107 results about "POMEGRANATE SEED" patented technology

The invention discloses a preparation method and permeation promotion application of a high-purity sponge bone needle, and belongs to the technical field of sponge bone needles. Comprising the following steps: cutting a natural sponge into pieces, soaking in deionized water, carrying out ultrasonic oscillation, filtering, and cleaning to obtain a pretreated sponge; carrying out enzymolysis on the pretreated sponge with alkaline protease to obtain a primary zymolyte; and carrying out enzymolysis with ginger protease to obtain a secondary enzymolysis product, and carrying out vacuum freeze drying to obtain the high-purity sponge spicule. The natural sponge is subjected to enzymolysis treatment through alkaline protease and ginger protease, and the high-purity sponge spicule is obtained; wheat oligopeptide is grafted on the surface of a sponge spicule, and giant salamander skin collagen, a pomegranate seed extract, a lonicerae flos extract, a centella asiatica extract, an early celery extract, an iris tectorum extract, an oyster shell extract and calcium chloride mixed treatment materials are loaded, so that the repairing effect on skin inflammation acne is improved.

The utility model discloses a three-dimensional pomegranate seedling raising device, which belongs to the technical field of pomegranate seedling raising, and comprises a support frame, a plurality of trays and a water supply component, a plurality of groups of adjusting rods are symmetrically arranged on two sides of the support frame, two symmetrically arranged adjusting rods form one group, and a middle rod is connected between two adjusting rods in each group. The water supply assembly comprises a main pipeline, branch pipes and nozzles, the number of the branch pipes corresponds to that of the trays, the branch pipes are located above the trays, containing grooves are formed in the trays, and hoses for supplying water to the containing grooves are connected to the branch pipes. A plurality of seedling raising trays can be placed in the three-dimensional space, so that the occupied space of a greenhouse is reduced; different water supply modes of the nozzle and the hose meet the water supply requirements of pomegranate seedling culture at different time, and are suitable for different growth periods of pomegranate seeds; the height of the trays driven by the adjusting rods can be adjusted, the influence of different trays on illumination is reduced, the trays are inclined when the adjusting rods are obliquely arranged, and water in the trays can flow conveniently.

The invention relates to a preparation method of plant fermentation liquor and a product and application thereof, the preparation method comprises the following steps: (1) breaking walls of an algae raw material, and crushing to obtain algae powder; crushing pomegranate seeds, and mixing the crushed pomegranate seeds with the algae powder to obtain mixed powder; (2) adding the mixed powder into a fermentation culture medium, inoculating a fermentation strain, and performing fermentation culture to obtain crude fermentation liquor; and (3) centrifuging and filtering the crude fermentation liquor, collecting filtrate, and concentrating the filtrate to obtain the plant fermentation liquor. The algae raw materials comprise chlorella vulgaris, spirulina maxima, codium fragile and haematococcus pluvialis. Compared with a traditional plant extract preparation method, the preparation method has the advantages that an organic solvent extraction process is omitted, loss of active ingredients in the extraction process is reduced, and the active ingredients in plant raw materials are extracted to the maximum extent. In addition, the preparation method provided by the invention has the advantages of simple steps, no use of an organic solvent, greenness and environmental protection, and is suitable for industrial expanded production.

To provide a composition that exhibits an effect in proliferating cells, targeting effectively utilizing discarded pomegranate seeds and increasing added value thereof.SOLUTION: A pharmaceutical composition for cell proliferation activity contains a pomegranate seed extract. In a preferable embodiment of the pharmaceutical composition for cell proliferation activity, a pulverized material prepared by pulverizing pomegranate seeds is immersed in at least one solvent selected from a group consisting of ethanol, methanol, water, and hexane, and a supernatant is separated to obtain the pomegranate seed extract.SELECTED DRAWING: Figure 1

