44 results about "Phytochemistry" patented technology

Disclosed are novel pharmaceutical, animal feed compositions and methods of treating non-human animals comprising at least one component selected from the extract(s), fraction(s), active compound(s) and phytochemical(s), or mixtures thereof, derived from non-woody plants of the genus Hesperaloe. Animal feed compositions may comprise a basal animal feed and water soluble solids extracted from Hesperaloe and comprising at least one saponin. The water soluble solids may comprise from about 5 to about 30 wt % saponin. The compositions of the present invention can be used for the treatment of non-human animals, such as poultry and more particularly for preventing and treating coccidiosis. An embodiment provides an immunological composition useful for inducing the production of antibodies to an antigen in a non-human animal comprising an antigen, preferably a coccidia, and a saponin composition extracted from Hesperaloe. The saponins extracted from Hesperaloe biomass may comprise 25(27)-dehydrofucreastatin, 5(6),25(27)-disdehydroyuccaloiside C, 5(6)-disdehydroyuccaloiside C, furcreastatin and yuccaloiside C.

The present application relates to the field of plant physiology and ecology and plant chemistry, and particularly relates to a method for improving the content of gypenoside R2 in the root system of Suaeda by salt stress and application. The Suaeda plants are stressed by 100-300 mmol / L NaCl solution for 28 days, and the root system is collected to obtain the raw material rich in target saponins. The method can significantly improve the relative content of target saponins gypenoside R2 in the root system of Suaeda. Compared with the control group, the low-salt treatment can increase by 65.34%, the medium-salt treatment can increase by 161.83%, and the high-salt treatment can increase by 240.84%.

The application discloses application of an extract of Epiphyllum crenatum in preparation of a medicine for treating and improving intestinal diseases, relates to the fields of phytochemistry and microbiological technology, and the extract of the Epiphyllum crenatum is type I arabinogalactan. 6 The average molecular weight of the extract of the Epiphyllum crenatum extracted from petals of the Epiphyllum crenatum is 5.767*10 6 Da, and the backbone structure is a polysaccharide of β-Galp connected through (1→4) bonds, which expands the application potential of the Epiphyllum crenatum, improves the value of the Epiphyllum crenatum, and provides a new raw material for the field of the medicine for treating and improving intestinal diseases.

The invention belongs to the technical field of phytochemistry and medicines, and discloses a hemostatic active component from paris polyphylla Franch., an active ingredient, a composition and application of the hemostatic active component, the active ingredient and the composition. The active component mainly contains steroid saponin. The invention also relates to a compound with hemostatic activity, and the compound is 21-hydroxy polyphyllin VII. The active component, the active ingredient and the hemostatic active compound provided by the invention are obtained by extracting a paris polyphylla plant material. Experiments show that the active component and the active ingredient of the paris polyphylla pall have a remarkable hemostatic effect and can be used as a medicine for treating hemorrhagic diseases.

Smart Automated Medicinal Plant Extraction and Phytochemical Analysis Device

The plant chemical type rapid collection device and collection method provided by the application, wherein the plant chemical type rapid collection device comprises a mounting seat, a pull rod and a sampling needle wrapped with stainless steel fibers, the pull rod is coaxially connected with the sampling needle and is arranged in the axial direction of the mounting seat, a sealing sleeve is arranged on the side end face of the mounting seat facing the sampling needle, and the sampling needle can be accommodated in the sealing sleeve; the stainless steel fibers are provided with a silica resin-PMSQ microsphere coating. The plant chemical type rapid collection device and collection method provided by the application adopt a new type of polymethylsilsesquioxane microsphere coating, so that the plant chemical type rapid collection device, especially the sampling needle, has the characteristics of high temperature resistance, good acid and alkali resistance and high extraction efficiency, and can fully absorb plant tissue components in a short time; the plant chemical type rapid collection device is designed and manufactured with a sealing sleeve, and can temporarily store plant samples for a long time.

Water dispersible phyto-extract and / or phytochemical compound compositions suitable for the preparation of beverages, in particular beverages containing one or more phyto-extracts and / or phytochemical compounds, beverage concentrates and methods of preparing same.

