51 results about "VASCULAR FUNCTIONS" patented technology

The invention discloses a non-invasive wearable vascular arteriosclerosis assessment system and method based on multi-mode pulse wave signal fusion, and belongs to the field of vascular function assessment. The system comprises a distributed acquisition front end, a butterfly-shaped flexible substrate, an integrated double-accelerometer, a four-wavelength LED (530nm / 660nm superficial blood vessel measurement), a 810nm / 940nm deep artery measurement device, a double-photodiode, a double-impedance electrode and a pressure sensor. The central integrated control end processes a multi-mode signal and realizes pressure-LED current closed-loop control; the upper computer terminal extracts the multi-modal pulse wave time difference of the limbs and the neck, the local and regional pulse wave conduction velocity and the blood oxygen hemoglobin change parameters induced by the standardized posture, the dimension is reduced to 30 through principal component analysis, then the parameters are input into the random forest regression model, and the vascular elasticity index is output. Signal stability is improved through flexible fitting, single-source limitation is solved through multi-modal fusion, signal quality is guaranteed through closed-loop control, sensitivity is enhanced through dynamic physiological excitation, and accuracy and universality of arteriosclerosis assessment are improved.

The invention discloses a living blood vessel and lymph multi-parameter quantitative photoacoustic microscopic imaging system which comprises a high repetition frequency laser source, a photoacoustic scanning probe and a molecular imaging device. Through the cooperation of the multi-wavelength fast switching laser and the high-speed scanning probe, synchronous, dynamic and quantitative imaging of vascular function parameters and lymph concentration in a living tissue microenvironment is realized. The system has a video-level imaging rate and can capture a rapid biological process; through coaxial design of dispersion correction and a photoacoustic focus, high spatial resolution and high signal-to-noise ratio of a multispectral image are guaranteed; and the compact probe design realizes large-range scanning. The technology provides a powerful in-vivo visualization tool for research on life science problems such as tumor evolution and drug metabolism.

A method for increasing or improving nitric oxide signals or levels, the method comprising: administering a composition to a subject, the composition comprising: arginine or a pharmaceutically acceptable salt, ester, or derivative thereof; and tetrahydrocurcumin and / or β-aminoisobutyric acid or a pharmaceutically acceptable salt or ester thereof. The method and the composition can be used to increase, improve, or enhance nitric oxide signals or levels, inhibit nitric oxide decomposition, and increase or enhance nitrous acid and / or cyclic guanosine monophosphate levels, and can improve fatigue resistance or enhance muscle strength, maintain or improve cardiovascular health, maintain or improve vascular function and structure, inhibit or mitigate endothelial cell damage, or mitigate insufficient blood flow.

The invention relates to the technical field of intelligent medical treatment, and provides a blood vessel function detection method based on multi-physiological signal fusion and a related product. The method comprises the following steps: respectively acquiring arterial pulse wave signals of a first measurement part and a second measurement part of a user through a first sensor and a second sensor configured on the wearable equipment; collecting motion state data of a user in the process of collecting the arterial pulse wave signal through an inertial measurement unit configured on the wearable device, and dynamically compensating the arterial pulse wave signal based on the motion state data; extracting a characteristic waveform through a signal processing model based on the dynamically compensated arterial pulse wave signal; according to the first characteristic waveform and the second characteristic waveform after dynamic compensation, calculating the characteristic time difference of the pulse wave conducted from the first measurement part to the second measurement part; and inputting the characteristic time difference, the static physiological parameter of the user and / or at least one waveform morphological parameter into a blood vessel hardness evaluation model to obtain a blood vessel hardness evaluation value.