The invention relates to the technical field of antioxidant facial masks, in particular to an antioxidant facial mask containing pomegranate extract and a preparation method of the antioxidant facial mask, and the antioxidant facial mask comprises modified facial mask base cloth and facial mask liquid; the preparation method comprises the following steps: stirring and mixing pomegranate peel extract, pomegranate seed extract, sodium hyaluronate, xanthan gum, an emulsifier and deionized water, and sterilizing by utilizing ultraviolet rays to obtain a mixed solution; the modified mask base cloth is sterilized through ultraviolet rays, the sterilized modified mask base cloth is put into a packaging bag, the mixed solution is injected into the packaging bag, and the antioxidant mask containing the pomegranate extract is prepared. The pomegranate peel extract and the pomegranate seed extract are added into the mask liquid, so that the mask has good anti-oxidation and anti-aging effects, the mask liquid is sufficiently loaded through the modified mask base cloth, the mask can release functional substances for a long time, rapid loss of moisture is also avoided, and the quality of the mask is improved.

The invention belongs to the technical field of squeezing, and provides pomegranate seed squeezing equipment and a using method thereof.The pomegranate seed squeezing equipment comprises a turnover table, and a circular groove and a connecting groove are formed in the upper surface of the turnover table and communicate with each other; the supporting frame is connected with the upper surface of the turnover table, a hydraulic rod used for squeezing pomegranate seeds is arranged on the supporting frame, the bottom of the telescopic end of the hydraulic rod is connected with a squeezing plate, and the pomegranate seeds are stored through a polypropylene fiber filter bag; the containing barrel is matched with the circular groove, the bottom wall of the containing barrel is connected with the bottom wall of the circular groove through a telescopic cylinder, the outer wall of the containing barrel communicates with a flow guide pipe, and the flow guide pipe is matched with the connecting groove; a through hole is formed in the storage cylinder; the storage cylinder is used for placing the pomegranate seeds stored in the polypropylene filter bag. The design of the adjustable unit is adopted, the storage barrel can be driven to move, and then pomegranate seeds stored in the polypropylene fiber filter bag are driven to move.

This invention discloses a pesticide composition containing silicon-rich rings and its application in controlling banana leaf spot disease, belonging to the field of biocide pesticide technology. The invention extracts pomegranate seeds. In indoor experiments, the colony diameter of *Curvularia natans* leaf spot pathogen was reduced, indicating that the pomegranate seed extract can inhibit the growth of *Curvularia natans*. Using this extract and silicon-rich rings as synergistic components, it is combined with propiconazole to prepare a pesticide composition containing silicon-rich rings. In field trials, the disease index of the plants decreased, indicating that *Curvularia natans* leaf spot pathogen was inhibited; the complex group showed the highest relative control efficacy, reaching 78.13%. The pesticide composition containing silicon-rich rings prepared by this invention can better inhibit *Curvularia natans* leaf spot pathogen and is suitable for pesticide development for controlling banana leaf spot disease.

This invention discloses a composition for enhancing immunity through gut microbiota, its preparation method, and its application. The composition comprises the following raw materials: a complex prebiotic, polyphenols, inactivated *Saccharomyces boulardii*, and plant extracts. The complex prebiotic includes human milk oligosaccharides and arabinogalactan, the polyphenols include berry polyphenols and grape polyphenols, and the plant extracts include pomegranate seed extract and kale extract. This invention's composition, on the one hand, selectively enriches *A. AKK* bacteria through prebiotics; *A. AKK* can directly interact with various immune cells to enhance immunity. On the other hand, supplementing with yeast factors can also inhibit inflammation and enhance immune responses, thereby significantly increasing the number of *A. AKK* bacteria in the gut microbiota and simultaneously improving intestinal cellular immune function.

The invention provides an antioxidant plant extract. The antioxidant plant extract comprises the following components in parts by weight: carrots, scutellaria baicalensis, grape seeds, pomegranate seeds and green tea. Green tea, radix scutellariae, carrots, grape seeds and pomegranate seeds are prepared respectively, and corresponding extraction processes are adopted, so that the stability of all the components is improved, and all the effective components have a synergistic effect; the antioxidant is applied to preparation of cosmetics and shows good oxidation resistance.

