95 results about "Fucoidan" patented technology

The application belongs to the technical field of cosmetics, and discloses a fucoidan polysaccharide composition with bacteriostatic efficacy, and a preparation method and application thereof. The fucoidan polysaccharide composition comprises phaeophycus triquetrum fucoidan, small new moon rhombus fucoidan and false micro-halochain fucoidan, and the mass ratio of the phaeophycus triquetrum fucoidan, the small new moon rhombus fucoidan and the false micro-halochain fucoidan is (1-2):(1-2):(1-2). The fucoidan polysaccharide composition is prepared by compounding specific phaeophycus triquetrum fucoidan, small new moon rhombus fucoidan and false micro-halochain fucoidan, has a synergistic effect, and has excellent antibacterial efficacy. When the fucoidan polysaccharide composition is applied to cosmetics, it has good formula adaptability, does not affect the exertion of efficacy and the stability of the cosmetics.

The present application relates to the field of pharmacy, disclose the medicine composition for antibacterial and anti-inflammatory of Chinese herbal medicine and marine extract combination, including: baicalin extract 5~10 parts; andrographolide extract 3~7 parts; sulfated fucoidan 2~5 parts; spongin extract 0.2~1 part; wherein: baicalin extract is derived from the root of scrophulariaceae, is extracted by ethanol-water mixed solvent; andrographolide extract is derived from the whole plant of andrographis, is extracted by ethanol-water mixed solvent; sulfated fucoidan is derived from brown algae, is prepared by enzymolysis and alcohol precipitation method; spongin extract is derived from sponges, is extracted and separated and purified by organic solvent. Through the technical scheme of the synergistic combination of active ingredients of Chinese herbal medicine and marine extract, the technical effect of destroying the biofilm barrier and clearing the stubborn infection focus in the treatment of bacterial vaginitis, candida vaginitis and cervical inflammation associated with biofilm infection is achieved.

The invention provides a planting method for promoting early maturing and high yield of spring wheat in Ningxia irrigated areas, and belongs to the technical field of crop regulation and control. The method comprises the following steps: soaking seeds with a seed soaking agent, and then early sowing from February 15th to February 25th; the seed soaking agent is prepared from 5 to 10g / L of calcium chloride, 2 to 3g / L of alginate oligosaccharide, 100 to 200mg / L of proline and 0.05 to 0.12 mg / L of brassinolide. Through the synergistic effect of the calcium chloride, the alginate oligosaccharide, the proline and the brassinolide, the germination rate of the early sowing spring wheat seeds at the low temperature of 5 DEG C is increased to 85% or above, the problem of poor spring wheat seedling emergence caused by early sowing low temperature is solved, and the purpose of early maturing without yield reduction is achieved.

The invention discloses a rosaxostat pharmaceutical composition. The pharmaceutical composition is prepared from rosaxostat, fucoidan, a filling agent, a disintegrating agent and a lubricating agent. In the research process, it is found that the dissolution rate of the rosaxostat can be improved by mixing the rosaxostat compound and the fucoidan polysaccharide sulfate, and photodegradation impurities can be reduced; the preparation method of the rosaxostat capsule is obtained through further research, and through fluidized bed wet granulation, the dissolution effect and the stability are remarkable and are obviously superior to those of an existing preparation. The method is simple, easy to operate and suitable for industrial production.

The invention provides a compound feed additive for relieving stress response of marine fishes, which is prepared by the following steps: mixing raw materials such as hermetia illucens protein and the like to prepare a premix, and embedding the premix by using a lac-glycyrrhizic acid system to prepare lac microcapsules; then modifying the fucoidin by adopting glycyrrhizin and gamma-linolenic acid, embedding rhodosporidium palustris and bacillus pumilus by using the fucoidin to prepare compound bacterium nano-particles, and finally mixing the lac microcapsules and the compound bacterium nano-particles in proportion. According to the invention, excessive secretion of cortisol of marine fish can be effectively inhibited, hermetia illucens protein provides rich nutrition and reduces muscle decomposition, and compound microorganisms are beneficial to maintaining intestinal microecological balance and improving the utilization rate of nutrition. The prepared compound feed additive can be directly splashed into a culture or transportation water body or added into a feed, so that the stress reaction of the marine fish is effectively relieved, the survival rate of the marine fish is increased, and powerful support is provided for culture of the marine fish.

