33 results about "Phytochemical" patented technology

Disclosed are novel pharmaceutical, animal feed compositions and methods of treating non-human animals comprising at least one component selected from the extract(s), fraction(s), active compound(s) and phytochemical(s), or mixtures thereof, derived from non-woody plants of the genus Hesperaloe. Animal feed compositions may comprise a basal animal feed and water soluble solids extracted from Hesperaloe and comprising at least one saponin. The water soluble solids may comprise from about 5 to about 30 wt % saponin. The compositions of the present invention can be used for the treatment of non-human animals, such as poultry and more particularly for preventing and treating coccidiosis. An embodiment provides an immunological composition useful for inducing the production of antibodies to an antigen in a non-human animal comprising an antigen, preferably a coccidia, and a saponin composition extracted from Hesperaloe. The saponins extracted from Hesperaloe biomass may comprise 25(27)-dehydrofucreastatin, 5(6),25(27)-disdehydroyuccaloiside C, 5(6)-disdehydroyuccaloiside C, furcreastatin and yuccaloiside C.

Described are processes for the production of a composition comprising (2R, 3R, 4R, 5S)-3, 4, 5-trihydroxypiperidine-2-carboxylic acid (idoBR1), said process comprising the steps of: a) providing plant material from a botanical source comprising plant of the family Cucurbitaceae; b) fractionating said plant material to produce an extract enriched in idoBR1 c) assaying said extract for: i) inhibitory activity against sialidase or TNF-alpha or ii) IL-10 stimulatory activity; and d) formulating said assayed extract with a cosmetically-, nutraceutically- or pharmaceutically-acceptable excipient or carrier to produce a cosmetic, nutraceutical or pharmaceutical composition.

The present disclosure relates to an albumin nanocomposite comprising a phytochemical and a composition for muscle disease comprising the same, and more specifically, to an albumin nanocomposite comprising a phytochemical that exhibits an effect of inhibiting muscle loss caused by oxidative stress or inflammatory response and promoting the differentiation of myoblasts into muscle cells. The albumin nanocomposite comprising the phytochemical effectively delivers the phytochemical by targeting immune cells that induce reactive oxygen species and inflammatory responses. Accordingly, by regulating muscle-loss signaling pathways induced by reactive oxygen species and inflammatory responses, the nanocomposite inhibits muscle cell atrophy and promotes differentiation. Therefore, a composition comprising the albumin nanocomposite comprising the phytochemical according to the present disclosure can be provided as a composition for improving, preventing, or treating muscle diseases.

Pharmaceutical formulations and methods to increase the bioactivity and bioavailability of plant compound having hydrophobic phytochemicals which have poor bioavailability due to poor water solubility. Dispersions of extracts of Boswellia and / or Curcuma longa in sesame seed oil. Analgesic and anti-inflammatory composition having a) an extract of Boswellia, b) one or more of an extract of Curcuma longa, a curcuminoid composition and combinations thereof, and, c) a sesame seed oil. The analgesic and anti-inflammatory composition has particles having a particle size ranging from less than about 20 micrometers to about 1 micrometer. The analgesic and anti-inflammatory composition provides a total combined specific surface area provided by particles in the composition ranging from about 900 meter2 per kilogram to about 3000 meter2 per kilogram of the composition. Methods of preparing the compositions and methods of treating inflammation and musculoskeletal disorders are provided.

The present invention relates to a phytochemical-containing albumin nanocomplex and a composition containing the same for improving muscle diseases. More specifically, the present invention relates to a phytochemical-containing albumin nanocomplex that has the effect of suppressing muscle loss caused by oxidative stress or inflammatory responses and promoting the differentiation of myoblasts into muscle cells. The phytochemical-containing albumin nanocomplex effectively delivers phytochemicals to immune cells that induce reactive oxygen species and inflammatory responses, thereby regulating the muscle loss signaling mechanism induced by reactive oxygen species and inflammatory responses, suppressing muscle cell atrophy, and promoting differentiation. This can improve muscle loss and prevent and treat muscle atrophy. Therefore, a composition containing the phytochemical-containing albumin nanocomplex of the present invention can be provided as a composition for improving muscle diseases.

A nanomaterial is gold or silver nanoparticle having a nanoparticle surface that consists of one or more of the following extracts from sweet gum leaves: shikimic acid, sweet gum leaf family of Catechins, sweet gum leaf family of Quercetin, Sweroside, Afzelechin, p-Coumaric Acid, Epiafzelechin Trimethyl Ether, Myricetin, Naringenin, Phloretin, Procyanidin B1 and related polyphenols, flavonoids and alkaloids. An antiviral / antibacterial agent includes sweet gum mediated silver nanoparticles having a core size and in a concentration having efficacy as an antiviral / antibacterial exceeding a 3 log 10 reduction in viral titer.