The invention discloses a 3D bio-printing bone marrow mesenchymal stem cell extravascular stent as well as a preparation method and application of the 3D bio-printing bone marrow mesenchymal stem cell extravascular stent. The 3D bio-printing bone marrow mesenchymal stem cell extravascular stent is obtained by performing 3D bio-printing on bio-ink of bone marrow mesenchymal stem cells (BMSCs) containing SIRT3 overexpression, and the bio-ink contains methacrylated hyaluronic acid (HAMA) and methacrylated gelatin (GelMA). The invention further discloses a preparation method of the 3D bio-printing bone marrow mesenchymal stem cell extravascular stent, and the 3D bio-printing bone marrow mesenchymal stem cell extravascular stent has the advantages that the 3D bio-printing bone marrow mesenchymal stem cell extravascular stent is obtained by performing 3D bio-printing on the bio-ink; the effect of improving the long-term patency rate of the vein bridge is evaluated by establishing a rat artery-vein transplantation model. Experimental results show that the 3D bio-printing bone marrow mesenchymal stem cell extravascular stent not only has good structural stability and biocompatibility, but also can significantly improve the long-term patency rate of a venous bridge, promote repair of damaged tissues and enhance the vascular function recovery capability, and has potential application prospects in improving the treatment effect of cardiovascular diseases.

This invention discloses the application of MYDGF in pharmaceuticals and medical devices for treating vascular intimal hyperplasia, belonging to the field of pharmaceutical technology. This invention utilizes MYDGF as a target in the preparation of products for protecting vascular function, and applies MYDGF in the preparation of drugs for treating vascular intimal hyperplasia, drugs for metabolic disorders related to vascular intimal hyperplasia, and medical devices for treating vascular intimal hyperplasia. This invention provides new candidate drugs and protein therapies for the clinical treatment of intimal hyperplasia.

A method of monitoring a blood vessel, the method comprising using a system for monitoring blood vessel function, imaging a patient's body to obtain a geometry of a blood vessel; imaging a patient's body to obtain a shape of a location of the patient's body using image analysis; and analyzing vibrations of the patient's body at a location of the patient's body including the blood vessel to observe, listen to, and feel blood vessel function. A method for monitoring blood vessel function, the method comprising illuminating one or more blood vessels passing through a patient's skin; taking at least one image of the blood vessels; analyzing the at least one image; and calculating a parameter related to blood vessel function based on image analysis. Related devices and methods are also described.

The invention discloses a blood vessel parameter processing method and medical equipment, and the method comprises the steps: displaying a blood vessel function switching control which displays a plurality of blood vessel function options and statistical options; first user input or second user input is received, the first user input is used for selecting at least one of the multiple blood vessel function options, and the second user input is used for selecting the statistical option; in response to the first user input, displaying a measurement result of a blood vessel parameter corresponding to the selected blood vessel function option; and in response to the second user input, displaying a measurement result of at least one blood vessel parameter corresponding to at least two blood vessel function options in the plurality of blood vessel function options, and a statistical analysis result of at least one blood vessel parameter corresponding to the at least two blood vessel function options. According to the method and the medical equipment, great convenience is provided for multi-parameter and multi-dimensional evaluation of the vascular function of the user.

This invention discloses a nano-bandage for preserving cut flowers, belonging to the field of horticultural technology. The nano-bandage consists of a polymer carrier and a bactericide encapsulated therein. The polymer is a mixture of PEG and PDMAEMA. By adjusting the mass fraction and total concentration of PDMAEMA, the particle size of the nanoparticles can be controlled, and their surface can be positively charged. It is prepared using microfluidic co-assembly technology, where the drug-containing organic phase and aqueous phase are instantaneously mixed and purified by dialysis. This nano-bandage actively targets and persistently accumulates on the negatively charged cut surface of fresh cut flowers using electrostatic interactions, forming a physical barrier. It also synergistically inhibits microbial infection through slow-release bactericide and charge adsorption, while its nano-size does not affect vascular function. This invention achieves precise and long-lasting protection for cut flower wounds, significantly extending vase life with extremely low dosage, and has the advantages of high efficiency, safety, and intelligent adjustability.

