2762 results about "Curative effect" patented technology

The invention discloses a knowledge graph construction method and system based on traditional Chinese medicine classics, and relates to the technical field of knowledge graph construction, and the method comprises the steps: collecting multi-source heterogeneous data of traditional Chinese medicine classics, carrying out the standardization processing, and generating a cross-time aligned standardized corpus through optical character recognition and multi-modal feature extraction; based on a language model and a causal reasoning engine, extracting an entity relationship and a dialectical rule from the standardized corpus, and generating a dynamic dialectical reasoning model supporting nonlinear reasoning; obtaining an output result of the dynamic dialectical reasoning model, and constructing a redundancy-removed and dynamically-calibrated traditional Chinese medicine knowledge base through knowledge fusion and conflict resolution of various traditional Chinese medicine classics; based on edge calculation and privacy protection technologies, real-time iteration and clinical curative effect feedback optimization of the knowledge graph are realized. According to the method, the problems of trans-era evolution, regional expression difference, multi-modal feature splitting and the like in the traditional Chinese medicine classics digitalization process are solved.

The invention relates to the technical field of traditional Chinese medicine acupuncture and moxibustion and big data processing, in particular to a massive human tissue structure big data accurate identification method and system for traditional Chinese medicine acupuncture and moxibustion, and the system comprises a data fusion module, a knowledge graph module, a baseline model construction module, an effect prediction module, a remote monitoring module and a curative effect evaluation module. Compared with the prior art, a closed loop of'precise modeling-real-time feedback-intelligent optimization-safe evidence storage 'is formed through deep fusion of data driving and an intelligent algorithm, the acupuncture point positioning precision is improved by 30% or above, the risk early warning response time is shortened to be within 200 ms, the curative effect prediction accuracy rate reaches 85%, and the method has the advantages of being high in practicability and easy to popularize. Systematic technical support is provided for standardization and intellectualization of acupuncture treatment, and clinical safety and effectiveness are remarkably improved.

The invention provides a man-machine collaborative intelligent writing method and system for medical documents, and relates to the technical field of man-machine collaboration.The method comprises the steps that multi-modal clinical data of a patient is obtained for cross-modal semantic alignment, reasoning expansion is conducted based on a multi-level traditional Chinese medicine knowledge graph to generate a structured dialectical framework, and the structured dialectical framework is subjected to data processing; a logic consistency verification graph of a candidate medical record fragment set is constructed to solve semantic conflicts, and a medical record generation model is dynamically optimized in combination with clinical actual curative effect data, so that the intelligence degree, the standardization level and the clinical diagnosis and treatment value of traditional Chinese medicine medical record writing are improved.

The invention provides a large-model-driven traditional Chinese medicine curative effect multi-dimensional intelligent evaluation system and device, and relates to the technical field of traditional Chinese medicine curative effect intelligent evaluation. The system mainly comprises a data layer, a knowledge layer, a model layer and an application layer which are arranged in sequence; the data layer is used for collecting tongue images, pulse condition data, cardiovascular data, structured data, unstructured data and the like, and carrying out data treatment operations such as structured transformation, block chain evidence storage and abnormal value correction; the knowledge layer comprises a traditional Chinese medicine diagnosis and treatment knowledge map, a traditional Chinese medicine prescription compatibility relationship library, a curative effect evaluation standard library, a component-target network, a semantic mapping engine and a syndrome-treatment association map; the model layer comprises a multi-modal feature extraction module and a curative effect prediction module; the application layer comprises a doctor end and a patient end. According to the scheme, quantitative analysis of traditional Chinese medicine syndrome differentiation rules is realized through a large model, and the syndrome classification consistency of patients is improved.