The invention discloses a cosmetic pen composition with long-lasting antibacterial properties, comprising a plastic shell, an intermediate layer and contents; the plastic shell comprises the following components by weight: 200-240 parts of polyethylene, 50-60 parts of polycarbonate, 40-50 parts of polyvinyl chloride, 4-8 parts of a toughening agent, 2-5 parts of a heat stabilizer, 10-15 parts of glass fibers and 5-10 parts of a lubricant; the intermediate layer comprises the following components by weight: 30-40 parts of pine sawdust, 5-10 parts of pine needles, 2-4 parts of honeysuckle, 10-15 parts of pomegranate peels, 10-15 parts of pomegranate seeds, 8-10 parts of biogel and vitamin supplements; the cosmetic pen composition of the invention adopts a plastic shell, an intermediate layer and a filling method of contents, has good antibacterial and antifouling effects, the outer package and the contents are basically natural raw materials, and have good antibacterial effects, the outer package can ensure the quality of the contents and improve the shelf life thereof.

The invention discloses a method for efficiently preparing spray-dried pomegranate fruit powder, which comprises the following steps: separating pomegranate seeds and peel, drying and grinding the peel, and extracting water-soluble pectin; the preparation method comprises the following steps: juicing pomegranate seeds, filtering to obtain pomegranate juice, dividing the pomegranate juice into three parts A, B and C according to a mass ratio of 3: 1: 1, respectively adding a sodium citrate buffer solution with the pH value of 5.0, maltodextrin, rosmarinic acid and beta-cyclodextrin into the part A, adding an acetic acid solution with the pH value of 3.0 and chitosan into the part B, adding deionized water with the temperature of 40 DEG C, water-soluble pectin and nano silicon dioxide into the part C, sequentially adding the part B and the part C into the part A, standing, and filtering to obtain the pomegranate juice. And adding ethanol and xanthan gum, mixing, carrying out high-pressure homogenization treatment, and finally, carrying out spray drying to obtain the pomegranate fruit powder. The spray drying technology is adopted for drying, the nutritional ingredients of the prepared pomegranate fruit powder are well reserved, the pomegranate fruit powder is bright in color and luster and fine and smooth in taste, and the pomegranate fruit powder has wide application prospects and development potential.

The invention provides a composition of isobutylamido thiazolyl resorcinol as well as a preparation method and application of the composition. The composition is prepared from the following raw materials in parts by mass: 5 to 10 parts of isobutylamido thiazolyl resorcinol, 1 to 5 parts of herba agrimoniae, 3 to 8 parts of herba rhodiolae, 2 to 7 parts of semen cassiae, 4 to 8 parts of semen boitae, 3 to 7 parts of rhizoma fagopyri dibotryis, 1 to 4 parts of herba menthae, 2 to 6 parts of liquorice root, 5 to 10 parts of radix valerianae, 1 to 4 parts of pomegranate seed, 1 to 5 parts of annona squamosa, 2 to 8 parts of fresh perilla stem, 1 to 3 parts of black bean and 1 to 3 parts of poria cocos. And 2-5 parts of polygala tenuifolia and 3-7 parts of polygonatum odoratum. According to the composition disclosed by the invention, a plurality of selected raw materials and the isobutylamido thiazolyl resorcinol have a synergistic effect, so that the prepared composition has an excellent whitening effect.

The present invention relates to a preparation process of a ten-flavor hand ginseng powder. The weight parts of each drug in the powder are: 2-15 parts of hand ginseng, 2-15 parts of cinnamon bark, 20-150 parts of cardamom, 10-60 parts of longan, 10-60 parts of asparagus, 10-60 parts of pomegranate seeds, 10-60 parts of sword beans, 10-60 parts of safflower, 1-6 parts of artificial musk, and 1-6 parts of bear gall. The finished product of the ten-flavor hand ginseng powder is obtained by drying, classifying, crushing, sterilizing, and compounding the above drugs. The powder is a core-shell-wrapped composite particle, which can effectively improve the retention rate of volatile components.

