2162 results about "Curative effect" patented technology

The invention provides a man-machine collaborative intelligent writing method and system for medical documents, and relates to the technical field of man-machine collaboration.The method comprises the steps that multi-modal clinical data of a patient is obtained for cross-modal semantic alignment, reasoning expansion is conducted based on a multi-level traditional Chinese medicine knowledge graph to generate a structured dialectical framework, and the structured dialectical framework is subjected to data processing; a logic consistency verification graph of a candidate medical record fragment set is constructed to solve semantic conflicts, and a medical record generation model is dynamically optimized in combination with clinical actual curative effect data, so that the intelligence degree, the standardization level and the clinical diagnosis and treatment value of traditional Chinese medicine medical record writing are improved.

The invention provides a large-model-driven traditional Chinese medicine curative effect multi-dimensional intelligent evaluation system and device, and relates to the technical field of traditional Chinese medicine curative effect intelligent evaluation. The system mainly comprises a data layer, a knowledge layer, a model layer and an application layer which are arranged in sequence; the data layer is used for collecting tongue images, pulse condition data, cardiovascular data, structured data, unstructured data and the like, and carrying out data treatment operations such as structured transformation, block chain evidence storage and abnormal value correction; the knowledge layer comprises a traditional Chinese medicine diagnosis and treatment knowledge map, a traditional Chinese medicine prescription compatibility relationship library, a curative effect evaluation standard library, a component-target network, a semantic mapping engine and a syndrome-treatment association map; the model layer comprises a multi-modal feature extraction module and a curative effect prediction module; the application layer comprises a doctor end and a patient end. According to the scheme, quantitative analysis of traditional Chinese medicine syndrome differentiation rules is realized through a large model, and the syndrome classification consistency of patients is improved.

The invention belongs to the cross technical field of nanomedicine, tumor treatment and immunotherapy, and particularly provides tumor mitochondria-targeted copper death selective induction nanoparticles, which are prepared by the following preparation method: S1, specifically coupling TPY and MHI through condensation reaction to obtain MTPY; s2, MTPY and copper ions are subjected to complexation, and an MTPY-Cu complex is obtained; and S3, the MTPY-Cu complex and albumin are subjected to self-assembly, and the MTPY-Cu-coated Alb nanoparticles are formed. The dosage of copper is only 1 / 1000 of that of free Cu < 2 + >, and equivalent immune regulation and killing effects can be achieved; primary tumors and distant tumor focuses can be inhibited, and lung metastasis is reduced; immune memory can be induced, and relapse can be prevented; the traditional Chinese medicine composition is combined with cis-platinum to remarkably enhance the curative effect and reverse the induced immunosuppression; the invention has the advantages of high biological safety and no obvious liver and kidney toxicity or hemolytic reaction.

The invention discloses a drug-combined anticancer composition and application of the composition in preparation of anticancer drugs. According to the present invention, the drug combination composition comprises the PARP inhibitor Olaparib and the calcium ion antagonist amlodipine maleate, the PARP inhibitor Olaparib and the calcium ion antagonist amlodipine maleate provide the synergistic effect, and compared with the single PARP inhibitor, the drug combination composition has characteristics of high stomach cancer sensitivity, significant gastric cancer efficiency improving, and wide application prospect. The Amlodipine in the drug combination composition provided by the invention enhances the curative effect of the PARP inhibitor Olaparib on the gastric cancer.

The invention belongs to the technical field of traditional Chinese medicine preparations, and particularly relates to a traditional Chinese medicine preparation for treating Parkinson's disease and a preparation method thereof. The traditional Chinese medicine preparation for treating Parkinson's disease comprises the following raw materials in parts by weight: 20-30 parts of bischofia polycarpa, 17-25 parts of eucommia ulmoides, 12-16 parts of artemisia sphaerocephala, 10-15 parts of lycopodium clavatum, 8-13 parts of elm leaves, 7-14 parts of pericarpium citri reticulatae, 5-10 parts of semen cuscutae and 2-7 parts of liquorice. In the formula, monarch, minister, assistant and guide are reasonably matched, the curative effect is exact, and the effects of regulating qi and blood, nourishing liver, warming kidney, activating blood and dissipating blood stasis are achieved. The compound can effectively improve core symptoms of Parkinson's disease and delay disease progression, is expected to be further developed into clinical drugs for treatment of Parkinson's disease, and provides an innovative scheme for traditional Chinese medicine treatment of neurodegenerative diseases.

