65 results about "Aconitum carmichaeli" patented technology

This invention provides a traditional Chinese medicine composition, preparation method, and application for treating uric acid nephropathy, specifically belonging to the field of traditional Chinese medicine preparation technology. The traditional Chinese medicine composition of this invention comprises the following components in parts by weight: Aconitum carmichaelii 3-7 parts, Cinnamomum cassia 1-7 parts, Morinda officinalis 3-10 parts, Sinapis alba 3-9 parts, Fritillaria thunbergii 5-10 parts, Atractylodes lancea 3-9 parts, Coix lacryma-jobi 10-30 parts, Phellodendron chinense 3-12 parts, Pyrrosia lingua 6-15 parts, Dioscorea hypoglauca 9-15 parts, Smilax glabra 15-60 parts, and Prunus persica 5-10 parts. The traditional Chinese medicine composition of this invention can treat uric acid nephropathy, specifically including uric acid nephropathy of kidney yang deficiency type. It has a mild medicinal property, warms the kidney and invigorates the spleen, clears turbidity and detoxifies, and has no toxic side effects.

The invention discloses application of a yang-warming and cold-dispelling traditional Chinese medicine composition in preparation of a medicine for improving cold limbs, and belongs to the field of traditional Chinese medicines. The prescription consists of folium artemisiae argyi, cassia twig, ligusticum wallichii, notopterygium root, divaricate saposhnikovia root, ginger, pepper, safflower, radix clematidis, radix aconiti carmichaeli, dried ginger and cinnamon according to a specific mass part ratio. The prescription disclosed by the invention has the effects of warming channels and expelling cold, and promoting blood circulation to remove meridian obstruction, and is mainly used for improving the symptoms such as cold hands and feet, intolerance of cold and sensation of chill, joint crymodynia and the like caused by insufficiency of yang qi and congealing cold in meridians. The invention also provides a preparation method of dosage forms such as an application agent of the prescription. Clinical tests show that the prescription preparation, especially the acupoint application agent, can obviously improve the symptoms, the total effective rate can reach 93.3%, the safety is good, and a safe, effective and convenient-to-use external treatment choice is provided for related diseases.

This invention relates to a method, kit, and application for assessing the cardiotoxicity risk of processed Aconitum carmichaelii products based on NFKB1, PSMB1, and FGR biomarkers, belonging to the field of traditional Chinese medicine processing technology. The invention provides a biomarker specifically any one of the NFKB1, PSMB1, or FGR genes, or any combination thereof. This invention is the first to identify the key causal biomarkers NFKB1, PSMB1, and FGR that cause cardiotoxicity from Aconitum carmichaelii toxic components. A dynamic response model composed of these three genes can accurately quantify the degree of toxicity transformation during Aconitum carmichaelii processing: elevated NFKB1 expression indicates a risk of inflammatory activation, decreased PSMB1 expression reflects the critical point of protein homeostasis collapse, and persistent inhibition of FGR expression indicates the failure of endogenous cardioprotective mechanisms. The predictive model constructed using these three genes can accurately assess the cardiotoxicity of processed Aconitum carmichaelii products and evaluate the Aconitum carmichaelii processing technology.

The invention provides a tendon-relaxing, collateral-activating and pain-relieving breast plaster for shoulder, neck, lumbar vertebra, arthralgia and traumatic injury. The plaster is prepared from the following raw materials in parts by weight: 22-35 parts of frankincense, 41-55 parts of mirabilite, 26-40 parts of ligusticum wallichii, 31-40 parts of lycopodium clavatum, 5-20 parts of dragon's blood, 5-20 parts of pseudo-ginseng, 10-25 parts of radix clematidis, 40-55 parts of pawpaw, 35-45 parts of radix angelicae pubescentis, 40-50 parts of pericarpium zanthoxyli, 40-50 parts of ginger, 30-35 parts of rhizoma drynariae, 42-47 parts of radix aconiti kusnezoffii, 43-48 parts of radix aconiti, 45-50 parts of asarum, 40-50 parts of 20 to 30 parts of chamomile, 10 to 25 parts of menthol oil, 10 to 25 parts of camphor oil, 15 to 25 parts of lavender essential oil and 10 to 25 parts of wintergreen oil; 15-25 parts of radix saposhnikoviae oil, 15-25 parts of garden balsam stem oil and 15-30 parts of safflower oil. The ointment has special effects on shoulder, neck and lumbar vertebra, arthralgia, traumatic injury, tendon relaxing, collateral activating and pain relieving; and the traditional Chinese medicine composition has the effect of treating both symptoms and root causes without relapse and side effects.

