216 results about "Fucoidan" patented technology

The invention discloses application of fucoidin degrading enzyme OUC-MgFucD1 in preparation of fucoidin oligosaccharide, and belongs to the technical field of preparation of the fucoidin oligosaccharide. The amino acid sequence of the fucoidin degrading enzyme OUC-MgFucD1 is as shown in SEQ ID NO. 1, and the fucoidin degrading enzyme OUC-MgFucD1 is as shown The fucose oligosaccharide is fucose, fucodisaccharide and fucotriose, the molecular formula of the fucose is C6H12O8S, the molecular formula of the fucodisaccharide is C12H22O15S2, and the molecular formula of the fucotriose is C18H32O16S. The invention further discloses a preparation method of the fucose oligosaccharide. The fucoidin degrading enzyme OUC-MgFucD1 disclosed by the invention can specifically act on fucoidin, and a specific fucoidin oligosaccharide combination is generated by precisely cutting a main chain glucosidic bond of the fucoidin. The invention provides a key technical support for the development of high-added-value fucoidan oligosaccharide products, and has important significance for promoting the industrial application of the fucoidan oligosaccharide in the fields of functional foods, biological medicines and the like.

The invention discloses a preparation method of sargassum fusiforme low-molecular-weight fucoidin with an auxiliary protection effect on chemical liver injury. The preparation method comprises the following steps: S1, degreasing treatment; s2, preparing crude polysaccharide; s3, degradation of crude polysaccharide: dissolving the sargassum fucoidin crude product with water to obtain a polysaccharide solution, and performing ultrasonic treatment; then, H2O2 is added for degradation, and the sargassum fusiforme low-molecular-weight fucoidin DSFF is obtained; and S4, purification: dissolving the sargassum fusiforme low-molecular-weight fucoidin DSFF in water to obtain a polysaccharide solution, loading the polysaccharide solution on a DEAE-52 cellulose anion exchange column, eluting with a NaCl-phosphate buffer solution, dialyzing and desalting the eluent, and freeze-drying to obtain the sargassum fusiforme low-molecular-weight fucoidin DSFF2. The sargassum fusiforme low-molecular-weight fucoidin prepared by the method can be used for preparing medicines with an auxiliary protection effect on chemical liver injury. The research of the invention lays a foundation for the development of liver protection products related to sargassum fucoidin.

The invention discloses a medicinal and edible anti-alcoholism composition and a preparation method thereof, and relates to the crossing field of biotechnology and food and medicine, the composition comprises the following components: dried orange peel powder, vitamin C, glutathione, phellinus igniarius extract, polygonatum sibiricum extract, oriental wormwood extract, isatis root extract, schisandra chinensis extract, ginseng powder, lucid ganoderma extract and licorice extract. Silymarin, puerarin, white tomato powder, watermelon powder, fucoidin, tomato powder, mung bean powder, celery powder, turmeric powder, hawthorn fruit powder, honey powder, corn peptide, soybean peptide powder, xanthan gum and stevioside are added. The composition provided by the invention has the effect of increasing the content of ethanol dehydrogenase and acetaldehyde dehydrogenase in blood after drinking, and has the capability of promoting alcohol metabolism.

The invention relates to the field of pharmacy, and discloses a Chinese herbal medicine and marine extract combined antibacterial and anti-inflammatory pharmaceutical composition which comprises the following components in parts by weight: 5-10 parts of baicalin extract; 3 to 7 parts of an andrographolide extract; 2-5 parts of sulfated brown algae polysaccharide; 0.2 to 1 part of sponge extract; wherein the baicalin extract is derived from roots of scutellaria baicalensis and is obtained by extracting with an ethanol-water mixed solvent; the andrographolide extract is derived from the whole herb of andrographis paniculata and is obtained by extracting with an ethanol-water mixed solvent; the sulfated fucoidan is derived from fucoidan and is prepared by enzymolysis and alcohol precipitation methods; the sponge extract is derived from sponge and is obtained by organic solvent extraction, separation and purification. By adopting the technical scheme of synergistically compounding the Chinese herbal medicine active ingredients and the marine extract, the technical effects of destroying a biological membrane barrier and removing stubborn infection lesions in treatment of bacterial vaginitis, candida vaginitis associated biological membrane infection and cervicitis are achieved.