The application relates to the technical field of plant chemistry and active ingredient heterocyclic compounds of traditional Chinese medicine, and discloses a C17 sesquiterpene alkaloid, a preparation method and application, wherein the C17 sesquiterpene alkaloid and a pharmaceutically acceptable salt thereof are shown as formula I; the C17 sesquiterpene alkaloid of formula I is separated from an ethanol extract n-butanol extraction phase of Dendrobium huoshanense stems through three-step operations of silica gel column chromatography, acid solution and base precipitation and recrystallization; the structure of the compound is determined through nuclear magnetic resonance, high-resolution mass spectrometry and single crystal diffraction analysis; experiments show that the C17 sesquiterpene alkaloid can effectively inhibit the survival and proliferation of A549 lung cancer cells, has good anti-lung cancer activity, and can be used for preparing anti-lung cancer drugs.

The present disclosure relates to an albumin nanocomposite comprising a phytochemical and a composition for muscle disease comprising the same, and more specifically, to an albumin nanocomposite comprising a phytochemical that exhibits an effect of inhibiting muscle loss caused by oxidative stress or inflammatory response and promoting the differentiation of myoblasts into muscle cells. The albumin nanocomposite comprising the phytochemical effectively delivers the phytochemical by targeting immune cells that induce reactive oxygen species and inflammatory responses. Accordingly, by regulating muscle-loss signaling pathways induced by reactive oxygen species and inflammatory responses, the nanocomposite inhibits muscle cell atrophy and promotes differentiation. Therefore, a composition comprising the albumin nanocomposite comprising the phytochemical according to the present disclosure can be provided as a composition for improving, preventing, or treating muscle diseases.

The invention relates to the field of plant physiological ecology and phytochemistry research, in particular to a method for increasing flavonoid substances in suaeda salsa root exudates under saline-alkali stress and application. And carrying out stress treatment on the suaeda salsa plant for 6-8 weeks by using a NaCl solution with the concentration of 50-300 mmol / L or an alkali solution with the pH value of 8.0-9.0, and collecting a culture solution to obtain the root exudates rich in target flavonoid substances. According to the method, the relative content of the target flavonoid substance 3, 5-Di-O-methyl-8-prenylafelectin-4beta-ol in the suaeda salsa root exudates can be remarkably increased, and compared with a control group, the relative content of the target flavonoid substance 3, 5-Di-O-methyl-8-prenylafelectin-4beta-ol in the suaeda salsa root exudates can be increased by 44.64% through low-salt (100 mmol / L NaCl) treatment and can be increased by 28.9% through high-alkali (pH 9.0) treatment.

The present invention relates to a phytochemical-containing albumin nanocomplex and a composition containing the same for improving muscle diseases. More specifically, the present invention relates to a phytochemical-containing albumin nanocomplex that has the effect of suppressing muscle loss caused by oxidative stress or inflammatory responses and promoting the differentiation of myoblasts into muscle cells. The phytochemical-containing albumin nanocomplex effectively delivers phytochemicals to immune cells that induce reactive oxygen species and inflammatory responses, thereby regulating the muscle loss signaling mechanism induced by reactive oxygen species and inflammatory responses, suppressing muscle cell atrophy, and promoting differentiation. This can improve muscle loss and prevent and treat muscle atrophy. Therefore, a composition containing the phytochemical-containing albumin nanocomplex of the present invention can be provided as a composition for improving muscle diseases.

The application discloses a separation and purification preparation method of high-purity gleditsia saponin monomer, and relates to the technical field of phytochemistry. The method comprises the following steps: obtaining gleditsia sinensis raw material powder; adding the gleditsia sinensis raw material powder into an ethanol solution, adjusting pH, performing ultrasonic extraction, collecting supernatant after centrifugation, repeatedly extracting residues, combining the extraction solutions, and obtaining gleditsia sinensis saponin crude extract; adding a flocculating agent into the crude extract, stirring, sedimentation, suction filtration, filtering through an ultrafiltration membrane, and collecting permeate; loading the permeate into a macroporous adsorption resin column, gradient elution, collecting target eluent, vacuum concentration, and obtaining gleditsia sinensis saponin crude product; gradient elution of the gleditsia sinensis saponin crude product through a silica gel column, collecting components containing gleditsioside A, high-performance liquid chromatography refining, and obtaining gleditsioside A product; dissolving the gleditsioside A product in a mixed solvent, dissolving, cooling, standing crystallization, suction filtration, washing, and obtaining a crystal; vacuum drying the crystal, and obtaining high-purity gleditsia sinensis saponin monomer gleditsioside A.

