130 results about "Fluoroacetic acid" patented technology

The invention relates to the technical field of organic synthesis, and discloses a preparation method of bromo-pyrrole nitrile. The method comprises the following steps: (1) mixing p-chlorophenylglycine, acetonitrile, trifluoroacetic acid and a catalyst, then dropwise adding acyl chloride and carrying out acylation reaction, and after the reaction is completed, purging with an inert gas; (2) under the inert gas, mixing the mixture obtained in the step (1) with inorganic salt, then dropwise adding 2-chloroacrylonitrile, carrying out cyclization reaction, and separating a liquid phase from the obtained mixture; and (3) under the inert gas, mixing the liquid phase obtained in the step (2), hydrobromic acid and hydrogen peroxide, carrying out a bromination reaction, then extracting with acetonitrile to obtain an acetonitrile layer, then removing the acetonitrile, and then carrying out cooling crystallization to obtain the bromo-pyrrolenitrile. According to the technical scheme, the reaction yield is high, different solvents do not need to be frequently replaced, and the solvents can be recycled.

A method for producing an aromatic heterocycle-substituted difluoroacetic acid derivative having a partial structure represented by the formula (III), by reacting an N-oxido aromatic heterocyclic compound having a partial structure represented by the formula (I) with tetrafluoroethylene in the presence of a compound represented by the formula (II): R—YH, in a solvent selected from an aromatic hydrocarbon solvent, an ester solvent and an ether solvent:

The invention belongs to the technical field of chromatographic separation materials, and discloses a preparation method and application of a GM-8 nanosheet material. The preparation method of the material comprises the following steps: respectively dissolving Cu (NO3) 2.3 H2O and 1, 3, 6, 8-tetra (4-carboxybenzene) pyrene in an organic solvent, mixing, transferring into a reaction bottle, adding trifluoroacetic acid and pyridine, and uniformly mixing and stirring to obtain a reaction mixture; and heating the reaction mixture to react for 7-9 hours to obtain a blue precipitate, cooling the blue precipitate to room temperature, and washing and drying the blue precipitate to obtain the ultra-stable microporous GM-8 nanosheet material. The nanosheet GM-8 is used as a gas chromatography stationary phase, high-efficiency separation and trace detection of xylene isomers can be realized, and the chromatographic column still keeps excellent separation capacity after being stored in an environment with air humidity of 65-90% for 31 months. The capillary gas chromatographic column can realize high-efficiency separation of disubstituted benzene isomers such as xylene, the separation degree of m-xylene / p-xylene is up to 18.2, and a new solution is provided for high-efficiency separation of isomers with similar properties.

The application relates to the technical field of metal organic thin layer material preparation, in particular to a kilogram-level preparation method of metal organic thin layer material. The preparation method comprises the following steps: S1, adding zirconium tetrachloride and H2BPYDC into a polytetrafluoroethylene reaction kettle, dissolving the zirconium tetrachloride and the H2BPYDC, and then adding a composite; S2, sequentially adding a DMF solution of palladium fluoroacetate, a catalyst and concentrated hydrochloric acid into the reaction kettle; S3, transferring the reaction kettle into an oven, centrifuging to obtain a cyan suspension after 18-20 hours, dispersing the cyan suspension in a DMF solution in batches at 60 DEG C, placing for 5-6 hours, removing unreacted substrates, and obtaining a solid; S4, cleaning the solid obtained in S3 by using DMF and tetrahydrofuran respectively, and vacuum drying for 12 hours to obtain the metal organic thin layer material. The kilogram-level preparation method of metal organic thin layer material is provided, so as to solve the problems of low preparation yield, slow rate and difficulty in kilogram-level preparation of metal organic thin layer material in the related art.