The invention discloses a fungus extract capable of effectively regulating uric acid metabolism and relieving inflammation as well as a preparation method and application of the fungus extract, and belongs to the technical field of deep processing of edible fungi. Schizophyllumcommuneh and poplar phellinus sporocarp are mixed and extracted, and the prepared fungus extract can effectively inhibit activity of xanthine oxidase in serum and liver of mice, reduce content of uric acid, creatinine, urea nitrogen and the like in serum and promote excretion of uric acid, creatinine, urea nitrogen and the like in urine; meanwhile, the content of inflammatory markers such as IL-6 and TNF-alpha in mouse serum can be effectively reduced, inflammatory infiltration of liver and kidney cells is relieved, and the problem that an existing edible mushroom extract is not ideal in treatment effect on hyperuricemia is solved.

The invention belongs to the cross technical field of nanomedicine, tumor treatment and immunotherapy, and particularly provides tumor mitochondria-targeted copper death selective induction nanoparticles, which are prepared by the following preparation method: S1, specifically coupling TPY and MHI through condensation reaction to obtain MTPY; s2, MTPY and copper ions are subjected to complexation, and an MTPY-Cu complex is obtained; and S3, the MTPY-Cu complex and albumin are subjected to self-assembly, and the MTPY-Cu-coated Alb nanoparticles are formed. The dosage of copper is only 1 / 1000 of that of free Cu < 2 + >, and equivalent immune regulation and killing effects can be achieved; primary tumors and distant tumor focuses can be inhibited, and lung metastasis is reduced; immune memory can be induced, and relapse can be prevented; the traditional Chinese medicine composition is combined with cis-platinum to remarkably enhance the curative effect and reverse the induced immunosuppression; the invention has the advantages of high biological safety and no obvious liver and kidney toxicity or hemolytic reaction.

The invention provides a preparation method of a recombinant collagen dressing, and belongs to the technical field of medical dressings. According to the technical scheme, stacked short sequences and continuous human collagen amino acid short sequences are repeatedly combined for multiple times to form recombinant collagen with specificity, and high similarity of the recombinant collagen with human collagen is ensured. On the basis, 4-FPBA is used as a cross-linking agent to respectively form a Schiff base bond responsive to pH and a boric acid ester bond responsive to glucose with CMCS and two kinds of HA with different molecular weights, and then the double-dynamic covalent cross-linked network adhesive hydrogel is synthesized. The triple-helix structure of the recombinant collagen is combined with a specific receptor on a cell membrane, and cell behaviors are regulated and controlled by inducing signal transduction through a cytoskeleton, so that skin microcirculation can be effectively improved, and a skin barrier can be repaired; the hydrogel dressing matrix has the effects of resisting inflammation, resisting oxidation, resisting bacteria, promoting healing and the like, the biological performance of the dressing is remarkably improved, and a better curative effect is achieved.

The invention relates to the technical field of medical data processing, in particular to a knee osteoarthritis acupuncture curative effect prediction system based on deep learning. The system obtains acupuncture treatment parameters and acupuncture effect parameters of historical knee osteoarthritis patients; the historical knee osteoarthritis patients are divided into patient categories based on the acupuncture effect parameters, and the contribution degree is obtained according to the distribution of each acupuncture treatment parameter in each patient category and the distribution difference between the acupuncture treatment parameter and the acupuncture treatment parameter in other patient categories; acquiring a local curative effect feedback value according to the contribution degree and the acupuncture effect parameter, and further acquiring an evaluation score; and training the acupuncture curative effect prediction model through the acupuncture treatment parameters, the evaluation scores and the acupuncture effect parameters to obtain a trained acupuncture curative effect prediction model. According to the method, the evaluation score is dynamically obtained, the participation degree of each acupuncture treatment parameter of each historical knee osteoarthritis patient is accurately determined, and the accuracy of acupuncture treatment effect prediction model training is effectively improved.

