50 results about "Indole-3-carbinol" patented technology

New dietary supplement compositions are disclosed that comprise the phytochemical Diindolylmethane (DIM), as well as its precursor, Indole-3-carbinol (I3C), and cogener, 2-(Indol-3-ylmethyl)-3,3' diindolylmethane (LTR-1), dietary supplement acceptable carriers and / or excipients. The use of these dietary supplement compositions facilitate weight loss as part of a nutritional system targeting release and metabolism of stored fat.

A pharmaceutical composition for the treatment of an estrogen-dependent disease or condition comprises: (1) at least one polysaccharide selected from the group consisting of an alginate and a fucoidan in a quantity effective to treat an estrogen-dependent disease or condition; and (2) a pharmaceutically acceptable carrier. The composition can include both an alginate and a fucoidan. The composition can include other ingredients such as at least one compound selected from the group consisting of diindolylmethane and indole-3-carbinol in a quantity sufficient to inhibit the activity of estrogen. Methods for use of the composition for the treatment of an estrogen-dependent disease or condition, especially endometriosis, are described.

New compositions are disclosed that comprise the phytochemical Diindolylmethane (DIM), as well as its precursor, Indole-3-carbinol (I3C), and cogener, 2-(Indol-3-ylmethyl)-3,3'diindolylmethane (LTR-1), acceptable carriers and / or excipients. These compositions are administered to prevent or reduce symptoms associated with mastalgia and endometriosis.

The invention relates to non-surgical methods for treating cervical or vaginal neoplasia including cervical intraepithelial neoplasia, intraepithelial neoplasia, vulvar intraepithelial neoplasia and ano-genital warts. The treatment, which utilizes an effective amount of indole-3-carbinol and / or diindolylmethane, is effective whether or not the patient is also infected with human papillomavirus, the most common sexually transmitted viral disease in the United States and a known risk factor for both cervical intraepithelial neoplasia and cervical cancer.

Compounds useful as antibacterial agents are provided. The compounds are analogs of indole-3-carbinol and have a backbone selected from dihydroindolo[2,3-b]carbazole, 2,2′-diindolylmethane, 2′,3-diindolylmethane, and 3,3′-diindolylmethane. The compounds are useful therapeutic and prophylactic treatment of bacterial infections in mammals. Methods of synthesis of the compounds are provided, as are pharmaceutical compositions containing the compounds.

New compositions are disclosed that comprise the phytochemical Diindolylmethane (DIM), as well as its precursor, Indole-3-carbinol (I3C), and cogener, 2-(Indol-3-ylmethyl)-3,3′diindolylmethane (LTr-1), acceptable carriers and / or excipients. These compositions are administered to prevent or reduce symptoms associated with mastalgia, endometriosis and HPV-related conditions including cervical dysplasia.

The present invention relates to methods and compositions effective in preventing, attenuating, inhibiting the progression of, and treating eye diseases, e.g., age-related macular degeneration (AMD). The compositions comprise, as an active ingredient, an effective amount of 3,3′-diindolylmethane (DIM) and / or its precursor indole-3-carbinol (I3C). The compositions can further comprise additional agents such as carotenoids and other phytochemicals, which produce a synergistic effect in preventing, attenuating, inhibiting the progression of, and treating AMD and other eye diseases such as glaucoma, cataracts and diabetic retinopathy (DR). The compositions are particularly effective in treating and preventing wet AMD, and in preventing or inhibiting the progression of dry AMD (non-neovascular) to wet AMD (neovascular).

The invention provides new application of indole-3-carbinol, diindolylmethane and derivatives thereof to preparation of a medicine for preventing and controlling atherosclerosis (AS). The indole-3-carbinol, diindolylmethane and derivatives thereof have obvious effects of resisting oxidation and improving endothelial functions, can ensure that the expression and proportion of all vaso-active substances in a human body are normal and the endothelial functions can be recovered normally, and have the good effects of reducing blood fat, and resisting AS. Meanwhile, the active ingredients of the used small molecule medicines can be obtained easily, and the indole-3-carbinol, diindolylmethane and derivatives thereof are low in price, have stable performance and are convenient to store and transport, and have wide application prospect.

A method is provided for reducing side effects while treating a mammal using indole-3-carbinol, which method includes the steps of administering an effective amount of indole-3-carbinol along with side effect-reducing amounts of a side-effect reducing component. A composition is also provided, as are various combinations of side effect-reducing agents.