This invention discloses a ternary composite foaming agent of flaxseed protein-fucose-rutin, its preparation method, and its application in meringue cookies. The foaming agent is a non-covalent complex formed by flaxseed protein isolate (FPI), fucoidan (FUC), and rutin (RU) through electrostatic interactions, hydrogen bonds, and hydrophobic interactions, with a mass ratio of FPI:FUC:RU = 1:2:(0.2~0.4). This invention forms a structurally stable composite system through the non-covalent interactions of FPI, FUC, and rutin, achieving a foaming height of 95.69±8.77%. The foam retention rate after 30 minutes is more than double that of natural FPI, and the interfacial tension is reduced to below 25 mN / m, overcoming the shortcomings of poor foaming properties and insufficient stability of single plant proteins. Even after high-temperature baking, the foam retention rate remains above 75%, meeting the processing requirements of meringue cookies.

The invention discloses a method for sterilizing a vegetable protein beverage, which comprises the following steps of: adding a composite antibacterial microsphere preparation into a vegetable protein beverage to be treated, uniformly mixing, and performing high-density CO2 treatment and magnetic induction electric field sterilization to obtain a vegetable protein beverage finished product, the composite antibacterial microsphere preparation is prepared by taking fucoidan and a gallic acid acylated quercetin-phospholipid conjugate as a substrate and loading lysozyme and hydroxytyrosol. High-density CO2 and a magnetic induction electric field are adopted for synergistic sterilization, so that the structure of a microbial film can be changed, metabolism is disturbed, a good matrix is provided for electric field sterilization, and the sterilization efficiency is further improved through electric breakdown, magnetic field refining of water molecular groups and heat effect; the composite microspheres are sensitive to an electric field, so that lysozyme and hydroxytyrosol can be triggered to be accurately and quickly released under the action of a magnetic induction electric field, stubborn spores can be efficiently killed, and the killing effect is improved by destroying cell wall structures and disulfide bonds of the spores; meanwhile, protein aggregation and flocculation in the beverage can be effectively prevented, and the stability of a beverage system is guaranteed.

The present invention relates to an antiviral composition against influenza virus containing xanthan gum or fucoidan as an active ingredient, a pharmaceutical composition for preventing or treating influenza virus infection, and a method for preventing or treating influenza virus infection using the same.

The invention provides an astaxanthin composite emulsion for resisting ionizing radiation intestinal injury and a preparation method thereof.The preparation method comprises the steps that firstly, sea cucumber peptide and fucoidin are mixed and stirred in water, the obtained mixture is placed in a water bath kettle to react, dialysis and freeze drying are conducted after the reaction is finished, and a Maillard reaction compound is obtained; the preparation method comprises the following steps: mixing astaxanthin and DHA algal oil, stirring in a dark place overnight, centrifuging to remove insoluble substances, and collecting supernate to obtain an astaxanthin DHA algal oil solution; and redissolving the obtained Maillard reaction compound, mixing the redissolved Maillard reaction compound with an astaxanthin DHA algae oil solution, carrying out full vortex treatment, and then carrying out high-speed homogenization treatment to obtain the astaxanthin composite emulsion. According to the method, an astaxanthin-loaded Pickering emulsion delivery system is prepared by utilizing the interfacial activity of a Maillard reaction product of sea cucumber peptide and fucoidin, the system realizes covalent binding of the sea cucumber peptide and the fucoidin, the water solubility and the stability of the astaxanthin are improved, and meanwhile, the astaxanthin-loaded Pickering emulsion is prepared. The application of astaxanthin in health food and synthetic drugs for preventing ionizing radiation damage is widened.

This application discloses a multilayer microcapsule, its preparation method, and its application, comprising the following steps: preparing solutions A and B with opposite charges; mixing and reacting solution B with solution A, allowing it to stand for aging, and separating and drying to obtain a drug-loaded CaCO3 template; preparing a 0.1 wt% chitosan solution and a 0.1 wt% fucoidan solution at pH 5.0; using electrostatic layer-by-layer self-assembly technology, using the 0.1 wt% chitosan solution and the 0.1 wt% fucoidan solution as polyelectrolytes with opposite charges, alternately coating the surface of the drug-loaded CaCO3 template to form a multilayer shell structure; and removing the drug-loaded CaCO3 template by treating it with EDTA solution to obtain hollow microcapsules. This invention provides microcapsules that effectively protect 5-ALA HCl from environmental degradation and possess pH-responsive sustained-release properties, enabling intelligent release under specific environments (such as the weakly acidic environment of plant rhizosphere). The overall process is simple, the conditions are mild, and it is a green preparation method that does not use toxic reagents.