The invention discloses an AI syndrome differentiation and treatment model system suitable for a multi-dimensional difference environment, which comprises a data integration layer and a three-cause characteristic processing and dynamic dialectical model, and is characterized in that the data integration layer comprises outpatient service data, hospitalization data, follow-up visit data, physical characteristics, pathogenesis solar terms / five-transportation six-qi and regional medicinal material relationships; the three-factor feature processing comprises human-factor feature processing, time-factor feature processing and place-factor feature processing; the dynamic dialectical model comprises multi-modal data fusion, three-factor weight dynamic allocation and curative effect correction syndrome reasoning. The syndrome differentiation accuracy of chronic epigastric pain patients reaches 89.2%, the clinical curative effect and acceptability of a treatment scheme are improved, the average iteration period of the model is shortened to 72 h through a feedback closed-loop system, the method deeply conforms to Chinese geographical population characteristics, and the method has the advantages of being high in adaptability and good in application prospect through an environment perception-physique evaluation-dynamic syndrome differentiation three-level linkage mechanism. Precise diagnosis and treatment of one person with one prescription at once is achieved, and core technical support is provided for modernization of traditional Chinese medicine.

The invention relates to the technical field of medical knowledge retrieval, in particular to a traditional Chinese medicine acupuncture field knowledge retrieval method and system based on deep learning, and the method comprises the following steps: obtaining an acupoint sequence and combining with semantics to construct a vector fragment, extracting symptom-related acupoint analysis response to generate a path sequence, and extracting a root combination vector matrix; according to the method, the sequence information of the acupuncture points in the meridian path is extracted, the semantic description and the major content are combined to construct the structured expression, the path organization and recognition capability is enhanced, the curative effect level and the treatment cycle are fused to form the sequence, the response pertinence of the acupuncture points is improved, and the method has the advantages of being simple in structure, convenient to operate and high in practicability. Through major treatment, direction and positioning root three-dimensional combination vectorization expression, semantic comparison and standardization are enhanced, keyword matching frequency and distribution density are combined, semantic association between input and knowledge is enhanced, and acupoint combinations are screened based on semantic matching and path continuity, so that the result is ensured to have relevance and practicability.

The invention discloses poplar and phellinus igniarius polysaccharide SVP-1 as well as a preparation method and application thereof, and belongs to the field of biological medicines. The poplar phellinus igniarius polysaccharide SVP-1 provided by the invention has remarkable anti-tumor activity, and can effectively inhibit proliferation, invasion and migration of tumor cells so as to block malignant progression of tumors. The structure is clear, the preparation method is controllable, the stability and biological activity of polysaccharide components are ensured, and a reliable basis is provided for development of antitumor drugs. When the traditional Chinese medicine composition is used together with radiotherapy and chemotherapy medicines, a synergistic effect can be achieved, the sensitivity of tumors to treatment can be improved, the toxic and side effects of radiotherapy and chemotherapy can be relieved, and the effects of reducing toxicity and increasing efficiency are achieved. According to the combined treatment strategy, the curative effect of the existing tumor therapy can be remarkably improved, meanwhile, adverse reactions are reduced, and a new optimization scheme is provided for clinical tumor treatment.

The invention discloses a traditional Chinese medicine composition for soothing liver-qi stagnation, softening hard mass and dissolving phlegm and a preparation method thereof, and particularly relates to the technical field of traditional Chinese medicines. Comprising the following components: roasted rhizoma atractylodis macrocephalae, angelica sinensis, cortex moutan, peach kernels, raw oyster shells, rhizoma sparganii, radix curcumae, spina gleditsiae, rhizoma acori graminei, rhizoma bolbostemmae, immature bitter oranges, selfheal, roses, lindera aggregata leaves, prepared arisaema consanguineum schott, fructus liquidambaris, orange peels, feverfew, hawksbill flowers, paeonia ostii flowers, exocarpium citri rubrum, mulberries, fructus lycii, flos caryophylli, fingered citron, rosemary, jasmine flowers, saffron, mulberry leaves, dandelions, gorse, kumquats, radix fici simplicissimae, purple perilla and mint. The traditional Chinese medicine composition has multiple effects of soothing the liver, promoting the circulation of qi, softening hardness to dissipate stagnation, tonifying the spleen, reducing phlegm, activating blood and clearing heat, gives consideration to overall conditioning and target treatment, and contains medicinal and edible components, so that the safety is improved. According to the preparation method, the processes of segmented decoction, vacuum low-temperature concentration, high-pressure homogenization and pasteurization are adopted, so that sufficient extraction and retention of effective components are ensured, and the curative effects of soothing liver-qi stagnation, softening hard mass and dissolving phlegm are remarkably improved.