The invention provides new application of indole-3-carbinol, diindolyl methane and derivatives thereof in preparation of medicaments for treating osteoporosis. The indole-3-carbinol (I3C), the diindolyl methane (DIM) and the derivative compounds thereof can inhibit growth and functions of osteoclasts through medicaments, and can be used for preventing and treating the osteoporosis in principle. The DIM, the I3C and the derivative compounds can effectively reduce the pathogenetic symptoms of osteoporosis animal models, and can be used as candidate medicament molecules for treating the osteoporosis. Meanwhile, the adopted small molecular substances are easily obtained, are low in price, stable in properties and convenient for storage and transportation, and have broad application prospect.

Compounds and methods for treating cancer and inducing apoptosis in unwanted rapidly proliferating cells. The compounds are shown in formula I:wherein X is hydroxyl or amino; Y is carboxyl or sulfonyl; R1, R2, R3, and R4 can be the same or different and are selected from hydrogen, halogen, methoxy, trifluoromethyl, hydroxyl and combinations thereof, R5, R6, and R7 may be the same or different and are selected from hydrogen, chloro, bromo, nitro, phenyl, amino, methoxy, and combinations thereof, and derivatives or metabolites thereof.

Novel compounds useful as chemotherapeutic and chemopreventive agents are provided. The compounds are analogs of indole-3-carbinol metabolites wherein the structures and substituents of the compounds are selected to enhance the compounds' overall efficacy, particularly with respect to therapeutic activity, oral bioavailability, long-term safety, patient tolerability, and therapeutic window. The compounds are useful not only in treatment of cancer but also in prevention of cancer. One preferred class of the novel compounds have the structure of formula (I)wherein R1, R2, R3, R4, R5, R6, R7, R8, R9, R10, R11, and R12 are defined herein. Pharmaceutical compositions are provided as well, as are methods of synthesis and use.

Novel metabolites and enzymes involved in skatole metabolism are disclosed. The novel metabolites are 3-OH-3-methylindolenine (HMI); 3-methyloxindole (3MOI); indole-3-carbinol (I-3C); and 2-aminoacetophenone (2-AM). Measuring levels of these metabolites in a pig may be useful in identifying the pig's ability to metabolize skatole and its susceptibility to boar taint. The novel enzymes involved in skatole metabolism are aldehyde oxidase and CYP2A6. Enhancing the activity of these enzymes may be useful in enhancing skatole metabolism and reducing boar taint. The identification of the enzyme also allows the development of screening assays for substances that interact with these enzymes and skatole metabolism or for genetic screening to identify pigs on the basis of their skatole metabolism. Pigs having high levels of these enzymes may be selected and bred to produce pigs that have a lower incidence of boar taint.

Provided herein are pharmaceutical compositions and methods for treating disorders characterized by reduced expression of anti-oxidative stress enzymes in a subject. In one aspect, the present invention provides a method for inducing expression of anti-oxidative stress enzymes in a subject in need thereof. The method includes administering to the subject a therapeutically effective amount of a demethylating agent. The demethylating agent includes a phytochemical that induces expression of Nrf2 and Nrf2-mediated genes expressing anti-oxidative stress. Such phytochemicals include indoles, such as 3,3′-diindolylmethane (DIM) and indole-3-carbinol (I3C), and isothiocyanates, such as phenethyl isothiocyanate (PEITC) and sulforaphane (SFN).

The invention belongs to the technical field of biological medicine, specifically relates to an application of diindolylmethane, a precursor compound indole-3-carbinol, and diindolylmethane derivatives in preparation of drugs for treating liver fibrosis, hepatitis and liver cirrhosis-related liver diseases. With the indole-3-carbinol, the diindolylmethane and the diindolylmethane derivatives, thebody can be effectively prevented from damage due to free radical, such that free radical induced stellate cell activation and associated collagen expression are prevented so as to reduce the degree of the liver fibrosis. Therefore, the indole-3-carbinol, the diindolylmethane and the diindolylmethane derivatives can be provided for treating the fibrosis-related liver fibrosis, the hepatitis and the liver cirrhosis diseases.