The invention discloses a preparation method and application of a silicon-based functionalized fluorenyl polysubstituted acetylene copolymer and a gas separation membrane thereof. Belongs to the technical field of polymer material and gas separation. The invention provides a new thought for preparation of a high-permeability gas separation membrane material. The preparation method comprises the following steps: carrying out copolymerization on 1-phenyl-2-(7-trimethylsilyl-9, 9-bis (trimethylsilyl-fluorene-2-yl) acetylene and 1-phenyl-2-(7-trimethylsilyl-9, 9-dimethyl-fluorene-2-yl) acetylene under the catalysis of TaCl5-n-Bu4Sn, so as to prepare a copolymer with high molecular weight; the preparation method comprises the following steps of: carrying out film casting on a solution of the nano-silver oxide, and then carrying out desiliconization treatment by using normal hexane / trifluoroacetic acid to obtain a gas separation membrane with the thickness of 100-220 microns, the specific surface area of 298-492 m / g and the total pore volume of 0.134-0.299 cm / g. The prepared separation membrane has the advantages that the COpermeability is up to 36,900 Barrer, the Opermeability is 19,800 Barrer, the thermal decomposition temperature exceeds 420 DEG C, the separation membrane can be used for separating gases such as COO, ON and the like, the preparation process is simple and convenient, and the industrial potential is realized.

FIELD: pharmacology.SUBSTANCE invention can be used to determine the concentration of an anti-tuberculosis drug in blood serum. The method for determining the concentration of bedaquiline in the blood serum in patients with tuberculosis or mycobacteriosis is that whole blood samples are centrifuged at 3000 rpm for 20 minutes, then the blood plasma is collected in sterile 1.5 mL Eppendorf tubes, then 900 mcL of acetonitrile are added to 300 mcL of plasma and centrifuged at 13500g for 15 minutes, then 1 mL of the supernatant is transferred to a chromatographic vial and make the assay by UHPLC MS / MS using an Athena UHPLC C18, 1.8 mcM, 120A, 2.1×100 mm chromatography column, when using an aqueous solution containing 5 g / L of ammonium acetate, 25 ml / L of concentrated acetic acid, 2 ml / L trifluoroacetic acid as mobile phase A and 100% acetonitrile as mobile phase B, the concentration of bedaquiline is determined using a pre-plotted calibration curve.EFFECT: determination of bedaquiline in human blood plasma in a time not exceeding 6 minutes.1 cl, 9 dwg, 6 tbl

The invention provides a method for preparing 2, 6-diamino-3, 5-dinitropyridine, which comprises the following steps: (1) reacting 2, 6-diaminopyridine with an amino protection reagent to obtain an intermediate A; (2) in the presence of a dehydrating agent, carrying out double nitration reaction on the intermediate A and a nitration reagent to generate an intermediate B; (3) 2, 6-diamino-3, 5-dinitropyridine is obtained after the intermediate B is subjected to deprotection, and an amino protection reagent is selected from one or more of acetic anhydride, trifluoroacetic anhydride, di-tert-butyl dicarbonate, benzyl chloroformate and concentrated sulfuric acid; wherein the molar ratio of the amino protection reagent to the 2, 6-diaminopyridine is (2: 1)-(30: 1) by mole; and preferably, the ratio is 2: 1-12: 1.

The invention relates to a preparation method of trifluoromethylsulfonyl fluoride, which comprises the following steps: taking fluorosulfonyl difluoroacetic acid, fluorosulfonyl difluoroacetate or fluorosulfonyl difluoroacetyl fluoride as raw materials, and reacting with fluorine gas to obtain the product trifluoromethylsulfonyl fluoride. According to the method, the fluorosulfonyl difluoroacetic acid (ester or acyl fluoride) directly reacts with the fluorine gas, and complex multi-step reaction and separation and purification of intermediate products are not needed, so that the process flow is simplified, the production links are reduced, and the production efficiency is improved; the method has the advantages of low price of raw materials, mild reaction conditions, low requirements on equipment, realization of continuous production, and reduction of the equipment investment and the production cost; the preparation method is carried out under an anhydrous condition, does not need to use any organic solvent, and is environment-friendly and green; by controlling the reaction conditions, the yield of the trifluoromethylsulfonyl fluoride can reach 85%, the purity of the trifluoromethylsulfonyl fluoride can reach 99.9%, the requirements of different fields for high-purity products can be met, and the method has a good industrial application prospect.

