63 results about "Chloroform" patented technology

This invention provides a method for preparing dibenzoyl-p-benzoquinone dioxime using a microchannel reactor. The method includes the following steps: 1,3-dicyclohexylcarbodiimide and a catalyst are mixed uniformly and preheated to obtain a premix; a chloroform solution of p-benzoquinone dioxime, a chloroform solution of benzoic acid, and the premix are simultaneously introduced into the microchannel reactor for reaction; the resulting reaction solution is subjected to vacuum distillation, washing, filtration, and drying to obtain dibenzoyl-p-benzoquinone dioxime. The synthesis method of this invention features high reaction conversion rate, high production efficiency, few side reactions, and high safety. The obtained dibenzoyl-p-benzoquinone dioxime product has stable quality. Furthermore, the organic solvent used can be recovered and reused after vacuum distillation, overcoming the problems of inaccurate temperature control, poor safety, numerous side reactions, and difficult waste treatment in traditional processes. This provides a new approach for the synthesis of dibenzoyl-p-benzoquinone dioxime.

This invention discloses a method for preparing hydrophilic drug nanoliposomes based on microfluidic-low-shear coupling double emulsion and the hydrophilic drug nanoliposomes prepared according to the following method: (1) Prepare aqueous solutions of hydrophilic drugs and chloroform solutions of soybean lecithin respectively; (2) Add the chloroform solution of soybean lecithin to the chamber as the oil phase, and inject the aqueous solution of hydrophilic drugs into the oil phase in the low-shear stirring field through a microtube under low-speed stirring and shearing, and collect the W / O pre-emulsion sample; (3) Use the W / O pre-emulsion sample as the dispersed phase, and inject it into the external aqueous phase in the same way as in step (2), and emulsify it under low-speed stirring and shearing to form a W / O / W double emulsion; (4) Remove the chloroform by vacuum evaporation of the W / O / W double emulsion to obtain hydrophilic drug nanoliposomes. The prepared Ganoderma lucidum polysaccharide nanoliposomes have a particle size controlled at 200-300 nm, a polydispersity index of about 0.2, and an encapsulation efficiency of more than 70%, which is more than twice that of the traditional thin film hydration method. It solves the technical problem of low encapsulation efficiency of water-soluble macromolecular Ganoderma lucidum polysaccharides.

This invention relates to DNA extraction methods from soil and sediments with high humic substances content. The method focuses on the soil preparation phase; removing salts and cations with two different Tris-EDTA (TE) buffers, followed by precipitating humic substances with aluminum hydroxide solution and washing again with TE and cell lysis phase; urea is used as denaturing agents for the cell lysis phase and protein degradation phase while preventing the rediffusion of humic substances with CTAB. The purification can be performed following both the classic phenol chloroform method and using commercial DNA purification columns. This method is very accessible with operation time varying from 1h40 min to 2h30 min. The invention involves the use of TE and aluminum hydroxide solutions for soil preparation, and urea and CTAB as denaturing agents during cell lysis, in the specified concentrations, order, and incubation time, to prevent contamination of final DNA with humic substances

The application relates to the field of triple-negative breast cancer treatment and relates to synthesis of an acid-responsive amphiphilic liposome and application of the acid-responsive amphiphilic liposome in tumor treatment. A chemotherapeutic drug, a phospholipid, cholesterol and a polyethylene glycolized lipid are dissolved in an organic solvent chloroform, vacuum rotary evaporation is carried out under certain temperature and rotation rate, a water phase is added for hydration, a polypeptide nanogold cluster solution is added for ultrasonic treatment, then crushing, molecular sieve screening, dialysis and ultrafiltration are carried out to obtain a pH-sensitive liposome; in the preparation process, the phospholipid spontaneously forms a kind of biological membrane-like phospholipid bilayer membrane vesicle in water, and the chemotherapeutic drug and the nanogold cluster are wrapped in the vesicle. The pH-sensitive liposome can target the triple-negative breast cancer tumor site through pH response, can improve the solubility of the chemotherapeutic drug, can realize high-efficiency treatment effect of the drug at a low dose, can obviously reduce the toxic side effect of the chemotherapeutic drug, and can realize effective treatment of the triple-negative breast cancer.