The invention discloses a traditional Chinese medicine composition for treating lumbago and application of the traditional Chinese medicine composition. Rehmannia glutinosa, astragalus membranaceus and radix puerariae are used as monarch drugs; black prepared common monkshood daughter root, dried ginger, cassia twig, asarum, pseudo-ginseng, safflower and the like are used as ministerial drugs; gleditsia sinensis lam, semen brassicae, radix scutellariae, fructus arctii, radix paeoniae alba, fructus lycii, rhizoma atractylodis macrocephalae and the like are used as adjuvant drugs, radix bupleuri, cudrania cochinchinensis, radix dipsaci, eucommia ulmoides, herba epimedii and cynomorium songaricum are used as adjuvant drugs, radix bupleuri is used for soothing liver and regulating qi, and lifting qi to strengthen yang and warm qi, cudrania cochinchinensis is used for promoting blood circulation to remove meridian obstruction, and radix puerariae is used for relieving muscles and relaxing tendons and removing stasis and removing food retention. The traditional Chinese medicine can effectively treat kidney-yang deficiency type and complex lumbago (such as lumbar muscle degeneration, lumbar disc herniation and osteoarthritis), such as cold-dampness stasis and the like, treats both symptoms and root causes, and is not easy to relapse.

The invention discloses a pharmaceutical composition for treating corpus luteum insufficiency type infertility as well as a preparation method and application thereof, and belongs to the technical field of traditional Chinese medicines. The technical problem to be solved is to provide the pharmaceutical composition for treating the LPD type infertility, which is simpler in formula, lower in cost and better in treatment effect. According to the technical scheme, the pharmaceutical composition is prepared from the following raw materials: codonopsis pilosula, astragalus membranaceus, fried rhizoma atractylodis macrocephalae, angelica sinensis, semen cuscutae, fried eucommia ulmoides, fried teasel root, honey-fried licorice root, processed radix aconiti carmichaeli and cornu cervi degelatinatum. The pharmaceutical composition provided by the invention can improve ovarian injury, ferroptosis phenomenon, embryo implantation disorder, uterine artery blood perfusion and the like caused by LPD, and is helpful for various pathological problems related to LPD.

The invention relates to a Tibetan medicine compound preparation for relieving stomach discomfort and protecting gastric mucosa. The Tibetan medicine compound preparation is prepared from 11 medicinal materials including gypsum rubrum (prepared), safflower carthamus, liquorice and the like through a special process. The core innovation is as follows: gypsum rubrum is processed by co-melting borax, potassium nitrate and aconite, a high-dissolution-rate calcium-boron compound is generated, and the toxicity is reduced; the highland barley wine and the yellow milk cooperate to form a gastric mucosa protective film. The medicinal materials are subjected to dynamic three-stage ultrasonic extraction (300 W to 200 W to 200 W) to realize graded dissolution of fat-soluble and heat-sensitive components, and the purity of the effective components reaches 98% in combination with a membrane filtration system (5 mu m to 0.45 mu m to 0.2 mu m). According to the compound, three-axis synergy of acid-relieving and pain-relieving (the pH value is increased to 3.5-4.0 in 30 minutes), blood-activating and film-protecting (the DPPH clearance rate is 89%) and qi-regulating and distention-eliminating (the helicobacter pylori MIC value is 0.5 mg / mL) is adopted, and nitrogen-filled packaging (the stability is 18 months) and palatability optimization (the compliance is 92%) are adopted as auxiliary materials. The acute toxicity LD50 is greater than 5g / kg, the long-term toxicity does not cause liver and kidney injury, the bottleneck of side effects of western medicines is broken through, and the traditional Chinese medicine is suitable for health care and adjuvant therapy of stomachache, sour regurgitation and other symptoms.

