The invention belongs to the technical field of traditional Chinese medicine and particularly relates to a compound preparation with effects of purging guts, protecting the stomach, soothing nerves and helping sleep. The compound preparation is mainly prepared from the following raw materials: probiotic powder, gamma-aminobutyric acid, banana fruit powder, flos rosae rugosae, bulbus lilii, Malpighia emarginata fruit, fructo-oligosaccharide, mannitol, fructus aristolochiae, herba aristolochiae, medulla junci, radix gentianae macrophyllae, Laggera pterodonta herb, herba thlaspis and cortex dictamni. The preparation method of the compound preparation comprises the following steps: S1, smashing is performed; S2, the Malpighia emarginata fruit and the smashed flos rosae rugosae, bulbus lilii, fructus aristolochiae and cortex dictamni are subjected to water extraction; S3, the herba aristolochiae, the medulla junci, the radix gentianae macrophyllae, the Laggera pterodonta herb and the herbathlaspis are subjected to acetone extraction and petroleum ether crystallization; S4, decoction dregs obtained in S2 and S3 are subjected to ethanol extraction; S5, extract solutions obtained in the steps are concentrated to dryness and mixed uniformly with the probiotic powder, gamma-aminobutyric acid, the banana fruit powder, fructo-oligosaccharide and mannitol, and the oral preparation is prepared. The curative effects of purging the guts, protecting the stomach, soothing the nerves and helping sleep are improved.