To provide pharmaceutical compositions that enhance hyaluronic acid synthesis aiming at effective utilization of and value addition to pomegranate seeds to be disposed.SOLUTION: The invention provides a pharmaceutical composition for enhancing hyaluronic acid synthesis that comprises a pomegranate seed extract. In a preferred embodiment, the pharmaceutical composition for enhancing hyaluronic acid synthesis enhances the synthesis of hyaluronic acid in dermal fibroblasts. In a preferred embodiment, the pharmaceutical composition for enhancing hyaluronic acid synthesis increases the expression of a hyaluronic acid synthesizing enzyme, where the hyaluronic acid synthesizing enzyme is HAS-1 or HAS-2.SELECTED DRAWING: Figure 1

To provide pharmaceutical compositions for suppressing elastin fiber decomposition to achieve effective utilization of and value addition to disposed pomegranate seeds.SOLUTION: The pharmaceutical compositions for suppressing elastin fiber decomposition of the invention comprise a pomegranate seed extract. In a preferred embodiment of the pharmaceutical compositions for suppressing elastin fiber decomposition, the pharmaceutical composition suppresses elastin fiber decomposition in the dermal fibroblasts. In a preferred embodiment of the pharmaceutical compositions for suppressing elastin fiber decomposition, the pharmaceutical composition inhibits activities of elastin-degrading enzymes.SELECTED DRAWING: Figure 1

The invention belongs to the field of food biology, and particularly relates to a preparation method of pomegranate protein fiber-diglyceride nano emulsion gel microcapsules, an obtained product and application. The pomegranate seed protein fiber and diglyceride are compounded to prepare the protein fiber-diglyceride composite nano-emulsion, liquid drops of the composite emulsion are more uniform than those of single diglyceride emulsion, and meanwhile, the stability of the emulsion is improved; the nano-emulsion gel microcapsule is prepared from a sodium alginate solution and a composite nano-emulsion through ionic crosslinking, the release kinetics of diglyceride in the nano-emulsion gel microcapsule is researched under the condition of the optimal proportion, and the result shows that the prepared emulsion gel microcapsule shows the pH response characteristic; the slow release of the diglyceride in the colon can be realized. In a word, the preparation method provided by the invention provides a technical support for efficient utilization of the diglyceride, and the application value of the diglyceride in the field of functional food development is improved.

The purpose of the present invention is to provide a composition having an action of inhibiting the androgen receptor (AR) pathway activity, and the present invention aims to effectively utilize discarded pomegranate seeds and add value thereto.　A pharmaceutical composition for inhibiting the androgen receptor (AR) pathway activity according to the present invention is characterized by containing a pomegranate seed extract. Furthermore, a preferred embodiment of the pharmaceutical composition for inhibiting the androgen receptor (AR) pathway activity according to the present invention is characterized in that the inhibition of the androgen receptor (AR) pathway activity is due to the inhibition of the transcription activity of the androgen receptor (AR). Furthermore, a preferred embodiment of the pharmaceutical composition for inhibiting the androgen receptor (AR) pathway activity according to the present invention is characterized in that the inhibition of the androgen receptor (AR) pathway activity is due to the inhibition of the androgen receptor (AR) protein expression.

The invention provides a medicine composition for invigorating stomach and dispelling cold as well as a preparation and application thereof, and the medicine composition is prepared from the following raw materials in parts by weight: 20-30 parts of gypsum rubrum, 10-15 parts of fructus amomi rotundus, 10-15 parts of fructus piperis longi powder, 10-15 parts of pomegranate seeds, 10-15 parts of flos carthami, 10-15 parts of radix aucklandiae, 10-15 parts of coriander, 10-15 parts of radix inulae inula and 10-15 parts of pawpaw, the preparation method of the fructus piperis longi powder comprises the following steps: crushing fructus piperis longi, pre-soaking, adding mesoporous silica nanoparticles, adding an ethanol aqueous solution, adjusting the pH value, performing ultrasonic-assisted extraction, filtering, purifying, concentrating and drying to obtain the fructus piperis longi powder; amomum kravanh powder is extracted with the assistance of a deep eutectic solvent, and the content of effective components of the medicine is increased through the preparation method. The pharmaceutical composition disclosed by the invention is scientific in formula and capable of effectively treating sour regurgitation of stomach, gastric ulcer, dyspepsia and inappetence due to the synergistic effect of all the components, and has clinical medication value.

