7 results about "Experimental drug" patented technology

A method and apparatus of a device that performs a robust federated IPTW analysis to leverage multicentric real-world data or historical clinical trials as a control group for a single-arm trial while accounting for sampling biases due to the lack of randomization is described. In an exemplary embodiment, the device trains a first model using a plurality of training centers, wherein each training center includes a private set of training data and a compute unit, where the first model estimates the probability of receiving the experimental treatment for each sample given a private set of training data. Furthermore, the device may train a second model using the plurality of training centers, wherein the training of the second model includes computing weights for each sample using the estimated probabilities from the first model, and the second model then estimates the effect of the drug on time-to-event outcomes on weighted data. In addition, the device may use the second model as well as a third federated procedure to test whether the experimental drug has a significant effect on the survival outcome in a robust fashion.

The invention relates to the technical field of medicine feeding devices, and discloses a quantitative medicine feeding device for mouse experiments, which comprises a box body, a collecting tank body is placed at the bottom end of the box body, quantitative feeders are symmetrically mounted and connected to the inner wall of the box body, and a glass sealing plate is fixedly connected to the top end of the box body; the disinfection mechanism horizontally slides on the inner wall of the box body and comprises a bottom plate, holes are uniformly formed in the middle of the bottom plate, sliding openings are formed in the two sides of the bottom plate, L-shaped plates are slidably connected into the sliding openings, and a shell is fixedly connected to the tops of the L-shaped plates. According to the device, the disinfection mechanism is mechanically driven to conduct automatic intermittent cleaning in the bottom plate, the disinfection assembly is matched to abut against the bottom plate, residual urine and the like on the bottom plate can be cleaned while the bottom plate is disinfected and killed, due to the movable design of the shell, the pressure of mice can be reduced, and the mouse disinfection effect is improved. Extra influence factors under quantitative drug feeding of the mice are reduced, and the drug detection and comparison effect is guaranteed.

The invention discloses a chemical experiment medicine grinding, screening and drying device and method, and relates to the technical field of medicine grinding, screening and drying devices. The chemical experiment medicine grinding, screening and drying device comprises a chemical medicine box, a lifting button is fixedly mounted at the top of the chemical medicine box, a cover plate is fixedly connected to the bottom of the lifting button, and a grinding mechanism and a drying mechanism are arranged in the chemical medicine box; according to the chemical medicine grinding device, when chemical medicine is continuously shrunk, a grinding roller continuously extrudes an extrusion plate until the chemical medicine is crushed and reaches a first screening layer through screening holes, so that the effect of grinding the chemical medicine is achieved, the first screening layer and a second screening layer can be restored after each time of shaking, and the grinding efficiency is improved. And the drying groove continuously turns over and dries the chemicals in the triangular sliding groove and the circular sliding groove, the phenomenon that crystallization is prone to occurring due to direct heating and drying is effectively avoided, and a user can observe the drying effect of the chemicals in the drying groove through an observation hole.

The present application relates to the field of concentration detection, and specifically to a kind of experimental drug concentration rapid determination instrument, including extraction assembly, centrifugal component and material taking assembly, the extraction assembly includes extraction cup, stirring assembly is installed in the inside of extraction cup, the stirring assembly includes with the outer stirring rod of extraction cup rotation connection, inner stirring rod and helical blade;It further includes scraping component, the scraping component includes with the inner scraper of helical blade sliding connection, with the middle scraper of inner stirring rod sliding connection and with the outer scraper of outer stirring rod sliding connection.The present application is integrated by stirring extraction and centrifugal purification function, without sample transfer, the degree of automation of high integration equipment, to solve the pain points of sample loss, pollution, cumbersome process, low degree of automation in the prior art, meet the efficient, accurate demand of pharmacokinetic experiment and all kinds of biological, chemical sample pretreatment, provide stable support for subsequent automatic material distribution, detection link.

The utility model discloses a rapid distinguishing device for a control medicine and an experimental medicine, and belongs to the technical field of tea processing equipment. Which comprises a hinge seat, the middle section of the hinge seat is provided with a long rod, and is characterized in that the surface of the hinge seat is sleeved with a plurality of material storage structures, the top of the uppermost material storage structure is provided with a display disc, and the bottom of the lowermost material storage structure is provided with a bottom disc; lamp holders are arranged on one side of the top and one side of the bottom of the rear side of the hinge seat; according to the utility model, the plurality of storage structures are stacked up and down, and the storage structures are rotationally connected through the long rods of the hinge seats on one sides, so that each independent storage structure can be rotationally opened, and actual storage and taking are facilitated; the interior of the material storage disc is divided into two cavities for storing control medicine and experiment medicine through the partition plate, so that the corresponding medicine can be quickly found during subsequent taking.

The utility model relates to the field of animal experiments, in particular to a feed uniform blending device for experimental animal feeding. Comprising a feeding frame, one side of the feeding frame is fixedly connected with a supporting frame, the end, away from the feeding frame, of the supporting frame is provided with an adjusting structure, the adjusting structure comprises a blending barrel, the blending barrel is fixedly connected with the supporting frame, the lower surface of the blending barrel is fixedly connected with a discharging pipe, and the arc surface of the discharging pipe is provided with a valve; two conveying pipes are fixedly connected to the arc surface of the blending barrel, and conveying barrels are fixedly connected to the ends, away from the blending barrel, of the two conveying pipes. According to the feed uniform blending device for experimental animal feeding, the two conveying barrels are used for measuring feed with different components and experimental medicine, the blending barrel and the stirring barrel are used for stirring and mixing the feed, operation is easy and convenient, the feed blending efficiency is improved, the feed is fully mixed, and the experimental animal feeding quality is improved. And the accuracy of animal experiment results is improved.

The invention discloses a research method for reducing atherosclerosis risk mechanism, and belongs to the technical field of medicine application. Selecting laboratory mice, feeding the laboratory mice in a 12-hour light-dark period environment, replacing the laboratory mice with high-phosphorus feed, continuously feeding the laboratory mice, monitoring the serum phosphorus level, and grouping the mice which reach the standard; respectively preparing experimental drugs for each group of mice through calcium carbonate, calcium acetate, sevelamer and a composite drug, administering the experimental drugs to the mice in the group, and monitoring the body weight and the serum phosphorus level and adjusting the administration dosage during the period; dynamic monitoring is alternately carried out during administration, and the dynamic monitoring comprises metabolism cage monitoring and blood fat and inflammation detection; collecting blood, aorta and kidney samples after administration; and atherosclerotic plaques and kidney tissues are detected. The invention verifies whether the phosphorus-binding agent phosphorus-reducing drug can reduce the risk of atherosclerosis of hyperphosphatemia patients by reducing the serum phosphorus level, improving blood lipid metabolism, reducing inflammatory response, improving vascular functions and the like, and provides a theoretical basis for clinical treatment.