32 results about "Gastric digestion" patented technology

The invention provides an in-vitro determination and classification method for the dynamic digestion rate of feed nutrient components and application, and belongs to the technical field of feed science and analysis. According to the technical scheme, the method comprises the following steps: performing simulated in-vitro digestion on a feed sample, wherein the digestion sequentially comprises a simulated stomach digestion stage and a simulated small intestine digestion stage; sampling at a plurality of preset time points in the simulated small intestine digestion stage, and measuring the cumulative digestibility of the target nutrient component in the sample at each time point; the target nutritional component is classified based on the determined cumulative digestibility. Quantitative data of fast, slow and non-digestible components obtained by the method can provide a key scientific basis for designing a precise feed formula and realize optimal matching of nutrition supply and dynamic requirements of animals, so that the utilization efficiency of the animals on feed nutrients is remarkably improved, the growth performance of the animals is improved, the feed cost is reduced, and the economic benefits of the animals are improved. Resource consumption and environmental pollution are reduced, and remarkable economic benefits and application values are achieved.

The present invention relates to the field of nutritional compositions, methods of providing nutritional compositions and uses thereof. More particularly, the present invention relates to a ready-to-eat powdered infant formula or ready-to-eat powdered growth formula exhibiting desirable gastric digestion characteristics. There is provided a nutritional composition comprising casein, whey protein comprising alpha-lactalbumin (aLac) and beta-lactoglobulin (bLac), and protein-coated fat droplets wherein the composition has a protein content of from 5% to 20% (w / w) based on total solids; the bLac content is at least 3% (w / w) based on the total protein level, and the aLac + bLac content is at least 25% (w / w) based on the total protein level; the fat content is in the range of 10% to 50% (w / w) based on total solids; the fat droplets are coated with an average protein load of 2 to 10 mg / m2, and wherein the weight ratio of casein: (aLacc + bLac) on the fat droplets is at least 4 times the weight ratio of casein: (aLacc + bLac) in the total composition; the level of sphingomyelin per 100 g of the composition is between 70 mg and 200 mg; the level of phospholipids per 100 g of the composition is between 280 mg and 950 mg.

The invention relates to the technical field of aquaculture and feed engineering, and discloses a bionic fish digestion simulation system based on heat pump temperature control and software driving, which comprises an environment simulation subsystem, a bionic stomach digestion subsystem, a bionic pylorus subsystem, a bionic intestinal tract subsystem and an intelligent control and detection subsystem. The whole bionic digestive organ is immersed in an extremely stable water body environment, and accurate and stable control of the water temperature of + / -0.1 DEG C of the experimental water tank is realized. The problems that a traditional method is poor in temperature uniformity and large in fluctuation are fundamentally solved, the body temperature requirements of various fishes such as cold water fishes and warm water fishes can be accurately met, a reliable temperature basis is provided for digestive enzyme activity simulation, and the scientificity and repeatability of experimental data are remarkably improved.

This invention discloses a method for evaluating the bioavailability of soybean oil based on an in vitro digestion / cell co-culture model. Soybean oil is emulsified using WPI emulsifier and then digested sequentially through simulated gastric and intestinal fluids to obtain the gastric digestion products of soybean oil. Fatty acids are extracted from the intestinal digestion products of soybean oil, dissolved in dimethyl sulfoxide, and linked to fatty acid-free bovine serum albumin to obtain in vitro digestion products of soybean oil that can be absorbed by the intestines. These are then added to a cell co-culture model for cell incubation and transport. HepG2 cells from the cell co-culture model are collected, and Oil Red O staining and total triglyceride content are measured to obtain lipid deposition, thereby evaluating the bioavailability of soybean oil. The in vitro digestion / cell co-culture model of this invention is specifically designed for soybean oil digestion. This method objectively and scientifically evaluates the bioavailability of soybean oil at different metabolic stages, providing a standard basis for the scientific and healthy consumption of soybean oil and possessing significant practical value.