The invention discloses a drug-combined anticancer composition and application of the composition in preparation of anticancer drugs. According to the present invention, the drug combination composition comprises the PARP inhibitor Olaparib and the calcium ion antagonist amlodipine maleate, the PARP inhibitor Olaparib and the calcium ion antagonist amlodipine maleate provide the synergistic effect, and compared with the single PARP inhibitor, the drug combination composition has characteristics of high stomach cancer sensitivity, significant gastric cancer efficiency improving, and wide application prospect. The Amlodipine in the drug combination composition provided by the invention enhances the curative effect of the PARP inhibitor Olaparib on the gastric cancer.

The invention belongs to the technical field of traditional Chinese medicines, and particularly relates to a composite sleep-aiding composition based on agilawood and a preparation method thereof. The preparation method comprises the following steps: carrying out ultrasonic-assisted enzymolysis on agilawood by adopting amylase and cellulase, carrying out mixed fermentation on the agilawood subjected to enzymolysis by inoculating lactobacillus plantarum, lactobacillus johnsonii and saccharomyces cerevisiae, and carrying out sterilization, filtration, concentration and drying treatment on the fermented agilawood to obtain the agilawood fermentation product. According to the method, the release rate of active substances in the agilawood is increased, the composite sleep-aiding composition containing the agilawood fermentation product has a remarkable sleep-aiding effect, the preparation method is simple, the problem that an existing agilawood product is poor in sleep treatment effect is solved, and the agilawood fermentation product is safe, free of irritation and high in application value.

The invention discloses a maxillofacial surgery postoperative curative effect monitoring system, which relates to the technical field of medical diagnosis and comprises a data collection module, a transmission module, a data processing module, an interaction module and a recovery suggestion module, the data collection module comprises a face collection unit, an occlusion unit and a voice unit, the data collection module is used for being regularly worn by a postoperative patient, the face collection unit scans the maxillofacial surface of the patient, the occlusion unit is used for the patient to occlude and collect occlusion data, and the voice unit is used for collecting sound of the patient; uploading the collected data to a transmission module; and the transmission module uploads the acquired data to the interaction module based on the Internet of Things mode. According to the method, abnormal fluctuation or potential problems in the recovery process are found in time through data uploaded regularly, rehabilitation training plans and diet suggestions are customized for patients, or review time is adjusted for personalized treatment schemes, and the pertinence and effectiveness of treatment are improved.

The invention belongs to the technical field of traditional Chinese medicine preparations, and particularly relates to a traditional Chinese medicine preparation for treating Parkinson's disease and a preparation method thereof. The traditional Chinese medicine preparation for treating Parkinson's disease comprises the following raw materials in parts by weight: 20-30 parts of bischofia polycarpa, 17-25 parts of eucommia ulmoides, 12-16 parts of artemisia sphaerocephala, 10-15 parts of lycopodium clavatum, 8-13 parts of elm leaves, 7-14 parts of pericarpium citri reticulatae, 5-10 parts of semen cuscutae and 2-7 parts of liquorice. In the formula, monarch, minister, assistant and guide are reasonably matched, the curative effect is exact, and the effects of regulating qi and blood, nourishing liver, warming kidney, activating blood and dissipating blood stasis are achieved. The compound can effectively improve core symptoms of Parkinson's disease and delay disease progression, is expected to be further developed into clinical drugs for treatment of Parkinson's disease, and provides an innovative scheme for traditional Chinese medicine treatment of neurodegenerative diseases.