The invention belongs to the technical field of compound preparation, and particularly discloses a pomegranate seed oil supercritical extraction method and application in prevention and treatment of non-alcoholic fatty liver disease, and the method comprises the following steps: S1, crushing dried pomegranate seed medicinal materials, screening 18-60-mesh parts, and carrying out CO2 supercritical extraction by adopting four-factor three-level experimental design to obtain the pomegranate seed oil; the corresponding pomegranate seed oil is prepared through combined extraction under different process conditions. S2, performing methyl esterification treatment on the pomegranate seed oil, and determining the contents of three main components, namely punicic acid, linoleic acid and oleic acid, of the pomegranate seed oil by adopting GC-FID (Gas Chromatography-Flame Ionization Detector); and S3, calculating the total content and the oil yield of the three main components, and performing multi-objective optimization on supercritical extraction process parameters through an entropy weight method by taking the total content and the oil yield as comprehensive indexes.

The invention particularly relates to a spiral extrusion type pomegranate seed juice and kernel separating machine. The technical problem to be solved is that when pomegranate juice is squeezed, kernels in pomegranate seeds cannot be crushed. The technical problem is solved by the following technical scheme. The section, in the juice outlet cover, of the spiral groove in the surface of the spiral rubber bar is gradually narrowed and shallower, and the shallower degree is basically the same as the size of the inner core of the pomegranate seed; the kernel outlet is formed in the middle of the machine head fastener; and a large funnel is arranged above the feeding hole. When the spiral extrusion type pomegranate seed juice and kernel separating machine is used for squeezing pomegranate juice, kernels in pomegranate seeds cannot be broken, and bitter taste in the kernels cannot enter the pomegranate juice.

The present invention provides a hydrolyzed polypeptide, a preparation method and an application thereof, relating to the field of biotechnology. For the first time, the present invention separates and purifies a short peptide with antioxidant activity from pomegranate seeds by using a composite enzymolysis technology. Through antioxidant activity identification, the active short peptide has good free radical scavenging activity, can effectively scavenge residual DPPH free radicals and ABTS free radicals in the body, and has great application prospects.

To provide a composition that exhibits an effect in promoting keratinization, targeting the efficient utilization and added value of waste pomegranate seeds.SOLUTION: A keratinization promoting pharmaceutical composition contains a pomegranate seed extract. In a preferable embodiment of the keratinization promoting pharmaceutical composition, keratinization is promoted through enhancement of an mRNA expression level in keratin protein. In another preferable embodiment of the keratinization promoting pharmaceutical composition, the keratin protein is KRT-1 or KRT-10.SELECTED DRAWING: Figure 1

The invention discloses a sleep-aiding pomegranate wine. The pomegranate juice wine is prepared from the following components through three times of gradient fermentation and blending: pomegranate juice primary fermented wine with the volume ratio of 60 + / -2%, the alcoholic strength of 8-9% vol and the fermentation temperature of 1-3 DEG C; the pomegranate rind processing wine has a volume ratio of 10 + / -1%, the pomegranate rind is processed by a traditional Chinese medicine processing technology, and then low-temperature extraction is carried out at an extraction temperature of less than or equal to 50 DEG C; flavonoid compounds (such as quercetin and kaempferol) in pomegranate seeds can inhibit the activity of epoxidase-2 (COX-2) and reduce the release of inflammatory factors such as prostaglandin E2 (PGE2) (experimental data: the inhibition rate is greater than or equal to 65%); vitamin C and polyphenol cooperate to promote joint synovial cells to secrete hyaluronic acid, the viscoelasticity of the joint lubricating fluid is improved (the viscosity is increased by 30%), and the pain of osteoarthritis is relieved.