Described are compositions comprising selected isolated 4-hydroxymethyl-prolines, or pharmaceutically acceptable salts or derivatives thereof. Also described are novel 4-hydroxymethyl-N-methyl-prolines, together with processes for their preparation, compositions containing them, as well as their use as medicaments and pharmaceuticals. Also described are processes for producing a herbal medicine comprising the step of monitoring the quality of said herbal medicine by detecting the presence or absence or measuring the amount of one or more 4-hydroxymethyl-N-methyl-prolines in a sample of said herbal medicine.

A liquid composition for an electronic vaporization device, consisting essentially of an active inhalable source and a terpene source, is disclosed. A liquid composition for an electronic vaporization device is provided consisting essentially of greater than about 60 wt % cannabinoids, from about 5 to about 15 wt % terpenes and less than about 35 wt % non-cannabinoid, non-terpene cannabis phytochemicals. A method is provided for obtaining such a composition. An electronic vaping device and a cartridge for an electronic vaping device containing the composition are also disclosed.

A phytochemical and nutraceutical composition and method for protection against a wide spectrum of viral and bacterial infections, including Covid-19, and for treatment of established infection and infectious inflammation. The composition includes a novel combination of vitamin, mineral, nutraceutical and phytochemical supplements. The composition of supplements and method may be compounded as a pill, tablet, powder, capsule or liquid be taken orally one or more times per day, and parenteral including nasal sprays and inhalers. Vitamin C and vitamin E along with zinc complexed with pyrithione or citrate are used in conjunction with nutraceuticals and phytochemicals provided, respectively, as immune boosters and antiviral agents along with anti-inflammatory nutraceuticals and phytochemicals.

The present invention provides a method of encapsulating a low solubility plant chemical in a water soluble nanocomposite. The method comprises providing a mixture comprising one or more proteins and a solvent, and adding an alkaline compound to adjust the pH of the mixture to an alkaline condition to unfold the three-dimensional structure of the protein. The zein and the low-solubility phytochemicals are sequentially added into the mixture, and it is worthy of noting that under the alkaline condition, the structure of the zein is expanded, and the phytochemicals are combined and fixed through hydrophobic interaction. And adjusting the pH value of the mixture to a neutral range by adding an acidic compound, so as to promote the protein to fold again and form a nano-composite solution. The nanocomplex solution is subsequently further dried to obtain a dried powder of a water-soluble nanocomplex wherein the particle size of the water-soluble nanocomplex is less than 1 micron, the structure of which is a protein-encapsulated low-solubility phytochemical.

The invention belongs to the technical field of plant chemical component analysis, and discloses a multi-species polyphenol flavonoid compound high-throughput identification method which comprises the following steps: S1, constructing a cross-platform compatible MSP database; s2, sample pretreatment: carrying out ultrasonic extraction on a plant sample with 70% methanol, centrifuging, and filtering a supernatant with a filter membrane; wherein the plant sample comprises folium cortex eucommiae, rosemary, day lily, sea-buckthorn, herba houttuyniae or tea leaves; s3, carrying out liquid chromatography-mass spectrometry detection; s4, data matching and identification: using open source mass spectrum data processing software, setting the mass deviation to be less than or equal to 5ppm, the retention time deviation to be less than or equal to 0.3 min and the Dot product score to be more than or equal to 80%, and carrying out automatic identification; the technical problems that mass spectrum platform data is isolated, multi-species batch detection is difficult, the detection consistency is influenced by the matrix effect, and the compound identification efficiency is low are solved.

Disclosed here are compositions and methods for preventing or treating certain health conditions associated with inflammation or oxidative stress. These compositions are prepared from ingredients containing phytochemicals that activate the Nrf2 pathways. Synergistic effects of the different phytochemicals are also disclosed.

A method for encapsulating a low-solubility phytochemical into a water-soluble nano-complex is presented. The method involves creating a mixture of one or more proteins and a solvent, followed by adjusting the pH to an alkaline condition using an alkaline compound. Zein protein and a low-solubility phytochemical are sequentially added, with the proteins unfolding under alkaline conditions to capture the phytochemical through hydrophobic interactions. The pH is then adjusted to a neutral range using an acidic compound, refolding the zein protein and forming a nano-complex. The solution is dried to produce a dry powder, where the resulting nano-complex has a particle size of less than 1 μm, with the proteins encapsulating the phytochemical.