The invention relates to an algin sulfate (PMGS) patch as well as a preparation method and application thereof, and belongs to the technical field of medicines. According to the application, the fucoidan polysaccharide sulfate (PMGS) is used as a main raw material of the microneedle for the first time, the needle tip is completely composed of PMGS, the PMGS plays a role in medicine and adjuvant integration, on one hand, the PMGS is used as a needle tip matrix to provide enough mechanical strength to pierce warts and surrounding skin and is more suitable for related warts with obvious skin thickening, and on the other hand, the PMGS is diffused and released at the position where viruses are located, so that the effect of preventing and treating warts is achieved. The skin wart treatment effect is achieved by preventing virus from entering and enhancing skin immunity, compared with a previous authorized patent scheme, the problems that PMGS as macromolecular polysaccharide enters the skin and is insufficient in absorption are solved in a microneedle mode, PMGS can be directly delivered to basal layer cells where HPV is located, and fixed-point drug delivery is achieved.

The invention relates to the technical field of lipidosome compounds, in particular to a cosmetic lipidosome compound with an anti-allergy effect and a preparation method of the cosmetic lipidosome compound. The preparation method of the cosmetic liposome compound with the anti-allergy effect comprises the steps of preparation of a wrapping modification modifier, preparation of wrapping modification liposome and preparation of the cosmetic liposome compound. Efficient allergy relieving is achieved through the synergistic effect of the hovenia dulcis thunb extract and the white willow bark extract. The former inhibits release of inflammatory factors and scavenges free radicals, the latter reduces synthesis of prostaglandin and promotes epidermal renewal, and the former and the latter form a dual anti-inflammatory network, cooperate with lipid, regulate water and oil and accelerate inflammation regression. Meanwhile, the two extracts are wrapped by lipidosome, and a modifier formed by zein and fucoidin is combined, so that the stability of the lipidosome is enhanced, the percutaneous delivery efficiency and the percutaneous absorption effect of the components are improved through multiple effects, and it is ensured that the active components effectively exert the anti-allergy effect.

The invention discloses an amino acid water-soluble fertilizer and a production process thereof, and relates to the technical field of water-soluble fertilizers. Free amino acid is used as an organic nitrogen source, and the medium element calcium is combined, so that the crop quality is improved. The formula is low in cost, high in absorptivity, suitable for crop growth, simple and convenient to use and high in cost performance, and promotes the synergistic effect of nutrient elements. The method takes amino acid and calcium as raw materials, and has the characteristics of wide applicability, high output-input ratio and easiness in market promotion. The product is completely water-soluble, environment-friendly and safe, can regulate the physiological function of crops, increase the yield and amino acid content and improve the quality, and has remarkable economic benefits. In addition, activated ricinoleic acid carboxyl is combined with fucoidan enzymatic hydrolysis oligosaccharide to construct the microcapsule, so that efficient utilization of resources is realized.

The invention discloses a pharmaceutical composition for preventing and treating chronic atrophic gastritis. The pharmaceutical composition is prepared from the following raw materials in the following weight ratio: 14-18 parts of peach kernel, 10-14 parts of Chuanxiong rhizome, 8-12 parts of Panax notoginseng, 6-10 parts of safflower, 20-28 parts of kelp, 10-14 parts of selfheal, 15-25 parts of codonopsis pilosula, 10-14 parts of atractylodes macrocephala, 12-16 parts of fructus aurantii, 8-12 parts of amomum villosum, 12-16 parts of bupleurum, 10-18 parts of citron, and 5-10 parts of fucoidan. The pharmaceutical composition is used to treat chronic atrophic gastritis of gastric collateral blood stasis type by promoting blood circulation and removing blood stasis, unblocking meridians and relieving pain, eliminating phlegm, softening and dispersing nodules, invigorating qi and promoting qi circulation, and soothing the liver and harmonizing the stomach. The invention also discloses a preparation method of the pharmaceutical composition.

