61 results about "Phytochemical" patented technology

Disclosed are novel pharmaceutical, animal feed compositions and methods of treating non-human animals comprising at least one component selected from the extract(s), fraction(s), active compound(s) and phytochemical(s), or mixtures thereof, derived from non-woody plants of the genus Hesperaloe. Animal feed compositions may comprise a basal animal feed and water soluble solids extracted from Hesperaloe and comprising at least one saponin. The water soluble solids may comprise from about 5 to about 30 wt % saponin. The compositions of the present invention can be used for the treatment of non-human animals, such as poultry and more particularly for preventing and treating coccidiosis. An embodiment provides an immunological composition useful for inducing the production of antibodies to an antigen in a non-human animal comprising an antigen, preferably a coccidia, and a saponin composition extracted from Hesperaloe. The saponins extracted from Hesperaloe biomass may comprise 25(27)-dehydrofucreastatin, 5(6),25(27)-disdehydroyuccaloiside C, 5(6)-disdehydroyuccaloiside C, furcreastatin and yuccaloiside C.

The invention belongs to the field of food processing and safety, and provides a steam explosion improved grain processing byproduct and application thereof in preparation of low-GI coarse grain biscuits. The triticale bran is pretreated through a steam explosion (SE) technology, the content of soluble dietary fibers is increased by 53.63% under the conditions of 1.0 MPa and 90 s, and the content of free phytochemicals and the oxidation resistance are the highest; the color of the wheat bran is changed into dark brown / dark brown from light brown, the interior of the wheat bran is of a porous honeycomb structure, the water binding capacity and the swelling property are improved, and an infrared spectrum shows that methyl and methylene structures are damaged and tissues are loosened; the fatty acid value is remarkably reduced, the storage period and the shelf life are effectively prolonged, comprehensive improvement of nutritional ingredients, physicochemical properties, biological activity and storage characteristics is achieved, and remarkable technical advantages are achieved.

The present invention relates to an albumin nanocomposite comprising a phytochemical, and a composition for improving muscle diseases comprising the same, and more specifically, to an albumin nanocomposite comprising a phytochemical, the present invention relates to an albumin nanocomposite containing phytochemicals, and more specifically, to an albumin nanocomposite containing phytochemicals, which exhibits the effects of inhibiting muscle reduction caused by oxidative stress or inflammatory response and promoting the differentiation of myoblasts into muscle cells. The albumin nanocomposite containing the phytochemicals can target and induce immune cells of active oxygen and inflammatory reaction and effectively deliver the phytochemicals, so that muscle cell atrophy is inhibited and differentiation is promoted by adjusting a muscle reduction signal mechanism induced by the active oxygen and the inflammatory reaction, and further muscle reduction can be improved, so that the curative effect of the albumin nanocomposite is improved. The muscular dystrophy is prevented and treated. Therefore, the composition containing the albumin nanocomposite containing phytochemicals of the present invention can be provided as a composition for improving muscle diseases.

The present invention provides a composition comprising adenosine or adenosine triphosphate (ATP) acting as an absorption enhancer when combined with a nutritional material(s) such as nutrients, protein, peptides, vitamins, phytochemicals, minerals, fatty acids, or amino acids or a drug. Methods of administering ATP or adenosine to improve the bioavailability of a nutritional material(s) such as nutrients, protein, peptides, vitamins, phytochemicals, minerals, fatty acids, or amino acids or a drug are described.

A light source for plant cultivation includes a first light source emitting a first type of light for photosynthesis of a plant and a second light source emitting a second type of light for adjustment of phytochemicals in the plant. The first type of light has at least one peak in the visible spectrum, and the second type of light has a peak in a different wavelength band from the first light source. The second type of light has a peak in the wavelength band of about 360 nm to about 420 nm.

A composition comprising Bidens pilosa or an active compound isolated from the Bidens pilosa for use in treating, inhibiting and / or decreasing the presence of pathogenic gut microbiota in an animal in need thereof is disclosed. The pathogenic gut microbiota are at least one selected from the group consisting of Brachyspira, porcine epidemic diarrhea virus (PEDV), transmissible gastroenteritis coronavirus (TGEV) and Rotavirus (RV). The composition is also for use in treating, inhibiting and / or decreasing occurrence of swine diarrhea, swine dysentery, swine viral infection and increasing the percentage of swine carcass and bone weight. In one embodiment, the composition is for use in treating, inhibiting and / or decreasing occurrence of swine dysentery associated with Brachyspira.