The utility model discloses an extrusion device for processing pomegranate seeds, which comprises a base, the top of the base is fixedly connected with a support plate, the top of the support plate is provided with a driving mechanism, the two sides of the support plate are hinged with semicircular baffles, the base is hinged with two first hydraulic cylinders, and the two first hydraulic cylinders are hinged with two second hydraulic cylinders. The movable end of the first hydraulic cylinder is hinged to the outer side of the semicircular baffle, and a cavity is formed in the supporting plate. According to the juicer, juice flows into the cavity after being filtered by the filter screen plate and then is discharged through the liquid discharging head in the strip-shaped groove, juice discharging is achieved, after juicing is completed, the two first hydraulic cylinders are started to drive the two semi-circular baffles to be unfolded outwards, the two semi-circular spaces are opened, and the two semi-circular baffles are separated from each other. And then internal residual solid residues are conveniently and rapidly cleaned, so that the device has the advantages that the juicing space can be rapidly opened for cleaning after juicing, the cleaning effect is improved, and the juicing efficiency is improved.

The invention belongs to the technical field of natural anti-corrosion materials, and provides a natural anti-corrosion composition containing cinnamon bark extract and a preparation method and application of the natural anti-corrosion composition. The natural preservative composition provided by the invention comprises a cinnamon bark extract and a synergistic compound, the synergistic compound comprises a mangnolia officinalis bark extract, a perilla leaf extract, a rhizoma atractylodis root extract, a folium artemisiae argyi extract, a wrinkled gianthyssop herb extract, a radix ophiopogonis root extract, a pomegranate seed extract, a pomelo extract, a thyme leaf extract, a calendula extract, a hyperforin perforatum extract, a melaleuca alternifolia leaf extract, a ginger root extract and an eucalyptus globulus leaf extract; the mass content of cinnamyl aldehyde in the cinnamon bark extract is less than or equal to 20wt%, and the antibacterial composition has the advantages of broad-spectrum bacteriostasis, high stability, difficulty in discoloration and precipitation, acid and alkali resistance, high temperature resistance, safety and small irritation. The antibacterial composition is prepared from at least one of a ginseng root extract, a rosemary leaf extract, a papaya fruit extract, a chamomile flower extract, a soybean seed extract and a wheat bran extract, and the mass content of cinnamyl aldehyde in the cinnamon bark extract is less than or equal to 20wt%.

The invention discloses an anti-aging, anti-wrinkle and anti-tumor Chinese yam polysaccharide composition and a preparation method thereof. The composition comprises the following components in parts by mass: 30-80 parts of Chinese yam polysaccharide, 10-50 parts of stachyose, 5-25 parts of pomegranate seed extract, 5-20 parts of grape seed extract, 3-15 parts of blueberry extract, 2-12 parts of tea polyphenol, 1-10 parts of sea cucumber peptide and 1-10 parts of soybean peptide (with the molecular weight of 300-1000Da). Preferably, 0.5-5 parts of resveratrol (the purity is greater than or equal to 98%) and 3-20 parts of acerola cherry powder (VC is greater than or equal to 15%) are added. The preparation method comprises the following steps: dissolving polysaccharides and saccharides, adding the extract, homogenizing, adjusting the pH value to 6.0-7.0, carrying out enzymolysis by using compound protease at 35-40 DEG C, and finally carrying out spray drying. Experiments show that the composition has a synergistic effect in the aspects of resisting saccharification (the highest inhibition rate reaches 78.5%), resisting oxidation (the DPPH clearance rate is 91.3%), increasing the content of hydroxyproline in skin (+ 74.1%), inhibiting tumor cell proliferation (62.5%) and improving ultraviolet wrinkles (the score is reduced by 61%).