The invention discloses low-hydration-heat iron aluminate cement and a preparation method thereof, and belongs to the technical field of maritime work cement, and the low-hydration-heat iron aluminate cement comprises 70-85 parts of iron aluminate cement clinker, 5-7 parts of a bio-based retarder, 4-8 parts of a nano friction regulator, 3-4.5 parts of a microcapsule dual repair agent, 5-10 parts of gypsum and 15-25 parts of a mixed material. The fucoidan polysaccharide sulfate and calcium ions in a cement hydration product form a complex through sulfate groups in molecules of the fucoidan polysaccharide sulfate, and further hydration of cement particles is prevented, so that the early heat release rate is effectively reduced, temperature cracks are prevented from being generated in a concrete structure, and the stability and durability of the structure are improved. According to the microcapsule dual-repairing agent, the problem of delayed volume expansion of the steel slag powder caused by fluctuation of the content of free calcium oxide is effectively solved through the matching effect of the inner-layer repairing agent and the outer-layer carrier. According to the gradient clinker sintering process, mineral distribution and chemical reaction paths in clinker are optimized, so that the generation amount of cement hydration heat is remarkably reduced, and meanwhile, the thermal stability of slurry is improved.

The invention belongs to the technical field of functional preparations, and discloses a composite emulsion for improving insomnia and a preparation method thereof. The composite emulsion is prepared from the following components in percentage by volume: 70 to 95 percent of modified fucoidin solution with the concentration of 0.5 to 3 mg / mL, and the balance of melatonin-containing medium chain triglyceride, the content of the melatonin in the composite emulsion is 0.02 wt%. The compound emulsion is strong in stability and high in bioavailability, and can effectively resist an acid environment in a stomach and protect melatonin from being delivered to intestinal tracts. Through verification, the average core sleep duration of a subject taking the compound emulsion is increased by 21.05% compared with that of the subject taking melatonin only; the average waking time is shortened by 40% compared with that of melatonin, and the effect is remarkable.

The invention discloses a high-temperature-resistant mining high-wetting type spray dust-settling material and a preparation method thereof, and relates to the technical field of spray dust removal, the high-temperature-resistant mining high-wetting type spray dust-settling material comprises the following raw materials by weight: 3-10 parts of fucoidan, 1.5-5.5 parts of citric acid, 3-9 parts of polyurethane, 2-7 parts of sodium hydroxide, 2-8 parts of a condensation reagent, 2-7 parts of a catalyst, 6-12 parts of a wetting agent, and 2-10 parts of a water-retaining agent. And the balance of distilled water. The preparation method comprises the following steps: preparing a fucoidan aqueous solution; adding citric acid into the fucoidan aqueous solution, and adjusting the pH value to prepare a modified solution I; preparing a polyurethane aqueous solution; adding a polyurethane aqueous solution into the modified solution I, and adding a condensation reagent and a catalytic reagent to prepare a modified solution II; and adding a wetting agent and a water-retaining agent into the modified solution II to obtain the high-temperature-resistant mining high-wetting type spray dust-settling material. The high-temperature-resistant mining high-wettability spray dust-settling material prepared by the invention has various excellent properties such as high wettability, high temperature resistance and high dust suppression efficiency.

The invention relates to the technical field of papermaking, in particular to food waterproof and oilproof paper and a preparation method thereof.The food waterproof and oilproof paper is composed of base paper and a coating layer covering the surface of the base paper; the base paper is prepared from the following raw materials: sisal fibers, polylactic acid fibers, water glass, nano silicon dioxide, starch and polyacrylamide; preparing a coating layer: coating the surface of base paper with the coating liquid, and then drying and calendering to obtain the coating layer; the coating liquid is prepared from the following raw materials: modified fucoidin, poly (butylene succinate), modified nano cellulose, sorbitol, polysilicate aluminum sulfate, polyvinyl alcohol, sodium thiosulfate and water. Through matching and combination of the raw materials, the food waterproof and oil-proof paper has certain antibacterial property and strength while improving waterproof and oil-proof properties, and the food fresh-keeping effect is improved.