This invention provides an acid-resistant nutrient-carrying nanomicelles and its preparation method, comprising: (1) dissolving ursolic acid, 1-hydroxybenzotriazole, and 1-ethyl-(3-dimethylaminopropyl)carbodiimide hydrochloride in a solvent and stirring to obtain an activated ester; (2) reacting an amine-containing cationic polymer with the activated ester obtained in step (1) to obtain an amphiphilic cationic polymer; (3) mixing the amphiphilic cationic polymer with a lipid-soluble active substance in a good solvent, removing the good solvent by rotary reflux in the dark to obtain nutrient-carrying nanomicelles; and (4) mixing the polyanionic polymer solution with the nutrient-carrying nanomicelles in water to obtain acid-resistant nutrient-carrying nanomicelles. The nanomicelles prepared by this invention can withstand gastric digestion and gel and aggregate in the enteritis area of ​​mice by prolonging the intestinal retention time.

The invention discloses a silage data processing device, method and computer program for predicting rumen digestion gas production. Based on silage properties (13 input variables) and rumen gas production and digestion results (14 output variables at different moments), a model for predicting the gas production and digestion results of the silage in the rumen is constructed by using five tree models such as CatBoost and the like. R2 of the total gas production rate prediction model and R2 of the methane yield prediction model can be higher than 0.83, and the highest R2 can reach 0.96; the R2 of the digestibility model is more than 0.79, except for the IVDMD24h model (0.58), the data processing device and method can be applied to precise feeding and green breeding of ruminants.

The invention discloses a dynamic bionic stomach digestion model and application thereof in micro-plastic detection.The dynamic bionic stomach digestion model comprises a box body, a fixing plate, an artificial stomach model, rolling wheels, a pylorus squeezing plate, a pH meter, a heating mechanism, a gastric acid solution cavity, a gastric juice solution cavity, a peristaltic pump and a micro-dialysis probe, and the rolling wheels are rotationally arranged on the fixing plate and located on the periphery of the outer surface of the artificial stomach model; the pylorus extrusion plate is movably arranged on the fixing plate and located on the outer side of the lower end of the artificial stomach model so as to extrude the lower end of the artificial stomach model, and the gastric acid solution cavity and the gastric juice solution cavity are communicated with the upper end of the artificial stomach model through the peristaltic pump. The method comprises the following steps: adding an aged biofilm-loaded micro-plastic sample or a micro-plastic sample loaded with heavy metal and the like and agar balls into an artificial stomach model, digesting in the artificial stomach model, detecting discharged liquid, solids and the like after digestion is completed, detecting the concentration change of digestive juice, micro-plastic particles and micro-plastic precipitates on agar ball particles, and determining the concentration change of the micro-plastic precipitates on the micro-plastic particles and the agar balls. Product identification and the like.

The invention belongs to the technical field of carrier delivery, and provides a W / O / W emulsion for efficiently delivering active substances to intestinal tracts and a preparation method of the W / O / W emulsion. The W / O / W emulsion provided by the invention is prepared by constructing an outer water phase through hydrated whey protein isolate and cellulose nanocrystals, taking a glycerol-trehalose aqueous solution as an inner water phase, compounding an emulsifier oil phase and performing high-speed dispersion twice. According to the preparation method, the storage stability (TSilt, 5, Zeta potential absolute value gt, 30mV for storage in 5d) and digestion tolerance of the emulsion can be remarkably improved through the synergistic effect of the protein-cellulose nanocrystals, and internal-phase bioactive substances are prevented from being inactivated through dual protection; the external water-phase cellulose nanocrystals form a physical barrier, so that the digestion rate of whey protein is delayed (the digestion rate at the gastric digestion stage is reduced by more than 40%), the controlled release of functional components is realized, and a structural guarantee is provided for an oral delivery system.

