44results about How to "Improve hypercoagulable state" patented technology

The invention discloses a health-care food for reducing blood sugar and blood fat. The health-care food for reducing the blood sugar and the blood fat is characterized by comprising, by weight, hawthorn 20-50 parts, bitter gourd 20-50 parts, black soya bean 10-30 parts, medlar 10-30 parts, pumpkin 10-20 parts, Chinese yam 10-20 parts and poria cocos 5-10 parts. The health-care food for reducing the blood sugar and the blood fat is unique and scientific in formula, is made from natural foods, is safe and non-toxic, contains a large amount of amino acid, vegetable protein, mineral elements and the like, and can reduce blood sugar, the blood fat, blood viscidity and strengthen immunity of the organism after long-term taking.

The blood lipoid reducing medicine is prepared with 12 kinds of Chinese medicinal materials including notoginseng, haw, oriental water plantain, cassia seed, giant knotwood, etc. The present invention compounds the blood lipoid reducing medicine via selecting the medicine materials without toxicity, harm and side effect. The medicine may be taken directly without decoction to absorb the effective blood lipoid reducing components to lower blood viscosity, dredge microcirculation, strengthen body's immunity, remit hyperlipemia complication.

The blood pressure reducing pill for treating hypertension is prepared with ten kinds of Chinese medicinal materials, including fleeceflower root, white peony root, angelica, Chuanxiong rhizome, eucommia bark, etc. The Chinese herbal medicine materials without toxicity, harm and side effect are selected to constitute the medicine for treating hypertension, and the medicine is taken directly without need of decoction for well absorptioin of the effective components to reduce blood pressure. The present invention has high curative effect, and can improve high viscosity state of blood, dredge microcirculation, strengthen body's immunity and remit the complication.

The invention relates to a pharmaceutical composition for treating diabetic nephropathy. Based on traditional Chinese medicine theories, the pharmaceutical composition comprises traditional Chinese medicine raw material medicines such as cooked rehmannia root, astragalus root, polygonati, salvia root, Chinese yam, white atratylodes rhizome, atractylodes rhizome, notoginseng root, alisma rhizome, and poria, has the effects of tonifying qi and yin, and clearing dampness and dredging collaterals; and is used for treating the diabetic nephropathy.

The invention provides a traditional Chinese medicine composition for treating primary nephrotic syndrome. The traditional Chinese medicine composition comprises the following active pharmaceutical ingredients: membranous milkvetch root, liquorice root, epimedium herb, medicinal Indianmulberry root, flastem milkvetch seed, sappan wood, cowherb seed, zedoary tumeric, common anemarrhena rhizome, amur corktree bark, barbed skullcap herb, radix salviae miltiorrhizae, rice bean, common yam rhizome, manyprickle acanto-panax root, gordon euryale seed, rhizome, sharpleaf galangal fruit, fourstamen stephania root, walnut kernel, glabrous greenbrier rhizome, sinkiang arnebia root, sevenlobed yam rhizome, cochinchnese asparagus root, belvedere fruit, medcinal evodia fruit, lychee seed, dendrobium, glossy privet fruit and Chinese angelica. The traditional Chinese medicine composition provided by the invention is used for treating the primary nephrotic syndrome, can antagonize the side effects of hormones and other Western medicines, improve the blood flow of kidney, reduce urine proteins, retard kidney damages, improve the hypercoagulable state of a patient, consolidate efficacy, reduce the rebound phenomenon of the disease and realize few side effects, low recurrence rate and high complete relief rate, and has a certain efficacy for treating the primary nephrotic syndrome.

The invention relates to a capsule for clearing away turbid and tonifying kidneys. The capsule is prepared from the following raw materials by weight: 100g of cordyceps sinensis, 1400g of astragalus membranaceus, 280g of root of red-rooted salvia, 280g of flowers carthami, 280g of spina date seeds, 500g of semen cuscutae and 100g of rheum officinale. The applied capsule for clearing away turbid and tonifying the kidneys is used for treating both deficiency and excess and treating both symptoms and root causes, is accurate in curative effect, rigorous in formula, and simple and convenient to prepare, and has a broad application prospect.

The invention relates to a pure traditional Chinese medicine preparation for treating glomerular diseases. The pure traditional Chinese medicine preparation is prepared from the following raw materials in parts by weight: 30 parts of membranous milkvetch root, 12 parts of amur corktree bark, 15 parts of rhubarb, 40 parts of glabrous greenbrier rhizome, 20 parts of radix salviae miltiorrhizae, 15 parts of oriental waterplantain rhizome, 20 parts of epimedium herb, 15 parts of lalang grass rhizome and 30 parts of motherwort herb, and prepared by decoction, filtration, concentration of filtrate and drying. The pure traditional Chinese medicine preparation has significant efficacy for kidney diseases comprising acute and chronic glomerulonephritis, nephrotic syndrome, hypertensive nephropathy, diabetic nephropathy and early renal insufficiency caused by various reasons; furthermore, the raw materials are easily available, the production process is simple, the toxicity and side effects are small, and the administration is convenient, thereby providing the effective pure traditional Chinese medicine preparation for treating the kidney diseases.