The application belongs to the technical field of photoelectric detectors, and discloses a high-performance two-dimensional perovskite photoelectric detector and a preparation method thereof. First, a SiO2 glass substrate is cleaned, and a precursor solution is dropped on the surface of the glass substrate. Chloroform antisolvent solution doped with ZnO quantum dots is dropped on the precursor solution. Then, ZnO quantum dots / (PEA)2PbI4 nanosheet thin film is formed by spin coating, and the thin film is annealed. The above steps are repeated multiple times to obtain a uniform thin film. The glass substrate with the uniform thin film is plated with gold by a vacuum evaporation method to obtain an electrode. The application improves the carrier migration rate by doping the concentration of ZnO quantum dots, improves the photocurrent size, obtains higher responsivity and detection rate, and shorter response time. The manufacturing process is simple and has strong repeatability. The application has high photocurrent size, high responsivity and high detection sensitivity. The application selects a suitable concentration of ZnO quantum dots. The application can be prepared in an air environment and has strong stability.

This invention discloses a method for preparing a uniform and dense organic-inorganic hybrid perovskite thick film based on the principle of homogeneous bridging. The steps are as follows: glacial acetic acid is added to an organic-inorganic hybrid perovskite precursor solution as a nucleation promoter; chloroform is added as an antisolvent to precipitate perovskite microcrystals; after centrifugation, washing, and drying, the resulting microcrystal powder is mixed with a small amount of γ-butyrolactone to prepare a supersaturated slurry; the slurry is uniformly coated onto an ITO substrate and annealed in a vacuum drying oven until the solvent is completely evaporated, obtaining the organic-inorganic hybrid perovskite thick film. This invention obtains large-particle-size perovskite microcrystal powder by adding glacial acetic acid and prepares it into a supersaturated slurry for thick film coating. Based on the principle of homogeneous bridging, the new grains grown in the saturated solution during annealing fill the pores created by solvent evaporation and connect the original grains, thereby forming a uniform and dense perovskite thick film for X-ray detection.

This invention relates to a bag-film laminate comprising a base layer, a gas barrier layer, and a sealant layer sequentially laminated together, wherein the amount of lubricant present on the surface of the sealant layer is 5 mg / m³. 2 Up to 25 mg / m 2 The surface roughness (Ra) of the sealant layer is 0.1 μm to 0.5 μm. The amount of lubricant is obtained by cutting the bag-film assembly into 100 mm × 100 mm sections in the MD direction and TD direction, dropping 5 ml of chloroform onto the surface of the sealant layer of the bag-film assembly and letting it stand for 1 minute to prepare a lubricant extraction solution, and then using gas chromatography to measure the amount of lubricant contained in the lubricant extraction solution.

The present invention aims to provide a polyphenylene ether having excellent solubility in a general-purpose ketone-based solvent and a production method thereof. It also aims to provide a thermosetting composition, a prepreg, and a laminate each using the polyphenylene ether. The polyphenylene ether of the present invention is characterized by containing 5 to 85 mol% of repeating units derived from a phenol of formula (1) and 15 to 95 mol% of repeating units derived from a phenol of formula (2) relative to 100 mol% of the total of the repeating units derived from the phenol of formula (1) and the repeating units derived from the phenol of formula (2), and having a specific viscosity (ηsp / c) of 0.03 to 0.30 dL / g measured in a 0.5 g / dL concentration chloroform solution at 30°C.

This invention discloses a solid sodium aminosulfonate β-H elimination promoter, its preparation method, and its application, relating to the technical field of β-H elimination promoters. The technical solution is as follows: S1, diethylenetriamine is dissolved in an organic solvent; S2, chlorosulfonic acid organic solution is added dropwise to the diethylenetriamine organic solution at 0-10℃ to carry out the reaction; after the addition is complete, the temperature is raised to continue the reaction; S3, the white solid generated by the reaction is filtered and washed with chloroform and ethanol respectively. The washed white solid is poured into anhydrous methanol and dispersed evenly. The reaction temperature is lowered to 0℃, sodium hydroxide is added for neutralization, and the solvent is removed by vacuum distillation. The resulting pale yellow solid is washed with ethanol and finally dried under vacuum to obtain the solid sodium aminosulfonate β-H elimination promoter. The solid sodium aminosulfonate β-H elimination promoter prepared by this invention has advantages such as high metal salt content, strong alkalinity, and easy separation, making it a promising additive for industrial application.