The application discloses a probiotic directional embedding freeze-dried milk tea powder and a preparation process thereof, and relates to the food processing technical field. The probiotic directional embedding freeze-dried milk tea powder comprises freeze-dried milk tea powder and probiotic microcapsule powder, and the mass ratio of the freeze-dried milk tea powder to the probiotic microcapsule powder is (90-95):(5-10). The probiotic microcapsule powder comprises probiotics and an embedding layer wrapped outside the probiotics, and the embedding layer comprises, from inside to outside, a sodium alginate-calcium ion gel layer, a chitosan-pectin composite film layer and an inulin layer. The probiotic directional embedding freeze-dried milk tea powder can maintain the milk tea flavor, does not need to be prepared with hot water, can effectively protect the probiotic activity and improve the survival rate of the probiotics in the stomach digestive tract.

The invention provides a sodium alginate nano-liposome embedded with squid-derived polypeptide, the sodium alginate nano-liposome comprises a core material and a wall material, the core material is squid-derived glycyl-prolyl-skeleton structure peptide, the wall material is sodium alginate, and the sodium alginate nano-liposome is prepared through high-pressure homogenization and molecular self-assembly. The sodium alginate-nano liposome prepared by the preparation method disclosed by the invention is relatively high in encapsulation efficiency which can reach 68.05%, the average particle size is 250.5 nm, the PDI value is 0.204, and the zeta potential is-58.4 mV. SA-LIP is small in particle size, good in monodispersity and high in stability. SA-LIP has a slow release property, and can continuously release squid-source glycyl-prolyl-skeleton structure peptide within 45-50 hours, so that the squid-source glycyl-prolyl-skeleton structure peptide can continuously play an active role in vivo. SA-LIP can protect the squid-source glycyl-prolyl-skeleton structure peptide from being damaged in the gastric digestion stage, the release rate is only 10-20%, and targeted release is achieved at the small intestine part.

The invention provides a bionic stomach micro-fluidic chip based on liquid drop micro-fluidic control and mechanical force stimulation and application of the bionic stomach micro-fluidic chip. The bionic stomach micro-fluidic chip comprises a liquid drop generation module and a mechanical force stimulation module. The liquid drop generation module is used for dispersing artificial stomach digestive juice and a to-be-digested Newtonian fluid sample in an oil phase by utilizing a micro-fluidic chip structure to form monodispersed water-in-oil liquid drops to simulate a discrete chyme group; and the mechanical force stimulation module is provided with a micro-channel with a periodically variable cross section. When liquid drops flow through the flow channel, the liquid drops are extruded and deformed periodically, a complex flow field is generated in the liquid drops, and the mechanical kneading effect of stomach wall wriggling on chyme balls is simulated. By limiting biochemical reaction in micro-droplets and applying controllable physical shear force, collaborative high-fidelity simulation of chemical and mechanical effects in the gastric digestion process is realized, and the problems that a traditional static model is low in simulation degree and large dynamic equipment is low in flux and high in cost are solved. And a brand new high-throughput research platform is provided for the fields of food and medicine.

The invention is applicable to the technical field of compound preparations, and provides a traditional Chinese medicine compound microecological preparation capable of invigorating spleen to promote digestion and a preparation process thereof. Atractylodes macrocephala koidz, immature bitter orange, elecampane, katsumadai seed, endothelium corneum gigeriae galli, hawthorn and pericarpium citri reticulatae are used as core components, lactic acid bacteria and saccharomycetes are combined to form a traditional Chinese medicine spleen and stomach regulating and micro-ecological absorption promoting synergistic system, the spleen and stomach digestion function can be improved, meanwhile, intestinal flora is directly regulated, and digestion and absorption are promoted; traditional Chinese medicine is extracted through two times of decoction, traditional Chinese medicine liquid is sterilized, and the traditional Chinese medicine liquid is subjected to segmented fermentation through lactic acid bacteria and saccharomycetes with precisely controlled viable count, so that synergistic conversion of effective components of traditional Chinese medicine and probiotics can be effectively promoted, absorption is more facilitated, and the traditional Chinese medicine is more suitable for long-term spleen and stomach function conditioning.