The invention relates to the technical field of probiotics, in particular to a gastric acid resistant composite prebiotic and probiotic co-loaded soft capsule as well as a preparation method and application thereof. The gastric acid-resistant composite prebiotic and probiotic co-loaded soft capsule comprises a capsule shell material and a content emulsion, the content emulsion comprises an oil phase and a water phase, the oil phase comprises sunflower seed oil, beewax, lecithin and vitamin E, and the water phase comprises a water phase. The water phase comprises a plurality of composite probiotics such as bifidobacterium bifidum and casein rhamnosus and a plurality of composite prebiotics such as galactooligosaccharide and beta-glucan, and the capsule shell material is a gelatin-chitosan glue solution. According to the co-loaded soft capsule, the compound prebiotics and the probiotics are compounded, so that the anti-oxidation and intestinal regulation synergistic effect is achieved, and the vascular function and the metabolic homeostasis are jointly improved; the gelatin-chitosan composite capsule is prepared by combining a low-temperature film forming technology, a compact and stable gelatin-chitosan composite capsule shell is formed, and the stability and gastric acid tolerance of active ingredients are greatly improved, so that the comprehensive protection effect of delaying senile cardiovascular aging is favorably realized.

This invention relates to the field of biomedicine, specifically to the application of banana fruit extract in the preparation of anticoagulant or antithrombotic drugs. The banana fruit extract provided by this invention contains flavonoids, polyphenols, polysaccharides, hydroxyanthraquinones, triterpenoids, and other components. Flavonoids and polyphenols have been widely proven to have anti-inflammatory and antioxidant effects, which can synergistically enhance the anticoagulant effect. The high potassium content of banana fruit can indirectly improve vascular function by regulating sodium-potassium balance. The banana fruit extract provided by this invention can inhibit platelet production or promote platelet metabolism, prolong clotting time, and inhibit platelet aggregation. Its natural plant components interfere with platelet aggregation by inhibiting the production of thromboxane A2, achieving anticoagulant and antithrombotic effects. The mechanism of action of banana fruit extract differs from traditional anticoagulants such as heparin, reducing the risk of bleeding. Its natural component characteristics provide a direction for the development of novel plant-derived anticoagulant drugs.

Systems and methods for post-PCI coronary analysis. An example method includes accessing a plurality of angiographic images depicting at least one vessel of a patient's heart, the angiographic images including two or more post-percutaneous coronary intervention (post-PCI) images and one or more diagnostic images, wherein the post-PCI images depict a PCI location in which a PCI is included to revascularize a lesion, and wherein the diagnostic images depict the lesion; receiving, via a user interface presenting the post-PCI images, user input specifying positions of the PCI location in the post-PCI images; determining an index indicative of vascular function based on the angiographic images, wherein the index is derived based on a three-dimensional model of the portion of the patient's heart, and wherein individual portions of the diagnostic images depicting the lesion are masked during generation of three-dimensional model; and presenting, via the user interface, summary information associated with PCI, the summary information including at least the determined index.

The present invention relates to the technical field of pulmonary vascular function analysis methods, and specifically to a pulmonary ICG fluorescence dynamic diffusion quantitative analysis method, comprising the following steps: acquiring a patient's lung slice image; receiving fluorescent tracer injection information; constructing a three-dimensional lung model based on the lung slice image; establishing a blood vessel model and a blood flow model based on the three-dimensional lung model; simulating the fluorescent tracer diffusion process in the three-dimensional lung model and the blood vessel model according to the fluorescent tracer injection information; calculating the flow rate of all pipelines using an optical flow method; determining key time points according to preset conditions; calculating the flow value of each pipeline at the key time point of the tracing process based on the key time points; calculating the maximum flow change rate and the maximum flow difference according to the flow values; acquiring physiological parameter information corresponding to the three-dimensional lung model, and generating a vascular function evaluation model, thereby improving the accuracy of blood vessel recognition, especially significantly improving the recognition ability of tiny blood vessels.

A method for displaying data on a patient's arm, comprising the steps of taking an image of the patient's arm, analyzing the image to thereby obtain information about the blood vessels in the patient's arm, and displaying the information by projecting a light pattern onto the patient's arm. A system for displaying data on a patient's arm, comprising a light source for illuminating the patient's arm, a sensor for taking an image of the patient's arm, a computer for analyzing the image to thereby obtain information about the blood vessels in the patient's arm, and a projector for displaying the information by projecting a light pattern onto the patient's arm. Related apparatus and methods are also described.