The present invention provides novel water-soluble compositions comprising sesquiterpene coumarin enriched fractions containing different ratios of sesquiterpene coumarin derived from Ferula species for the treatment of Parkinson's disease via inhibition of MAOenzyme (MAO-A and MAO-B). The invention also provides a method of preparation of ethyl-acetate extract and sesquiterpene coumarin enriched fractions from asafoetida (Hing) that is oleo-gum-resin of Ferula assafoetida using silica gel column chromatography wherein the mobile phase consists of differing compositions of hexane, toluene, chloroform,ethyl-acetate, and methanol. The invention provides the method to prepare the formulation using a multistep process comprising of preparing sesquiterpene coumarin enriched fraction followed by preparing water-soluble formulation. The final composition improves the water solubility, imparts long-term stability, exerts MAO inhibitory activity, and improves pharmaceutical compliance.

The purpose of the present invention is to provide a production method with which it is possible to obtain a low-viscosity polyphenylene ether while controlling the reaction activity during polyphenylene ether production.　In order to solve the aforementioned problem, the present invention is characterized by comprising a step for introducing an oxygen-containing gas into a solution that contains a phenol represented by formula (1) and a phenol represented by formula (2) and performing oxidative polymerization, the moisture content of the oxygen-containing gas being 0.2-50 mg / L, and the reduced viscosity (ηsp / c) of the resulting polyphenylene ether measured by using a chloroform solution having a concentration of 0.5 g / dL at 30°C being 0.03-0.30 dL / g.

The application relates to the field of adsorption separation, in particular to a novel ion type bipyridyl group COF material and a preparation method and application thereof. The preparation method comprises the following steps: mixing 2,2',6,6'-tetramethyl-4,4'-bipyridine, 2,2'-bipyridine-5,5'-diformaldehyde, sodium hydroxide, trimethylbenzene and methanol to carry out reaction 1, and COF-CQWU-2 is obtained; the COF-CQWU-2 is placed in a mixed solution of iodomethane and chloroform to carry out reaction 2, and the novel ion type bipyridyl group COF material is obtained. The application successfully designs and prepares a novel ion type bipyridyl group COF material I@COF-CQWU-2 for removing perfluorinated compounds in water, the COF material has the advantages of simple preparation method, high adsorption capacity and recyclability, and the target of selectively adsorbing perfluorinated compounds from water is achieved.

To provide activated carbon and activated carbon filter bodies that exhibit superior chloroform removal performance. [Solution] The BET specific surface area calculated from nitrogen adsorption isotherms using the BET method is 900-1200 m². 2 The value is / g, and the pore volume of pores in the range of 0.25-0.65 nm, calculated by GCMC method from carbon dioxide adsorption isotherms, is 0.28 cm³. 3 The pore volume of pores larger than 2 nm, calculated by NLDFT method from nitrogen adsorption isotherms, is 0.0135 cm³ or more. 3 The pore volume of pores in the range of 0.37-0.65 nm, calculated by NLDFT method from nitrogen adsorption isotherms, is 0.09 cm³. 3 Activated carbon having a surface oxide content of 0.160 meq / g or less, and a surface oxide content of 0.160 meq / g or less.

The application provides a method for promoting Talaromyces cucurbitiradicus to utilize ethanol to produce PHA by activated carbon, and belongs to the technical field of bio-chemical industry.The method comprises the following steps: adding ethanol, a nitrogen source and buffer salt into water to prepare a fermentation substrate, then inoculating Talaromyces cucurbitiradicus into the fermentation substrate, adding activated carbon and uniformly dispersing, fermenting the obtained fermentation liquid, filtering, treating the obtained fermentation liquid with sodium hypochlorite solution, filtering, dispersing the obtained wet filter cake with chloroform, then adding methanol or ethanol to precipitate PHA, filtering, and obtaining PHA solid.The method can significantly strengthen the metabolic ability and PHA accumulation ability of Talaromyces cucurbitiradicus by adjusting the adding amount of activated carbon and setting a nutrition limiting condition, so that the high-efficiency utilization of ethanol carbon source and the high-level accumulation of PHA are realized.