The invention discloses a water-retaining agent as well as a preparation method and application thereof, and relates to the technical field of high polymer materials. The preparation method of the water-retaining agent comprises the following steps: providing the cross-linking agent; providing an alginate oligosaccharide dispersion liquid, wherein the alginate oligosaccharide dispersion liquid comprises alginate oligosaccharide and a first solvent; adding acrylic acid into the alginate oligosaccharide dispersion liquid, and reacting to obtain a base material; and mixing the cross-linking agent and the base material, and reacting to obtain the water-retaining agent. The water-retaining agent prepared by the preparation method of the water-retaining agent provided by the invention has high water absorption, urea slow release function, plant nutrition absorption stimulation function and high mechanical toughness, and has wide application prospects.

The invention relates to a fungus-diatom synergistic immunopotentiator for stichopus japonicus, and belongs to the technical field of microbial engineering and echinoderm immunology. The immunopotentiator is a symbiont microsphere taking yarrowia lipolytica and navicula seminuda as main components; the method comprises the following steps: respectively activating yarrowia lipolytica and navicula seminuda, carrying out expanding culture, resuspending, and adjusting the concentrations of a bacterial solution and algae cells; the preparation method comprises the following steps: adding a navicula seminuda concentrated solution and a yarrowia lipolytica suspension into a triangular flask containing a YPD liquid culture medium, adding selenium-containing fucoidan polysaccharide sulfate accounting for 0.4-1.2% of the total mass of microspheres, carrying out constant-temperature shake culture, filtering by using sterile gauze to obtain microspheres, and flushing by using sterile normal saline to obtain fungus-diatom symbiont microspheres; the yarrowia lipolytica, the navicula seminuda and the selenium-containing fucoidan polysaccharide sulfate in the prepared immunopotentiator are mutually beneficial and have a synergistic effect, and the non-specific immune function of the stichopus japonicus is comprehensively improved by improving the growth index, enhancing the activity of immune enzyme and digestive enzyme and improving the disease resistance.

The invention relates to technical development and application of new special medical food on the basis of a new food raw material framework, and belongs to the technical field of special medical purpose formula food (FSMP). According to the series of foods, new food raw materials (euglena, haematococcus pluvialis and ampelopsis grossedentata leaves) are taken as cores, medicinal and edible components (lotus leaves, haws and mulberry leaves) and marine active substances (fucoidan polysaccharides and chitin) are combined, functional factors are extracted through a prehydrolysis SBE technology and a biological enzymolysis technology, and the bioavailability is improved by adopting a nano-carrier technology. The product comprises a total nutrient base material (20-30% of protein and 15-25% of dietary fiber), functional components (10-15% of a new food raw material extract and 8-12% of a traditional Chinese medicine extract) and a metabolism regulator (conjugated linoleic acid and L-carnitine). Clinical tests show that after an obese patient takes 400 kcal of the replacement meal every day, the weight of the obese patient is reduced by 10.2 kg on average (4.8 kg of a control group) 12 weeks later, and the body fat rate is reduced by 16.3%. The product supports line iteration (such as powder, tablets and liquid food) through modular formula design, and fills the application blank of new food raw materials in special medical food.

The invention discloses a water-soluble fertilizer for preventing and treating leaf yellowing after cucumber vine falling and a prevention and treatment method, and mainly relates to the technical field of cucumber cultivation. The water-soluble fertilizer is prepared from the following raw materials: alginate oligosaccharide, bacillus velezensis fermentation liquor, amino acid, an inorganic salt composition, polypeptide, melatonin, a surfactant and water, wherein the ratio of the alginate oligosaccharide to the bacillus velezensis fermentation liquor is 1: (2-3). The invention has the following beneficial effects: through an alginate oligosaccharide-bacillus velezensis synergistic system, the anti-infection ability of cucumbers to harmful germs is improved; the bacillus metabolite can further synergistically interact with the alginate oligosaccharide, so that the root system of the cucumber is more robust, the problem of leaf yellowing after cucumber vine falling is effectively prevented and treated, and the purposes of robust leaf stalks, dark green leaves and straight and bright cucumber strips are achieved.