The invention relates to the technical field of food, in particular to rumex hanus and burdock green juice with multiple effects, and the rumex hanus and burdock green juice mainly comprises rumex hanus and burdock. The rumex hanus and the burdock are nutritional supplements based on plants, contain a large amount of protein, amino acid, vitamins, mineral substances and various plant compounds, and can achieve the effects of improving gastrointestinal digestion, resisting oxidation, reducing blood sugar and blood pressure and improving immunity.

Described are processes for the production of a composition comprising (2R, 3R, 4R, 5S)-3, 4, 5-trihydroxypiperidine-2-carboxylic acid (idoBR1), said process comprising the steps of: a) providing plant material from a botanical source comprising plant of the family Cucurbitaceae; b) fractionating said plant material to produce an extract enriched in idoBR1 c) assaying said extract for: i) inhibitory activity against sialidase or TNF-alpha or ii) IL-10 stimulatory activity; and d) formulating said assayed extract with a cosmetically-, nutraceutically- or pharmaceutically-acceptable excipient or carrier to produce a cosmetic, nutraceutical or pharmaceutical composition.

The present disclosure relates to an albumin nanocomposite comprising a phytochemical and a composition for muscle disease comprising the same, and more specifically, to an albumin nanocomposite comprising a phytochemical that exhibits an effect of inhibiting muscle loss caused by oxidative stress or inflammatory response and promoting the differentiation of myoblasts into muscle cells. The albumin nanocomposite comprising the phytochemical effectively delivers the phytochemical by targeting immune cells that induce reactive oxygen species and inflammatory responses. Accordingly, by regulating muscle-loss signaling pathways induced by reactive oxygen species and inflammatory responses, the nanocomposite inhibits muscle cell atrophy and promotes differentiation. Therefore, a composition comprising the albumin nanocomposite comprising the phytochemical according to the present disclosure can be provided as a composition for improving, preventing, or treating muscle diseases.

Pharmaceutical formulations and methods to increase the bioactivity and bioavailability of plant compound having hydrophobic phytochemicals which have poor bioavailability due to poor water solubility. Dispersions of extracts of Boswellia and / or Curcuma longa in sesame seed oil. Analgesic and anti-inflammatory composition having a) an extract of Boswellia, b) one or more of an extract of Curcuma longa, a curcuminoid composition and combinations thereof, and, c) a sesame seed oil. The analgesic and anti-inflammatory composition has particles having a particle size ranging from less than about 20 micrometers to about 1 micrometer. The analgesic and anti-inflammatory composition provides a total combined specific surface area provided by particles in the composition ranging from about 900 meter2 per kilogram to about 3000 meter2 per kilogram of the composition. Methods of preparing the compositions and methods of treating inflammation and musculoskeletal disorders are provided.

The present invention relates to a phytochemical-containing albumin nanocomplex and a composition containing the same for improving muscle diseases. More specifically, the present invention relates to a phytochemical-containing albumin nanocomplex that has the effect of suppressing muscle loss caused by oxidative stress or inflammatory responses and promoting the differentiation of myoblasts into muscle cells. The phytochemical-containing albumin nanocomplex effectively delivers phytochemicals to immune cells that induce reactive oxygen species and inflammatory responses, thereby regulating the muscle loss signaling mechanism induced by reactive oxygen species and inflammatory responses, suppressing muscle cell atrophy, and promoting differentiation. This can improve muscle loss and prevent and treat muscle atrophy. Therefore, a composition containing the phytochemical-containing albumin nanocomplex of the present invention can be provided as a composition for improving muscle diseases.

A nanomaterial is gold or silver nanoparticle having a nanoparticle surface that consists of one or more of the following extracts from sweet gum leaves: shikimic acid, sweet gum leaf family of Catechins, sweet gum leaf family of Quercetin, Sweroside, Afzelechin, p-Coumaric Acid, Epiafzelechin Trimethyl Ether, Myricetin, Naringenin, Phloretin, Procyanidin B1 and related polyphenols, flavonoids and alkaloids. An antiviral / antibacterial agent includes sweet gum mediated silver nanoparticles having a core size and in a concentration having efficacy as an antiviral / antibacterial exceeding a 3 log 10 reduction in viral titer.

A cancer therapeutic agent includes a caffeic acid or cadambine phytochemicals cocktail on surfaces of gold nanoparticles. The agent can include a caffeic acid and cadambine phytochemicals cocktail on the surfaces of the gold nanoparticles. The surfaces are preferably stabilized with gum Arabic. The surfaces can consist of caffeic acid stabilized with gum Arabic, cadambine stabilized with gum Arabic, or caffeic acid and cadambine stabilized with gum Arabic. A method of forming the agents uses electrons of caffeic acid and / or cadambine to reduce gold salt(s) to gold nanoparticles without the use of any external toxic chemical reducing agents.