The application provides an evaluation method of pesticide residue bioavailability of aquatic products, which comprises the following steps: simulating oral mastication, simulating gastric digestion and simulating intestinal digestion of aquatic product samples to obtain digested chyme; detecting pesticide residues in the digested chyme and the aquatic product samples by gas chromatography respectively, and calculating the bioavailability of pesticides in the aquatic products after gastrointestinal digestion; and further evaluating the bioavailability of pesticides across the cell membrane in the aquatic products by performing cell absorption and transport experiments. The method is simple, convenient and operable, and can be used to evaluate the bioavailability of pesticide residues in aquatic products in human body, and provides a reference for further evaluating the bioavailability of pesticide residues in aquatic products.

The invention relates to the technical field of biology, in particular to a novel calcium chelating peptide capable of keeping high activity in a gastrointestinal tract environment. The fishbone peptide comprises a polypeptide with an amino acid sequence as shown in SEQ ID NO. 1. The fishbone peptide can be used for preparing a novel calcium chelating peptide, and a calcium peptide chelate prepared from the chelating peptide can resist degradation of digestive enzymes in the gastric digestion process and maintain high calcium retention rate and chelating activity in the intestinal digestion process, so that high calcium bioavailability is guaranteed.

The utility model relates to a bionic stomach mechanism with a pressure feedback function and a bionic digestive system, the bionic stomach mechanism comprises a flexible bionic stomach, a flexible sensor and a driving mechanism, the flexible sensor is arranged in the stomach wall of the flexible bionic stomach; the two sets of driving mechanisms are symmetrically arranged on the two sides of the flexible bionic stomach, each driving mechanism comprises a rotary driving source, the output end of each rotary driving source is provided with a telescopic driving source, the output end of each telescopic driving source is connected with a mounting base, a connecting shaft is arranged on each mounting base, and a plurality of rolling wheels are rotationally arranged on each connecting shaft. According to the bionic stomach mechanism, the magnitude of the acting force of the flexible bionic stomach can be adjusted under the condition that the driving mechanism does not need to be shifted, assembled and disassembled, the flexible sensor is integrated in the stomach wall, and the magnitude and distribution of the stress of the stomach wall can be monitored in real time through the flexible sensor; meanwhile, the acting force of the driving mechanism on the stomach wall can be adjusted according to feedback pressure data, so that an experiment closer to the real stomach digestion process of a human body is simulated.

The invention discloses a starch-based gel carrier for collaborative delivery of vitamin D-calcium and a preparation method thereof. According to the invention, calcium ions and vitamin D nutrients are delivered by preparing a starch-based gel carrier, and the release of the carrier in a simulated in-vitro stomach and intestine digestion stage is determined. The starch-based gel carrier prepared by the invention can realize targeted release of calcium ions and vitamin D in an intestinal digestion stage, and is relatively low in cost and simple in process. By taking common corn starch and sodium laurate as examples, after a starch-sodium laurate compound and a starch-vitamin D compound suspension are added into nano calcium carbonate, formation of gel is induced in situ, and slow release of calcium ions and vitamin D in a gastric digestion stage and rapid release of calcium ions and vitamin D in an intestinal digestion stage are realized. The gel carrier can realize protection of vitamin D in a stomach digestion stage and targeted release of vitamin D in an intestinal digestion part, and can effectively improve absorption of vitamin D by a human body so as to assist absorption of calcium ions by the human body.

The present application belongs to the technical field of medicine, and especially relates to a kind of appetizing and digesting tablets. The problem caused by dyspepsia is solved to solve dyspepsia. The technical scheme is as follows: the main use is to relieve dyspepsia.