The invention provides a traditional Chinese medicine compound which is prepared from the following raw material medicines: rhizoma smilacis glabrae, rhizoma dioscoreae septemlobae, semen coicis, rhizoma curcumae longae, herba taxilli, radix salviae miltiorrhizae, cortex phellodendri, rhizoma acori graminei, plantain herb, rhizoma atractylodis macrocephalae, wine-treated rhubarb, radix angelicae pubescentis, bran-fried rhizoma atractylodis and vinegar-treated rhizoma corydalis, and also provides application of the traditional Chinese medicine compound composition in medicines for treating gout and gouty nephropathy. In addition, the invention also provides a preparation method of the sustained-release granule of the compound composition, which comprises the following steps: firstly, preparing the raw medicinal materials into a traditional Chinese medicine fluid extract, then adding the filler into the traditional Chinese medicine fluid extract, stirring to form a soft material, passing the soft material through a swinging granulator, and drying to obtain a medicine-containing pill core; and putting the pill cores into a fluidized bed, laterally spraying the slow-release coating solution, drying, and sieving to prepare the slow-release granules. The prepared traditional Chinese medicine formula sustained-release granules can release 90% or above within 8-10 hours, have a good constant-speed sustained-release characteristic, can meet the clinical requirement of 1-2 times of administration every day, and have good clinical application prospects and market value.

This invention relates to a fumigation and analgesic powder packet, made from 20 pure Chinese medicinal herbs including processed Aconitum carmichaelii. It is a powder for fumigation and washing, and can also be used for targeted transdermal therapy. It is for external use only. The invention involves preparing the herbal decoction pieces from the prescription into a coarse powder, which is then packaged into non-woven bags of different sizes according to the patient's condition and treatment method. The powder is taken out as needed and dissolved in an appropriate amount of boiling water to create a medicinal solution for fumigation or re-steaming. Alternatively, a suitably sized powder packet can be thoroughly soaked until it is no longer dripping wet. The wet packet is then placed on the chip of a targeted transdermal therapy device, positioned on the treatment area, and the device is turned on according to the operating procedures for treatment. Clinical application is convenient, quick, fast-acting, effective, and without side effects.

The invention discloses an external traditional Chinese medicine composition for treating cold-heat mixed type diseases. The external traditional Chinese medicine composition is prepared from the following traditional Chinese medicine raw materials in parts by weight: 4-5 parts of radix aconiti carmichaeli, 4-5 parts of garden balsam stem, 4-5 parts of radix et rhizoma rhei, 2-3 parts of radix clematidis, 2-3 parts of frankincense, 2-3 parts of myrrh, 2-3 parts of herba asari, 2-3 parts of raw rhizoma arisaematis, 2-3 parts of fresh ginger, 2-3 parts of herba taraxaci and 2-3 parts of loofah sponge. Compared with the prior art, the traditional Chinese medicine composition has the advantages that cold and heat are used together, yin and yang are harmonized, exterior syndromes are treated by tonifying yang to condition roots, softening hardness to dissipate stagnation, promoting blood circulation to remove blood stasis, dispelling wind and relieving pain, necrotic tissue removing and granulation promoting are adopted to condition and recover, a multi-target and broad-spectrum treatment effect is formed, and the traditional Chinese medicine composition is mainly used for treating cold and heat intermingled diseases and can effectively treat or relieve rheumatoid bone diseases, traumatic injuries, scalds, prostatitis and other diseases.

The invention discloses a massage composition for relieving muscle and neck, shoulder, waist and leg joint pain and a preparation method. The composition is prepared from pallas pit viper oil, a snow lotus herb extract, a pilose antler extract, a dragon's blood extract, garden balsam stem oil, a myrrh extract, saffron crocus oil, vanillyl butyl ether, ginger root oil, tortoise shells, menthol, frankincense oil, cetostearyl alcohol, a stearyl trimethyl ammonium chloride mixture, 2-bromine-2-nitropropane-1, 3-diol, methylparaben and water. The invention further provides a preparation method of the massage composition for relieving muscle and neck-shoulder-waist-leg joint pain and application of the composition. The massage composition for relieving the pain of the muscles, the neck, the shoulders, the waist and the legs shows remarkable effects in the aspects of relieving the pain of the muscles, the neck, the shoulders, the waist and the legs and relieving fatigue, the pain degree of a patient can be effectively relieved, and the life quality of the patient is improved.

