36 results about "Experimental drug" patented technology

A system and method for studying a test subject includes monitoring the test subject as it traverses through a programmable maze. The test subject may be under the influence of experimental drugs or genetic manipulation. The dynamic maze can be changed automatically or manually to test the abilities of the test subject. The dynamic maze comprises of a starting point, an ending point, and an electronically programmable floor capable of constructing various obstacles and passageways. The programmable floor may be programmed by a human user using an interface, or it may be programmed by an automated control system that programs the maze in accordance with the ability of the test subject to traverse the maze. Various devices are incorporated with the use of the maze to monitor the activities and welfare of the test subject.

The present invention provides new intermediate compounds or formulae (III) and (IVa), and salts thereof, and their use in a new synthetic process for the production of 1-(2-((2,4-dimethylphenyl)thio)phenyl)piperazine (vortioxetine) an experimental drug under development for the treatment of depression and anxiety.

The invention relates to quantitative taking equipment, in particular to chemical experimental drug quantitative taking equipment. The technical problem to be solved is to provide chemical experimental drug quantitative taking equipment capable of reducing labor intensity and improving quantitative taking efficiency. According to the technical scheme, the chemical experimental drug quantitative taking equipment comprises a sucker base and the like, a cup capable of measuring chemical experimental drugs is arranged in the middle of the top of the sucker base; two supports are respectively fixedon the left side and the right side of the top of the sucker base; a feeding hopper capable of containing a drug bottle is arranged between the top of the left support and the top of the right support; and a quantitative device capable of measuring the chemical experiment drugs is arranged at the lower part of the feeding hopper. According to the equipment, a user can conveniently and quantitatively take chemical experimental drugs through the quantitative device, and the chemical experiment drugs can be prevented from spilling out on the ground through inclined baffle plates, so that labor intensity can be reduced, and quantitative taking efficiency can be improved.

The invention relates to a chemical laboratory drug placement rack, in particular to a chemical laboratory drug detachable placement rack. The technical problem to be solved is to provide the chemicallaboratory drug detachable placement rack which is easy to assemble and disassemble and can reduce the occupied space. The technical solution of the present invention is the chemical laboratory drugdetachable placement rack, the laboratory drug detachable placement rack comprises a square placement plate, a moving plate, a placing frame, partition plates, a handle, a large roller, a small roller, and the like; the right side of the square placement plate is provided the moving plate, the lower part of the right side of the moving plate is connected with the placing frame, a plurality of partition plates are placed on the placing frame, the handle is connected to the middle of the right side surface of the moving plate, and the handle is located at the front side of the partition plate. The square placement plate and the moving plate of the invention are separated, the partition plates are placed between the left and right placement grooves to place the experimental drug on the partition plates; a clamping ball is inserted into a clamping slot, and the square placement plate and the moving plate can be fixed together, so that the chemical laboratory drug placement rack can be easily assembled and disassembled, and the occupied space can be reduced.

The invention relates to a quantitative taking device, in particular to a quantitative taking device for chemical experiment drugs. The technical problem to be solved is to provide a quantitative taking device for chemical experimental medicines that can reduce labor intensity and improve quantitative taking efficiency. The technical scheme of the present invention is: a quantitative taking device for chemical experimental drugs, including a suction cup base, etc.; a cup that can measure chemical experimental drugs is placed in the middle of the top of the suction cup base, and there are two brackets, which are respectively fixed on the top of the suction cup base. On the left and right sides, the lower hopper that can place the medicine bottle is arranged between the tops of the left and right brackets, and the quantitative device that can measure the chemical experiment medicine is installed at the lower part of the lower hopper. The invention can facilitate users to quantitatively take the chemical experimental medicine through the quantitative device, and can prevent the chemical experimental medicine from overflowing and falling on the ground through the inclined baffle, thereby reducing labor intensity and improving quantitative taking efficiency.