The invention relates to a traditional Chinese medicine composition for treating spleen-kidney qi deficiency and stasis toxin obstruction type diabetic nephropathy, which can effectively solve the medication problem for treating spleen-kidney qi deficiency and stasis toxin obstruction type diabetic nephropathy. The traditional Chinese medicine composition is prepared from, by weight, 37-33 g of astragalus membranaceus, 27-33 g of centella asiatica, 18-22 g of ligusticum wallichii, 18-22 g of winged euonymus twig, 18-22 g of salvia miltiorrhiza and 14-16 g of prepared rehmannia root. The traditional Chinese medicine composition is prepared by removing impurities from the raw materials, washing, airing, smashing and evenly mixing. The components are simple, scientific and reasonable, are compatible according to the main and secondary relationship of monarch, minister, assistant and guide, are mutually correlated and compatible in function to play a role, and are combined to play the roles of clearing heat and promoting diuresis, detoxifying and activating blood, reinforcing qi and nourishing yin, and tonifying kidney and replenishing essence, so that the traditional Chinese medicine is effectively used for preparing the medicine for treating spleen-kidney qi deficiency and blood stasis toxin blocking type diabetic nephropathy, and is good in curative effect and free of toxic and side effects. The traditional Chinese medicine composition is a great innovation of medicines for treating spleen and kidney qi deficiency and stasis toxin blocking collateral type diabetic nephropathy, and has remarkable social and economic benefits.

The invention discloses a lactobacillus plantarum strain from healthy people in a cold region and application of the lactobacillus plantarum strain. The lactobacillus plantarum strain is named as PL-H1, and is preserved in the China General Microbiological Culture Collection Center (CGMCC), and the preservation number is CGMCC No.22286. The lactobacillus plantarum PL-H1 screened by the invention can obviously relieve the disease index, intestinal canal pathological change, inflammatory response and the like of an inflammatory bowel disease (IBD) model mouse. Moreover, compared with a standard strain WCSF1, the strain has the high metabolism characteristic of tryptophan and the function of adjusting the metabolism of IBD host intestinal tryptophan, and the curative effect of preventing and treating IBD is more remarkable. In addition, the lactobacillus plantarum strain PL-H1 can also improve the liver lipid accumulation and NAFLD activity of MCD fed mice, improve the blood lipid level and liver injury of the MCD fed mice and prevent liver fibrosis of the MCD fed mice, can be used for preventing and treating fungal infection related diseases, and is good in safety.

The invention relates to an antidepressant pharmaceutical composition and application thereof, and particularly discloses a pharmaceutical composition for treating depression as well as a preparation method and application thereof. The active pharmaceutical ingredients of the pharmaceutical composition are prepared from the following traditional Chinese medicines in parts by weight: 500 to 600 parts of radix bupleuri, 500 to 600 parts of fructus aurantii immaturus, 500 to 600 parts of radix aucklandiae, 500 to 600 parts of pericarpium citri reticulatae, 500 to 600 parts of rhizoma pinelliae preparata, 750 to 900 parts of herba taraxaci, 500 to 600 parts of scorched fructus crataegi, 300 to 360 parts of scorched semen arecae, 500 to 600 parts of paederia scandens, 300 to 400 parts of radix codonopsis, 300 to 400 parts of rhizoma corydalis and 500 to 600 parts of fried medicated leaven. The pharmaceutical composition has a remarkable curative effect on depression, animal experiments show that the pharmaceutical composition can remarkably enhance the social coefficient (showing that the pharmaceutical composition can improve social fear of depression patients) and improve sweet water preference (showing that the pharmaceutical composition is beneficial to transformation of negative emotions such as interest deficiency of the depression patients), and the pharmaceutical composition is safe to take, free of adverse reaction and toxic and side effects and free of toxic and side effects. And the composition can take effect quickly, and can take effect generally within 1-2 weeks after medication.

The invention discloses an AI syndrome differentiation and treatment model system suitable for a multi-dimensional difference environment, which comprises a data integration layer and a three-cause characteristic processing and dynamic dialectical model, and is characterized in that the data integration layer comprises outpatient service data, hospitalization data, follow-up visit data, physical characteristics, pathogenesis solar terms / five-transportation six-qi and regional medicinal material relationships; the three-factor feature processing comprises human-factor feature processing, time-factor feature processing and place-factor feature processing; the dynamic dialectical model comprises multi-modal data fusion, three-factor weight dynamic allocation and curative effect correction syndrome reasoning. The syndrome differentiation accuracy of chronic epigastric pain patients reaches 89.2%, the clinical curative effect and acceptability of a treatment scheme are improved, the average iteration period of the model is shortened to 72 h through a feedback closed-loop system, the method deeply conforms to Chinese geographical population characteristics, and the method has the advantages of being high in adaptability and good in application prospect through an environment perception-physique evaluation-dynamic syndrome differentiation three-level linkage mechanism. Precise diagnosis and treatment of one person with one prescription at once is achieved, and core technical support is provided for modernization of traditional Chinese medicine.