The invention belongs to the technical field of biological medicines, and relates to application of Ackermann muciniphile or its external vesicles in preparation of a drug for treating schistosomiasis. The anti-infection immunity of a host is enhanced by adjusting intestinal flora balance (recovering diversity and composition) and improving immune response (adjusting macrophage, CD8 + T cell recruitment and Th1 / Th2 balance); meanwhile, the intestinal barrier function is improved, and pathogen invasion and inflammation are reduced; hepatic granuloma and hepatic fibrosis caused by schistosome infection are obviously relieved, and the liver function is improved; the key effect of the MIF gene in immunoregulation is disclosed, and a new direction is provided for schistosomiasis immunotherapy. Besides, the probiotics are high in treatment safety and free of obvious side effects, can be combined with chemotherapy to enhance the curative effect and reduce the side effects and drug resistance of chemical drugs, provides a lasting and comprehensive adjuvant therapy scheme for the schistosomiasis, and has important clinical application potential.

The invention belongs to the technical field of biological medicines, and particularly relates to application of poecilobdella manillensis in preparation of a medicine for treating renal injury. The invention provides a new application of poecilobdella manillensis in preparation of a medicine for treating renal injury, serum biochemical index detection proves that the poecilobdella manillensis can effectively reduce serum creatinine and blood urea nitrogen levels, increase serum albumin and total protein content, remarkably improve glomerular filtration function and protein metabolism function, and improve renal function. And the improvement degree of the traditional Chinese medicine composition is superior to that of a traditional Chinese medicine contrast. Although the curative effect is slightly poorer than that of a chemical drug group, the safety advantage is remarkable. The poecilobdella manillensis can comprehensively regulate renal function metabolism indexes, relieve kidney injury and avoid common side effects of chemical drugs, provides a new choice for clinical treatment of kidney injury, and is especially suitable for chronic kidney disease patients needing long-term treatment.

The invention discloses a traditional Chinese medicine composition for treating aplastic anemia and application thereof, and belongs to the technical field of traditional Chinese medicines. The traditional Chinese medicine composition comprises active substances, and the active substances are prepared from, by weight, 6-12 parts of semen cuscutae, 6-12 parts of fructus psoraleae, 6-12 parts of fructus ligustri lucidi, 10-14 parts of radix rehmanniae recen, 4-12 parts of radix scutellariae, 4-12 parts of cortex phellodendri, 10-20 parts of poria cocos, 10-30 parts of radix codonopsis, 6-12 parts of rhizoma atractylodis macrocephalae stir-fried with bran and 2-10 parts of radix glycyrrhizae preparata. The traditional Chinese medicine composition is low in cost, high in AA treatment effect and free of toxic and side effects, and has the effects of tonifying kidney, replenishing essence, detoxifying, descending turbidity and the like; the therapeutic effect on AA can be achieved by adjusting glycolysis of macrophages.

The invention belongs to the technical field of biological medicine, and particularly relates to morinda officinalis polysaccharide-synanthrin composite gel as well as a preparation method and application thereof. The radix morindae officinalis polysaccharide-synanthrin composite gel provided by the invention is prepared from radix morindae officinalis polysaccharide, synanthrin and water. The radix morindae officinalis polysaccharide-synanthrin composite gel has good biocompatibility and multifunctionality, can intervene in the intestinal microenvironment and renal fibrosis at the same time, and fills the blank of existing treatment methods. The polypeptide has potential curative effects in the aspects of intestinal barrier repair, inflammation regulation and control, microorganism regulation and renal fibrosis inhibition, and a new treatment choice is provided for clinic. The raw materials of the composite gel are based on natural polysaccharides, have good safety and degradability, and meet the high requirements of the medical field on the safety of biological materials. Compared with the existing single-component hydrogel, the composite design of the hydrogel can realize a multi-target effect, the treatment effect is remarkably improved, and the hydrogel has a relatively great market competitive advantage.

