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Application of boenninghausenia sessilicarpa cough-asthma tablet to prepare medicaments for inhibiting lung cancer cell LLC proliferation

A technology of Shijiaocao Kechuan Tablets and LLC cells, which can be applied to drug combinations, antitumor drugs, pharmaceutical formulations, etc., can solve the problems of affecting application, many impurities, and rough process.

Inactive Publication Date: 2014-04-23
JINAN XINQIDIAN MEDICAL TECH
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0003] In the prior art, there is no report on the application of Shijiaocaokechuan Granules in the preparation of drugs to inhibit the proliferation of lung cancer cells LLC cells, and there is no report on the use of supercritical and microwave technology in the extraction and preparation of Shijiaocaokechuan Granules , but the method of volatile oil extraction and water decoction, the process is rough and backward, and there are many impurities, which leads to excessive dosage for patients and is inconvenient to take, which seriously affects the clinical application of this product

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0024] Take 156g of tangerine peel, 96g of Shichangpu, 312g of Polygonum cuspidatum, 188g of Asparagus, 375g of Shijiaocao, 96g of Baibu, 750g of Tongguanteng, 375g of Stinking Pill, 96g of Bitter Almond, 375g of Houttuynia cordata, 188g of Mulberry Cortex. , Stinking Pill, Shijiaocao, and Houttuynia cordata were added to the CO 2 In the supercritical extractor, ethanol is used as an entrainer, and the volume percentage of the entrainer to the total extraction solvent is 5%, the extraction pressure is 25MPa, the temperature is 40°C, and the CO 2 The flow rate is 2ml / g crude drug·min, the extraction time is 200min, and the supercritical extract is obtained for use; the rest of the traditional Chinese medicine is taken, crushed, added 5L of 50% ethanol, and put into a microwave extraction device for microwave extraction. The extraction power is 700W, and the extraction is performed twice. Each time for 8 minutes, the extracts were combined, concentrated, added to a Diaion HP-10 ...

Embodiment 2

[0027] Take 156g of tangerine peel, 96g of Shichangpu, 312g of Polygonum cuspidatum, 188g of Asparagus, 375g of Shijiaocao, 96g of Baibu, 750g of Tongguanteng, 375g of Stinking Pill, 96g of Bitter Almond, 375g of Houttuynia cordata, 188g of Mulberry Cortex. , Stinking Pill, Shijiaocao, and Houttuynia cordata were added to the CO 2 In the supercritical extractor, ethanol is used as an entrainer, and the volume percentage of the entrainer in the total extraction solvent is 4%, the extraction pressure is 30MPa, the temperature is 50°C, and the CO 2 The flow rate is 3ml / g crude drug·min, the extraction time is 180min, and the supercritical extract is obtained for use; the rest of the traditional Chinese medicine is taken, crushed, added 5L of 50% ethanol, and put into a microwave extraction device for microwave extraction. The extraction power is 600W, and the extraction is performed twice. The extracts were combined for 5 minutes each time, concentrated, added to a Diaion HP-10 m...

Embodiment 3

[0030] Take 156g of tangerine peel, 96g of Shichangpu, 312g of Polygonum cuspidatum, 188g of Asparagus, 375g of Shijiaocao, 96g of Baibu, 750g of Tongguanteng, 375g of Stinking Pill, 96g of Bitter Almond, 375g of Houttuynia cordata, 188g of Mulberry Cortex. , Stinking Pill, Shijiaocao, and Houttuynia cordata were added to the CO 2 In the supercritical extractor, ethanol is used as an entrainer, and the volume percentage of the entrainer to the total extraction solvent is 6%, the extraction pressure is 15MPa, the temperature is 30°C, and the CO 2The flow rate is 1ml / g crude drug·min, the extraction time is 220min, and the supercritical extract is obtained for use; the rest of the traditional Chinese medicine is taken, pulverized, added 5L of 50% ethanol, and put into a microwave extraction device for microwave extraction. The extraction power is 800W, and the extraction is performed twice. The extracts were combined for 10 minutes each time, concentrated, added to a Diaion HP-1...

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Abstract

The invention belongs to the technical field of traditional Chinese medicines, and specifically relates to application of a boenninghausenia sessilicarpa cough-asthma tablet to prepare medicaments for inhibiting lung cancer cell LLC proliferation and a preparation method for the boenninghausenia sessilicarpa cough-asthma tablet. The boenninghausenia sessilicarpa cough-asthma tablet provided by the invention possesses the application to prepare medicaments for inhibiting lung cancer cell LLC proliferation. The boenninghausenia sessilicarpa cough-asthma tablet is prepared from the following bulk drugs: 156 g of dried orange peel, 96 g of acorus gramineus, 312 g of reynoutria japonica, 188 g of radix asparagi, 375 g of boenninghausenia sessilicarpa, 96 g of stemona sessilifolia, 750 g of caulis marsdeniae tenacissimae, 375 g of laggera pterodonta, 96 g of semen armeniacae Amarum., 375 g of houttuynia cordata and 188 g of cortex mori. Supercritical extraction and microwave extraction are employed for preparing the boenninghausenia sessilicarpa cough-asthma tablet, and thus hesperidin content is substantially improved.

Description

technical field [0001] The invention belongs to the technical field of traditional Chinese medicines, and in particular relates to the application of Shijiaocao Kechuan Tablets in the preparation of drugs for inhibiting the proliferation of lung cancer cell LLC cells and the preparation method of Shijiaocao Kechuan Tablets. Background technique [0002] The standard number of Shijiaocao Kechuan Granules is WS-10449 (ZD-0449)-2002, which is recorded in the Spleen and Stomach Subvolume of the National Compilation of Chinese Patent Standards. Made from 156g of tangerine peel, 96g of Shichangpu, 312g of Polygonum cuspidatum, 188g of Asparagus, 375g of Shijiaocao, 96g of Baibu, 750g of Tongguanteng, 375g of Stomach Pill, 96g of Bitter Almond, 375g of Houttuynia cordata, and 188g of Morus alba It has the effects of clearing away heat and resolving phlegm, relieving cough and relieving asthma. It is used for cough with thick phlegm, dry mouth and itchy throat caused by lung heat, ...

Claims

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Application Information

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IPC IPC(8): A61K36/904A61K9/20A61P11/00A61P11/10A61P11/14A61P11/06A61P35/00
Inventor 孙波
Owner JINAN XINQIDIAN MEDICAL TECH
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