The invention relates to the technical field of medical knowledge retrieval, in particular to a traditional Chinese medicine acupuncture field knowledge retrieval method and system based on deep learning, and the method comprises the following steps: obtaining an acupoint sequence and combining with semantics to construct a vector fragment, extracting symptom-related acupoint analysis response to generate a path sequence, and extracting a root combination vector matrix; according to the method, the sequence information of the acupuncture points in the meridian path is extracted, the semantic description and the major content are combined to construct the structured expression, the path organization and recognition capability is enhanced, the curative effect level and the treatment cycle are fused to form the sequence, the response pertinence of the acupuncture points is improved, and the method has the advantages of being simple in structure, convenient to operate and high in practicability. Through major treatment, direction and positioning root three-dimensional combination vectorization expression, semantic comparison and standardization are enhanced, keyword matching frequency and distribution density are combined, semantic association between input and knowledge is enhanced, and acupoint combinations are screened based on semantic matching and path continuity, so that the result is ensured to have relevance and practicability.

The invention provides a sarcandra glabra and honeysuckle compound preparation and a preparation method thereof, and during preparation, part of sarcandra glabra and honeysuckle are subjected to supercritical carbon dioxide extraction, volatile oil and medicine residues are collected, and the medicine residues and the rest of sarcandra glabra and honeysuckle are subjected to water extraction. A proper amount of beta-cyclodextrin is added into a water extract for inclusion, then concentration and supercritical extraction are performed to obtain volatile oil, and beta-cyclodextrin is used for inclusion, so that on the basis of increasing the efficacy of the volatile oil, the contents of chlorogenic acid and isofraxidin are increased, the curative effect of the medicine is enhanced, the synergistic effect of all components of the medicine is exerted, and the treatment effect of the medicine is improved. Menthol is clathrated with beta-cyclodextrin and then added into the paste powder to be mixed, granulated and tableted. On the premise of not influencing the dissolution of menthol and the direct stimulation effect on the throat, the effects of dispelling wind, clearing heat, relieving sore throat and relieving pain of the medicine are further enhanced, and meanwhile the problems that the quality of the product is not stable enough due to environmental change during storage, menthol is volatilized and is easy to crystallize, separate out and deteriorate are effectively solved.

The invention belongs to the technical field of microorganisms, and particularly relates to application of parabacteroides dielsii SYSU-210 and metabolites thereof in cancer treatment. The parabacteroides dieldrii is a parabacteroides dieldrii SYSU-210 strain, and is preserved in the China General Microbiological Culture Collection Center (CGMCC), the preservation number is CGMCC No.32494, and the preservation date is November 04, 2024. According to the application disclosed by the invention, by carrying out anti-tumor treatment on tumor-bearing mice with colon cancer and breast cancer by using the single parabacteroides dieldrii SYSU-210 and a metabolite thereof, the screened SYSU-210 has a good treatment effect on both the colon cancer and the breast cancer, and effector T cell infiltration in tumors of the mice in a treatment group is remarkably increased; and when the compound is combined with an immunotherapy alpha PD-1 inhibitor or a chemotherapeutic drug oxaliplatin for use, the effect of synergistically enhancing the curative effect is shown.