The invention relates to a bionic gastrointestinal digestive system in a lunar environment, and belongs to the technical field of bionic digestive systems. The bionic stomach digestion system, the bionic small intestine digestion system and the bionic colon fermentation system which are suspended in the water tank are arranged and are circularly connected to form the bionic gastrointestinal digestion system in the simulated moon environment; according to the astronaut gastrointestinal tract digestion simulation device, the stomach metabolism condition, the small intestine metabolism condition and the intestinal flora distribution and metabolism condition in the colon of an astronaut in a weightless environment can be simulated, the gastrointestinal tract digestion problem of the astronaut can be deeply studied, spaceflight food is developed, automation is achieved, and according to a preset program, the astronaut gastrointestinal tract digestion problem can be effectively solved. The PLC controls the addition of a sample, digestive juice and a buffer solution, and simulates the wriggling and emptying of a gastric digestive system, so that the operation is more convenient.

The invention discloses a method for preparing alpha-linolenic acid-chlorogenic acid co-delivery particles based on complex coacervation and electrostatic spray drying technologies, which comprises the following steps: carrying out enzymatic reaction on 1, 2-dilinolenic acid diglyceride and chlorogenic acid to prepare 1, 2-dilinolenic acid-3-chlorogenic glyceride; the alpha-linolenic acid-chlorogenic acid co-delivery particles are prepared by covalently grafting 1, 2-dilinolenic acid-3-chlorogenic glyceride and soybean protein isolate, carrying out complex coacervation with chitosan, and carrying out electrostatic spray drying on the covalently grafted 1, 2-dilinolenic acid-3-chlorogenic glyceride and the chitosan. Water-soluble chlorogenic acid and fat-soluble linolenic acid can be combined together, and the solubility, physical stability, oxidation stability and environmental stability of the chlorogenic acid and the fat-soluble linolenic acid are improved at the same time, so that the chlorogenic acid and the fat-soluble linolenic acid can be prevented from being degraded due to extreme pH, a high-concentration ion environment and the action of enzyme in the stomach digestion process; the biocompatibility of the co-delivery particles and the bioavailability of the alpha-linolenic acid and the chlorogenic acid are improved.

The invention belongs to the technical field of wine brewing, and relates to an in-vitro simulated digestion method of baijiu and application thereof, the method comprises the following steps: mixing a baijiu sample, simulated saliva, an enzyme activator and salivary amylase with activity of 45-70U / mL to simulate oral digestion for 1.5-4.5 seconds to obtain oral digestion endpoint liquid; mixing the oral digestion endpoint liquid with simulated gastric juice, an enzyme activator, pepsase with the activity of 2000-2800U / mL and gastric lipase with the activity of 45-55U / mL, and digesting for 1.5-2.5 hours to obtain gastric digestion endpoint liquid; the gastric peristalsis frequency is 165-235 times / h, and the gastric emptying rate is 80-90 mL / h; mixing the gastric digestion endpoint liquid with simulated intestinal juice and an enzyme activator, and adding pancreatin with the activity of 110-190U / mL and bile acid with the concentration of 11-19mM to obtain small intestine digestion endpoint liquid; the intestinal peristalsis frequency is 560-670 times / h, the intestinal digestion time is 0.6-2.9 h, and the intestinal emptying rate is 51-59 mL / h. The dynamic process of digestion of Baijiu in a human body is simulated, simulated digestion parameters of digestion stages of an oral cavity, a stomach and a small intestine are optimized and simulated, and the digestion, metabolism and absorption conditions of the human body after Baijiu drinking are systematically reflected.

The present application provides a pleurotus eryngii protein-oat beta-glucan complex and a preparation method and application thereof, and relates to the technical field of modified protein.The present application mixes pleurotus eryngii protein, oat beta-glucan and water, and performs complex modification to obtain a pleurotus eryngii protein-oat beta-glucan complex; the complex modification includes wet glycosylation complex modification, high-pressure homogenization complex modification, ultrasonic cavitation complex modification or electrostatic self-assembly complex modification.Compared with existing whey protein isolate / oat beta-glucan thermal complex and naked oat protein / beta-glucan glycosylation complex, the digestion rate of the pleurotus eryngii protein-oat beta-glucan complex prepared by the present application in the gastric digestion stage and the gastrointestinal continuous digestion stage is reduced, the satiety after eating is strong, a theoretical basis is provided for creating healthy low-fat food, and the present application has a good application prospect in the preparation of weight loss drugs or low-fat food.