The invention discloses bio-based polyamide with low water absorption and a preparation method thereof, and belongs to the technical field of polyamide preparation. The bio-based polyamide with the low water absorption rate is prepared from the following components in parts by weight: 30 to 50 parts of pentamethylene diamine, 15 to 30 parts of sebacic acid, 5 to 12 parts of citric acid, 5 to 10 parts of hexamethylenediamine, 2 to 5 parts of a hydrophobic auxiliary agent and 1 to 5 parts of a modified high-temperature-resistant additive, the hydrophobic additive is prepared from acetoxybenzoic acid, nonadecanoic acid, m-dimethoxybenzene, trifluoroacetic anhydride and methyl tert-butyl ether as raw materials, and the modified high-temperature-resistant additive is prepared from o-phenylenediamine, chloroacetic acid, vanillin, benzoyl bromide and thiourea as raw materials. The bio-based polyamide prepared from the substances has low water absorption and excellent thermal stability.

The invention discloses a method for microwave digestion of an express packaging material and application, and the method comprises the following steps: S1, crushing and grinding the express packaging material until the particle size is less than 100 [mu] m; s2, adding a composite acid-chitinase mixed solution into the digestion tank, and preliminarily contacting with the sample to weaken the structure of the sample; the composite acid-chitinase mixed solution comprises a composite acid mixed solution and a chitinase aqueous solution; the composite acid mixed solution comprises nitric acid, trifluoroacetic acid, hydrogen peroxide and formic acid; s3, placing the digestion tank treated in the step S2 on a turntable of a microwave digestion instrument, and carrying out pulse type microwave digestion; the microwave time is 25 minutes to 35 minutes; according to the method, pulse type microwaves are matched with the composite acid to digest the express packaging material, the digestion solution with high digestion completeness is obtained, HP-beta-CD and DTPA are used as double ligands to synergistically extract heavy metals such as lead and cadmium, the selectivity is good, and the efficiency is high.

The embodiment of the invention provides a bromo-ethyl difluoroacetate-mediated novel amide dehydration cyaniding method, which comprises the following steps of: heating and reacting 0.2 mmol and 1.0 equivalent weight of amide compound and 0.6 mmol and 3.0 equivalent weight of bromo-ethyl difluoroacetate for 24 hours under an oil bath condition of 90 DEG C to generate an experimental reactant; concentrating the experimental reactant under reduced pressure to obtain a residue; and purifying the residue by silica gel rapid column chromatography to obtain the target product nitrile compound. According to the scheme, the process reaction conditions are mild, a strict anhydrous and anaerobic environment is not needed, the harsh requirements on equipment and operation are greatly reduced, and the production safety and practicability are improved. Acetone is used as a solvent, so that high-efficiency reaction can be realized, the solvent after reaction is convenient to recycle and recycle, the production cost and the environmental burden are remarkably reduced, and the remarkable green chemical engineering characteristic is embodied.

The invention belongs to the technical field of electrolysis, and discloses a method for preparing p-hydroxyanisole through electrolytic oxidation of anisole. The method comprises the following steps: S1, adding anisole, an acylation reagent, an organic alkali proton trapping agent and an alkaline amine group-containing solvent into a single-chamber electrolytic bath together, starting electrification, carrying out electrolysis, and obtaining a product liquid containing p-methoxytrifluoroacetic acid phenyl ester in the single-chamber electrolytic bath after electrolysis is finished; the organic base proton trapping agent is at least one of N, N-diisopropylethylamine, tributylamine and tripropylamine; and S2, adding a saturated sodium bicarbonate aqueous solution into the product liquid containing p-methoxytrifluoroacetic acid phenyl ester in the step S1 to hydrolyze p-methoxytrifluoroacetic acid phenyl ester, and extracting to obtain p-hydroxyanisole. The selectivity of para-position and ortho-position products of methoxyl on anisole is regulated and controlled, so that the selectivity of p-hydroxyanisole prepared by the method is higher.