The invention discloses poplar and phellinus igniarius polysaccharide SVP-1 as well as a preparation method and application thereof, and belongs to the field of biological medicines. The poplar phellinus igniarius polysaccharide SVP-1 provided by the invention has remarkable anti-tumor activity, and can effectively inhibit proliferation, invasion and migration of tumor cells so as to block malignant progression of tumors. The structure is clear, the preparation method is controllable, the stability and biological activity of polysaccharide components are ensured, and a reliable basis is provided for development of antitumor drugs. When the traditional Chinese medicine composition is used together with radiotherapy and chemotherapy medicines, a synergistic effect can be achieved, the sensitivity of tumors to treatment can be improved, the toxic and side effects of radiotherapy and chemotherapy can be relieved, and the effects of reducing toxicity and increasing efficiency are achieved. According to the combined treatment strategy, the curative effect of the existing tumor therapy can be remarkably improved, meanwhile, adverse reactions are reduced, and a new optimization scheme is provided for clinical tumor treatment.

The invention discloses a traditional Chinese medicine composition for soothing liver-qi stagnation, softening hard mass and dissolving phlegm and a preparation method thereof, and particularly relates to the technical field of traditional Chinese medicines. Comprising the following components: roasted rhizoma atractylodis macrocephalae, angelica sinensis, cortex moutan, peach kernels, raw oyster shells, rhizoma sparganii, radix curcumae, spina gleditsiae, rhizoma acori graminei, rhizoma bolbostemmae, immature bitter oranges, selfheal, roses, lindera aggregata leaves, prepared arisaema consanguineum schott, fructus liquidambaris, orange peels, feverfew, hawksbill flowers, paeonia ostii flowers, exocarpium citri rubrum, mulberries, fructus lycii, flos caryophylli, fingered citron, rosemary, jasmine flowers, saffron, mulberry leaves, dandelions, gorse, kumquats, radix fici simplicissimae, purple perilla and mint. The traditional Chinese medicine composition has multiple effects of soothing the liver, promoting the circulation of qi, softening hardness to dissipate stagnation, tonifying the spleen, reducing phlegm, activating blood and clearing heat, gives consideration to overall conditioning and target treatment, and contains medicinal and edible components, so that the safety is improved. According to the preparation method, the processes of segmented decoction, vacuum low-temperature concentration, high-pressure homogenization and pasteurization are adopted, so that sufficient extraction and retention of effective components are ensured, and the curative effects of soothing liver-qi stagnation, softening hard mass and dissolving phlegm are remarkably improved.

The invention belongs to the technical field of biological medicines, and relates to application of Ackermann muciniphile or its external vesicles in preparation of a drug for treating schistosomiasis. The anti-infection immunity of a host is enhanced by adjusting intestinal flora balance (recovering diversity and composition) and improving immune response (adjusting macrophage, CD8 + T cell recruitment and Th1 / Th2 balance); meanwhile, the intestinal barrier function is improved, and pathogen invasion and inflammation are reduced; hepatic granuloma and hepatic fibrosis caused by schistosome infection are obviously relieved, and the liver function is improved; the key effect of the MIF gene in immunoregulation is disclosed, and a new direction is provided for schistosomiasis immunotherapy. Besides, the probiotics are high in treatment safety and free of obvious side effects, can be combined with chemotherapy to enhance the curative effect and reduce the side effects and drug resistance of chemical drugs, provides a lasting and comprehensive adjuvant therapy scheme for the schistosomiasis, and has important clinical application potential.

The invention belongs to the technical field of biological medicines, and particularly relates to application of poecilobdella manillensis in preparation of a medicine for treating renal injury. The invention provides a new application of poecilobdella manillensis in preparation of a medicine for treating renal injury, serum biochemical index detection proves that the poecilobdella manillensis can effectively reduce serum creatinine and blood urea nitrogen levels, increase serum albumin and total protein content, remarkably improve glomerular filtration function and protein metabolism function, and improve renal function. And the improvement degree of the traditional Chinese medicine composition is superior to that of a traditional Chinese medicine contrast. Although the curative effect is slightly poorer than that of a chemical drug group, the safety advantage is remarkable. The poecilobdella manillensis can comprehensively regulate renal function metabolism indexes, relieve kidney injury and avoid common side effects of chemical drugs, provides a new choice for clinical treatment of kidney injury, and is especially suitable for chronic kidney disease patients needing long-term treatment.