The directional extraction process comprises the following steps: taking a monkshood raw material, crushing the monkshood raw material, and sequentially carrying out water extraction, resin enrichment, silica gel column chromatography purification, sephadex refining and HPLC (High Performance Liquid Chromatography) separation, so as to obtain the pyrazine heart-strengthening component in the monkshood; the pyrazine heart strengthening component in the radix aconiti lateralis praeparata is radix aconiti lateralis praeparata pyrazine A and / or radix aconiti lateralis praeparata pyrazine B; the structure of the monkshood pyrazine A is shown in the specification; the structure of the monkshood pyrazine B is shown in the specification. The directional extraction process of the pyrazine heart-strengthening components in the radix aconiti carmichaeli is established for the first time, efficient separation of toxic components and impurities is achieved through stepped multi-step purification of water extraction, macroporous resin enrichment, silica gel purification, gel refining and preparative HPLC separation, and efficient directional extraction of the pyrazine heart-strengthening components can be achieved; the purity of the obtained pyrazine heart-strengthening component is greater than or equal to 98%, and the problem that the components of the product extracted by the traditional process are mixed is solved.

The invention discloses a traditional Chinese medicine composition for soothing channels and activating collaterals. The traditional Chinese medicine composition comprises the following components: 2-4 parts of asiatic toddalia root, 1-3 parts of raw pinellia ternate, 1-3 parts of monkshood, 1-3 parts of radix aconiti agrestis, 1-3 parts of radix aconiti carmichaeli, 3-5 parts of safflower, 3-5 parts of asarum, 3-5 parts of angelica sinensis, 3-5 parts of ligusticum wallichii, 1-3 parts of croton root, 3-5 parts of pepper, 3-5 parts of ground beeltle, 5-7 parts of pseudo-ginseng root, 3-5 parts of radix clematidis, 3-5 parts of sappan wood, 2-4 parts of cortex dictamni, 2-4 parts of radix angelicae pubescentis, 2-4 parts of honeycomb and 2-4 parts of frankincense. , 3-5 parts of pomegranate rind, 1-3 parts of hippocampus, 1-3 parts of centipede and 1-3 parts of dragon's blood. The traditional Chinese medicine composition for relaxing the channels and activating the collaterals has the effects of relaxing the channels and activating the collaterals, dispelling wind and eliminating dampness, and relieving swelling and pain, can effectively relieve swelling and pain caused by traumatic injury, blood stasis, joint dysfunction and the like, can be used for treating diseases such as traumatic injury, rheumatic arthralgia and the like after a fracture operation, also has a certain curative effect on stroke, is sprayed or smeared on an affected part, and has no toxic or side effect. A preservative film can be used for covering, so that the pesticide effect is greatly improved.

The present invention relates to a plant composition, a traditional Chinese medicine composition and use thereof. The plant composition comprises Prepared Monkshood Daughter Root (Aconitum carmichaelii), Fragrant Solomonseal Rhizome (Polygonatum odoratum), Indian Bread (Poria cocos), Pinellia tuber (Pinellia ternata), Oriental Wormwood Herb (Artemisia scoparia), Scutellaria Root (Scutellaria baicalensis), Mongolian Snakegourd Fruit (Trichosanthes kirilowii), Magnolia Bark (Magnolia officinalis), Heartleaf Houttuynia Herb (Houttuynia cordata) and Baked Licorice Root and Rhizome (Glycyrrhiza glabra), which is used as a traditional Chinese medicine composition. In addition, the traditional Chinese medicine composition can be used to treat pulmonary embolism or pulmonary fibrosis.