This invention belongs to the field of responsive material production technology, specifically relating to a high-viscosity fluoropolymer solution and its applications. The preparation method of the high-viscosity fluoropolymer solution is as follows: (meth)acrylate naphthyl ester, fluorinated methacrylate, and vinylcarbazole are dissolved in a solvent and stirred to obtain a clear and transparent solution. Then, an initiator is added, and the mixture is heated to 60-90℃ under magnetic stirring for 16-24 hours to polymerize. After the reaction is completed, a transparent high-viscosity polymer solution with a viscosity range of 800-8000 Pa·s is obtained. After the high-viscosity fluoropolymer solution forms a film on the substrate, it forms an anti-counterfeiting coating that can be stimulated by ultraviolet light and trifluoroacetic acid, exhibiting excellent multi-stimulus responsiveness. The preparation method of this anti-counterfeiting coating is simple, has good film-forming properties, long service life, and low cost. It can be industrially produced and provides dual anti-counterfeiting capabilities, showing great application prospects in anti-counterfeiting, information encryption, and other fields.

The application relates to the field of biological medicine, and discloses an active oxygen response thione aldehyde linker as well as a preparation method and application thereof. The thione aldehyde linker structure is a thione aldehyde structure with a p-hydroxyphenyl as a center. The thione aldehyde carbon atom is connected with two -CH2CH2COOH groups through a sulfur atom. The preparation method of the active oxygen response thione aldehyde linker comprises the following steps: dissolving 3-mercapto propionic acid and p-hydroxybenzaldehyde in ethyl acetate, adding trifluoroacetic acid as a catalyst, stirring and reacting at room temperature, and after the reaction is completed, the thione aldehyde linker is obtained through separation and purification. The thione aldehyde linker can respond to the increased ROS level in a tumor microenvironment, is broken under a high ROS condition, and thus realizes the release of a drug molecule connected therewith, which is beneficial to realizing the specific release of the drug at a tumor site.

The invention relates to the field of macromolecules, and discloses a method for refining polyetherketoneketone and a polyetherketoneketone refined product. The method comprises the following steps: (1) treating a polyetherketoneketone complex by adopting a pretreatment agent; (2) the polyether ketone ketone crude product and a mixed chain supporting solution are mixed and washed, a first product is obtained, the mixed chain supporting solution comprises a main chain supporting agent and a cosolvent, the main chain supporting agent comprises one or more selected from parachlorophenol, trifluoroacetic acid, difluoroacetic acid, dichloroacetic acid and chloroacetic acid, the cosolvent comprises one or more selected from N, N-dimethylformamide and dimethyl sulfoxide, and the main chain supporting agent comprises one or more selected from dichlorophenol, trifluoroacetic acid, difluoroacetic acid, dichloroacetic acid and chloroacetic acid. The solvent is one or more of water, N-methyl pyrrolidone and N-methyl formamide; (3) adding a mixed aqueous solution into the first product to remove at least part of metal ions to obtain a second product; and (4) washing the second product for multiple times by using an organic solvent, and washing and drying to obtain the refined polyether ketone ketone. The content of aluminum ions in the polyetherketoneketone prepared by the method is low.

The present invention relates to a 13 C. 18 The synthesis method of trifluoroacetic acid with O stable isotope double labeling is as follows: firstly, trifluoroacetic acid is dissolved in a solvent, metal ions are added, and 13 C-labeled carbon dioxide, react to obtain a reaction solution, then separate and dry the reaction solution to obtain 13 C-enriched trifluoroacetic acid, and finally 13 C-enriched trifluoroacetic acid is dissolved in an aprotic solvent, thionyl chloride is added, stirred for reaction, and then a catalyst and oxygen 18 water are added, heated for reaction, and the reaction product is separated to obtain 13 C. 18 O stable isotope double labeled trifluoroacetic acid is the target product. Compared with the prior art, the present invention has a simple reaction process, a simple post-processing process, and a high yield. 13 The C isotope abundance is over 98%. 18 The O isotope abundance is over 97%.

The application relates to the field of liquid chromatography analysis, and provides a method for high-performance liquid chromatography analysis of DNA dyes, which comprises the following steps: performing high-performance liquid chromatography analysis on a DNA dye-containing sample to be measured; wherein the DNA dye comprises at least one of PicoGreen and SYBR Green I; the high-performance liquid chromatography analysis adopts gradient elution, and mobile phase A, mobile phase B and mobile phase C are mixed in different proportions as mobile phases; the mobile phase A comprises at least one of acetonitrile and methanol; the mobile phase B comprises at least one of phosphoric acid aqueous solution, formic acid aqueous solution and trifluoroacetic acid aqueous solution; and the mobile phase C comprises ammonium acetate aqueous solution. The method can be used for detecting the purity of Picogreen, SYBR Green I and the DNA dyes, and realizes effective separation of target peaks and impurity peaks.