The invention discloses a traditional Chinese medicine prescription effective small molecule identification method fusing EGA and PPO algorithms, and relates to the technical field of traditional Chinese medicine decoction small molecule identification, and the method comprises the following steps: constructing a molecular seed bank containing TPACD known components and phytochemicals with similar structures, simulating material selection, conversion and recombination mechanisms in a traditional Chinese medicine decoction process through EGA, and identifying the effective small molecules in the traditional Chinese medicine decoction process. Three parallel modules of a basic multi-objective genetic algorithm (BMGA), an enhanced multi-objective genetic algorithm (EMGA) and an intelligent multi-objective genetic algorithm (IMGA) are established by combining sequential decision optimization capability of PPO reinforcement learning, and anti-CRC lead molecules with effectiveness, stability and druggability are screened out through molecular evolution, targeted screening, iterative refining and closed-loop feedback. The molecules generated by the invention are obviously superior to the original component of TPACD in drug-likeness, structural stability and anti-CRC activity, the IMGA module has the best comprehensive performance, and an efficient and explainable new strategy is provided for excavation of active components of traditional Chinese medicine compounds.

Color cosmetic infused with active phytochemical compounds, including cannabinoids endocannabinoids terpene or combinations of the same, and their methods of production and use.

Compositions and methods for protecting against a wide spectrum of viral and bacterial infections, including Covid-19, and for treating established infection and infectious inflammation are described. The composition includes a novel combination of vitamins, minerals, nutraceuticals, and phytochemicals, which may be compounded as a pill, tablet, powder, capsule or liquid to be taken orally or via other administration routs one or more times per day, to serve as immune boosters, antibacterial agents, and antiviral agents along with providing anti-inflammatory effects in humans and animals.

The present invention relates to a method for drying turmeric rhizomes to achieve high curcumin content (+8%) using a controlled natural drying process. The method comprises several key steps: thoroughly washing the turmeric rhizomes and keeping them in a dark room for approximately three days, followed by partial dehydration under shade with about 40% light exposure for another three days. The rhizomes are then soaked in water with added turmeric and turmeric leaf juice to maintain near-neutral pH levels and prevent oxidative degradation for three days. The drying process is initiated in the early morning hours for three hours over the first three days, extended to four hours in the morning for the next three days, and further extended from mid-morning until the evening for an additional three days. The method is also applicable to other spices in the Zingiberaceae family, such as ginger, ensuring the preservation of valuable phytochemicals.

Methods for increasing carotenoid content in a plant and increasing lycopene content in a plant are provided. The methods comprise using blue light and UV-B light alone or in combination in order to increase carotenoid content in a plant. Also provided are methods for increasing the nutritional content of a plant by inducing the conversion of trans-lycopene to cis-lycopene in whole fruit.

This invention discloses a method for identifying effective small molecules in traditional Chinese medicine (TCM) prescriptions by integrating EGA and PPO algorithms. It relates to the field of small molecule identification technology for TCM decoctions, and includes constructing a molecular seed library containing known components from TPACD and structurally similar phytochemicals. EGA simulates the selection, transformation, and recombination mechanisms during the TCM decoction process, while PPO leverages the sequential decision-making optimization capabilities of reinforcement learning. Three parallel modules—Basic Multi-Objective Genetic Algorithm (BMGA), Enhanced Multi-Objective Genetic Algorithm (EMGA), and Intelligent Multi-Objective Genetic Algorithm (IMGA)—are built. Through molecular evolution, targeted screening, iterative refinement, and closed-loop feedback, anti-CRC leader molecules with efficacy, stability, and drug-like properties are screened. The molecules generated by this invention significantly outperform the original TPACD components in terms of drug-likeness, structural stability, and anti-CRC activity. The IMGA module shows the best overall performance, providing an efficient and interpretable new strategy for mining active ingredients in TCM compound prescriptions.

To provide a process for producing a composition containing 4-hydroxymethyl proline, a pharmaceutical composition, a crude drug, or a method for monitoring the quality of a nutritional supplement, and a method for selecting a breeding line and / or variety of a plant.SOLUTION: A composition contains selected isolated 4-hydroxymethyl-proline or a pharmaceutically acceptable salt or a derivative thereof. Further, provided is novel 4- hydroxymethyl-N-methyl-proline together with a preparation process thereof, a composition containing the same, and use thereof as a medical drug and a medicine. Further, also provided is a process of producing a crude drug including a step of monitoring the quality of the crude drug by detecting the presence or absence of one or more of 4-hydroxymethyl-N-methylproline in a sample of the crude drug or by measuring the amount thereof.SELECTED DRAWING: Figure 1

The invention provides biological antibacterial mouthwash for removing helicobacter pylori in an oral cavity. The biological antibacterial mouthwash is prepared from the following components: phytochemicals, antibacterial peptide mCRAMP (mouse), mint hydrolat, vitamin B and deionized water, the plant essential oil comprises the following components in percentage by weight: 9%-10% of phytochemicals, 2%-3% of mCRAMP (mouse), 3% of mint hydrolat, 4%-5% of vitamin B and 80%-83% of deionized water. By adjusting the proportion of the phytochemicals, the antibacterial peptide, the mint hydrolat and the vitamin B, the biological antibacterial mouthwash which has an eradication effect on oral helicobacter pylori and can protect the activity of oral probiotic lactobacillus is obtained, and the mouthwash does not contain antibiotics, is simple in component and simple and convenient to synthesize, and does not damage the steady state of normal flora in the oral cavity.