The invention discloses a method for rapidly extracting total RNA from lotus root tissue. The steps are: first, the preparation of experimental medicines and the treatment of experimental supplies; second, the collection of materials, the young leaves of lotus root and the petioles connected with the leaves; the third, extraction, precipitation, and centrifugation to obtain total RNA; the fourth is The identification of total RNA was detected by UV spectrophotometer and formaldehyde-denatured agarose gel electrophoresis respectively. According to the obtained data and electrophoresis results, it was shown that the obtained lotus root tissue total RNA had good integrity, high purity and high yield. The invention has the advantages of simple and convenient experimental process, convenient and safe operation, accurate and effective results and good repeatability, and the method is also suitable for extracting total RNA from plant tissues of other species rich in polysaccharides and polyphenols.

The invention relates to a middle school experimental medicine distribution device which is characterized by comprising a base, two hollow circular discs and a circular plate, wherein a vertical supporting rod is arranged at the middle of the base; a supporting ring is arranged at the middle of the vertical supporting rod; a sleeve hole allowing the supporting rod to penetrate through is formed in the center of each of the two hollow circular discs; the diameter of each of the sleeve holes is smaller than that of the supporting ring; the hollow circular discs adopt hollow structures and the hollow parts of the circular discs adopt fan-shaped structures; the fan-shaped hollow parts of the corresponding hollow circular disc are annularly distributed by taking the center of the circular disc as the circle center; the diameter of the circular plate is greater than or equal to that of each hollow circular disc; a sleeve hole is further formed in the middle of the circular plate; the diameter of the sleeve hole is greater than or equal to that of the supporting ring; the circular plate is composed of two semicircle parts. According to the middle school experimental medicine distribution device provided by the invention, drugs can be partitioned by the medicine distribution device, and partitioned drugs can drop down after the circular plate is taken out, so that the purpose of uniform partition can be achieved.

The present invention belongs to the pharmaceutical field, and relates to a benzoyl polyhydroxy cyclohexene compound and a synergetic antibacterial effect of the benzoyl polyhydroxy cyclohexene compound on efflux pump drug-resistance Staphylococcus aureus. According to the present invention, the compound of the present invention does not have the bacteria growth inhibition effect, and when the compound and antibiotic norfloxacin are subjected to compatibility, based on the bacteria efflux pump drug-resistance mechanism, NorA gene-containing fluoroquinolone-resistant and methicillin-resistant Staphylococcus aureus experimental drug-resistance bacterial SA1199B is used to test, and the results show that the minimum bacteria inhibition concentration valves of the norfloxacin are respectively reduced by 4 times and 16 times through the compounds Zeylenol and Ellipeiopsol B. According to the present invention, the compound Zeylenol provides the same bacteria efflux pump inhibition effect as the positive control drug, and can be used for preparing synergistic antibiotic drugs.

The invention discloses a polymer-resveratrol bonded drug and a preparation method thereof. The resveratrol polymer-bonded drug has the following general formula: P-RES'm wherein: P is a water-soluble polymer, m is an integer from 1 to 50; RES' is a resveratrol derivative , the resveratrol derivative is made of resveratrol and acid chloride. The polymer bonded drug of the present invention has good hydrophilicity and biocompatibility, can avoid human reticuloendothelial system phagocytosis in the blood circulation, and ensure sufficient time to reach the tumor site through the EPR effect, and then enter the cell through endocytosis , efficient targeting of experimental drugs.

The invention provides an investigational drug inventory management system applied to research centers, the system comprising a processor and a computer readable storage medium. The system can implement the following steps: judging whether current inventories E of various investigational drugs in a research center are all greater than or equal to a preset safe inventory V of the research center in real time; if not, obtaining the current inventory E and historical data of use of each investigational drug in the research center, and calculating the predicted total number L of dropout people in a prediction period T according to the preset warehouse prediction period T; according to the number N of drugs a preset subject takes upon each visit and a subject visit period of P weeks, calculating the number S of visits in the prediction period of enrolled subjects, the number U of visits in the prediction period of to-be-enrolled subjects and the total number R of drugs to be taken; calculating the drug supply quantity Q in the prediction period; generating a drug transport list according to which warehouses supplement the inventories of the investigational drugs for the research center.