The application discloses a kind of ultrafast metal-free and solvent-free preparation method for preparing symmetric and asymmetric disulfide, which comprises the following steps: at room temperature, raw material R-SH, R'-SH and oxidant and base are added to reaction bottle, shake rapidly for 10-30 seconds, and R-S-S-R' is prepared after the reaction product is purified;Wherein R in R-SH is aliphatic or aromatic group, R' in R'-SH is aliphatic or aromatic group;R in R-SH and R' in R'-SH are same or different;The aromatic group has substituent or no substituent, and the aliphatic is straight chain or has branch;The oxidant is chloroform, and the base is N, N-diisopropylethylamine (DIPEA).The method is simple in operation, high in yield (60-99%), ultrafast in reaction kinetics, greatly improves production efficiency, wide in applicability, avoids the use of organic reaction solvent, raw material is cheap and easy to obtain, and does not contain residual metal and other sticky contaminants from reagent and ligand, provides a safer and more effective method for the synthesis and production of symmetric and asymmetric disulfide-containing compounds.

This invention discloses a method and system for measuring and calibrating the concentration of an oil mist nano-dispersion, belonging to the field of mechanical testing technology. The invention prepares a nanobubble solution using a porous membrane tube permeation method, employing a ceramic porous membrane tube in conjunction with a pressure tank to control the nanobubble particle size and concentration. A Malvern particle size analyzer is used to measure the solution concentration, which is then adjusted to the desired concentration through proportional dilution. The nanobubble solution is considered equivalent to an oil mist dispersion, and an optical measurement device is built based on the extinction method. A 900nm laser is used to irradiate the solution in a high-transmittance container, and the transmitted light attenuation intensity is measured using an optical power meter. The solvent used is carbon tetrachloride, chloroform, or dichloromethane, and the nanobubble gas is carbon dioxide, water vapor, or methane. The concentration is calculated based on Lambert-Beer's law. This method achieves stable control of oil mist concentration, avoids sampling errors, and improves the calibration accuracy and reliability of the oil mist detector.

This invention discloses a highly stable amphotericin B liposome and its preparation method, belonging to the field of pharmaceutical formulation technology. This invention utilizes a methanol-water-chloroform ternary mixed solvent system to achieve complete molecular-level dissolution of the raw materials, eliminating the conventional drying process and directly hydrating and homogenizing. It also provides optimal formulation ratios and process parameters. The preparation method includes steps such as oil phase preparation, aqueous phase preparation, homogenization, incubation, cooling, filtration, volumetric filling, and lyophilization. This invention creatively proposes optimal formulation composition and process conditions, resulting in a product with high encapsulation efficiency, uniform particle size, and strong stability. Furthermore, the preparation process is simple and easily industrialized, solving the problems of complex preparation processes and poor stability of existing injectable amphotericin B liposomes, and possesses good clinical application value.

In this lead-acid battery, a positive electrode plate comprises a plurality of porous tubes, a core metal, a positive electrode material, and a current collector. The positive electrode material includes 0.03 mass% or more of Sb, and the density of the positive electrode material is 3.2 g / cm3 or more. The tube includes an oxygen-containing organic compound, and the LC / MS spectrum of the oxygen-containing organic compound measured with chloroform as a solvent has multiple peaks in a region where the m / z value is 400-2000. The multiple peaks are present at intervals of m / z values 20-25 and 40-50. All oxygen atoms in the oxygen-containing organic compound are contained in at least one of an ether bond and a hydroxyl group. The ratio of the total mass of oxygen atoms in the oxygen-containing organic compound to the mass of the oxygen-containing organic compound is less than 0.320. The mass of the oxygen-containing organic compound contained in the tube is 0.03-0.6 mass% of the mass of the electrolyte.

To provide an optical lens that suppresses the occurrence of clouding and can maintain transmittance over a long period of time. [Solution] An optical lens 12 formed from polycarbonate resin pellets, wherein the optical lens 12 has a transmittance of 65% or more and 98% or less of chloroform for light with a wavelength of 310 nm after being dissolved in 5 wt% chloroform, and / or a transmittance of 77% or more and 98% or less of chloroform for light with a wavelength of 320 nm after being dissolved in 5 wt% chloroform.