The invention discloses a medicinal and edible composition relaxing cream and a preparation method thereof. Comprising the following raw materials in parts by weight: 8-12 parts of kelp, 10-15 parts of oysters, 6-10 parts of fingered citron, 5-8 parts of dandelions, 5-8 parts of peach kernels, 10-15 parts of malt, 3-6 parts of brassica juncea, 10-15 parts of poria cocos, 5-8 parts of platycodon grandiflorum, 5-8 parts of fructus gardeniae, 8-12 parts of pericarpium citri reticulatae, 3-6 parts of rhizoma zingiberis, 10-15 parts of mulberries, 10-15 parts of rhizoma polygonati, 8-12 parts of codonopsis pilosula, 10-15 parts of hawthorn fruits, 3-6 parts of cinnamon, 5-8 parts of angelica sinensis and 3-6 parts of radix angelicae. The traditional Chinese medicine composition disclosed by the invention has the advantage of good use effect, and solves the problems that in the use process of the existing composition-relaxing cream, the multi-target synergistic effect is lacked, the curative effect is limited, heat-sensitive components are easy to degrade after long-time high-temperature boiling, and the drug effect exertion is influenced.

The invention belongs to the field of traditional Chinese medicines, and relates to a traditional Chinese medicine composition for treating liver depression and spleen deficiency syndrome metabolism-related fatty liver disease, which is prepared from the following raw materials in parts by weight: 8 to 10 parts of ginseng, 10 to 15 parts of radix bupleuri, 10 to 15 parts of radix curcumae, 6 to 9 parts of ginger processed pinellia, 6 to 10 parts of fructus amomi, 10 to 15 parts of rhizoma atractylodis, 10 to 15 parts of poria cocos, 10 to 15 parts of semen hoveniae, 10 to 15 parts of radix rehmanniae, 8 to 10 parts of rhizoma polygoni cuspidati and 6 to 9 parts of lignum dalbergiae odoriferae. The traditional Chinese medicine composition is used for treating the metabolism-related fatty liver diseases from the aspects of liver depression, spleen deficiency and phlegm-blood stasis, starts from the core pathological chain of liver depression, spleen deficiency, phlegm-dampness and blood stasis, has the functions of soothing the liver, tonifying the spleen, resolving dampness, reducing fat and promoting blood circulation to remove meridian obstruction, and is particularly suitable for patients with liver depression, spleen deficiency and metabolism-related fatty liver diseases. Clinical tests prove that the traditional Chinese medicine composition has a good treatment effect on patients with liver depression and spleen deficiency syndrome metabolism-related fatty liver diseases, the total effective rate reaches 94% or above, and the traditional Chinese medicine composition is mild in medicine property, good in safety, stable in curative effect, not prone to relapse and suitable for being taken for a long time.

The invention discloses a traditional Chinese medicine decoction piece full life cycle data management system and method, and relates to the field of data processing, and the method comprises the steps: collecting traditional Chinese medicine planting environment data through a sensor, and encrypting and storing the data through a block chain; in the processing link, the moisture evaporation condition is predicted through an LSTM neural network, and an early warning mechanism is set; in the processing process, the process is adjusted through a Raman spectrum; components and pesticide residues of the finished product are ensured to be qualified through mass spectrometric detection; the clinical end collects prescription and curative effect data optimization process; all data are synchronized through a block chain and a cross-chain protocol; through a data lake architecture and a graph neural network model, a planting area and a processing technology are optimized. The system has the advantages that through technologies such as a sensor, a block chain and an AI model, whole-process data tracing and optimization from planting to clinical use are realized, the quality and curative effect of a traditional Chinese medicine product are improved, and transparency and safety of the whole process are ensured.

The invention relates to the field of anti-tumor drugs, and discloses an anti-diffuse large B-cell lymphoma pharmaceutical composition, a preparation method and application thereof, the composition comprises azacitidine and Sanilisoma, the composition can improve the accumulation amount of VDUP1 protein in a cell nucleus through the combination of the methylation effect of DNMT3b on VDUP1 protein and the inhibition of XPO1 activity by Sanilisoma, and the anti-diffuse large B-cell lymphoma pharmaceutical composition can be used for preparing anti-diffuse large B-cell lymphoma. The chemotherapy effect is remarkably improved, the sensitivity of the DLBCL to the Sanisole is remarkably improved, and particularly, the pharmaceutical composition has a remarkable curative effect on R / R DLBCL patients.