The invention adds Chinese Angelica and Danshen into the original prescription of traditonal Liuwei dihuang pills, and prepares them into medicines in related forms, having functions of nourishing Yin and tonifying kidney, enriching and nourishing blood, and promoting blood circulation and removing blood stasis, and able to nourish Yin and tonify kidney, enrich blood and promote blood circulation, and cure or prevent patients with kidney and blood deficiency, sub-healthy persons, the middle-aged and aged and paitents with diabetes from many related diseases caused by anaemia and blood stasis. And the invention is a 'Dihuang preparation with four tonifying functions and four removing functions'.

The invention relates to a medicament for preventing and curing thrombus and a preparation method thereof. The medicament comprises the following components according to the weight portion: 10-25 of earthworm fibrinolysin, 5-15 of ganoderan, 5-10 of salvia miltiorrhiza, 1-5 of radix astraquli and 1-5 of ophiopogon root. The selected raw materials are respectively prepared and treated according to different characteristics, a proper amount of accessories are added after the obtained powders, extracting solutions and the like are mixed, and granular formulation, capsule, tablet, medicinal granules, and the like are respectively prepared by adopting different procedures. The invention is prepared by such raw materials as natural animal plant medicinal materials and cures the thrombus by the comprehensive function of various traditional Chinese medicine components; in addition, acute toxicology and long-time toxicology tests prove that the medicine has no harm to a human body, has high medicine effect, can improve the blood hypercoagulative state and the blood-fat, lower the blood sugar, dissolve the thrombus, dredge the microcirculation and increase the immunity.

The invention provides a removed-sugar honey and a preparation method of the removed-sugar honey. The method comprises the following steps of: (1) carrying out sterilization on honey for 10-15 minutes at the temperature of 80-100 DEG C by a pasteurization process; (2) diluting the honey by water according to the weight ratio of the honey to the water being 1: 2.5-1: 3.5 to control the specific gravity of the honeydew to be within the range of 1.080-1.110, carrying out inoculation according to the weight ratio of 0.02% by selecting dried yeast for brewing, controlling the fermentation temperature to be 20-35 DEG C, and fermenting for 10-30 days; (3) distilling to obtain alcohol substance and carrying out dehydration treatment; and (4) after that, carrying out sterilization treatment for 10-30 minutes at the temperature of 90-110 DEG C to obtain the removed-sugar honey. The removed-sugar honey is prepared by removing sugar, fermenting and purifying, so that the contents of amino acid, vitamins and flavonoid substances are obviously increased. The problem that the diabetic can not drink the honey directly can be solved, and the removed-sugar honey can reduce the blood fat and promote microcirculation after being drunk by the diabetic.

The invention provides new medical application of ticagrelor, namely a medicine for assisted therapy on anaphylatic purpura nephritis. The new medical application has the advantages that the anaphylatic purpura nephritis can be used for inhibiting the sticking and agglomeration of blood platelet, the formation of blood coagulation and microthrombus in glomerulus is reduced, the positive function on treating the anaphylatic purpura nephritis is realized, the survival state and living quality of a patient with the anaphylatic purpura nephritis can be greatly improved, the reliance of the patient on hormone is avoided, and the toxic or side effect of the hormone is reduced.

The invention discloses a traditional Chinese medicine preparation for treating hypertension and a preparation method thereof. The preparation is prepared from the following raw materials in parts by weight: 10-20 parts of apocynum venetum extract, 10-20 parts of corn stigma extract, 10-20 parts of celery extract, 10-20 parts of sophora japonica, 5-15 parts of radix polygoni multiflori, 5-15 parts of kudzu vine root, 1-5 parts of garlic, 5-15 parts of thalictrum robustum extract, 5-15 parts of selfheal, 10-20 parts of golden wave, 20-30 parts of lalang grass rhizome, 20-30 parts of saururus chinensis, 20-30 parts of polygonum cuspidatum, 5-10 parts of cirsium japonicum and 5-10 parts of herba cepbalanoplosis segeti. The preparation has the effects of removing toxicity, stopping bleeding, diminishing inflammation, improving blood hypercoagulability state, dredging micro-circulation, promoting blood circulation to remove stasis, reducing blood fat, nourishing yin, purging internal fire, smoothing blood circulation, stabilizing blood pressure without rebound, reinforcing body immunity and relieving occurrence of hypertensive complications, and has the advantages of small side effect, quick response, simple preparation process and convenience in popularization.