The invention belongs to the technical field of protein polypeptides, and particularly discloses a CD93 affinity peptide and application thereof in preparation of antitumor drugs or detection reagents. The polypeptide with a CD93 protein affinity effect is obtained through repeated screening and optimization, and an affinity blocking activity experiment proves that the CD93 affinity peptide can affine an extracellular IgV-like structural domain of the CD93 protein and block the interaction of CD93 / IGFBP7 protein. An HUVECs cell in-vitro migration experiment and a tube formation experiment verify that the CD93 affinity peptide can inhibit migration of HUVECs cells and tube formation, promote normalization of tumor vascular functions and further inhibit growth of tumors, and has no obvious toxic or side effect. The CD93 affinity peptide provided by the invention can be used for preparing anti-tumor drugs (including anti-tumor immunotherapy drugs) or detection reagents taking CD93 as a target spot, has a better medical application prospect, and provides a new choice for tumor immunotherapy.

Systems and methods for enhanced user interface and crosstalk analysis for cardiac index determination. An example method includes accessing a cardiac model of a portion of a patient's heart, the portion including one or more vessels of the patient's heart, and the cardiac model indicating a plurality of lesions along a length of at least one of the vessels; obtaining, based on the cardiac model for the lesions, respective positions along the length for which the lesions are associated with index drops, wherein the index drops are with respect to an index indicative of vascular function; and causing presentation of a user interface, wherein the user interface: presents a graph mapping the length to the index indicative of vascular function, presents individual toggles enabling nulling of individual lesions, and updates the graph in response to received user input to one or more of the toggles, wherein the user input nulls effects of one or more lesions.

A computer-implemented method for determining a vascular function of a perfusion imaging sequence, includes the steps of: (i) receiving a perfusion imaging sequence including a voxel time series for a plurality of voxels; (ii) applying a trained classifier on the perfusion imaging sequence for receiving voxel-wise weights; (iii) receiving voxel-wise weights from the classifier; and (iv) determining the vascular function as the weighted sum of the voxel time series; wherein the classifier is trained by optimizing over the similarity between a predicted vascular function and a ground truth vascular function using a set of examples.

1. The name of the design product: non-invasive cardiac function detection trolley. 2. The use of the design product: medical devices for non-invasive detection of cardiac and vascular function indicators. 3. The design points of the design product: in shape. 4. The picture or photo that best indicates the design points: perspective view.

Systems and methods for PCI post-operative coronary artery analysis. One example method includes acquiring a plurality of angiographic images depicting at least one blood vessel of a patient's heart, the angiographic images including two or more percutaneous coronary intervention (PCI post-operation) images depicting a PCI site where a PCI is included to perform a blood supply reconstruction of a lesion, and one or more diagnostic images depicting at least one blood vessel of the patient's heart, the PCI post-operation images depicting the PCI site where the PCI is included to perform a blood supply reconstruction of the lesion. And wherein the diagnostic image depicts a lesion; receiving a user input specifying a PCI site in the PCI post-operation image via a user interface presenting the PCI post-operation image; determining an indicator indicative of vascular function based on the angiographic image, where the indicator is derived based on a three-dimensional model of portions of the patient's heart, and where portions of the diagnostic image depicting the lesion are masked during generation of the three-dimensional model; and presenting, via a user interface, summary information associated with the PCI, the summary information including at least the determined indicator.