The invention relates to the technical field of medical cosmetology, discloses a laser hair removal method based on multi-parameter feedback, and aims to solve the problems of unstable curative effect and insufficient safety caused by single parameter of traditional laser hair removal. The method comprises the following steps: synchronously acquiring multi-dimensional physiological parameters such as skin type, hair follicle depth and epidermis temperature through multispectral imaging, high-frequency ultrasound and temperature sensing; constructing a personalized treatment parameter model based on a deep neural network, and generating initial energy density, pulse width and cooling parameters; laser output is regulated and controlled in real time by using a fuzzy logic controller in the treatment process, and it is ensured that thermal injury accurately acts on the hair papilla; performing adaptive optimization on the treatment strategy in combination with reinforcement learning, and continuously updating the model through a closed-loop learning mechanism; meanwhile, a treatment history database is established, curative effect prediction and parameter backtracking are supported, precision, individuation and high safety of laser depilation are achieved, depilation efficiency is remarkably improved, and the risk of skin adverse reaction is reduced.

The invention discloses a quinazolinone compound as well as a preparation method, a pharmaceutical composition and application thereof, and relates to the technical field of pharmaceutical chemistry. In particular to a quinazolinone compound as shown in a formula I or pharmaceutically acceptable salt, prodrug, stereoisomer, diastereoisomer, enantiomer, tautomer, solvate, salt of solvate, polymorphic substance and isotope labeled compound of the quinazolinone compound. The quinazolinone compound designed and synthesized by the invention can effectively inhibit TAK1 protein activity, achieves an excellent curative effect at a molecular level, and can be applied to preparation of medicines for treating and / or preventing inflammation, chronic fibrosis diseases, hyperproliferative diseases and cardiovascular diseases.

The invention discloses a crisaborole Pickering emulsion as well as a preparation method and application of the crisaborole Pickering emulsion. The crisaborole Pickering emulsion prepared by the invention solves the problem of poor water solubility of crisaborole, improves the drug solubility, and has the characteristics of small particle size, high centrifugal stability, good long-term stability and the like. Compared with the traditional nanoemulsion, the Pickering emulsion disclosed by the invention shows certain advantages in the aspects of biocompatibility, cumulative transdermal amount and cutin retention, improves the curative effect of a local preparation and reduces skin toxicity, and can be used as an ideal local preparation for treating atopic dermatitis and other diseases.

The invention provides a stem cell exosome for overexpressing A beta degrading enzyme as well as a preparation method and application of the stem cell exosome. Specifically, the invention provides an application of the stem cell exosome overexpressing A beta degrading enzyme in preparation of drugs, and the drugs are used for at least one of the following: prevention, improvement or treatment of cognitive impairment related diseases; neuronal cell damage is improved; wherein the stem cells for overexpressing the A beta degrading enzyme are prepared through lentivirus transfection. According to the stem cell exosome overexpressing the A beta degrading enzyme, the content of the A beta degrading enzyme is obviously higher than that of the exosome prepared by a traditional method. Therefore, when the compound is prepared into a medicine for treating or preventing cognitive impairment related diseases, the medicine can be efficiently conveyed to the brain, and the concentration of the medicine in the brain is remarkably improved, so that the curative effect is enhanced, the dosage of the medicine can be reduced, the side effect is reduced, and the prognosis of brain diseases is effectively improved.

Illumination devices for impinging light on tissue, for example within a body cavity of a patient, to induce various biological effects are disclosed. Biological effects may include at least one of inactivating and / or inhibiting growth of one or more pathogens, upregulating a local immune response, increasing endogenous stores of nitric oxide, releasing nitric oxide from endogenous stores, and inducing an anti-inflammatory effect. Biological effects may include upregulating and downregulating inflammatory immune response molecules within a target tissue. Wavelengths of light are selected based on intended biological effects for one or more of targeted tissue types and targeted pathogens. Light treatments may provide multiple pathogenic biological effects, either with light of a single wavelength or with light having multiple wavelengths. Devices for light treatments are disclosed that provide light doses for inducing biological effects on various targeted pathogens and tissues with increased efficacy and reduced cytotoxicity.