This invention belongs to the field of probiotic screening and application technology, specifically relating to a strain of *Lactobacillus rhamnosus* and its application in the prevention and treatment of colon polyps and colon cancer. The *Lactobacillus rhamnosus* is named *Lactobacillus rhamnosus* (…). Lacticaseibacillus rhamnosus S28, deposited on January 15, 2026, at the China Center for Type Culture Collection (CCTCC), Wuhan University, Wuhan, China, with accession number CCTCC NO: M2026129, exhibits strong inhibitory activity against *Streptococcus bovis* and demonstrates a strong agglutination effect with it. It can be used to prevent or treat colonic polyps and colon cancer caused by *Streptococcus bovis*. This invention also provides probiotic pellets containing *Lactobacillus rhamnosus* S28, which exhibit strong resistance, effectively protecting the probiotics from gastric digestion, ensuring their smooth arrival in the intestines, and achieving rapid disintegration within the intestines, showing broad market prospects.

This application discloses a method for preparing water-saving surimi gel based on polyphenol-enzyme synergistic crosslinking and its application. The method includes: rinsing surimi raw materials no more than twice; sequentially adding EGCG and TGase to the rinsed surimi, utilizing their synergistic effect to induce protein crosslinking; and then filling and undergoing two-stage heating gelation to obtain the surimi gel. This application significantly improves the breaking strength, elasticity, water-holding capacity, and other textural properties of the surimi gel by introducing synergistic crosslinking of EGCG and TGase into the water-saving rinsing process, successfully overcoming the quality degradation problem caused by reduced rinsing. Simultaneously, the gel exhibits unique digestive-resistant and slow-release properties, delaying protein hydrolysis in the early stages of gastric digestion and ensuring the full release of essential amino acids, thus preserving its nutritional value. This application provides an effective solution for developing high-quality, high-nutrition, and environmentally friendly novel surimi products.

This invention discloses a feed additive for improving rumen digestion efficiency in livestock and its preparation method, belonging to the field of animal feed additive technology. It utilizes nano-magnesium oxide intercalated into bentonite particles as a feed additive to promote food absorption and improve digestion efficiency. Urea is adsorbed into zeolite, and the esterification reaction between the surface hydroxyl groups and the carboxyl groups of acrylic acid solution forms a spatial network structure of starch-grafted modified acrylic acid solution and protein supplement, further enhancing the sustained release of urea. By encapsulating composite amino acid particles within this spatial network structure, amino acid degradation in the rumen is reduced, promoting full absorption of amino acids in the small intestine, thereby improving amino acid utilization and promoting rumen microbial growth. Zeolite and bentonite synergistically reduce ammonia emissions and improve the feeding environment through the adsorption effect of the starch-grafted modified acrylic acid solution resin.

The invention relates to a bionic gastrointestinal digestive system in a weightless environment, and belongs to the technical field of bionic digestive systems. The bionic stomach digestion system, the bionic small intestine digestion system and the bionic colon fermentation system which are suspended in the water tank are arranged and are circularly connected to form a bionic gastrointestinal digestion system in a simulated weightless environment; according to the astronaut gastrointestinal tract digestion simulation device, the stomach metabolism condition, the small intestine metabolism condition and the intestinal flora distribution and metabolism condition in the colon of an astronaut in a weightless environment can be simulated, the gastrointestinal tract digestion problem of the astronaut can be deeply studied, spaceflight food is developed, automation is achieved, and according to a preset program, the astronaut gastrointestinal tract digestion problem can be effectively solved. The PLC controls the addition of a sample, digestive juice and a buffer solution, and simulates the wriggling and emptying of a gastric digestive system, so that the operation is more convenient.

