The invention belongs to the field of extraction of traditional Chinese medicines, and in particular relates to a method for simultaneous preparation of 7-hydroxy-4 '-methoxy flavan and pterostilbene. The method includes the steps of: 1) taking dracaena cochinchinensis grease-containing wood or ethanol extract thereof, grinding, adding petroleum ether to extract, filtering to obtain filter residue for standby use; 2) using chloroform for reflux extraction of the obtained filter residue, and recovering the chloroform to obtain chloroform extract; 3) using methanol to dissolve the obtained chloroform extract, performing column chromatography, eluting with methanol with every 250ml being one flow part, and merging 2-8 flow parts; 4) concentrating the merged 2-8 flow parts to dry, dissolving with methanol, using a reverse phase silica gel column for column chromatography, eluting with methanol with every 100ml being one flow part, and respectively merging 14-18 flow parts and 20-27 flow parts; and 5) concentrating the respectively merged 14-18 flow parts and 20-27 flow parts to dry, and respectively recrystallizing to obtain the two compounds of 7-hydroxy-4'-methoxy flavan and pterostilbene. The two compounds of 7-hydroxy-4 '-methoxy flavan and pterostilbene are firstly and simultaneously prepared from dracaena cochinchinensis by the method.