The invention relates to a skin care composition and method for treating partially sensitive skin, particularly in the vulval area. The skin care composition includes a hydrating mixture of liquid saturated hydrocarbons, a plant extract with anti-inflammatory phytochemicals, and water. The skin care composition is designed for aerosol dispensing. The invention also relates to a method that involves providing the composition and applying it to the sensitive skin area as an aerosol. The invention is not limited to vulval skin and can be used for other sensitive skin areas.

The present invention provides an isolated or engineered polypeptide, a microorganism comprising a nucleic acid sequence encoded by the polypeptide, and a method for synthesizing a polyphenolic phytochemicals phosphate derivative using the polypeptide or the microorganism. The polypeptide having a homologous protein sequence that is more than 70% identical to the polyphenol phosphorylation synthetase (SEQ ID NO: 13) comprises a conserved domain which sequentially comprises: an ATP-binding domain, which includes active catalytic sites of Lys27, Arg102, and Glu282; a substrate-binding domain, which includes a conserved motif of DDHHFYIDAMLDAKAR (SEQ ID NO: 14), and includes active catalytic sites of Asp627, His629, and His630; and a phosphorylated histidine catalytic domain, which includes His795 based on SEQ ID NO: 13.

Described are compositions comprising selected isolated 4-hydroxymethyl-prolines, or pharmaceutically acceptable salts or derivatives thereof. Also described are novel 4-hydroxymethyl-N-methyl-prolines, together with processes for their preparation, compositions containing them, as well as their use as medicaments and pharmaceuticals. Also described are processes for producing a herbal medicine comprising the step of monitoring the quality of said herbal medicine by detecting the presence or absence or measuring the amount of one or more 4-hydroxymethyl-N-methyl-prolines in a sample of said herbal medicine.

A liquid composition for an electronic vaporization device, consisting essentially of an active inhalable source and a terpene source, is disclosed. A liquid composition for an electronic vaporization device is provided consisting essentially of greater than about 60 wt % cannabinoids, from about 5 to about 15 wt % terpenes and less than about 35 wt % non-cannabinoid, non-terpene cannabis phytochemicals. A method is provided for obtaining such a composition. An electronic vaping device and a cartridge for an electronic vaping device containing the composition are also disclosed.

The present invention discloses the phytochemicals extracted from plants as bio-pesticides and bio-stimulant, its composition and method of controlling various harmful organisms without being toxic to humans.

A phytochemical and nutraceutical composition and method for protection against a wide spectrum of viral and bacterial infections, including Covid-19, and for treatment of established infection and infectious inflammation. The composition includes a novel combination of vitamin, mineral, nutraceutical and phytochemical supplements. The composition of supplements and method may be compounded as a pill, tablet, powder, capsule or liquid be taken orally one or more times per day, and parenteral including nasal sprays and inhalers. Vitamin C and vitamin E along with zinc complexed with pyrithione or citrate are used in conjunction with nutraceuticals and phytochemicals provided, respectively, as immune boosters and antiviral agents along with anti-inflammatory nutraceuticals and phytochemicals.

The present invention provides a method of encapsulating a low solubility plant chemical in a water soluble nanocomposite. The method comprises providing a mixture comprising one or more proteins and a solvent, and adding an alkaline compound to adjust the pH of the mixture to an alkaline condition to unfold the three-dimensional structure of the protein. The zein and the low-solubility phytochemicals are sequentially added into the mixture, and it is worthy of noting that under the alkaline condition, the structure of the zein is expanded, and the phytochemicals are combined and fixed through hydrophobic interaction. And adjusting the pH value of the mixture to a neutral range by adding an acidic compound, so as to promote the protein to fold again and form a nano-composite solution. The nanocomplex solution is subsequently further dried to obtain a dried powder of a water-soluble nanocomplex wherein the particle size of the water-soluble nanocomplex is less than 1 micron, the structure of which is a protein-encapsulated low-solubility phytochemical.

Provided herein are genetically engineered mammalian cells that endogenously express one or more phytochemicals, vitamins or therapeutic agents and are suitable for culturing meat products. Methods of making and using the genetically engineered mammalian cells and the cultured meat products are also provided.

The invention belongs to the technical field of plant chemical component analysis, and discloses a multi-species polyphenol flavonoid compound high-throughput identification method which comprises the following steps: S1, constructing a cross-platform compatible MSP database; s2, sample pretreatment: carrying out ultrasonic extraction on a plant sample with 70% methanol, centrifuging, and filtering a supernatant with a filter membrane; wherein the plant sample comprises folium cortex eucommiae, rosemary, day lily, sea-buckthorn, herba houttuyniae or tea leaves; s3, carrying out liquid chromatography-mass spectrometry detection; s4, data matching and identification: using open source mass spectrum data processing software, setting the mass deviation to be less than or equal to 5ppm, the retention time deviation to be less than or equal to 0.3 min and the Dot product score to be more than or equal to 80%, and carrying out automatic identification; the technical problems that mass spectrum platform data is isolated, multi-species batch detection is difficult, the detection consistency is influenced by the matrix effect, and the compound identification efficiency is low are solved.