The application relates to the technical field of biomedical materials, and particularly discloses a tracheal catheter with antibacterial and lubricating functions and a preparation method thereof. The tracheal catheter is modified by 2,3-epoxypropyl trimethyl ammonium chloride on the basis of polyethylene imine, so that the antibacterial performance of the polyethylene imine is enhanced. Then, the modified polyethylene imine and tannic acid are used as a composite antibacterial coating, so that the tracheal catheter has good antibacterial activity on various bacteria. Then, N-vinyl pyrrolidone and modified fucoidan are used as functional monomers, and after ultraviolet initiation polymerization, a hydrophilic lubricating coating is obtained. The sulfate groups in the hydrophilic lubricating coating are negatively charged, can be attracted to the quaternary ammonium salt cations in the antibacterial coating through electrostatic interaction, so that the hydrophilic lubricating coating is firmly fixed on the surface of the tracheal catheter. Compared with a single polyvinylpyrrolidone (PVP) hydrophilic coating which is easy to fall off, the application effectively solves the problem that the traditional hydrophilic coating is easy to fall off.

This invention provides a composite biosynergist, its preparation method, and its application. The composite biosynergist is composed of polyglutamic acid, humic acid, fucoidan oligosaccharide, and plant polyphenols. The synergistic effect of the active substances polyglutamic acid γ-PGA, humic acid HA, fucoidan oligosaccharide AOS, and plant polyphenol PP in the composite biosynergist is essentially manifested in microscopic-scale functional complementarity and mechanism closed-loop. It achieves four functional pathways: blocking salt toxicity through chelate channels, ensuring nutrient supply through complexation channels, enhancing nutrient absorption through root-promoting channels, and resisting stress damage through stress-resistant channels. Ultimately, it achieves the macroscopic effect of "improved soil physicochemical properties—enhanced root function—increased crop stress resistance and yield." Its core advantage lies in overcoming the functional limitations of single components and solving the industry pain points of "difficult-to-eliminate salt damage, easy nutrient loss, and unstable improvement effect" in saline-alkali land improvement through molecular-level synergistic effects.

The invention relates to a fertilizer synergist and a preparation method thereof, in particular to a fertilizer synergist which is based on natural components such as modified aspartic acid, alginate oligosaccharide, mannan oligosaccharide and magnetic polysaccharide and takes a fertilizer as a carrier. According to the fertilizer synergist, through the innovative modification of the modified aspartic acid and the synergistic effect of the natural polysaccharide, the utilization efficiency and the slow release property of a fertilizer and the nutrient absorption capacity of crops are remarkably improved. Compared with the traditional fertilizer synergist, the synergist disclosed by the invention can prolong the release time of nutrients, reduce the loss of the fertilizer and improve the yield of crops, has better environmental friendliness, and reduces possible pollution to soil and water in the fertilizer application process. The fertilizer synergist disclosed by the invention has remarkable advantages in the aspects of improving the fertilizer utilization rate, crop growth and soil environmental protection. The fertilizer synergist provides an efficient, environment-friendly and sustainable technical solution for agricultural production.

The application provides a preparation method and application of a complex microbial agent for promoting alfalfa growth, and relates to the technical field of agricultural microorganisms. The complex microbial agent is prepared by mixing a bacterial solution and a biological stimulant solution. The bacterial solution is a rhizobium solution, and the biological stimulant is a fucoidan solution. The volume ratio of the rhizobium solution to the fucoidan solution is 1:2-4. The complex microbial agent solves the bottleneck problem that a single rhizobium agent is unstable in actual application and is easily affected by the environment. The alfalfa treated by the complex microbial agent can improve the seedling emergence rate, plant height, biomass and stress resistance of the alfalfa.