This invention relates to the field of traditional Chinese medicine preparation technology, and particularly to a traditional Chinese medicine composition for treating cancer pain and numbness, as well as its preparation and application. This invention designs a traditional Chinese medicine composition for cancer pain and numbness, comprising: *Houttuynia cordata*, *Aconitum carmichaelii*, processed *Aconitum carmichaelii*, centipede, *Astragalus membranaceus*, *Ephedra sinica*, clove, frankincense, ephedra, menthol, and azone. The scientifically formulated combination of principal, assistant, and adjuvant herbs allows for multi-target action on both "cancer pain" (inflammation, compression, nerve infiltration) and "CIPN" (nerve damage), resulting in a superior analgesic effect, while also possessing anti-inflammatory, anti-swelling, potential tumor-suppressing, and nerve-repairing effects. The traditional Chinese medicine composition is prepared into a traditional Chinese medicine ointment, which is administered transdermally, allowing a high concentration of the drug to act directly on the lesion, avoiding the systemic side effects (addiction, constipation, etc.) associated with oral opioids. This is especially suitable for patients who cannot take oral opioids or cannot tolerate them.

The invention discloses a traditional Chinese medicine composition for treating leukoplakia vulvae, the traditional Chinese medicine composition is formed by combining an oral medicine and an external application medicine, the oral medicine is prepared from the following medicinal materials: angelica sinensis, ligusticum wallichii, radix paeoniae rubra, radix rehmanniae preparata, cassia twig, peach kernel, cortex moutan, poria cocos, Chinese yam, dogwood, safflower carthamus, radix bupleuri, herba epimedii, rhizoma curculiginis, morinda officinalis, radix aconiti carmichaeli and cynanchum paniculatum; the external application medicine is prepared from the following medicinal materials: radix angelicae sinensis, rhizoma chuanxiong, radix paeoniae rubra, radix rehmanniae preparata, cassia twig, peach kernel, cortex moutan, poria cocos, rhizoma dioscoreae, fructus corni, flos carthami, radix bupleuri, herba epimedii, rhizoma curculiginis, radix morindae officinalis, radix aconiti carmichaeli, radix cynanchi paniculati, fructus cnidii, cortex phellodendri, radix sophorae flavescentis, fructus kochiae and herba menthae. Clinical symptoms of a patient are effectively relieved, vulva skin lesion is effectively repaired, skin regeneration is promoted, vulva skin is recovered to a normal form, and the life quality of the patient is improved.

The present application belongs to the technical field of traditional Chinese medicine quality detection, and particularly relates to a characteristic spectrum construction method and detection method of Shangtong Tincture developed by using a new technology of ultra-high performance liquid chromatograph-diode array detector combined with multiple wavelength segment switching. The present application specifically comprises the following steps: a. Preparation of reference substance solution: taking appropriate reference substances of Bergenin, Herba Artemisiae Scopariae A, Rutin, Cinnamyl Aldehyde, Paeonol and Aconitine, dissolving the reference substances in a solvent to obtain the reference substance solution; b. Preparation of test sample solution: taking Shangtong Tincture, adding an ethanol solution to prepare the test sample solution; c. Detection: injecting the reference substance solution and the test sample solution into an ultra-high performance liquid chromatograph for detection, taking the characteristic spectrum of the reference substance solution as a reference spectrum, selecting common peaks from the characteristic spectrum of the test sample solution to construct the characteristic spectrum of Shangtong Tincture, and determining 13 common peaks; and the present application also provides a rapid and comprehensive detection method of Shangtong Tincture.

The invention belongs to the technical field of poultry breeding, and particularly relates to a traditional Chinese veterinary medicine for accelerating recovery of feed intake of poultry after illness, the traditional Chinese veterinary medicine is prepared from the following raw medicinal materials in parts by weight: 10-26 parts of rice sprout, 10-26 parts of gynostemma pentaphylla, 5-15 parts of tuber fleeceflower stem, 10-22 parts of radix bupleuri, 5-15 parts of radix aconiti carmichaeli, 10-35 parts of galangal, 10-22 parts of andrographis paniculata and 5-16 parts of liquorice. According to the traditional Chinese veterinary medicine for accelerating the recovery of the feed intake of the poultry after the disease and the preparation method of the traditional Chinese veterinary medicine, the rice sprout, the gynostemma pentaphylla, the tuber fleeceflower stem, the radix bupleuri, the radix aconiti carmichaeli, the rhizoma galangae, the herba andrographitis and the liquorice are added, and a plurality of Chinese herbal medicine raw medicinal materials are combined according to a proposed proportion and can complement each other and have a synergistic effect, so that the respective medicinal effects are exerted to the maximum extent; the multiple medicinal materials are mixed to achieve a synergistic effect, the spleen, stomach, heart and kidney functions of the poultry are comprehensively conditioned, the recovery efficiency of food consumption after diseases is further improved, and compared with chemical medicines, traditional Chinese veterinary medicines have the advantages of being small in side effect, few in residue and the like by selecting traditional Chinese medicines to be mixed and matched with the chemical medicines.

