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Euonymus /juːˈɒnɪməs/ is a genus of flowering plants in the staff vine family, Celastraceae. Common names vary widely among different species and between different English-speaking countries, but include spindle (or spindle tree), burning-bush, strawberry-bush, wahoo, wintercreeper, or simply euonymus. It comprises about 130 species of deciduous and evergreen shrubs, small trees and lianas. They are mostly native to East Asia, extending to the Himalayas, and they are also distributed in Europe, Australasia, North America, and Madagascar. 50 species are endemic to China.
Terpenoid in tripterygium wilfordii as well as preparation, application and medicine of terpenoid
PendingCN122071406Anovel structureSignificant ACLY inhibitory activityNervous disorderMetabolism disorderPharmaceutical SubstancesBush plant
The invention relates to a diterpenes type compound, a triterpenes type compound, a preparation method of the diterpenes type compound and the triterpenes type compound, and an application of the diterpenes type compound and the triterpenes type compound. The compounds 1 to 10 provided by the invention are novel diterpene and triterpene compounds which are obtained by extracting and separating from a vine shrub plant tripterygium wilfordii Hook.f. Of a winged euonymus tripterygium genus, and the novel diterpene and triterpene compounds are novel in structure, and the compounds 1 to 10 provided by the invention are novel diterpene and triterpene compounds which are obtained by extracting and separating from the vine shrub plant tripterygium wilfordii Hook.f. Of the winged euonymus tripterygium genus. Bioactivity experiments show that the compound 5 has significant ATP citrate lyase (ACLY) inhibitory activity, and has application potential in research and development of drugs for cancer, hyperlipidemia, atherosclerotic cardiovascular diseases and the like.
Owner:DALIAN INSTITUTE OF CHEMICAL PHYSICS CHINESE ACADEMY OF SCIENCES