This invention provides a method for preparing a modified SAM-perovskite interface and its application, as well as a method for preparing perovskite solar cells, relating to the field of perovskite solar cells. The method for preparing the SAM-perovskite interface includes: preparing a SAM solution using ethanol as a solvent, coating the SAM solution onto the surface of a TCO substrate, and obtaining a SAM-TCO substrate after annealing; preparing an acyl halide compound solution using chloroform as a solvent and coating it onto the surface of the SAM-TCO substrate to form an interface control layer, thereby obtaining a modified SAM-TCO interface; and preparing a perovskite solution using DMSO / DMF as a solvent and coating the perovskite solution onto the modified SAM-TCO interface to obtain a modified SAM-perovskite interface. This invention simultaneously achieves the chemical purification of the perovskite active layer and the strengthening of the SAM molecular anchoring structure, significantly improving device efficiency and greatly enhancing long-term stability.

This invention relates to the field of power cable technology, and proposes a high-toughness steel strand and its preparation method. The high-toughness steel strand includes bare stranded wire and an epoxy coating sprayed onto the surface of the bare stranded wire. The epoxy coating raw materials include the following components in parts by weight: 100 parts epoxy resin, 25-30 parts carboxylated ternary chloroform resin, 20-50 parts polyphenylene ether, 30-40 parts nano-calcium carbonate, 2-4 parts curing agent, and 1-3 parts degassing agent. This technical solution solves the problem of poor toughness of epoxy coatings on steel strands in related technologies.

The application discloses a high internal phase water-in-oil emulsion and application of the high internal phase water-in-oil emulsion as a fat substitute in salad dressing, and belongs to the technical field of fat substitutes. The preparation of the high internal phase water-in-oil emulsion comprises the following steps: dissolving dioscin and SP in chloroform, and then evaporating the chloroform to obtain DGSP particles; dispersing the prepared DGSP particles in rapeseed oil, and then dispersing a water phase drop by drop into the rapeseed oil to obtain a water-oil mixture, and then performing shearing emulsification to obtain W / O-HIPE. The oil gel-based W / O-HIPE with DGSP particles is used as a fat substitute to prepare a fat-reducing salad dressing, so that the fat-reducing salad dressing can have similar performance to normal salad dressing while reducing fat.

This invention discloses a thin-layer chromatography (TLC) identification method for five medicinal herbs in Lingqiao Jiedu Pills, belonging to the field of traditional Chinese medicine quality control technology. This invention uses only one sample. First, an ethyl acetate extract is obtained through volatile oil extraction. Petroleum ether (30-60℃)-ethyl acetate is used as the developing solvent, and anisaldehyde-sulfuric acid-ethanol solution is used for color development, simultaneously identifying Schizonepeta tenuifolia and Mentha haplocalyx. Then, the aqueous solution after volatile oil extraction is centrifuged, extracted with ethyl acetate, evaporated to dryness, and dissolved in methanol. Using chloroform-methanol-glacial acetic acid, ethyl acetate-formic acid-glacial acetic acid-water, and dichloromethane-diethyl ether-methanol-n-hexane systems as developing solvents, Forsythia suspensa, Glycyrrhiza uralensis, and Arctium lappa are identified sequentially. This method is simple, rapid, and efficient, producing clear spots without tailing or cross-interference. It exhibits good specificity and reproducibility, making it suitable for the quality control of Lingqiao Jiedu Pills.

The application discloses a ganoderma spore powder and a method for determining the content of ganoderma triterpenes in the raw material of the ganoderma spore powder, and has the steps that the ganoderma spore powder sample is ultrasonic-assisted extracted, chloroform is used as an extraction solvent, and a total triterpene crude extract is obtained; the crude extract is separated and purified through an ADS-8 macroporous adsorption resin column, a gradient elution mode is used to remove impurities, 70% ethanol is used for elution and enrichment of target ganoderma triterpene components; the eluent is concentrated to dryness under reduced pressure, dissolved accurately with methanol, filtered through an organic phase filter membrane to prepare a test sample solution; a ganoderma acid C2 reference substance solution is prepared under the same conditions, detection is carried out under specific column and mobile phase conditions through a high performance liquid chromatography system, and the content of ganoderma triterpenes in the sample is calculated through an external standard method. The method has the advantages of reasonable design, clear extraction and purification process parameters, easy standardized operation, moderate detection cost, short cycle, reliable results and the like, and has good industrial application prospect and popularization value.