The invention discloses a preparation method of a fucoidan oligomer, which realizes efficient degradation of fucoidan under specific conditions by strictly controlling the addition amount of TEMPO, sodium bromide and sodium hypochlorite. Specifically, the ratio of the addition amount of TEMPO to the mass of fucoidan sulfate is 0.5-5%, the ratio of sodium bromide to fucoidan sulfate is 5-40%, the use amount ratio of fucoidan sulfate to sodium hypochlorite is 1 g: (0.1-10) mmoL, strong acid or enzyme preparations do not need to be added, and auxiliary means such as microwaves or ultrasound are not depended on, so that the preparation process is simple, and the preparation cost is low. The oligomer with the average molecular weight lower than 80 kDa can be obtained within one hour, the oligomer with the average molecular weight about 20 kDa can be obtained within four hours, and meanwhile the content of sulfate groups is kept to be about 25%. The functional groups of the fucoidan are hardly damaged, and the prepared oligomer has a remarkable effect in the aspect of in-vitro anticoagulant activity.

The invention relates to the technical field of high polymer materials, in particular to a preparation method and application of double-modified cross-linked hyaluronic acid gels, the method adopts natural active matters to perform double modification on hyaluronic acid, and comprises the following steps: firstly, performing primary cross-linking on fucoidan, hyaluronic acid and salts thereof under proper conditions to form a stable core structure; carrying out secondary crosslinking on calycosin and the fucoidan hyaluronic acid gel subjected to the primary crosslinking, so as to form a hydrophobic outer layer; through introduction of a non-polar group on calycosin, the crosslinked fucoidan-hyaluronic acid-calycosin composite gel is formed, and the gel has a hydrophilic / hydrophobic vesicle structure at the same time; any chemical cross-linking agent does not need to be used, adverse reactions caused by cross-linking agent residues are avoided, meanwhile, the elastic modulus and the mechanical strength of the gel are optimized by adopting a mode of combining high-temperature and low-temperature step-by-step cross-linking reactions, and the gel can be used for medical filling materials, slow-release carriers or preparation of skin care products.

The application discloses a method for inhibiting growth of pseudomonas by using fucoidan and application thereof, and is characterized in that the fucoidan is a degradation product of natural seaweed (sodium alginate), and is a linear oligosaccharide with a polymerization degree of 2-25 and composed of guluronic acid and mannuronic acid, and has the advantages of safety, health and no toxic side effects; in combination with the research of the inventors that the fucoidan can target and inhibit growth of pseudomonas in vitro and in intestinal flora, the fucoidan can meet the demand of practical application, can be used for delaying corruption and deterioration of fresh food caused by pseudomonas, and can be used for inhibiting growth of pseudomonas on the surface or in the body of aquatic products or fresh food, and has good application prospect and safety.

The present invention provides a fucoidan kombucha nutrient beverage and a preparation method thereof, belonging to the field of food processing. In a first aspect, the present invention provides a fucoidan kombucha nutrient beverage, the raw materials of which include water, oligofructose, lychee juice concentrate, kombucha fermentation broth, selenium-enriched black fungus peptide, fucoidan, calcium lactate, pectin, vitamin C, sodium hyaluronate, instant black tea powder, and taurine. In a second aspect, the present invention also provides a method for preparing the fucoidan kombucha nutrient beverage. Compared with existing technologies, the fucoidan kombucha nutrient beverage has significantly improved stability, flavor, taste, aftertaste, and anti-fatigue performance.

The invention relates to the technical field of floridoside and an isomer monomer thereof, and discloses a method for preparing high-purity floridoside and an isomer monomer thereof on a large scale, which is used for carrying out large-scale preparation and purification research on the high-purity floridoside and the isomer monomer thereof and preparing the floridoside and the isomer monomer thereof from a porphyra haitanensis crude extract. And the structure and purity of the compound are identified. The method comprises the following steps: firstly, by utilizing a DART-MS technology, through a single factor experiment, optimizing experiment parameters such as extraction times and elution, and obtaining optimal extraction efficiency; and secondly, based on a two-step purification method of a prep-HPLC (Prep-High Performance Liquid Chromatography) technology, enriching the target compound by using a reversed-phase (C18) mode stationary phase in the first step, and separating the pair of isomers by using a normal-phase (NH3) mode stationary phase in the second step. The obtained floridoside and isomer monomers thereof are subjected to structure and purity identification by mass spectrometry (MS) and nuclear magnetism (NMR). Results are as follows: the two compounds are identified as floridoside and isomers thereof through high-resolution mass spectrometry, and the purities of the floridoside and the isomers thereof are up to 99.5% or above.