The invention relates to the field of traditional Chinese medicines, in particular to a traditional Chinese medicine composition for treating diabetic nephropathy, which is prepared from the following raw material medicines in parts by weight: 9-45 parts of raw astragalus membranaceus, 9-30 parts of radix rehmanniae, 3-9 parts of radix aconiti lateralis preparata, 6-15 parts of cassia twig, 15-30 parts of mung bean coat, 9-30 parts of serissa serissoide, 9-18 parts of perilla leaf, 9-18 parts of gordon euryale seed, 6-15 parts of cherokee rose fruit, 3-9 parts of rhizoma zingiberis, 3-9 parts of raw rhubarb and 2-6 parts of leech. The invention further provides a preparation and application of the traditional Chinese medicine composition.

This invention relates to the field of pharmaceutical technology, and in particular to a cleaved C19 diterpenoid alkaloid compound and its application in rapid-acting antidepressants. This invention isolates a novel cleaved C19 diterpenoid alkaloid compound, Carmaloidline G, from Aconitum carmichaelii and establishes a stable and controllable extraction, separation, and purification process, achieving high-purity preparation and industrial-scale feasibility of this compound. Studies have shown that this compound exhibits significant rapid-acting antidepressant activity in various animal models of depression, with a fast onset of action and stable efficacy. Its overall efficacy is comparable to the positive control drug esketamine, but the required dosage is significantly reduced, thereby effectively reducing the risk of potential adverse reactions.

The invention discloses Yao-strengthening ointment for improving immune disorder of an HIV infected person. The Yao-strengthening ointment is mainly prepared from the following raw materials: astragalus membranaceus, poria cocos, rhizoma cimicifugae, radix achyranthis bidentatae, roasted ephedra, prepared radix aconiti carmichaeli, asarum, roasted liquorice, philippine flemingia root, giantleaf ardisia rhizome, caulis sinomenii, tripterygium wilfordii and gynostemma pentaphylla. The preparation method of the Zhuang Yao ointment comprises the steps of medicinal material treatment, medicinal material extraction and ointment preparation. The whole formula is mainly used for strengthening the body resistance (tonifying qi and warming yang) and eliminating evil (dehumidifying, activating blood and detoxifying), through the compatibility of monarch, minister, assistant and guide, the traditional Chinese medicine aims at core qi deficiency and yang deficiency of immune disorder of HIV infected people and also eliminates pathological products such as dampness, stasis and heat toxin, meanwhile, honey-fried licorice root is used for regulating the medicine property, CD4 cells of the HIV infected people can be improved, immune disorder can be improved to a certain extent, and immune reconstitution is promoted.

The invention relates to the field of external plasters, in particular to a plaster for skin dialysis and a preparation method thereof, the plaster comprises 50-60 parts of radix aconiti carmichaeli, 80-100 parts of dried ginger, 20-30 parts of liquorice, 40-50 parts of rhizoma alismatis, 40-50 parts of dogwood, 80-100 parts of radix rehmanniae, 40-50 parts of salvia miltiorrhiza, 20-30 parts of fructus amomi, 40-50 parts of ginger, 40-50 parts of ligusticum wallichii, 40-50 parts of angelica sinensis, 40-50 parts of ginseng, 5-9 parts of asarum, 5-10 parts of radix angelicae pubescentis, 20-30 parts of eucommia ulmoides and 20-30 parts of rhizoma cyperi. The traditional Chinese medicine composition is prepared from, by weight, 20-50 parts of rhizoma atractylodis, 20-50 parts of poria cocos, 20-30 parts of radix clematidis and 20-30 parts of auxiliary materials. According to the plaster, through skin administration and transdermal technology, the medicine is absorbed by the skin, the skin area is large, the medicine absorption is strong, more toxins are discharged, and gastrointestinal discomfort caused by long-term oral administration is reduced.

