The invention discloses a five-
vine tranquilizing decoction for treating Parkinson's
disease and a preparation method thereof, the five-
vine tranquilizing decoction is composed of main materials and auxiliary materials, the main materials comprise suberect
spatholobus stem, wintercreeper, tuber fleeceflower stem,
tinospora sinensis merr and
uncaria rhynchophylla; the auxiliary materials comprise the following components: radix paeoniae alba and liquorice. Compared with the prior art, according to the strong
medicine etiology and
pathogenesis of Parkinson's
disease, the
traditional Chinese medicine composition takes tuber fleeceflower stem,
uncaria, suberect
spatholobus stem, wintercreeper and
tinospora sinensis merr as main medicines, takes white paeony root as an auxiliary
medicine and takes liquorice as an auxiliary
medicine through strict compatibility and
network pharmacology screening, and the seven medicines are combined to achieve the effects of dispelling wind and nourishing yin, balancing qi and blood, regulating qi and blood and dredging two ways. The Zhuang prescription has the effects of improving the
dyskinesia symptom, relieving the loss of black matter-
striatum dopaminergic neurons, regulating intestinal
flora and metabolites of a PD model and promoting the proliferation of regulatory T cells.