This invention belongs to the field of biochemistry technology, and relates to a near-infrared chemiluminescent probe responsive to tau protein, its preparation method, and its application. The preparation method of the near-infrared chemiluminescent probe includes the following steps: adding compound (I), compound (II), a catalyst, and an alkaline additive to a first solvent for reaction to obtain compound (III); adding compound (III), compound (IV), and piperidine to a second solvent for reaction to obtain compound (V); adding compound (V) and trifluoroacetic acid to a third solvent for reaction to obtain compound (VI); and adding compound (VI), compound (VII), and an acid compound to a fourth solvent for reaction to obtain the near-infrared chemiluminescent probe. The chemiluminescent probe of this invention exhibits high selectivity and efficient chemiluminescence capability, providing a promising tool for the diagnosis of Alzheimer's disease (AD). Its structural formula is: [Insert structural formula here].

The present invention belongs to the field of medicinal chemistry and relates to a triazine-thiazolidinone compound and its preparation method and application. Its structural formula is wherein R1 is any one of alkyl, pyranyl, indolyl, phenyl or thienyl. Its pharmaceutically acceptable salt is the acid salt of the compound, and the acid is any one of hydrochloric acid, hydrobromic acid, sulfuric acid, phosphoric acid, boric acid, methanesulfonic acid, p-toluenesulfonic acid, naphthalenesulfonic acid, benzenesulfonic acid, citric acid, lactic acid, pyruvic acid, tartaric acid, acetic acid, trifluoroacetic acid, maleic acid, succinic acid, mandelic acid, fumaric acid, salicylic acid or phenylacetic acid. The triazine-thiazolidinone compound skeleton provided by the present invention is novel, has a good inhibitory effect on glucose transporter 1 (GLUT1), and its inhibitory effect in HT29 cells is much better than that of positive control compound BAY-876, with good potential for further development as an anti-tumor drug.

The application relates to the technical field of compound synthesis, and discloses an aromatic dipeptide functionalized mercapto compound, 3,5-di(triphenylmethylthio)benzoic acid is obtained by adding 3,5-di(methylmercapto)benzoic acid and pyridine into a solution of chloromethyl triphenylphosphonium, purifying after sufficient reaction; then the 3,5-di(triphenylmethylthio)benzoic acid is mixed with N-hydroxysuccinimide and dissolved in an organic solvent, EDC.HCl is added, purifying after sufficient reaction; then 2,5-dioxopyrrolidin-1-yl 3,5-bis(triphenylmethylthiomethyl)benzoate is obtained; then phenylalanine-tryptophan and triethylamine are added, purifying after sufficient reaction; then (3,5-bis(triphenylmethylthiomethyl)benzoyl)tryptophylphenylalanine is obtained; then trifluoroacetic acid and triethylsilane are added, purifying after sufficient reaction; and finally the aromatic dipeptide functionalized mercapto compound is obtained. The aromatic dipeptide functionalized mercapto compound can quickly and effectively identify sodium and potassium ions, and has relatively low detection limit and relatively loose detection condition.

The invention discloses an HPLC (High Performance Liquid Chromatography) detection method for ipragmine hydrochloride enantiomers, and belongs to the technical field of pharmaceutical analysis. The HPLC detection method provided by the invention comprises the following steps: dissolving ipragmine hydrochloride to be detected in a diluent to prepare a test solution; detecting the test solution by adopting normal-phase high performance liquid chromatography; the stationary phase of the normal-phase high performance liquid chromatography is silica gel of which the surface is covalently bonded with cellulose-tri (3-chloro-4-methyl phenyl carbamate); a mobile phase of the normal-phase high performance liquid chromatography is a mixed solution of normal hexane, isopropanol, trifluoroacetic acid and diethylamine. According to the detection method established by the invention, the ipragmine hydrochloride main peak and the S-configuration enantiomer impurity peak can be subjected to baseline separation, the separation degree can reach 4.5 or above, the method is high in specificity and sensitivity, and various methodology verification parameters all meet the drug quality control requirements.