The application discloses a sesquiterpene compound in llex spicata and an extraction and separation method and application thereof, relates to the technical field of plant chemical extraction and separation, and provides a sesquiterpene compound in llex spicata, which is characterized by comprising at least one of llex spicata lactone F, llex spicata lactone G and llex spicata lactone H. The application provides an extraction method of the sesquiterpene compound in llex spicata, and the three sesquiterpenes obtained by the extraction and separation method are all new compounds which have not been reported. The llex spicata sesquiterpene compound has antibacterial and anti-inflammatory activities, and has potential development value for diseases such as fungal infection, pharyngitis and pneumonia. The llex spicata sesquiterpene compound also has the effects of skin damage repair and anti-aging, and can be applied to the field of cosmetics.

The invention belongs to the field of natural product chemistry and phytochemistry, and particularly relates to application of salvia miltiorrhiza crude polysaccharide, salvia miltiorrhiza oligosaccharide or salvia miltiorrhiza polysaccharide to identification of salvia miltiorrhiza from different producing areas. The production places of different salvia miltiorrhiza bunge are judged according to the different saccharide fragments, the molecular weights of SMP and SMO, monosaccharide components and the proportion of the monosaccharide components, and subsequent research on the salvia miltiorrhiza bunge saccharide structure and function is facilitated. The adopted identification method is simple and easy to operate, low in cost and beneficial to being widely used in production. Meanwhile, in-depth study is carried out on different sugar fragments of salvia miltiorrhiza crude polysaccharides from different producing areas and monosaccharide components and structures of SMO and SMP, and the structure of sugar has a certain influence on the physiological function of the salvia miltiorrhiza, so that a foundation is laid for subsequent study of the salvia miltiorrhiza.

A system for the environmentally friendly synthesis, adsorption testing and characterization of nickel oxide nanoparticles, comprising: a plant extract processing plant configured to extract a phytochemical-rich solution from gooseberry biomass by controlled Soxhlet reflux and continuous water circulation; a pre-reaction and mixing chamber which is operationally connected to the extract preparation unit and is configured to receive metered volumes of the extract and an aqueous nickel nitrate hexahydrate solution, the chamber comprising a temperature-controlled stirrer, a pH probe and a peristaltic feed pump to maintain the homogeneity of the solution and the pH within a predefined range; a microprocessor-controlled calcination and combustion unit connected downstream of the reaction chamber and configured to thermally decompose the reaction mixture into nickel oxide nanoparticles under programmed temperature cycles between 300 °C and 700 °C; a nanoparticle collector and drying system configured to separate, transport and dry the synthesized nanoparticles under inert air circulation at controlled temperature; an adsorption test module with two reaction chambers for simultaneous testing of the adsorption of amaranth dye and hexavalent chromium, each reaction chamber comprising an integrated UV-Vis probe, magnetic stirrer, heating plate and microvalve-controlled reagent inlets for pH modulation; a characterization interface configured to transmit optical and surface data from the nanoparticles via dedicated optical and mechanical coupling ports to analytical instruments such as UV-Vis spectrophotometers, FTIR spectrometers, XRD analyzers, and SEM imaging systems; and a central control and processing unit consisting of a microcontroller configured to receive sensor data from temperature, pH and optical transducers, execute synthesis and adsorption control techniques, calculate adsorption kinetics and output real-time process parameters as well as adsorption efficiency.

The present invention discloses synergistic herbal compositions comprising combination of a first ingredient selected from Centella asiatica extract containing at least one component selected from magnesium salt or complex of asiatic acid and magnesium salt or complex of madecassic acid or mixtures thereof along with asiaticoside and madecassoside; and a second ingredient selected from extract, fraction, phytochemical or mixtures thereof derived from Theobroma cacao; process for their preparation, methods of treatment and use of such nootropic compositions for improving cognitive functions or mental abilities and gaming performance.