This invention discloses a library of traditional Chinese medicine (TCM) compositions based on general and local anesthesia mechanisms, along with various dosage forms and preparation methods. The invention constructs a systematic library of TCM anesthetic compositions: the general anesthetic composition consists of extracts from herbs such as Datura stramonium, Datura stramonium, processed Aconitum carmichaelii, processed Aconitum kusnezoffii, Saussurea involucrata, Jasminum sambac root, Rhododendron molle, and Sanqie Sanqie; the local anesthetic composition consists of extracts from herbs such as Asarum heterotropoides, Murraya paniculata, Ephedra sinica, Toad venom, and Corydalis yanhusuo. This invention further develops the above compositions into various modern dosage forms, including injections, tablets, capsules, and sprays. In particular, this invention innovatively introduces a clove-cinnamon natural preservative and flavoring system to replace chemical preservatives. In terms of preparation technology, advanced technologies such as supercritical CO2 extraction, microwave-assisted extraction, nano-embedding, and nanoemulsions are integrated, and a self-extraction scheme is adopted to achieve controllable quality and cost. Simultaneously, a quality detection method based on HPLC fingerprinting is established. This invention achieves full-scenario coverage of anesthesia and analgesia, from general to local, from emergency to routine care, with outstanding advantages of safety, effectiveness, and controllable quality.

This invention discloses a traditional Chinese medicine composition for treating vascular dementia, its preparation method, and its application, belonging to the field of traditional Chinese medicine technology. It includes the following raw medicinal materials: Rehmannia glutinosa (processed), Dioscorea opposita, Cornus officinalis (processed with wine), Alisma plantago-aquatica, Poria cocos, Paeonia suffruticosa, Cinnamomum cassia, Aconitum carmichaelii (processed), Acorus tatarinowii, Polygala tenuifolia (processed), Curcuma longa (processed with vinegar), Tortoise shell glue, Cervi cornu glue, Achyranthes bidentata, Cuscuta chinensis (processed with salt), Gastrodia elata, Taxillus chinensis, and Eucommia ulmoides (processed with salt). This invention also discloses the preparation method and application of the above-mentioned traditional Chinese medicine composition. The beneficial effects of this invention are: Based on the Shenqi Wan formula and combined with traditional Chinese medicine theory, this application yields a novel traditional Chinese medicine composition for treating vascular dementia. This composition can significantly improve symptoms such as cognitive decline and slow thinking in patients with vascular dementia, effectively delaying the rapid progression of the disease and providing a new treatment option for patients with vascular dementia.

The invention relates to the technical field of traditional Chinese medicine preparations, and particularly discloses a traditional Chinese medicine preparation for treating heart failure and diuretic resistance and a preparation method of the traditional Chinese medicine preparation. The active extract is prepared from the following raw material medicines: astragalus membranaceus, ginseng, cinnamon, salvia miltiorrhiza, red paeony root, radix rehmanniae recen, cassia twig, ligusticum wallichii and pseudo-ginseng. On the basis of a traditional qi-tonifying and blood-activating treatment method, a treatment method for enhancing the effect of dredging collaterals and the effect of nourishing yin is combined, the cinnamon serves as a core monarch drug to warm and tonify yang of the heart and the kidney, and compatibility is scientific; the cortex cinnamomi is used for completely replacing radix aconiti lateralis preparata, so that potential cardiotoxicity and neurotoxicity risks caused by aconitum alkaloids are fundamentally eliminated; the traditional Chinese medicine preparation disclosed by the invention provides a solid guarantee for long-term and safe medication of patients with heart failure, is more suitable for treating intractable and complicated heart failure, and has a good clinical application value.