The invention discloses an ellagic acid composite solid dispersion and a preparation method thereof. The preparation method comprises the following steps: S1, respectively preparing a fucoidin aqueous solution and an ellagic acid ethanol suspension; s2, mixing the two solutions to obtain a mixed solution; s3, adding the modified polysorbate 20 and the chitosan-CPP compound, and performing ultrasonic stirring; s4, ball milling; and S5, carrying out reduced pressure rotary evaporation to remove the solvent, drying, crushing, and sieving with a 100-mesh sieve to obtain the product. Ternary synergistic compounding is formed through the fucoidin-modified polysorbate 20-chitosan-CPP compound, a multi-dimensional molecular interaction network is constructed, and the effect of remarkably improving the water solubility and dispersion stability of ellagic acid is achieved; wherein xylooligosaccharide branched chains of the modified polysorbate 20, hydroxyl groups of the fucoidin and phosphate groups of the chitosan-CPP compound form a multi-point hydrogen bond cross-linked structure through hydrogen bonds, and the hydrophobic association effect and lattice stacking among ellagic acid molecules are broken through the steric hindrance effect.

The application discloses a preparation method of a drug sustained-release modified starch hydrogel and application thereof, and belongs to the field of starch chemical modification and biomedical materials. The method is characterized by a starch hydroxyl modification and modification through PAA micelle mediation and a starch gelatinization-network interweaving synergistic enhancement strategy. A CTS-PEG-600 composite solution and a PAA micelle modified starch dispersion liquid are prepared first, a dense three-dimensional network is constructed through compounding and cross-linking and high-temperature gelatinization, and a starch-based hydrogel material is obtained through post-processing. After fucoidan is loaded on the hydrogel, an oral sustained-release preparation can be prepared, long-acting and stable release of drugs is realized, non-alcoholic fatty liver disease is treated through targeted therapy, the hydrogel has excellent biocompatibility, mechanical stability and controllable sustained-release property, the process is green and environmentally friendly, the hydrogel is suitable for large-scale production, and has a wide application prospect.

This invention provides a modified fucoidan composite hydrogel, its preparation method, and its application, belonging to the field of hydrogel technology. The preparation method of the composite hydrogel includes the following steps: dissolving fucoidan in an organic solvent, then adding a sulfonating agent to carry out a sulfation reaction; after the reaction, allowing it to stand, precipitate, wash, dry, and grind sequentially to obtain persulfated modified fucoidan; preparing a persulfated modified fucoidan solution, then mixing it evenly with a carboxymethyl chitosan solution, a laver polysaccharide solution, and a hyaluronic acid solution; then adding a polyethylene glycol solution, a 1,4-phenylenediboric acid solution, salmon protein active peptides, and docosahexaenoic acid; finally, adding a crosslinking agent to obtain a mixed solution, and stirring to obtain a composite polysaccharide hydrogel. This composite hydrogel has good mechanical properties and biocompatibility, and can accelerate the healing of chronic wounds in type 2 diabetes.

The invention discloses a fucoidin-marine mineral composition for promoting skin cell repair and application thereof, and belongs to the technical field of skin care products. The composition provided by the invention is derived from food or small-pollution deep sea, and is high in safety; various mineral substances and active ingredients are contained, so that the nutrition is rich; the components have a synergistic effect, can effectively reduce damage of light damage to cells and promote fibroblasts to secrete collagen, and have good effects on repairing cell damage, delaying skin aging and reducing damage caused by external and internal factors.

The application belongs to the technical field of medicine preparation, and particularly relates to a polysaccharide modified quercetin@ZIF-8 core-shell nanoparticle, a preparation method and application thereof. The polysaccharide modified quercetin@ZIF-8 core-shell nanoparticle comprises the following steps: mixing polysaccharide solution and ZIF-8 suspension loaded with quercetin in equal volume, reacting for 30-120 min, centrifuging, taking the precipitate, and cleaning to obtain the polysaccharide modified quercetin@ZIF-8 core-shell nanoparticle; the pH value of the polysaccharide solution and the ZIF-8 suspension loaded with quercetin is 5-7; the polysaccharide in the polysaccharide solution is any one of fucoidan, tremella polysaccharide and medlar polysaccharide; and the mass ratio of the ZIF-8 loaded with quercetin and the polysaccharide is 1-4:1:4.