A pharmaceutical composition for the treatment of an estrogen-dependent disease or condition comprises: (1) at least one polysaccharide selected from the group consisting of an alginate and a fucoidan in a quantity effective to treat an estrogen-dependent disease or condition; and (2) a pharmaceutically acceptable carrier. The composition can include both an alginate and a fucoidan. The composition can include other ingredients such as at least one compound selected from the group consisting of diindolylmethane and indole-3-carbinol in a quantity sufficient to inhibit the activity of estrogen. Methods for use of the composition for the treatment of an estrogen-dependent disease or condition, especially endometriosis, are described.

Compounds and methods for treating cancer or inducing apoptosis in proliferating cells. The compounds are shown in formula I:wherein X is selected from hydroxyl, thiol, and amino; Y is selected from carboxyl and sulfonyl; R1, R2, R3, and R4 are selected from hydrogen, lower alkyl, and combinations thereof; R5, R6, and R7 are selected from hydrogen, halo, nitro, amino, methoxy, and combinations thereof; and pharmaceutically acceptable salts thereof.

The invention relates to the field of medicines and particularly relates to an application of indole-3-carbinol. The indole-3-carbinol is introduced to vascular aging preventing researches and is expected to delay progression of diseases, such as coronary heart disease, cerebral apoplexy and Alzheimer disease, related to vascular aging such as atherosclerosis, to prolong lifetime and to promote health of the aged. The indole-3-carbinol in a scheme is convenient to use and low in treatment cost, and lays a foundation for treatment of cardiovascular and cerebtovascular disease related to vascular aging such as atherosclerosis by utilizing the I3C and oligomer medicines thereof.

Novel metabolites and enzymes involved in skatole metabolism are disclosed. The novel metabolites are 3-OH-3-methylindolenine (HMI); 3-methyloxindole (3MOI); indole-3-carbinol (I-3C); and 2-aminoacetophenone (2-AM). Measuring levels of these metabolites in a pig may be useful in identifying the pig's ability to metabolize skatole and its susceptibility to boar taint. The novel enzymes involved in skatole metabolism are aldehyde oxidase and CYP2A6. Enhancing the activity of these enzymes may be useful in enhancing skatole metabolism and reducing boar taint. The identification of the enzyme also allows the development of screening assays for substances that interact with these enzymes and skatole metabolism or for genetic screening to identify pigs on the basis of their skatole metabolism. Pigs having high levels of these enzymes may be selected and bred to produce pigs that have a lower incidence of boar taint.

The invention provides new application of indole-3-carbinol (I3C), diindolyl methane (DIM) and derivative compounds thereof in preparation of medicaments for treating senile dementia. By improving the expression of intracellular free radical resistant specific genes, the medicaments can enhance the automatic free radical clearing capacity of cells and lighten the harm of free radicals to the cells and tissues. The DIM, the I3C and the derivative compounds can effectively reduce the pathogenetic symptoms of senile dementia animal models, obviously improve the dyskinesia of SAM-P / 8 mice, obviously improve the superoxide dismutase (SOD) activity of brain tissues of the SAM-P / 8 mice, reduce the methylene dioxyamphetamine (MDA) content of brain tissues, reduce the choline esterase activity of the brain tissues and enhance the activities of Na<+>-K<+>-ATP enzyme and Ca<2+>-ATP enzyme of the brain tissues, so the DIM, the I3C and the derivative compounds can be used as candidate medicament molecules for treating the senile dementia. Meanwhile, the adopted small molecular substances are easily obtained, are low in price, stable in properties and convenient for storage and transportation, and have broad application prospect.

The invention provides 2-(((1H-indole-3-yl) methoxyl) methyl)-1H-benzimidazole derivatives represented as a general formula shown in the specification. Substituent groups R1 and R7 in the formula can be -H, -CH3, -CH2CH3, -CHCH=CH2, -CH2Ph, -COCH3 and p-CH3-C6H4-SO2-; R2, R3, R4, R5, R6, R8, R9, R10 and R11 can be -H, -CH3, -CH2CH3, -CHCH=CH2, -CH2Ph,-COCH3, -CF3, -CCl3, -CN, -NHCH3, -NO2, -OCH3, -CH2NH2, -COOCH3 and -CONHCH3. According to a method, indole-3-methanol, a derivative of indole-3-methanol, 2-chloromethylbenzimidazole and a derivative of 2-chloromethylbenzimidazole are adopted as reactants, or 3-chloromethyl indole, a derivative of 3-chloromethyl indole, benzimidazole-2-methanol and a derivative of benzimidazole-2-methanol are adopted as the reactants, the reactants have a one-step reaction under the conditions of an appropriate solvent and an appropriate catalyst, and the 2-(((1H-indole-3-yl) methoxyl) methyl)-1H-benzimidazole derivatives are generated. The preparation of the compounds is shown in the specification, wherein an X group in the formula is chlorine, bromine or iodine.