The application discloses a traditional Chinese medicine composition for treating chronic renal failure and a preparation method and application thereof, and belongs to the technical field of traditional Chinese medicine compositions. The traditional Chinese medicine composition comprises the following raw materials in parts by weight: 25-35 parts of radix astragali, 15-25 parts of radix salviae miltiorrhizae, 5-15 parts of raw radix et rhizoma rhei, 15-25 parts of fructus corni, 15-25 parts of radix paeoniae alba, 15-25 parts of poria cocos, 5-15 parts of rhizoma chuanxiong, 15-25 parts of radix atractylodis macrocephalae, 15-25 parts of radix codonopsis, 15-25 parts of radix alismatis, 15-25 parts of radix sophorae flavescentis and 15-25 parts of herba plantaginis. The traditional Chinese medicine composition for treating chronic renal failure is scientifically and reasonably formulated, and the traditional Chinese medicine composition has obvious and exact curative effects on chronic renal failure and has a shorter treatment cycle compared with the prior art.

The invention discloses an ROS-responsive prostate cancer targeting prodrug as well as a preparation method and application thereof, and belongs to the technical field of biological medicines. The prodrug is formed by covalently linking a prostate cancer targeting peptide SYEELR, a ROS (reactive oxygen species) response type ketal thiol (TK) connexon and an active molecule Devimistat. The preparation method comprises the following two steps: firstly, coupling Devimistat with a TK linker to obtain an intermediate Dev-TK, and then coupling the intermediate Dev-TK with an SYEELR peptide fragment to obtain a target product. The prodrug can specifically break and release Devimistat in a tumor high active oxygen microenvironment, and active targeting delivery is realized by virtue of the SYEELR peptide. The invention provides a novel prostatic cancer treatment strategy with accurate targeting, controllable release, enhanced curative effect and toxicity reduction potential.

The invention provides a traditional Chinese medicine monomer composition for preventing and / or treating pulmonary fibrosis as well as a preparation and application thereof, and belongs to the technical field of biological medicines. The traditional Chinese medicine monomer composition comprises the following components: schisandrin B and platycodin D. The traditional Chinese medicine monomer composition can obviously reduce fiber cell and collagen deposition, relieve inflammatory cell infiltration, obviously reduce the lung coefficient, alveolar inflammation score and pulmonary fibrosis score, and recover the normal physiological structure of rat lung tissue. The traditional Chinese medicine monomer composition provided by the invention can reduce the expression contents of KL-6, MMP-7, SP-A and SP-D and lung tissue HYP in serum, and has the effects of relieving collagen deposition and alveolar epithelium injury, maintaining alveolar homeostasis and improving pulmonary fibrosis. Therefore, the traditional Chinese medicine composition provided by the invention is definite and reliable in curative effect and can be used for preparing medicines for preventing and / or treating pulmonary fibrosis.

The invention discloses a drug-loaded polygonatum kingianum extracellular vesicle, a preparation method and an application of the drug-loaded polygonatum kingianum extracellular vesicle in preparation of an anti-photoaging product, and aims to provide a drug-loaded polygonatum kingianum extracellular vesicle which has relatively high encapsulation efficiency and drug loading rate and good stability and biocompatibility, can effectively treat skin UVB inflammation, solves the problem that a drug is insoluble in water, improves the curative effect, and can be used for preparing an anti-photoaging product and a preparation method of the drug-loaded polygonatum kingianum extracellular vesicle. According to the technical scheme, the drug-loaded polygonatum kingianum extracellular vesicles comprise the polygonatum kingianum extracellular vesicles and drug active components loaded in the polygonatum kingianum extracellular vesicles, and the drug-loaded polygonatum kingianum extracellular vesicles comprise the drug-loaded polygonatum kingianum extracellular vesicles and the drug active components loaded in the drug-loaded polygonatum kingianum extracellular vesicles. The pharmaceutical active component is at least one of resveratrol, glutathione, astaxanthin and vitamin C. The invention further discloses a preparation method of the pharmaceutical composition. The invention belongs to the technical field of biological medicine.