The application relates to a biomimetic hydrogel-based connective tissue and a preparation method and application thereof, and belongs to the technical field of plant-based food processing. In view of the defects of single taste and lack of real meat connective tissue feeling of existing plain meat products, a continuous phase component (containing plant protein, water-soluble dietary fiber and ferulic acid) is mixed with a pH-activated plant polysaccharide colloidal solution (containing a glucan gum, a galactomannan gum and a fucoidan gum); then, calcium ions and transglutaminase are introduced in sequence to trigger ion crosslinking and enzymatic crosslinking in sequence; and finally, a heat curing treatment and cold storage curing are carried out to obtain a biomimetic hydrogel-based connective tissue which is excellent in mechanical property, uniform in texture, high in water holding property and stable in heat. The biomimetic hydrogel-based connective tissue prepared by the application can be used for developing a new generation of high-end plant-based meat products.

The invention discloses an ovary and gonad axis function repairing preparation and a preparation process thereof, and relates to the technical field of biology, the preparation comprises the following components by weight: 22-38 parts of a marine organism polysaccharide composite raw material; 12-28 parts of a plant stem cell extract; 4 to 10 parts of deep sea sponge terpenoids; 3-7 parts of coral polysaccharide; 0.008 to 0.018 part of vitamin C palmitate; 0.4 to 0.6 part of xanthan gum; the marine organism polysaccharide composite raw material consists of fucoidan and fucoidan in a weight ratio of (1: 1)-(3: 1). The plant stem cell extract consists of a ginseng stem cell extract and an angelica sinensis stem cell extract in a weight ratio of (3: 1)-(4: 1); through compatibility of the composite marine polysaccharide, the plant stem cell extract and other components, a repair-activation-protection closed loop is formed, and the limitation of a single component is broken through; by adopting processes such as low-temperature extraction and supercritical technology, the activity is retained to the maximum extent, the curative effect and safety of the preparation are improved, and an efficient treatment choice is provided for ovarian function decline.

This invention belongs to the field of functional food technology and discloses a functional food for improving sleep and its preparation method. The raw materials, by mass parts, include 15-20 parts of fucoidan, 15-20 parts of sea cucumber oligopeptides, 10-15 parts of polygonatum polysaccharide, 10-15 parts of geniposide, and 20-25 parts of inulin. Through scientific component selection and proportioning design, this invention yields a functional food containing the marine active substances fucoidan and sea cucumber oligopeptides, exhibiting synergistic advantages in efficacy, absorption, and stability, resulting in a better sleep-aiding effect than using either component alone. This functional food containing marine active substances provides an efficient and stable solution for improving sleep, possessing significant scientific value and broad market prospects.

The invention relates to alginate fiber membrane cloth and a preparation method thereof, and belongs to the technical field of textile materials, the alginate fiber membrane cloth is prepared by compounding 25% of a seaweed extract and 75% of plant fibers, the seaweed extract contains an alginic acid active component, the plant fibers are lyocell fibers, the membrane cloth is of a crossed reticulate pattern structure, and the alginate fiber membrane cloth is prepared by compounding the alginate extract and the plant fibers. The seaweed extract contains natural moisturizing components such as polysaccharide and fucoidan, the lyocell fibers are skin-friendly, breathable and excellent in water locking performance, the seaweed extract and the lyocell fibers are subjected to 90-degree cross lapping and 0.3-0.5 MPa high-pressure water flow puncture to form a cross reticulated structure with developed pores, the moisture retention effect is good, the moisture retention effect is good, the moisture retention effect is good, and the moisture retention effect is good. The liquid absorption rate reaches 24 times, glittering and translucent gel-like gel is formed after liquid filling, moisturizing essence can be efficiently borne and released for a long time, the skin moisture can be improved after the moisturizing essence is attached to the skin for 15 minutes, the moisture is improved by 50% through a moisturizing test for 1 hour, and deep long-acting moisturizing is achieved.

The present invention belongs to the technical field of foods and pharmaceuticals, and relates to a novel use of fucoidan of sporophylls of Undaria pinnatifida. Provided in the present invention is a novel use of fucoidan of sporophylls of Undaria pinnatifida in the preparation of drugs, health foods, and foods for lowering uric acid, which can significantly reduce blood uric acid levels, alleviate and treat gout symptoms, has no toxic side effects, is safe and effective, can be used in the preparation of a URAT1 inhibitor and / or a GLUT9 inhibitor, and can be used in the preparation of drugs, health foods, or foods for lowering uric acid and treating gout, and has broad application prospects.

