditional Chinese medicine theory; can adjust and improve body microcirculation and cardiovascular function; can significantly improve and adjust the headache, vertigo, palpitaition, tinnitus and limb numbness symptoms of hypertension patients; can reduce hypertension complications. And, it can dredge microcirculation, improve cardio-cerebrovascular elasticity, blood component qualities and blood vessel functions, consequently, can control cardiovascular and cerebrovascular diseases effectively.