The application belongs to the technical field of cosmetics, and discloses a fucoidan polysaccharide composition with bacteriostatic efficacy, and a preparation method and application thereof. The fucoidan polysaccharide composition comprises phaeophycus triquetrum fucoidan, small new moon rhombus fucoidan and false micro-halochain fucoidan, and the mass ratio of the phaeophycus triquetrum fucoidan, the small new moon rhombus fucoidan and the false micro-halochain fucoidan is (1-2):(1-2):(1-2). The fucoidan polysaccharide composition is prepared by compounding specific phaeophycus triquetrum fucoidan, small new moon rhombus fucoidan and false micro-halochain fucoidan, has a synergistic effect, and has excellent antibacterial efficacy. When the fucoidan polysaccharide composition is applied to cosmetics, it has good formula adaptability, does not affect the exertion of efficacy and the stability of the cosmetics.

The present application relates to the field of pharmacy, disclose the medicine composition for antibacterial and anti-inflammatory of Chinese herbal medicine and marine extract combination, including: baicalin extract 5~10 parts; andrographolide extract 3~7 parts; sulfated fucoidan 2~5 parts; spongin extract 0.2~1 part; wherein: baicalin extract is derived from the root of scrophulariaceae, is extracted by ethanol-water mixed solvent; andrographolide extract is derived from the whole plant of andrographis, is extracted by ethanol-water mixed solvent; sulfated fucoidan is derived from brown algae, is prepared by enzymolysis and alcohol precipitation method; spongin extract is derived from sponges, is extracted and separated and purified by organic solvent. Through the technical scheme of the synergistic combination of active ingredients of Chinese herbal medicine and marine extract, the technical effect of destroying the biofilm barrier and clearing the stubborn infection focus in the treatment of bacterial vaginitis, candida vaginitis and cervical inflammation associated with biofilm infection is achieved.

The invention discloses a lutein composition for relieving asthenopia and a preparation method of the lutein composition, and belongs to the field of functional foods. Phycocyanin and kelp polyphenol are mixed and react to obtain modified phycocyanin; fucoidin and beta-glucuronidase are mixed and react to obtain modified fucose; mixing the fish collagen peptide and zinc chloride to react to obtain a collagen peptide-zinc chelate; the xanthophyll siliceous cage compound and the modified phycocyanin are mixed and react to obtain a first compound; mixing and reacting the first compound and modified fucose to obtain a second compound; mixing and reacting the second compound, collagen peptide-zinc chelate and krill oil to obtain a lutein compound; mixing and reacting the second compound, collagen peptide-zinc chelate and krill oil, adding trehalose, and mixing and reacting to obtain a xanthophyll compound; and mixing the xanthophyll compound and maltodextrin to obtain the xanthophyll composition.

The invention relates to the technical field of pet oral health care, in particular to a compound seaweed source composition for assisting in improving oral health of dogs and cats and application of the compound seaweed source composition. The invention discloses a compound seaweed source composition for assisting in improving oral health of dogs and cats. The compound seaweed source composition comprises sodium alginate and fucoidan, the value of mannuronic acid (M) / guluronic acid (G) in the sodium alginate is 0.96-1.18; the fucoidan is prepared from mannose, glucuronic acid, galactose, xylose and fucose; the weight ratio of the sodium alginate to the fucoidan is 9: 2. The compound seaweed source composition disclosed by the invention has the effects of inhibiting the proliferation of pathogenic bacteria in the oral cavity of a pet, slowing down the rising rate of health indexes of the oral cavity of the pet, inhibiting the generation of volatile organic compounds and ammonia gas in the oral cavity, improving saliva components, slowing down the generation of dental plaque and the like, and can effectively improve the health condition of the oral cavity of the pet.