The invention discloses a method for measuring metabolic energy of shelduck feed raw materials by using an in-vitro digestion method. The method comprises the steps of preparing a buffer solution and a digestive juice, simulating stomach digestion, simulating duodenum digestion, simulating empty ileum digestion, calculating metabolic energy and the like. The method is simple and convenient, low in price, wide in application scene and capable of meeting the requirement for rapid detection of metabolic energy of a large number of samples; the digestion integrating degree with the real in-vivo digestion of ducks is higher, and the metabolic energy measurement is more stable and accurate.

The invention discloses salidroside nano-stabilized particles and a preparation method thereof, and belongs to the technical field of medical biology. The salidroside nano-stabilized particle disclosed by the invention is prepared from WPI, MD and SA, the salidroside nano-stabilized particles are WPI-MD-SA (White Petroleum Institute-Methyl Diisocyanate-Sulfonic Acid The WPI-MD-SA composite carrier is of a ternary composite nanostructure formed by self-assembly of WPI, MD and SA through hydrogen bonds, electrostatic interaction or hydrophobic interaction; the protein content of the WPI is not less than 85%; the polymerization degree of the MD is 6 to 9; the molecular weight of the SA is 3 * g / mol to 5 * g / mol. After the prepared salidroside nano-stabilized particles are redissolved, the particle size is 200-500 nm, the encapsulation efficiency is not less than 80%, the in-vitro stomach digestion retention rate is not less than 80%, the intestinal tract release rate is not less than 80%, the problems that salidroside is low in bioavailability and poor in environmental stability are solved, and a new way is provided for nanocrystallization application of natural active ingredients.

The application discloses an in-vitro bionic intestinal barrier damage microphysiological system, which comprises a stomach digestion simulation system, a small intestinal digestion simulation system, a small intestinal interaction simulation system, a large intestinal fermentation simulation system and a large intestinal interaction simulation system. The application simulates the physicochemical environment of the digestion of an inflammatory bowel disease (IBD) patient by adjusting parameters such as pH, and simulates the physiological system of the IBD patient by using human organoids and microorganisms. The in-vitro substitute model not only simulates the digestion, absorption and fermentation process of the gastrointestinal tract of an intestinal barrier damage patient, but also simulates the interaction between food and its metabolites and the intestinal tract by introducing organoids. The model can be used to explore the metabolism or toxic effect of food in the body of an intestinal barrier damage patient, evaluate the bioaccessibility, metabolic fate, interaction with microorganisms and influence on the intestinal tract physiology of food, and realize precise risk assessment.

The invention discloses a child stomach digestion aiding auxiliary device, which adopts a form that an abdomen encircles a binding belt, can be tightly attached to the abdomen of a child, and ensures optimal exertion of massage and hot compress effects. By means of the design of a rotating motor and a telescopic motor of the massage assembly, the massage head can flexibly adjust the massage frequency and strength according to specific requirements of children, meanwhile, the hot compress effect of a heating pipe can relieve stomach discomfort, and the massage comfort and effect are enhanced. In addition, the electrode slice on the top of the massage head can provide current with different intensities to stimulate abdominal acupuncture points, and the digestion aiding effect is further improved. Parents can accurately adjust the heating temperature, the massage frequency and strength and the current output strength and frequency according to the actual situation of children, and it is ensured that the device can play the best effect in different use scenes.

A fully automatic intelligent modular biomimetic human digestive apparatus, and a method. A modular biomimetic complete human digestive system accurately simulates the human digestive process, and comprises key organs such as the oral cavity, the stomach, and the small intestine. Each module has real-time measurement, precise control, and sample collection functions, ensuring that the digestive process is highly controllable and observable. An intelligent control system utilizes sensor technology and microprocessor algorithms to automatically regulate and optimize module operations. The modular structure makes the system easy to assemble and maintain, enables customized configuration as required, and provides flexible, tailored solutions for digestive physiology research. The system comprises modules such as an oral digestion module, a gastric digestion module, a small intestine digestion module, a digesta recovery module, a sample testing module, a power supply module, and a digestive fluid supply module. Each module performs a specific function to collectively ensure the accuracy and controllability of the simulated digestive process.