The invention relates to a preparation method of a blood sugar reducing product. The method adopts herba cynomorii as raw material, which is prepared into a curative medicinal product that is mainly used for curing chemical diabetes caused by streptozotocin (STZ) and has prominent curative effect to liver and kidney damage arising from diabetes via the steps of crashing, refluxing, pumping filtering, centrifuging, zymolysis, extracting, depressing, compressing, adjusting pH value, dialyzing and centrifuging a dialysis tubing, etc. The invention fully utilizes herba cynomorii that is parasitized in zygophyllaceae Nitraria L. plants and pervasive in Gansu Province, Qinghai Province and Inner Mongolia Autonomous Region, and utilizes the excellent resource superiority of sufficient reserves to develop the product, which has a promising market prospect and broad economic benefits.

The invention discloses a tumor-specific recombinant hirudin. A tail end N of the recombinant hirudin contains an oligopeptide sequence Pro-Gly-Arg-Val-Val that can be identified and split by uPA, wherein the uPA can be highly expressed by a tumor tissue; and the hirudin for recombination is hirudin isomer, hirudin mutant, hirudin chimera, truncated hirudin peptide, and gene modified hirudin or hirudin fusion protein. Correspondingly, the invention further provides a preparation method of the tumor-specific recombinant hirudin and application thereof in preparation of anti-tumor medicines, and provides a preparation method and application of adoptive immune cells expressing the tumor-specific recombinant hirudin. The hirudin anticoagulant activity of the recombinant hirudin is featured by tumor targeted release, and the recombinant hirudin creates a micro-environment where thrombus is difficult to form, and even dissolves formed small thrombus so as to realize functions of anticoagulation, thrombolysis and prevention of metastasis of the tumor cell, so that the risk of systemic bleeding caused by application of wild hirudin to the whole body is prevented.

The invention discloses tumor-specific recombinant hirudin, of which an N-terminal contains an oligopeptide sequence PLGI, which can be recognized and cleaved by matrix metalloproteinase 9 (MMP9), wherein hirudin used for recombination may be a hirudin isomer, a hirudin mutant, truncated hirudin peptide, gene-modified hirudin or hirudin fusion protein. Correspondingly, the invention provides a preparation method of the tumor-specific recombinant hirudin and applications thereof in preparation of antitumor medicines, and also provides a preparation method and an application of adoptive immune-cells for expression of the tumor-specific recombinant hirudin. The recombinant hirudin herein allows anticoagulation activity of the hirudin is released in a tumor targeted manner, thus forming a microenvironment which is not liable to form thrombus, and even dissolving formed small thrombus to achieve the functions of anticoagulation, thrombolysis and prevention of tumor cell metastasis, thereby overcoming the risk of systematic hemorrhage due to systemic administration of wild-type hirudin.

The invention discloses an earthworm protein for reducing blood sugar, lipid and pressure, improving microcirculation and eliminating diabetes complications. The protein is prepared by the following steps: 1) performing a step of earthworm cleaning, namely a step of selecting live earthworms, removing impurities and dead earthworms, putting the live earthworms into water with a pH value of 4-5.8 for 10-15 minutes, adding 50 g of salt, and rinsing the cleaned live earthworms with warm water at 28 DEG C to remove excess water and impurities on the surfaces; 2) pulping; 3) filtering or centrifuging homogenate obtained in the step 2) to remove crude residues to obtain a homogenate solution, filtering the homogenate solution to obtain clarified liquid of more than 180 enzyme activity unit per milliliter, putting the clarified liquid into a sterilization container, injecting high-pressure CO2 gas, mechanically and fully stirring the clarified liquid to be treated for 3-8 min, releasing the pressure through output by a conductor pipe, wherein the solubility of the CO2 rapidly decreases after the pressure is reduced, filtering the clarified liquid to remove impurities, and precipitating for 12 hours to obtain a supernatant solution; and 4) drying the supernatant solution in a freeze dryer at minus 28 DEG C to obtain powder.

The invention discloses a drug with thrombus-curing function and a preparation method thereof. The drug for curing the thrombus comprises PEG-decorated earthworm plasmin and ganoderan with the purity larger than 93 percent and is prepared by the following steps: adding a buffer system, an isotonic agent, a stabilizing agent and a lyophilized protective agent to PEG-decorated earthworm plasmin protein and the ganoderan with the purity larger than 93 percent, mixing, freezing and drying to obtain power for injection. The invention adopts natural animal and plant medical materials as raw material sources, utilizes the comprehensive action of traditional Chinese medicine components to cure the thrombus, is proved to have no toxic action on human bodies by acute toxicity and long-term toxicological tests, has high medicine effect, can improve the hypercoagulative state of the blood and the blood fat, decreases the blood glucose, dissolves the thrombus, dredges the microcirculation and simultaneously improves the body immunity.

The fat reducing health care product is prepared with gingko, astragalus root, ophiopogon root, red date and licorice and through decoction, granulation, drying, sieving, weighing and packing. It has the functions of lowering blood fat, lowering blood viscosity, dredging microcirculation, strengthening body's immunity, and reducing and remitting hyperlipemia complication.