The invention belongs to the technical field of biochemistry, and relates to a ratio type probe compound, a preparation method thereof, a Cu (I) response photoacoustic probe composition and application. The preparation method of the ratiometric probe compound comprises the following steps: (1) reacting a compound (I), a compound (II), acetic acid and piperidine to obtain a compound (III); (2) reacting the compound (III) with trifluoroacetic acid to obtain a compound (IV); (3) carrying out a reaction on the compound (IV), the compound (V), 2-(7-azabenzotriazole)-N, N, N ', N'-tetramethylurea hexafluorophosphate and 1-ethyl-(3-dimethylaminopropyl) carbodiimide hydrochloride, so as to obtain a compound (VI); and (4) reacting the compound (VI), the compound (VII), acetic acid and piperidine to obtain the compound. The photoacoustic probe provided by the invention has excellent selectivity and high sensitivity.

This invention discloses an acylhydrazone-linked covalent organic framework material, its preparation method, and its application, belonging to the field of covalent organic framework material synthesis technology. The preparation method of the acylhydrazone-linked covalent organic framework material is as follows: benzo[1,2-b:3,4-b':5,6-b”]trithiophene-2,5,8-tricarboxaldehyde, benzodiazepine, o-dichlorobenzene, and n-butanol are mixed to obtain suspension A; trifluoroacetic acid is added to suspension A and mixed to obtain mixture A; mixture A is sequentially subjected to freeze degassing and heating treatment, followed by extraction to obtain the final product. This invention uses benzo[1,2-b:3,4-b':5,6-b”]trithiophene-2,5,8-tricarboxaldehyde and benzodiazepine with a specific structure as main raw materials, and by adjusting the concentration, type, and amount of catalyst, an acylhydrazone-linked covalent organic framework material with higher crystallinity and stability is prepared.

The invention discloses a fluorine-containing medical intermediate ethyl difluoroacetate and a preparation method thereof, and belongs to the technical field of synthesis of organic fluorine compounds. The method comprises the following steps: firstly, taking tetrafluoroethylene and ethanol as raw materials, and reacting under the action of a basic catalyst to prepare an intermediate 1, 1, 2, 2-tetrafluoroethyl ether with stable properties; and then gasifying the intermediate, and performing catalytic cracking through a modified gamma-aluminum oxide catalyst bed layer subjected to specific high-temperature pre-fluorination treatment under the mild condition of 160-190 DEG C to generate high-activity difluoroacetyl fluoride in situ, and finally, directly introducing the cracking gas containing difluoroacetyl fluoride into a low-temperature reaction solution containing ethanol and an acid-binding agent without separation, and carrying out esterification reaction. According to the method, a brand-new synthesis route and a special catalyst are adopted, reaction conditions are mild, the cracking step selectivity is high, the production efficiency and the total yield are remarkably improved through integrated process design, and the technological process is simple, safe and reliable.

The application relates to the technical field of organic synthesis, in particular to a preparation method of ethyl difluoroacetate, which comprises the following steps: S1, 2,2-difluoro-1,1-dichloroethyl ethyl ether is added into a reaction kettle, concentrated sulfuric acid is added dropwise under stirring at a certain reaction temperature, after the dropwise addition is completed, the reaction is continuously kept for reaction completion, and a compound shown in formula I is obtained; S2, water is added into a reaction container, the compound shown in formula I prepared in the step S1 is added dropwise into the reaction container for hydrolysis reaction at a certain temperature, after the reaction is completed, the reaction is allowed to stand and is separated into layers, and the lower organic layer is ethyl difluoroacetate; the application has the advantages of simple process, easily obtained raw materials, mild reaction conditions, easy control, high product yield, few by-products, reaction condition detection at any time, one-time reaction completion, secondary recovery treatment avoidance, raw material loss reduction and easy industrialized production.