The invention belongs to the technical field of nutrition fortifiers, and particularly relates to a nutrition fortifier containing kelp extract and a preparation method of the nutrition fortifier. The nutrition enhancer containing the kelp extract comprises the following components in parts by mass: 20-30 parts of the kelp extract, 50-60 parts of soybean protein powder, 5-15 parts of oat powder, 1-10 parts of inulin, 1-10 parts of sea cucumber powder and 1-5 parts of an undaria pinnatifida extract. The kelp extract is subjected to directional fermentation treatment by adopting a specific probiotic strain, so that the content and biological activity of fucoidin in the kelp extract are remarkably improved; meanwhile, a multi-level nutrition collaboration system is constructed; especially for chronic inflammatory diseases such as tumors, arthritis and psoriasis, the nutrition enhancer provides a safe and long-acting diet intervention scheme for specific people through anti-inflammatory and anti-angiogenesis dual-path effects, and has important clinical auxiliary application value.

The application belongs to the technical field of food processing, and particularly relates to a low-molecular-weight fucoidan and application thereof. The low-molecular-weight fucoidan is obtained by treating fucoidan, the number-average molecular weight of the fucoidan is 3-4 kDa, the sulfate radical content in the fucoidan is 10%-18%, and the fucoidan has specific monosaccharide composition. Experimental results show that the low-molecular-weight fucoidan has wide application prospect in preparation of medicine for auxiliary treatment of thyroid nodules, and fills the technical blank of the relationship between fucoidan and thyroid nodules.

This invention discloses a lutein composition for relieving eye fatigue and its preparation method, belonging to the field of functional foods. The process involves: reacting phycocyanin and kelp polyphenols to obtain modified phycocyanin; reacting fucoidan and β-glucuronidase to obtain modified fucose; reacting fish collagen peptides and zinc chloride to obtain collagen peptide-zinc chelate; reacting lutein silica cage complex and modified phycocyanin to obtain a first complex; reacting the first complex and modified fucose to obtain a second complex; reacting the second complex, collagen peptide-zinc chelate, and krill oil to obtain a lutein complex; reacting the second complex, collagen peptide-zinc chelate, and krill oil, then adding trehalose to obtain the lutein complex; and finally mixing the lutein complex with maltodextrin to obtain the lutein composition.

The invention belongs to the technical field of cosmetics, and particularly discloses an anti-oxidation fucoidan composition for delaying skin stem cell aging and a preparation method and application of the anti-oxidation fucoidan composition. The antioxidant algin composition is prepared from the following components in parts by weight: 5 to 10 parts of algin extract, 5 to 10 parts of herba houttuyniae extract, 2 to 4 parts of black pine needle extract, 4 to 6 parts of sorbitan olivate, 4 to 6 parts of squalane, 5 to 10 parts of glycerol, 0.1 to 0.5 part of sodium hyaluronate, 0.1 to 0.5 part of xanthan gum, 0.1 to 1 part of ethylhexylglycerin and 0.1 to 1 part of p-hydroxyacetophenone. The invention discloses an antioxidant fucoxanthin composition for delaying skin stem cell aging and a preparation method and application thereof. The antioxidant fucoxanthin composition is high in antioxidant capacity and capable of effectively promoting collagen synthesis and delaying skin stem cell aging.

The application belongs to the technical field of biological medicine, and discloses a kind of construction and application of biologic macromolecule gel microspheres that can be assembled.The application discloses a kind of gel microspheres, including gel microsphere 1 and / or gel microsphere 2.The application provides a kind of gel microspheres, which are delivered to pathological sites by the specific targeting effect of fucoidan on damaged endothelial cells.Further, gel microsphere 1 and gel microsphere 2 overcome the limitation of steric hindrance by supramolecular assembly between adamantane and cyclodextrin, provide more drug targeting anchor points, thereby improving the drug concentration at the pathological site to enhance the therapeutic efficacy of IBD.The assembly strategy of the gel microspheres provides an effective method for enhancing the drug concentration of micron-sized oral drugs at the pathological site, and provides a new idea for the delivery of micron-sized oral drugs.