The invention discloses application of a fucoidin degradation product Fuc-S in a pharmaceutical composition for preventing, relieving or treating type 2 diabetes mellitus and liver injury, and relates to the technical field of biological medicines. The invention provides a new effect of fucoidin Fuc-S in treating diabetic liver injury, and particularly, the fucoidin Fuc-S can significantly improve blood glucose control (reducing fasting blood glucose and enhancing sugar tolerance) and blood lipid spectrum (reducing TG, TC and LDL-C and increasing HDL-C) of diabetic mice, alleviate liver fatty degeneration and reduce serum ALT / AST level, and shows a significant liver protection effect. Furthermore, the Fuc-S can be used for remodeling the intestinal flora structure through specific enrichment of beneficial bacteria such as Bacteroides acdifaciens and the like, so that the generation of short-chain fatty acid (SCFAs) with a liver protection effect is promoted. The flora and metabolic change jointly improve the oxidative stress state of the liver, inhibit pro-inflammatory response and reduce lipid accumulation. The invention provides a novel nutrition intervention strategy for prevention and treatment of T2DM and liver complications thereof.

The invention provides a planting method for promoting early maturing and high yield of spring wheat in Ningxia irrigated areas, and belongs to the technical field of crop regulation and control. The method comprises the following steps: soaking seeds with a seed soaking agent, and then early sowing from February 15th to February 25th; the seed soaking agent is prepared from 5 to 10g / L of calcium chloride, 2 to 3g / L of alginate oligosaccharide, 100 to 200mg / L of proline and 0.05 to 0.12 mg / L of brassinolide. Through the synergistic effect of the calcium chloride, the alginate oligosaccharide, the proline and the brassinolide, the germination rate of the early sowing spring wheat seeds at the low temperature of 5 DEG C is increased to 85% or above, the problem of poor spring wheat seedling emergence caused by early sowing low temperature is solved, and the purpose of early maturing without yield reduction is achieved.

Applicants have discovered differential expression and activity of various miRNAs in neurodegenerative diseases. These miRNAs can serve as therapeutic targets for prevention and treatment of neurodegenerative diseases. Accordingly, embodiments of the invention include formulations and methods for treating neurodegenerative diseases such as dementia and Alzheimer's disease. The formulations and methods can include five microRNAs and two small molecule therapeutics. In aspects, the miRNAs are MIR-145-3p, let-7c-3p, MIR-383-5p, MIR-548aj-3p and MIR-548x-3p. In aspects, the small molecule therapeutics are GATC-49, fucosterol and fucoidan. In aspects, the compounds work synergistically with one another.

The invention discloses a rosaxostat pharmaceutical composition. The pharmaceutical composition is prepared from rosaxostat, fucoidan, a filling agent, a disintegrating agent and a lubricating agent. In the research process, it is found that the dissolution rate of the rosaxostat can be improved by mixing the rosaxostat compound and the fucoidan polysaccharide sulfate, and photodegradation impurities can be reduced; the preparation method of the rosaxostat capsule is obtained through further research, and through fluidized bed wet granulation, the dissolution effect and the stability are remarkable and are obviously superior to those of an existing preparation. The method is simple, easy to operate and suitable for industrial production.

The invention provides a compound feed additive for relieving stress response of marine fishes, which is prepared by the following steps: mixing raw materials such as hermetia illucens protein and the like to prepare a premix, and embedding the premix by using a lac-glycyrrhizic acid system to prepare lac microcapsules; then modifying the fucoidin by adopting glycyrrhizin and gamma-linolenic acid, embedding rhodosporidium palustris and bacillus pumilus by using the fucoidin to prepare compound bacterium nano-particles, and finally mixing the lac microcapsules and the compound bacterium nano-particles in proportion. According to the invention, excessive secretion of cortisol of marine fish can be effectively inhibited, hermetia illucens protein provides rich nutrition and reduces muscle decomposition, and compound microorganisms are beneficial to maintaining intestinal microecological balance and improving the utilization rate of nutrition. The prepared compound feed additive can be directly splashed into a culture or transportation water body or added into a feed, so that the stress reaction of the marine fish is effectively relieved, the survival rate of the marine fish is increased, and powerful support is provided for culture of the marine fish.