The invention discloses a traditional Chinese medicine composition for treating allergic rhinitis and application thereof. The traditional Chinese medicine composition is prepared from eugenol and total saponins of radix astragali seu hedysari. A nasal spray prepared from the traditional Chinese medicine composition can be used for treating allergic rhinitis through local nasal administration, has an experimental drug effect superior to that of a first-line treatment drug, takes effect quickly, can take effect after being sprayed for 1-3 minutes, reduces nasal obstruction, running nose and the like, has no side effect, and can achieve a radical treatment effect on part of people. After the nasal spray is administrated to rats, the results show that the nasal spray for the corydalis bungeana group is superior to triamcinolone acetonide (positive control group) in the aspects of reducing a main allergic medium IgE, reducing nasal mucous membrane secretory mucoprotein MUC5AC and improving rhinitis pathology, the eugenol and the total saponins of radix astragali seu hedysari are matched to play a synergistic effect, and the effect exceeds that of single eugenol and single total saponins of radix astragali seu hedysari.

The invention discloses an automatic distribution cabinet for laboratory drugs, which combines specific experimental drugs according to the requirements of experimental contents. When an experimenterreceives corresponding experimental drugs through automatic identity authentication, the system will automatically open a corresponding drawer for storing the experimental drugs required for the experiment according to the requirement of the specific experimenter, and the experimenter can receive the experimental drugs from the corresponding drawer. The automatic distribution cabinet for laboratory drugs has the following characteristics: (1) the experimental management personnel can combine experimental drugs to be distributed according to the experimental requirements; (2) the laboratory drugs are stored by category in the experimental cabinet; (3) the automatic drug distribution cabinet has an identity recognition system, and identity recognition includes but is not limited to card recognition and face recognition; and (4) the distribution cabinet for laboratory drugs automatically distributes specified drugs in advance based on an automatically identified specific object.

This application involves the use of non-nucleoside HIV-1 reverse transcriptase inhibitor 1-[(2-hydroxyethoxy)-methyl]-6-(phenylthio)thymine (HEPT) as the lead substance, which is combined into clinical The experimental drugs MKC-442 and TNK-651, based on the theory of bioelectron isosterism and hydrogen bonding, designed a new class of molecules with related structures. See general formula I, the definition of each group in the formula is as described in the claims. At the same time, it also relates to the evaluation of the reverse transcriptase activity of the compounds and the application of these compounds as HIV-1 reverse transcriptase inhibitors. The conformation of the synthesized new compound is more conducive to the combination with HIV-1 reverse transcriptase, which is more conducive to its inhibition of reverse transcriptase activity, and becomes a new type of HIV-1 reverse transcriptase inhibitor with high activity and low toxicity agent.

The invention belongs to the technical field of microbial separation kits, and particularly relates to a teaching kit for separating cellulose-decomposing microorganisms and application of the teaching kit, and the teaching kit realizes a guiding function of experimental steps and experimental drug effects by utilizing partitions with different colors. The kit comprises a cover body and a box body, the box body is composed of a plurality of separated spaces; the space is filled with other materials (such as plastic or foam), and the space is divided into an area A, an area B, an area C and an area D; and a corresponding label is arranged around each space. The invention provides a kit for separating microorganisms capable of decomposing cellulose, regional planning is carried out by utilizing reagent properties, combination is carried out according to a basic amount prepared by 1000mL of a culture medium, and the workload of experiment preparation is reduced; the color and the naming guidance of the contained reagent are utilized to guide the specific operation of the experiment step by step so as to make preparation for the principle behind the clarification experiment operation, and the difficulty of experiment teaching is reduced.

The invention relates to a pesticide composition, and especially relates to an emulsion in water of the pesticide composition for controlling cotton aphids and thrips. The emulsion in water of the pesticide composition for controlling cotton aphids and thrips comprises the following components in percentage by weight: 5-20% of Guadipyr, 5-20% of cyhalothrin, 10-15% of solvent, 4-10% of an emulsifier, 0.2-0.5% of a defoamer, 5-10% of an anti-freezing agent, 2-6% of a disintegrating agent and the balance of water. By compounding the Guadipyr and the cyhalothrin, the resistant cotton aphids can be effectively controlled, the control efficiency is superior to the reference, the lasting period is long, the control effect is up to 90%, and no phytotoxicity is caused to the target crops in the experimental drug scope. According to the emulsion in water of the pesticide composition for controlling cotton aphids and thrips, the defects that the cyhalothrin is relatively bad in environmental friendliness and the Guadipyr is relatively bad in fast-acting property and relatively slow in drug action can be effectively solved.