This invention provides a thin-layer chromatography (TLC) identification method for lotus root nodes and charred lotus root node formulation granules, comprising: A) pretreating lotus root node formulation granules to obtain a lotus root node test solution; pretreating lotus root node charred formulation granules to obtain a lotus root node charred test solution; B) taking lotus root node reference material, extracting by acid reflux, then extracting with chloroform, evaporating to dryness, dissolving the residue in methanol to obtain a reference material solution; C) performing TLC detection on the lotus root node test solution, the lotus root node charred test solution, and the reference material solution; D) examining under ultraviolet light. The TLC identification method for lotus root nodes and charred lotus root node formulation granules established in this invention is used for rapid, accurate, and effective identification of lotus root nodes and charred lotus root node formulation granules. Simultaneously, observing whether there are fluorescent spots in the TLC chromatogram within a certain ratio shift range serves as identification points to distinguish between lotus root nodes and charred lotus root node formulation granules.

Method for obtaining 3-(n-tolyl)-5,6-dihydroimidase[2,1-b][1,3]thiazole involves the reaction of imidazolidine-2-thione with α-bromoacetophenone. Starting imidazolidine-2-thione is dissolved in ethanol, and α-bromoacetophenone is added. Then reaction mixture is boiled for 4 hours without catalyst. After the reaction is complete, solvent is removed, solid residue is dissolved in 30 mL of acetone, neutralized with aqueous solution of NaHCO₃ , and extracted with chloroform three times in 10-mL portions. The combined organic phases are dried over Na₂ SO₄ and evaporated to obtain the target product, which is identified as 3-(n-tolyl)-5,6-dihydroimidase[2,1-b][1,3]thiazole.

The application relates to the technical field of biomedical materials, in particular to a double-layer pain-relieving and antibacterial nanofiber membrane and a preparation method and application thereof, which comprises the following steps: step 1, dissolving polycaprolactone (PCL) and curcumin in a mixed solvent of chloroform and N,N-dimethylformamide (DMF), adding collagen (COL) and stirring uniformly to obtain an inner layer spinning solution; step 2, using an electrospinning technology, a PCL / COL fiber membrane loaded with curcumin is prepared under the receiving of a roller; step 3, dissolving polystyrene (PS) and polycaprolactone (PCL) in a mixed solvent of chloroform and DMF to obtain an outer layer spinning solution; and step 4, spinning a non-oriented PS / PCL fiber layer on the surface of the inner layer membrane to obtain a double-layer nanofiber membrane. The double-layer membrane prepared by the application has different arrangement orientations in the inner layer, the tensile strength of the material is significantly improved, and cell directional growth can be induced; the outer hydrophobic layer provides a physical barrier and effectively inhibits drug burst release, and the slow release can be achieved for up to 72 hours.

This invention discloses a Pd nanodendritic structure, its preparation method, and its application. The preparation method includes cutting a glass slide into cubes and washing it; dissolving 1-butylpyridine chloride in chloroform solution, then adding 1-naphthol, and dissolving to prepare a chloroform mixture as the oil phase in the reaction system; preparing a precursor solution as the aqueous phase in the reaction system; placing the glass slide in a cylindrical vial for later use; adding the chloroform mixture to the vial, then adding the precursor solution to form an oil-water two-phase reaction system, and allowing the reaction to stand; extracting the organic phase, transferring the product onto the glass slide, then extracting the aqueous solution, loading the obtained product onto the glass slide, washing and drying it to prepare a Pd nanodendritic structure loaded on a glass slide. The catalyst prepared by this invention through a simple and efficient oil-water interface synthesis method exhibits excellent catalytic activity and selectivity in the selective hydrogenation of p-nitrobenzaldehyde to p-aminobenzaldehyde.