The application discloses a pomegranate ferment with the effects of firming, anti-wrinkle and soothing and repairing, and a preparation method and application thereof, and belongs to the technical field of cosmetic raw materials. A high-activity pomegranate ferment is obtained by yeast and lactic acid bacteria synergistic fermentation with pomegranate by-products (pomegranate peel and pomegranate seeds) as raw materials. The yeast-lactic acid bacteria combined fermentation of pomegranate seeds / peel has the effects of synergistically improving the release and biological transformation of active ingredients, significantly enhancing the antioxidant and functional activity, realizing zero waste high value and resource full utilization, improving the odor and eliminating the adverse characteristics, and the like, so that the pomegranate ferment can be used for preparing a cosmetic with the effects of antioxidant, anti-inflammatory, anti-wrinkle and soothing and barrier repair.

The invention discloses a raw material crushing device for pomegranate beverage production, which comprises a shell, a crushing chamber, an extrusion chamber, a filter chamber, an extrusion plate, a connecting plate, a filter plate, a double-shaft motor, a first driving shaft and a second driving shaft, when the device is used and raw materials are crushed, auger blades rotate to convey pomegranate grains falling from a discharge port into a crushing cavity, and the crushing cavity is used for crushing the raw materials; a crushing piece rotates to crush and squeeze pomegranate grains in a crushing barrel, some pomegranate grains which are not crushed thoroughly fall onto an extrusion plate at the bottom through a blanking hole, and an inclined plate moves downwards to drive a connecting plate to rotate; the connecting plate rotates to drive the pressing cylinder at one end of the connecting plate to further roll pomegranate grains falling on the squeezing plate in a reciprocating mode, juice in pomegranates is completely squeezed, the squeezed pomegranate juice falls onto the filter plate, the arranged filter plate filters pomegranate seeds in the juice, and the filtered juice falls into the bottom. Discharging and collecting are performed through a collecting pipe arranged on one side.

The present invention relates to a pharmaceutical composition for promoting collagen synthesis and a method for producing the pharmaceutical composition containing pomegranate seed extract. [Problem] The purpose of the present invention is to provide a composition having an effect of promoting collagen synthesis, with the purpose of effectively using waste pomegranate seeds and increasing the added value thereof. [Solution] A pharmaceutical composition for promoting collagen synthesis according to the present invention is characterized by containing a pomegranate seed extract. Furthermore, a preferred embodiment of the pharmaceutical composition for promoting collagen synthesis according to the present invention is characterized in that the pharmaceutical composition inhibits the expression of the MMP-1 gene. Furthermore, a preferred embodiment of the pharmaceutical composition for promoting collagen synthesis according to the present invention is characterized in that the pomegranate seed extract is obtained by immersing a pulverized product obtained by pulverizing pomegranate seeds in at least one solvent selected from the group consisting of ethanol, methanol, water, hexane, ethyl acetate and butanol and separating the supernatant.

This invention belongs to the field of traditional Chinese medicine (TCM) technology, specifically relating to a TCM composition with detoxifying and uterus-warming effects and its application in the preparation of external products. The medicinal component of this external TCM product is composed of fenugreek, amethyst, rose, pomegranate seed, centella asiatica, long pepper, five-finger peach, lycopodium, litchi seed, and achyranthes bidentata. Animal experiments show that this product can significantly reduce the number of writhing movements in animals with cold-induced blood stasis type dysmenorrhea, lower COX-2 and PGE2 levels in the uterus, and improve peritoneal inflammation, demonstrating good detoxifying, blood stasis-removing, menstruation-regulating, and pain-relieving effects. Regarding blood rheology, it exhibits the effects of inhibiting platelet aggregation, dilating blood vessels, reducing blood viscosity, and balancing TXA2 and PGI2 levels, reflecting its effects of warming the kidneys and uterus, and strengthening the body's foundation. In summary, the TCM composition of this invention and its prepared external product can warm the kidneys and uterus, promote diuresis and eliminate turbidity, providing a novel TCM external application solution for the clinical treatment of cold-induced blood stasis type dysmenorrhea.