The invention relates to a multi-parameter analysis method integrated with arteriosclerosis assessment and a health monitoring system, and the method comprises the steps: determining a pressure oscillatory wave signal based on a cuff pressure signal through synchronously collecting the cuff pressure signal and electrocardiosignals and photoelectric volume pulse wave signals of two-side finger tips; calibrating a blood pressure analysis process of the pressure oscillatory wave signal based on a systolic pressure calibration reference determined by the photoelectric volume pulse wave signal, and determining a blood pressure value; calculating a vascular function evaluation result including the arteriosclerosis degree based on a heartbeat time sequence reference determined by the electrocardiosignal, the cuff pressure signal and the photoelectric volume pulse wave signal; performing multi-parameter correlation analysis on the blood oxygen signal and the electrocardiosignal extracted from the photoelectric volume pulse wave signal to obtain a multi-parameter analysis result; the blood pressure value, the blood vessel function evaluation result and the multi-parameter analysis result are integrated, and a comprehensive health evaluation report is generated; according to the invention, integration of multi-parameter acquisition, accurate calculation and deep analysis can be realized, and comprehensive and reliable health assessment support is provided.

An assessment method for vascular function of a dialysis patient and system thereof are provided. The assessment method measures a venous end vascular pressure of the dialysis patient, and if the venous end vascular pressure of the dialysis patient exceeds a preset pressure variation range within a preset time, blood vessels of the dialysis patient are evaluated for a presence of at least one abnormality. The assessment system includes a hemodialysis device and an output device.

Systems and methods for displaying flow index values on a user interface. An example method may include receiving medical images imaging a portion of a vasculature of a subject, with the portion of the vasculature including vessels; producing, by automatic processing of the medical images, a three-dimensional vascular model of the portion of the vasculature comprising the one or more vessels based on the medical images; calculating flow index values quantifying vascular function along each of the one or more vessels based on the three-dimensional vascular model; displaying a representation of the three-dimensional vascular model comprising the one or more vessels; and for a designated vessel of the one or more vessels, simultaneously displaying the flow value index for a designated location of the designated vessel along with the flow value index for a predetermined distal location along a length of the designated vessel.

The application discloses a kind of composite material based on engineering spirulina, its preparation method and application, the composite material includes hydrogel matrix and the engineering spirulina carrier dispersed in the hydrogel matrix;Wherein, the surface of spirulina is loaded with polyethyleneimine-coated Fe3O4 Nanoparticles, obtain the engineering spirulina carrier, and the engineering spirulina high expression arginine.One aspect, the present application is metabolically restructured to spirulina, so that its intracellular L-arginine content is significantly improved, L-arginine can simultaneously improve vascular function through iNOS path, and through Arg-1 path, promote macrophages to repair type M2 polarization and tissue repair, from metabolic root to intervene the core obstacle of bone defect;On the other hand, spirulina is surface modified, can effectively activate osteogenesis-related gene expression, drive new bone formation.By the double modification of L-arginine enrichment and Fe3O4 Nanoparticles loading to spirulina, obtain the composite material of synergistic regulation anti-inflammatory, pro-angiogenic and pro-osteogenic, accurately match the demand of complex pathological microenvironment of bone defect, to effectively treat bone defect, especially drug-related jaw osteonecrosis.

The application belongs to the technical field of drug research and development, and particularly relates to a compound, a preparation method and application of the compound as an agonist of orphan receptor GPR99. The application first discovers and identifies a small-molecule compound capable of specifically activating the orphan receptor GPR99, and systematically clarifies the mechanism of the small-molecule compound in the regulation of vascular smooth muscle cell (VSMC) contraction and the improvement of pathological vascular dilation. The discovery not only fills the blank of GPR99 agonists in the field of treatment of rosacea, but also provides a new molecular target and a drug research and development direction for precise treatment of diseases related to abnormal vascular function.

Systems and methods for post-PCI coronary analysis. An example method includes accessing a plurality of angiographic images depicting at least one vessel of a patient's heart, the angiographic images including two or more post-percutaneous coronary intervention (post-PCI) images and one or more diagnostic images, wherein the post-PCI images depict a PCI location in which a PCI is included to revascularize a lesion, and wherein the diagnostic images depict the lesion; receiving, via a user interface presenting the post-PCI images, user input specifying positions of the PCI location in the post-PCI images; determining an index indicative of vascular function based on the angiographic images, wherein the index is derived based on a three-dimensional model of the portion of the patient's heart, and wherein individual portions of the diagnostic images depicting the lesion are masked during generation of three-dimensional model; and presenting, via the user interface, summary information associated with PCI, the summary information including at least the determined index.