The invention discloses a traditional Chinese medicine composition for treating aplastic anemia and application thereof, and belongs to the technical field of traditional Chinese medicines. The traditional Chinese medicine composition comprises active substances, and the active substances are prepared from, by weight, 6-12 parts of semen cuscutae, 6-12 parts of fructus psoraleae, 6-12 parts of fructus ligustri lucidi, 10-14 parts of radix rehmanniae recen, 4-12 parts of radix scutellariae, 4-12 parts of cortex phellodendri, 10-20 parts of poria cocos, 10-30 parts of radix codonopsis, 6-12 parts of rhizoma atractylodis macrocephalae stir-fried with bran and 2-10 parts of radix glycyrrhizae preparata. The traditional Chinese medicine composition is low in cost, high in AA treatment effect and free of toxic and side effects, and has the effects of tonifying kidney, replenishing essence, detoxifying, descending turbidity and the like; the therapeutic effect on AA can be achieved by adjusting glycolysis of macrophages.

The invention belongs to the technical field of biological medicine, and particularly relates to morinda officinalis polysaccharide-synanthrin composite gel as well as a preparation method and application thereof. The radix morindae officinalis polysaccharide-synanthrin composite gel provided by the invention is prepared from radix morindae officinalis polysaccharide, synanthrin and water. The radix morindae officinalis polysaccharide-synanthrin composite gel has good biocompatibility and multifunctionality, can intervene in the intestinal microenvironment and renal fibrosis at the same time, and fills the blank of existing treatment methods. The polypeptide has potential curative effects in the aspects of intestinal barrier repair, inflammation regulation and control, microorganism regulation and renal fibrosis inhibition, and a new treatment choice is provided for clinic. The raw materials of the composite gel are based on natural polysaccharides, have good safety and degradability, and meet the high requirements of the medical field on the safety of biological materials. Compared with the existing single-component hydrogel, the composite design of the hydrogel can realize a multi-target effect, the treatment effect is remarkably improved, and the hydrogel has a relatively great market competitive advantage.

The invention belongs to the technical field of drug delivery, and particularly relates to a multi-response colitis disease targeting hydrogel microsphere as well as a preparation method and application thereof. The hydrogel microsphere comprises a calcium ion cross-linked sodium alginate microsphere and HA-Cys / Cur NPs which is encapsulated in the calcium ion cross-linked sodium alginate microsphere, the preparation method comprises the following steps: self-assembling cysteine ethyl ester modified hyaluronic acid and curcumin to form nano-particles, encapsulating HA-Cys / Cur NPs into sodium alginate microspheres by an emulsification method, and carrying out calcium ion crosslinking, so as to obtain the hydrogel. The hydrogel microspheres have pH and GSH response characteristics and hyaluronic acid-mediated active targeting capability, are stable in a gastric acid environment, are accurately released at a colon part and target macrophages at an inflammation part, and NPs disconnects disulfide bonds and releases curcumin in an intracellular high GSH environment, so that synergistic treatment of anti-inflammation, anti-oxidation and intestinal mucosa repair is realized, and the curative effect is good. The medicine has a good application prospect in treatment of ulcerative colitis.

The invention discloses a traditional Chinese medicine composition, a preparation method of the traditional Chinese medicine composition, a traditional Chinese medicine preparation and application of the traditional Chinese medicine preparation, and relates to the technical field of medicine production. 9 to 12 parts of ginkgo leaf; 9-30 parts of radix astragali; 9 to 15 parts of hypericum perforatum; 6 to 15 parts of jujube; 3-9 parts of red ginseng; 9-15 parts of semen ziziphi spinosae; and 3-6 parts of valerian. All the medicines in the traditional Chinese medicine composition have a synergistic effect, the curative effect is enhanced, and the depressive symptom is improved together.