The present invention discloses an SBA molecular sieve encapsulated with nano-metal atoms, its preparation method, and its application in the direct vapor-phase epoxidation of propylene. The preparation method comprises the following steps: 1) mixing SBA molecular sieve raw powder with a passivating agent for a first reaction, then mixing with an alkaline solution for a second reaction, filtering, washing, and mixing with a metal complex solution to obtain solution A, wherein the metal complex is selected from at least one of haloauric acid, haloauric acid salt, haloplatinic acid, haloplatinic acid salt, sodium chloropalladate, palladium trifluoroacetate, and sodium tetrabromopalladate; 2) mixing an organic template, water, an acid, and a silicon source to form a gel to obtain solution B; 3) mixing solutions A and B and performing hydrothermal crystallization, filtering, washing, drying, and calcining. In the molecular sieve prepared by this method, the nanoparticles are all located in the molecular sieve pores, thereby improving the catalytic performance of the catalyst. During the direct vapor-phase epoxidation of propylene, the catalyst exhibits excellent propylene oxide selectivity.

The application belongs to the technical field of biochemistry, and relates to a ratio type probe compound, a preparation method thereof, a Cu(I) response photoacoustic probe composition and application. The preparation method of the ratio type probe compound comprises the following steps: (1) reacting compound (I), compound (II), acetic acid and piperidine to obtain compound (III); (2) reacting compound (III) and trifluoroacetic acid to obtain compound (IV); (3) reacting compound (IV), compound (V), 2-(7-azabenzotriazole)-N,N,N',N'-tetramethyluronium hexafluorophosphate and 1-ethyl-(3-dimethylaminopropyl) carbodiimide hydrochloride to obtain compound (VI); and (4) reacting compound (VI), compound (VII), acetic acid and piperidine to obtain the compound. The photoacoustic probe provided by the application has excellent selectivity and high sensitivity.

The invention relates to the technical field of batteries, in particular to a wide-temperature-range high-rate lithium battery ester-based electrolyte and application. The electrolyte comprises soluble lithium salt and a liquid component, the liquid component is a solvent; the solvent comprises at least three of propylene carbonate, fluoroethylene carbonate, isopropyl trifluoroacetate, ethyl trifluoroacetate, ethyl acetate, methyl acetate and methyl trifluoroacetate; the lithium salt lithium battery comprises at least two of common lithium salts. The electrolyte developed by the invention is used in the lithium battery and can stably work at 40-60 DEG C, the specific discharge capacity of the battery is still 62.83% of the specific discharge capacity of the battery at room temperature even at 30 DEG C and 4C multiplying power, and the electrolyte has excellent wide-temperature fast charge performance. In addition, the electrolyte effectively inhibits the growth of lithium dendrites and the side reaction of an electrode-electrolyte interface at low temperature, and promotes the formation of a solid interface film which is rich in inorganic matters and low in interface impedance. The invention has the advantages of reasonable component design and excellent product performance, and is convenient for industrial application.

The utility model relates to the technical field of trifluoroacetic acid processing, and discloses a solvent separation system for trifluoroacetic acid production. The first-stage extraction tanks and the second-stage extraction tanks are arranged, and one second-stage extraction tank corresponds to a plurality of first-stage extraction tanks, so that in the extraction layering process of the plurality of first-stage extraction tanks, liquid at a part of boundary lines can be fed into the second-stage extraction tanks to be extracted again, on one hand, continuous operation of the whole equipment is guaranteed, and on the other hand, the extraction efficiency is improved; on the other hand, the purity of the extracted finished product is improved. The liquid outlet pipe is respectively connected with the first discharge pipe, the second discharge pipe and the first pipeline to respectively correspond to the lower-layer liquid, the liquid at the middle interface and the upper-layer liquid of the first extraction tank, and the liquid is respectively drained into the first liquid collecting tank, the second liquid collecting tank and the material collecting tank.

The invention discloses an alpha-amino amide derivative and a synthesis method thereof. According to the synthesis method of the alpha-amino amide derivative, halogenated difluoroacetate, aromatic aldehyde or alkyl aldehyde and alkylamine or aromatic amine are used as raw materials, under the catalysis of metal copper salt, Bronsted acid is used as an additive, an organic reagent is used as a solvent, and the alpha-amino substituted amide derivative is obtained through a one-step reaction. The raw materials are cheap, easy to obtain, safe and non-toxic, the reaction conditions of the synthesis method are mild, the operation is simple and safe, and the synthesized alpha-amino substituted amide derivative can be widely applied to the fields of organic synthesis and drug research and development.