Disclosed here are compositions and methods for preventing or treating certain health conditions associated with inflammation or oxidative stress. These compositions are prepared from ingredients containing phytochemicals that activate the Nrf2 pathways. Synergistic effects of the different phytochemicals are also disclosed.

A method for encapsulating a low-solubility phytochemical into a water-soluble nano-complex is presented. The method involves creating a mixture of one or more proteins and a solvent, followed by adjusting the pH to an alkaline condition using an alkaline compound. Zein protein and a low-solubility phytochemical are sequentially added, with the proteins unfolding under alkaline conditions to capture the phytochemical through hydrophobic interactions. The pH is then adjusted to a neutral range using an acidic compound, refolding the zein protein and forming a nano-complex. The solution is dried to produce a dry powder, where the resulting nano-complex has a particle size of less than 1 μm, with the proteins encapsulating the phytochemical.

Disclosed are compositions containing chemical constituents from plants, uses of these compositions and methods for making them. In various embodiments, the present invention relates to an improved modes of administration of herbal remedies.

A device for the manufacture and administration of a smart therapeutic composition for the treatment of diabetes and Alzheimer's disease, the device comprising the following: an extraction chamber configured to isolate phytochemicals derived from turmeric, including curcuminoids and turmerones, from turmeric rhizome powder or pre-purified extracts, the extraction chamber further comprising a solvent-assisted ultrasonic unit and a temperature-controlled housing to maintain bioactive stability during extraction; a microfluidic encapsulation chamber which is operatively connected to the extraction chamber and is configured to embed the extracted phytochemicals in lipid-polymer hybrid nanoparticles, wherein the encapsulation chamber comprises a polydimethylsiloxane (PDMS) microchannel network, flow-controlled carrier inlets and a photonic scattering sensor to monitor the size distribution of the nanoparticles; a stabilization unit located downstream of the encapsulation chamber and configured to convert the encapsulated nanoparticles into stable formulations by means of freeze-drying or spray-drying, wherein the stabilization unit includes a humidity-controlled environment to maintain long-term storage stability; a delivery interface configured to deliver the stabilized formulations via oral capsules or transdermal patches, the delivery interface also including a microprocessor-operated dosage controller for programmable delivery schedules; a biosensor array integrated into the device, configured to detect biomarkers from the group consisting of glucose, indicators of oxidative stress, and β-amyloid fragments; and a feedback control system that is operationally connected to the biosensor array and the microfluidic encapsulation chamber, wherein the feedback control system includes an embedded microcontroller with adaptive techniques to dynamically adjust encapsulation ratios, nanoparticle size and dosing intervals based on patient-specific biomarker data.

The invention discloses a traditional Chinese medicine prescription effective small molecule identification method fusing EGA and PPO algorithms, and relates to the technical field of traditional Chinese medicine decoction small molecule identification, and the method comprises the following steps: constructing a molecular seed bank containing TPACD known components and phytochemicals with similar structures, simulating material selection, conversion and recombination mechanisms in a traditional Chinese medicine decoction process through EGA, and identifying the effective small molecules in the traditional Chinese medicine decoction process. Three parallel modules of a basic multi-objective genetic algorithm (BMGA), an enhanced multi-objective genetic algorithm (EMGA) and an intelligent multi-objective genetic algorithm (IMGA) are established by combining sequential decision optimization capability of PPO reinforcement learning, and anti-CRC lead molecules with effectiveness, stability and druggability are screened out through molecular evolution, targeted screening, iterative refining and closed-loop feedback. The molecules generated by the invention are obviously superior to the original component of TPACD in drug-likeness, structural stability and anti-CRC activity, the IMGA module has the best comprehensive performance, and an efficient and explainable new strategy is provided for excavation of active components of traditional Chinese medicine compounds.

Color cosmetic infused with active phytochemical compounds, including cannabinoids endocannabinoids terpene or combinations of the same, and their methods of production and use.

Compositions and methods for protecting against a wide spectrum of viral and bacterial infections, including Covid-19, and for treating established infection and infectious inflammation are described. The composition includes a novel combination of vitamins, minerals, nutraceuticals, and phytochemicals, which may be compounded as a pill, tablet, powder, capsule or liquid to be taken orally or via other administration routs one or more times per day, to serve as immune boosters, antibacterial agents, and antiviral agents along with providing anti-inflammatory effects in humans and animals.