The invention discloses a traditional Chinese medicine composition for treating sarcopenia, the traditional Chinese medicine composition is prepared from six medicines of sugared ginseng, cistanche, rhizoma polygonati, poria cocos, gastrodia elata and bighead atractylodes rhizome through compatibility, the traditional Chinese medicine composition takes spleen strengthening, qi supplementing, kidney tonifying and essence replenishing as the treatment rule, syndrome differentiation treatment is carried out aiming at the spleen and kidney deficiency pathogenesis of sarcopenia, multi-target intervention on sarcopenia is achieved, and the traditional Chinese medicine composition has the advantages that the curative effect is good; the traditional Chinese medicine composition not only can quickly improve muscle strength and endurance functions, but also can continuously promote muscle mass reconstruction, and has dual effects of atrophy resistance and fibrosis resistance, and animal experiment results show that the traditional Chinese medicine composition has a remarkable curative effect on liver and kidney deficiency type sarcopenia.

The invention discloses a medicinal and edible composition relaxing cream and a preparation method thereof. Comprising the following raw materials in parts by weight: 8-12 parts of kelp, 10-15 parts of oysters, 6-10 parts of fingered citron, 5-8 parts of dandelions, 5-8 parts of peach kernels, 10-15 parts of malt, 3-6 parts of brassica juncea, 10-15 parts of poria cocos, 5-8 parts of platycodon grandiflorum, 5-8 parts of fructus gardeniae, 8-12 parts of pericarpium citri reticulatae, 3-6 parts of rhizoma zingiberis, 10-15 parts of mulberries, 10-15 parts of rhizoma polygonati, 8-12 parts of codonopsis pilosula, 10-15 parts of hawthorn fruits, 3-6 parts of cinnamon, 5-8 parts of angelica sinensis and 3-6 parts of radix angelicae. The traditional Chinese medicine composition disclosed by the invention has the advantage of good use effect, and solves the problems that in the use process of the existing composition-relaxing cream, the multi-target synergistic effect is lacked, the curative effect is limited, heat-sensitive components are easy to degrade after long-time high-temperature boiling, and the drug effect exertion is influenced.

The invention belongs to the field of traditional Chinese medicines, and relates to a traditional Chinese medicine composition for treating liver depression and spleen deficiency syndrome metabolism-related fatty liver disease, which is prepared from the following raw materials in parts by weight: 8 to 10 parts of ginseng, 10 to 15 parts of radix bupleuri, 10 to 15 parts of radix curcumae, 6 to 9 parts of ginger processed pinellia, 6 to 10 parts of fructus amomi, 10 to 15 parts of rhizoma atractylodis, 10 to 15 parts of poria cocos, 10 to 15 parts of semen hoveniae, 10 to 15 parts of radix rehmanniae, 8 to 10 parts of rhizoma polygoni cuspidati and 6 to 9 parts of lignum dalbergiae odoriferae. The traditional Chinese medicine composition is used for treating the metabolism-related fatty liver diseases from the aspects of liver depression, spleen deficiency and phlegm-blood stasis, starts from the core pathological chain of liver depression, spleen deficiency, phlegm-dampness and blood stasis, has the functions of soothing the liver, tonifying the spleen, resolving dampness, reducing fat and promoting blood circulation to remove meridian obstruction, and is particularly suitable for patients with liver depression, spleen deficiency and metabolism-related fatty liver diseases. Clinical tests prove that the traditional Chinese medicine composition has a good treatment effect on patients with liver depression and spleen deficiency syndrome metabolism-related fatty liver diseases, the total effective rate reaches 94% or above, and the traditional Chinese medicine composition is mild in medicine property, good in safety, stable in curative effect, not prone to relapse and suitable for being taken for a long time.