The present invention provides a method of encapsulating a low solubility plant chemical in a water soluble nanocomposite. The method comprises providing a mixture comprising one or more proteins and a solvent, and adding an alkaline compound to adjust the pH of the mixture to an alkaline condition to unfold the three-dimensional structure of the protein. The zein and the low-solubility phytochemicals are sequentially added into the mixture, and it is worthy of noting that under the alkaline condition, the structure of the zein is expanded, and the phytochemicals are combined and fixed through hydrophobic interaction. And adjusting the pH value of the mixture to a neutral range by adding an acidic compound, so as to promote the protein to fold again and form a nano-composite solution. The nanocomplex solution is subsequently further dried to obtain a dried powder of a water-soluble nanocomplex wherein the particle size of the water-soluble nanocomplex is less than 1 micron, the structure of which is a protein-encapsulated low-solubility phytochemical.

The present invention relates to a composition effective in treating diabetes and dyslipidemia prepared according to the solid lipid nanotechnology from two natural phytochemical active ingredients: cinnamonaldehyde extracted from the Vietnamese cinnamon and berberine as a bioactive compound extracted from several plants, including a group of shrubs called Berberis. Via testing, all of the composition of the present invention has shown to have low toxicity and great bioavailability, reduced insulin resistance that allows the sugar level in blood to more effectively induce reduction of insulin, hyperglycolysis that aids the body in cellular sugar decomposition, reduced sugar production in the liver, carbohydrate decomposition slowed down in the intestines, and an increasing in the number of beneficial microbes in the intestines. The composition is effective in reducing the total cholesterol level (TC), and non-HDL-cholesterol, and has a tendency to reduce TG level.

Disclosed here are compositions and methods for preventing or treating certain health conditions associated with inflammation or oxidative stress. These compositions are prepared from ingredients containing phytochemicals that activate the Nrf2 pathways. Synergistic effects of the different phytochemicals are also disclosed.

A method for encapsulating a low-solubility phytochemical into a water-soluble nano-complex is presented. The method involves creating a mixture of one or more proteins and a solvent, followed by adjusting the pH to an alkaline condition using an alkaline compound. Zein protein and a low-solubility phytochemical are sequentially added, with the proteins unfolding under alkaline conditions to capture the phytochemical through hydrophobic interactions. The pH is then adjusted to a neutral range using an acidic compound, refolding the zein protein and forming a nano-complex. The solution is dried to produce a dry powder, where the resulting nano-complex has a particle size of less than 1 μm, with the proteins encapsulating the phytochemical.

The invention belongs to the field of phytochemistry and medicines, and discloses an antioxidant active ingredient, namely, indole amide glycoside Portulaleramides A-U from Portulaleralea L., and a preparation method of the indole amide glycoside Portulaleramides A-U, wherein the indole amide glycoside Portulaleramides A-U is prepared from Portulalea L.. The invention also relates to a herba portulacae active component with antioxidant activity. According to the present invention, the indole amide glycoside Portulamides A-U can scavenge free radicals ABTS and DPPH, and the Portulamides N can reduce the level of intracellular reactive oxygen species (ROS) so as to provide a significant protection effect on t-BHP induced oxidative damage, such that the indole amide glycoside Portulamides A-U can provide significant protection effects for the t-BHP induced oxidative damage, and can provide significant protection effects for the t-BHP induced oxidative damage,

The invention discloses a traditional Chinese medicine prescription effective small molecule identification method fusing EGA and PPO algorithms, and relates to the technical field of traditional Chinese medicine decoction small molecule identification, and the method comprises the following steps: constructing a molecular seed bank containing TPACD known components and phytochemicals with similar structures, simulating material selection, conversion and recombination mechanisms in a traditional Chinese medicine decoction process through EGA, and identifying the effective small molecules in the traditional Chinese medicine decoction process. Three parallel modules of a basic multi-objective genetic algorithm (BMGA), an enhanced multi-objective genetic algorithm (EMGA) and an intelligent multi-objective genetic algorithm (IMGA) are established by combining sequential decision optimization capability of PPO reinforcement learning, and anti-CRC lead molecules with effectiveness, stability and druggability are screened out through molecular evolution, targeted screening, iterative refining and closed-loop feedback. The molecules generated by the invention are obviously superior to the original component of TPACD in drug-likeness, structural stability and anti-CRC activity, the IMGA module has the best comprehensive performance, and an efficient and explainable new strategy is provided for excavation of active components of traditional Chinese medicine compounds.