This application relates to the field of traditional Chinese medicine (TCM) technology, disclosing a TCM compound composition, its preparation method, and its application in treating discogenic low back pain. The TCM compound composition comprises the following components in parts by weight: Astragalus membranaceus 30g, Ligusticum chuanxiong 18g, Angelica sinensis 9g, Rehmannia glutinosa (processed) 18g, Paeonia lactiflora (fried) 18g, Codonopsis pilosula 9g, Bupleurum chinense 9g, Poria cocos 9g, Stephania tetrandra 9g, Aconitum carmichaelii (processed) 9g, and Angelica pubescens 9g. This TCM compound composition improves the metabolism and structural state of multifidus muscle, restores the mechanical stability of spinal segments, reduces the continuous input of abnormal mechanical stimulation from the source, thereby inhibiting the activation of the Piezo1-Netrin-1 axis, reducing vascular and sensory nerve ingrowth, and ultimately resulting in the protection of the cartilaginous endplate structure and improved pain sensitivity.

This invention provides the application of a traditional Chinese medicine composition in the preparation of cardiovascular protective drugs after percutaneous coronary intervention (PCI) for myocardial infarction, specifically acute ST-segment elevation myocardial infarction (STEMI), with a TCM syndrome of "heart yang deficiency." The composition comprises raw Cornus officinalis, dried ginger, ginseng, Astragalus membranaceus, Atractylodes macrocephala, Alisma plantago-aquatica, Poria cocos, and Aconitum carmichaelii. The cardiovascular protective effects of this composition include improving cardiac function, inhibiting postoperative oxidative stress, reducing NT-proBNP, and decreasing the risk of cardiovascular events within one year post-surgery. It can be prepared as a decoction, oral liquid, or other dosage forms, and can be used in combination with conventional Western medicine treatments for synergistic effects. The composition of this invention is scientifically formulated, targets multiple points of action, and effectively addresses the problem of limited cardiovascular protection methods after PCI in STEMI patients, significantly improving patient prognosis and demonstrating good clinical application value.

This invention belongs to the field of traditional Chinese medicine technology, specifically relating to a transdermal drug delivery formulation for treating osteoarthritis. The invention provides a transdermal drug delivery formulation for treating osteoarthritis, comprising, by weight, the following raw materials: 10-15 parts Aconitum carmichaelii, 12-16 parts Smilax glabra, 25-30 parts Salvia miltiorrhiza, 6-12 parts Boswellia carterii, 1-3 parts Carthamus tinctorius, 8-12 parts Commiphora myrrha, 12-16 parts Angelica sinensis, 18-22 parts Tinospora sinensis, 6-10 parts Paeonia lactiflora, 20-30 parts Pinellia ternata, 14-18 parts Cinnamomum cassia, and 6-8 parts Rheum palmatum; it also includes a matrix and excipients for the transdermal drug delivery formulation. This invention uses natural Chinese herbal extracts as active ingredients, and through scientific and rational formulation, prepares a transdermal drug delivery formulation with good stability, permeability, and biocompatibility.

This invention relates to the field of health therapy technology, and in particular discloses a multifunctional acupoint pressure stimulation patch and its preparation method. The acupoint pressure stimulation patch includes: a backing layer, a pressure element, a drug reservoir layer, and a protective layer. The drug reservoir layer contains active drug components. The active drug components in the drug reservoir layer, by weight, are made from the following raw materials: Aconitum carmichaelii 1-20 parts, Aconitum kusnezoffii 1-20 parts, Clematis chinensis 10-50 parts, Commiphora myrrha 5-30 parts, Sinapis alba 5-30 parts, Angelica pubescens 10-40 parts, Zingiber officinale 10-40 parts, Artemisia argyi 10-50 parts, Spatholobus suberectus 10-50 parts, Drynaria fortunei 10-40 parts, Cinnamomum cassia 5-30 parts, Angelica dahurica 10-40 parts, Achyranthes bidentata 10-40 parts, Psoralea corylifolia 10-40 parts, Carthamus tinctorius 5-30 parts, Zanthoxylum bungeanum 5-30 parts, and Boswellia carterii 5-30 parts. The beneficial effects are: by integrating "physical pressure of raised points" with "transdermal absorption of traditional Chinese medicine", the pressure element not only provides continuous acupoint stimulation, but also opens the channels of skin appendages through local pressure, which significantly promotes the transdermal absorption rate of active ingredients in the drug reservoir layer.