The application discloses a preparation method of high-purity
sponge bone needles and application of the high-purity
sponge bone needles in penetration promotion, and belongs to the technical field of
sponge bone needles. The method comprises the following steps:
cutting natural sponges, soaking the sponges in deionized water and performing
ultrasonic oscillation, filtering, and cleaning to obtain pretreated sponges; subjecting the pretreated sponges to
alkaline protease enzymolysis to obtain primary enzymolysis products; subjecting the primary enzymolysis products to ginger
protease enzymolysis to obtain secondary enzymolysis products; and performing vacuum freeze-
drying to obtain the high-purity sponge bone needles; the natural sponges are subjected to enzymolysis treatment by
alkaline protease and ginger
protease to obtain the high-purity sponge bone needles; and the sponge bone needles are used in surface
grafting of wheat oligopeptides and loading of
giant salamander skin collagen,
pomegranate seed extract,
Honeysuckle extract, Gotu Kola extract, early
celery extract, iris extract,
oyster shell extract and
calcium chloride mixed treatment materials, so that the repair effect on
skin inflammation acne is improved.