Described herein is a method for reducing microplastic levels or reducing or minimizing microplastic accumulation rates in a subject, such as a human. The method includes administering to the subject orally an effective amount of a composition including: an iron (II) compound; a soluble fiber; a fruit or vegetable phytochemical; a turmeric powder or extract; a ginger powder or extract; an omega 3 compound; an alga; and lycopene. Also described herein is a kit for carrying out the methods described herein.

Compositions and methods for protecting against a wide spectrum of viral and bacterial infections, including Covid-19, and for treating established infection and infectious inflammation are described. The composition includes a novel combination of vitamins, minerals, nutraceuticals, and phytochemicals, which may be compounded as a pill, tablet, powder, capsule or liquid to be taken orally or via other administration routs one or more times per day, to serve as immune boosters, antibacterial agents, and antiviral agents along with providing anti-inflammatory effects in humans and animals.

The present invention relates to a method for drying turmeric rhizomes to achieve high curcumin content (+8%) using a controlled natural drying process. The method comprises several key steps: thoroughly washing the turmeric rhizomes and keeping them in a dark room for approximately three days, followed by partial dehydration under shade with about 40% light exposure for another three days. The rhizomes are then soaked in water with added turmeric and turmeric leaf juice to maintain near-neutral pH levels and prevent oxidative degradation for three days. The drying process is initiated in the early morning hours for three hours over the first three days, extended to four hours in the morning for the next three days, and further extended from mid-morning until the evening for an additional three days. The method is also applicable to other spices in the Zingiberaceae family, such as ginger, ensuring the preservation of valuable phytochemicals.

A Phytochemical Extraction Apparatus for Isolation of Bioactive Compounds Device

This invention discloses a method for identifying effective small molecules in traditional Chinese medicine (TCM) prescriptions by integrating EGA and PPO algorithms. It relates to the field of small molecule identification technology for TCM decoctions, and includes constructing a molecular seed library containing known components from TPACD and structurally similar phytochemicals. EGA simulates the selection, transformation, and recombination mechanisms during the TCM decoction process, while PPO leverages the sequential decision-making optimization capabilities of reinforcement learning. Three parallel modules—Basic Multi-Objective Genetic Algorithm (BMGA), Enhanced Multi-Objective Genetic Algorithm (EMGA), and Intelligent Multi-Objective Genetic Algorithm (IMGA)—are built. Through molecular evolution, targeted screening, iterative refinement, and closed-loop feedback, anti-CRC leader molecules with efficacy, stability, and drug-like properties are screened. The molecules generated by this invention significantly outperform the original TPACD components in terms of drug-likeness, structural stability, and anti-CRC activity. The IMGA module shows the best overall performance, providing an efficient and interpretable new strategy for mining active ingredients in TCM compound prescriptions.

This invention belongs to the field of pesticide and phytochemistry technology, specifically relating to an insecticidal alkaloid compound from *Prunus persica* var. *pinnata*, its preparation method, and its application. The structure of the *Prunus persica* var. *pinnata* alkaloid compound is shown below. This alkaloid compound, isolated from *Prunus persica* var. *pinnata*, is designated as compound Pactermine X. It is a novel alkaloid isolated from *Prunus persica* var. *pinnata*. Its stomach poison and repellency activities against pea aphids were determined. The results showed that compound Pactermine X exhibited strong LC50 activity against pea aphids at 48 h. 50 The concentration was 0.272 mg / mL. At concentrations of 0.5 mg / mL, 0.25 mg / mL, 0.125 mg / mL, and 0.0625 mg / mL, the avoidance rates over 12 hours were 100%, 72.5%, 42.5%, and 30%, respectively.

The invention discloses a compound additive for improving the quality of leguminous forage silage and application of the compound additive, and belongs to the technical field of agricultural livestock feed processing. The composite additive comprises perilla straw powder and a complex microbial inoculant, wherein the complex microbial inoculant comprises lactobacillus plantarum, streptomyces cellulosae SJS-15 and a carrier. According to the method, natural antibacterial substances in the purple perilla straw and a functional modular microbial agent are subjected to synergistic compatibility, the leguminous forage silage quality is remarkably improved through the principle that a plant chemical barrier is combined with microbial ecological regulation and control, and synergistic promotion of fermentation is systematically achieved; the aerobic stability is doubly guaranteed; the technical effects of systematically improving biological safety and resource circulation and cost advantages are achieved, and a new additive is provided for the field of leguminous forage silage.