A system for the extraction of bioactive phytochemicals from Achyranthes aspera seeds, comprising an extraction chamber, a solvent supply unit for providing hydroalcoholic mixtures and a filtration module for producing a clarified extract suitable for applications in the field of obesity treatment.

The present invention relates to roadside analyzer for determination of illegal drugs abuse, including, but not limiting to detection of explosives, toxic industrial chemicals and other banned or regulated compounds, biomarkers and phytochemicals in a sample in situ in at least one human body fluid sample, specifically in oral fluid (saliva), but not limiting to other clinical samples of interest (urine, blood, exhaled breath, exhaled breath condensate, etc.) It consists of automatic processor for preparing samples suitable for analysis. Analysis part of the instrument implements three technologies, namely solid phase extraction prior to analysis, capillary electrophoresis for separation of analytes from the sample matrix and impedance (contactless conductivity) or fluorescence or both impedance (contactless conductivity) and fluorescence for detection of analytes of interest.

A light source for plant cultivation includes at least two light emitting devices supplying light to a plant. Each of the light emitting devices includes a first semiconductor layer doped with a first conductivity type dopant, a second semiconductor layer disposed on the first semiconductor layer and doped with a second conductivity type dopant different from the first conductivity type dopant, and an active layer interposed between the first semiconductor layer and the second semiconductor layer. The light emitting devices emit light towards the plant under a different condition in terms of at least one of wavelength, radiation intensity, and emission timing to control the type and content of phytochemicals in the plant.

The present invention relates to a pesticidal composition comprising an effective amount of phytochemical(s), which optionally combined with commercially known pesticide and agrochemically acceptable excipients or vehicle, and a process for the preparation thereof. The present invention provides a pesticidal composition, which results in enhanced insecticidal efficacy, lower effective doses, multi-target pest control and decreases the possibility of developing the resistance in insects.

Antiviral compositions and methods for protecting against a wide spectrum of viral and bacterial infections and for treating established infection and infectious inflammation are described. The composition includes a novel combination of vitamins, minerals, nutraceuticals, and phytochemicals, which may be compounded as a pill, tablet, powder, capsule, liquid, or other form to be taken orally or via other administration routes one or more times per day, to serve as immune boosters, antibacterial agents, and antiviral agents along with providing anti-inflammatory effects in humans and animals.

The invention relates to the technical field of monitoring of preparation processes of natural plant chemical components, and discloses a real-time monitoring and analysis method for an extraction process of medicinal plant total flavonoids, which is characterized in that in the extraction process of the medicinal plant total flavonoids, the ethanol concentration, the material-to-liquid ratio, the extraction duration and the granularity are compared for many times; the ethanol concentration, the material-liquid ratio, the extraction time length and the granularity concentration in the extraction process of the medicinal plant total flavonoids are determined. According to the real-time monitoring and analysis method for the extraction process of the medicinal plant total flavonoids, the process parameters of the ethanol concentration, the material-to-liquid ratio, the extraction duration and the granularity in the ethanol extraction process of the medicinal plant total flavonoids are monitored to judge whether the requirements are met or not, and self-adaptive adjustment is carried out; the problem that the extraction rate of the total flavonoids is too low due to too large deviation of technological parameters of ethanol extraction of the total flavonoids of the medicinal plants is avoided, the stability of the ethanol extraction rate of the total flavonoids of the medicinal plants is guaranteed, and then the product quality is guaranteed.

A light source module for plant cultivation includes a main light source, an auxiliary light source unit, and a controller. The main light source unit emits background light which is visible light for growth of a plant. The auxiliary light source unit emits auxiliary light including UVB, UVC, or both to increase the content of phytochemicals in the plant. The controller controls operation of the main light source unit and the auxiliary light source unit based on a control signal.

The invention discloses a novel quercetin-hexahydric alcohol eutectic crystal and a preparation method thereof. These co-crystals have been developed as innovative pharmaceutical formulations. The invention encompasses methods for producing these eutectic materials and their use as biological enhancers of active pharmaceutical ingredients, phytochemicals, vitamins and minerals. The disclosed method for preparing quercetin-hexahydric alcohol co-crystals involves forming co-crystals by a kinetically controlled co-crystallization process, enhancing the bioavailability and efficacy of biologically active compounds.