Systems and methods for enhanced user interface and crosstalk analysis for cardiac index determination. An example method includes accessing a cardiac model of a portion of a patient's heart, the portion including one or more vessels of the patient's heart, and the cardiac model indicating a plurality of lesions along a length of at least one of the vessels; obtaining, based on the cardiac model for the lesions, respective positions along the length for which the lesions are associated with index drops, wherein the index drops are with respect to an index indicative of vascular function; and causing presentation of a user interface, wherein the user interface: presents a graph mapping the length to the index indicative of vascular function, presents individual toggles enabling nulling of individual lesions, and updates the graph in response to received user input to one or more of the toggles, wherein the user input nulls effects of one or more lesions.

Systems and methods for displaying flow index values on a user interface. An example method may include receiving medical images imaging a portion of a vasculature of a subject, with the portion of the vasculature including vessels; producing, by automatic processing of the medical images, a three-dimensional vascular model of the portion of the vasculature comprising the one or more vessels based on the medical images; calculating flow index values quantifying vascular function along each of the one or more vessels based on the three-dimensional vascular model; displaying a representation of the three-dimensional vascular model comprising the one or more vessels; and for a designated vessel of the one or more vessels, simultaneously displaying the flow value index for a designated location of the designated vessel along with the flow value index for a predetermined distal location along a length of the designated vessel.

The invention provides application of bacillus coagulans JA845 in preparation of health-care products or food for assisting in lowering blood pressure, and belongs to the technical field of health-care products. The bacillus coagulans JA845 has unique physiological activity, the bacillus coagulans JA845 is found and proved to have the effect of assisting in lowering blood pressure for the first time, the application blank of the bacillus coagulans in the field of hypertension adjuvant therapy is filled, the action mode of improving the vascular function by taking antioxidation as a core mechanism has uniqueness, and the bacillus coagulans JA845 can be applied to the field of hypertension adjuvant therapy. And a new microbial preparation selection is provided for adjuvant therapy of hypertension.

This invention discloses a method for monitoring cardiovascular data in cardiology, comprising the following steps: S1, Non-invasive collaborative acquisition of multimodal cardiovascular data: Constructing a multimodal non-invasive sensor array, fitting sensitive points on the wrist, chest, and behind the ear, to simultaneously acquire photoplethysmography (PPG) pulse wave signals, multi-lead electrocardiogram (ECG) signals, and bioimpedance signals, completing preliminary data encapsulation and synchronous transmission. This invention employs multimodal non-invasive sensor collaborative acquisition technology to simultaneously acquire multi-dimensional cardiovascular data such as ECG, pulse wave, and bioimpedance, breaking the limitations of single-dimensional monitoring and comprehensively covering core monitoring indicators such as cardiac electrophysiology, peripheral vascular function, and cardiac function, providing complete data support for disease assessment and effectively avoiding missed diagnoses of early cardiovascular abnormalities.

The application belongs to the technical field of microorganisms and their application, and specifically discloses a mucinophilic Akkermansia strain, a high-activity reserved inactivation method of the strain and application of the strain. The strain has a preservation number of CGMCC No. 33955, and when the strain is cultured in a mucin only carbon source culture medium for 48 hours, the OD600 value reaches 1.32 and the acetic acid yield is 18.3 mmol / L. The inactivation method uses a solution containing sulfated dextran, sucrose and epsilon-polylysine as a composite protective agent, and after the solution is mixed with the bacterial solution, the mixture is incubated at 45 DEG C to 50 DEG C for 16 min to 20 min. The inactivated strain reduces inflammation and protects lung vascular function through the "gut-lung axis", and in a MCT-induced PAH rat model, the intervention effect is close to sildenafil, and there is no increase in liver enzymes, the serum TNF-alpha and IL-6 are reduced, and the problems of large side effects and low activity reservation of existing PAH intervention are solved.