The invention discloses an iron-zinc diatomic nano enzyme with oxidase-like activity as well as a preparation method and application thereof, and belongs to the technical field of nano materials and antibiosis. The preparation method comprises the following steps: reacting dimethylimidazole with zinc nitrate hexahydrate in methanol to obtain a ZIF-8 nano-material, taking the ZIF-8 nano-material subjected to high-temperature annealing as a carbon source and a nitrogen source, the zinc nitrate hexahydrate as a zinc source, ferric nitrate nonahydrate as an iron source and ethanol as a solvent, and carrying out hot solvent loading and high-temperature annealing to obtain the FeZn diatomic nano-enzyme with a stable structure. The composite material is stable in configuration and good in biocompatibility, has efficient oxidase-like catalytic activity, does not need to additionally add hydrogen peroxide, is combined with a photothermal therapy, directly and efficiently generates active oxygen by catalyzing oxygen, is high in antibacterial activity, and has an excellent curative effect in deep drug-resistant bacterial infected wounds. The raw materials used in the invention have the advantages of low cost, good safety, mild synthesis conditions and simple synthesis steps, and can be industrially manufactured and applied on a large scale.

The invention relates to the technical field of medicines, and discloses an application of a traditional Chinese medicine composition in a humanized flora transplantation model.The application comprises the following steps that an experimental body is pretreated through sterile feeding or broad-spectrum antibiotics, then coprophilous fungus suspension of a functional dyspepsia patient is transplanted, and the humanized flora transplantation model is constructed; acquiring physiological data of the humanized flora transplantation model, and performing intervention on the traditional Chinese medicine composition after the humanized flora transplantation model is completed; acquiring physiological data of the traditional Chinese medicine composition intervened humanized flora transplantation model, and analyzing an evaluation result of the traditional Chinese medicine composition intervened humanized flora transplantation model by combining the evaluation parameters of the humanized flora transplantation model. The bottleneck that the traditional animal model is greatly different from the human microflora and the curative effect and the mechanism are difficult to transform is overcome, so that the research result is closer to the clinical practice, and the molecular mechanism of the traditional Chinese medicine composition is reliably revealed.

The invention relates to the technical field of traditional Chinese medicines, in particular to a traditional Chinese medicine composition for relieving pain, promoting blood circulation, diminishing swelling and removing blood stasis, application thereof and a blood stasis dispersing and pain relieving patch. The invention provides a traditional Chinese medicine composition for relieving pain, activating blood, diminishing swelling and removing stasis. The traditional Chinese medicine composition comprises the following components: lycopodium clavatum, radix clematidis, asarum, gentiana macrophylla, radix angelicae, rheum officinale, notopterygium root, roasted herba epimedii, radix achyranthis bidentatae, peach kernel, radix angelicae pubescentis, vinegar-processed rhizoma corydalis, vinegar-processed rhizoma cyperi, moutan bark, prepared kusnezoff monkshood root, prepared monkshood, vinegar-processed frankincense, Sinkiang lithospermum, vinegar-processed myrrh and sanguisorba officinalis. The blood stasis dispersing and pain relieving patch has the advantages of being good in curative effect, quick in effect taking, convenient to use, safe and reliable, can be used for treating traumatic injuries and pain caused by cervical spondylosis, scapulohumeral periarthritis, lumbar disc herniation, lumbar vertebrae hyperosteogeny, spinal stenosis, sciatica, ankylosing spondylitis, arthritis and other diseases, and can achieve the effect of treating both symptoms and root causes.

The invention discloses a traditional Chinese medicine composition for treating type 2 diabetes and a preparation method and application thereof. The traditional Chinese medicine composition is prepared from, by weight, 11-15 parts of radix acanthopanacis semticosi, 5-15 parts of male silkworm moth, 7-17 parts of white ginseng, 5-11 parts of rhizoma polygoni cuspidati, 15-25 parts of rhizoma coptidis, 1-5 parts of cortex cinnamomi, 11-15 parts of fructus ligustri lucidi, 11-15 parts of common fenugreek seed, 7-17 parts of lithocarpus litseifolius, 3-7 parts of raw radix astragali and 1-3 parts of wild lucid ganoderma. , 3-9 parts of tribulus terrestris and 11-17 parts of nigella nigra seeds. The traditional Chinese medicine composition has the effect of balancing and stabilizing blood sugar, is short in treatment course, quick in effect and free of toxic and side effects, and has an excellent curative effect on treating diabetic complications.