The invention belongs to the field of radiation injury protection medicaments and relates to new application of indole-3-methanol serving as a BRCA1 (breast cancer 1) inducer, i.e., the application to the preparation of a radiation injury protection medicament. The structural formula of the indole-3-methanol is shown in the specifications. The indole-3-methanol can be used for preparing the radiation injury protection medicament. By adopting the indole-3-methanol, the survival rates of cells and animals subjected to ionizing radiation are increased at a low concentration with no toxic or side effect.

Novel compounds useful as chemotherapeutic and chemopreventive agents are provided. The compounds are analogs of indole-3-carbinol metabolites wherein the structures and substituents of the compounds are selected to enhance the compounds' overall efficacy, particularly with respect to therapeutic activity, oral bioavailability, long-term safety, patient tolerability, and therapeutic window. The compounds are useful not only in treatment of cancer but also in prevention of cancer. One preferred class of the novel compounds have the structure of formula (III)wherein R1, R2, R3, R4, R5, R6, R7, R8, R11, R12, R20, and R21 are defined herein. Pharmaceutical compositions are provided as well, as are methods of synthesis and use.

Disclosed is a composition for preventing or treating obesity, dyslipidemia, fatty liver or diabetes, containing an indole-3-carbinol derivative as an active ingredient. The indole-3-carbinol derivative of the present disclosure can be usefully used as a pharmaceutical or functional food composition for preventing or treating obesity, dyslipidemia, fatty liver or diabetes by inhibiting differentiation of preadipocytes and reducing accumulation of triglyceride in cells.

The invention discloses a selenium enrichment fermentation method for improving indole-3-carbinol and indole-3-acetonitrile in fruit vinegar, and belongs to the field of beverage processing. The method comprises the preparation steps that 1, fruits are cleaned and crushed, saccharose is added for adjusting the sugar degree, and pectinase is added for hydrolyzing pectin; 2, Chinese cabbages are cleaned and smashed, and pectinase and cellulose are added for hydrolyzing pectin and cellulose; 3, fruit hydrolysate and Chinese cabbage hydrolysate are mixed; 4, sodium selenite and yeast are added for alcoholic fermentation; 5, acetic bacteria are used for acetic fermentation to prepare fruit vinegar; 6, blending is carried out; 7, filtration sterilization is carried out; 8, filling is carried out. The selenium content of each 100 ml of the product produced by the method is 35 micrograms or above, the oxygen radical scavenging efficiency is 4-5 times that of common fruit vinegar, and the fruit vinegar is rich in indole-3-carbinol and indole-3-acetonitrile and is the excellent anticancer healthcare fruit vinegar.

Novel compounds useful as chemotherapeutic and chemopreventive agents are provided. The compounds are analogs of indole-3-carbinol metabolites wherein the structures and substituents of the compounds are selected to enhance the compounds' overall efficacy, particularly with respect to therapeutic activity, oral bioavailability, long-term safety, patient tolerability, and therapeutic window. The compounds are useful not only in treatment of cancer but also in prevention of cancer. One preferred class of the novel compounds have the structure of formula (III) wherein R1, R2, R3, R4, R5, R6, R7, R8, R11, R12, R20, and R21 are defined herein. Pharmaceutical compositions are provided as well, as are methods of synthesis and use.

The invention provides application of indole-3-methanol, diindolylmethane and derivatives thereof in drugs used for treating psoriasis. Indole-3-methanol, diindolylmethane and the derivatives thereof can be used for treating psoriasis by inhibiting mitosis of basal cells. Indole-3-methanol, diindolylmethane and the derivatives thereof can effectively mitigate symptoms of psoriasis and can be used as candidate drug molecules for treatment of psoriasis. Meanwhile, micromolecular drugs used in the invention are easily available, low in price, stable in properties and convenient to store and transport, and have wide application prospects.