19 results about "Gastric digestion" patented technology

The invention provides an in-vitro determination and classification method for the dynamic digestion rate of feed nutrient components and application, and belongs to the technical field of feed science and analysis. According to the technical scheme, the method comprises the following steps: performing simulated in-vitro digestion on a feed sample, wherein the digestion sequentially comprises a simulated stomach digestion stage and a simulated small intestine digestion stage; sampling at a plurality of preset time points in the simulated small intestine digestion stage, and measuring the cumulative digestibility of the target nutrient component in the sample at each time point; the target nutritional component is classified based on the determined cumulative digestibility. Quantitative data of fast, slow and non-digestible components obtained by the method can provide a key scientific basis for designing a precise feed formula and realize optimal matching of nutrition supply and dynamic requirements of animals, so that the utilization efficiency of the animals on feed nutrients is remarkably improved, the growth performance of the animals is improved, the feed cost is reduced, and the economic benefits of the animals are improved. Resource consumption and environmental pollution are reduced, and remarkable economic benefits and application values are achieved.

The present invention relates to the field of nutritional compositions, methods of providing nutritional compositions and uses thereof. More particularly, the present invention relates to a ready-to-eat powdered infant formula or ready-to-eat powdered growth formula exhibiting desirable gastric digestion characteristics. There is provided a nutritional composition comprising casein, whey protein comprising alpha-lactalbumin (aLac) and beta-lactoglobulin (bLac), and protein-coated fat droplets wherein the composition has a protein content of from 5% to 20% (w / w) based on total solids; the bLac content is at least 3% (w / w) based on the total protein level, and the aLac + bLac content is at least 25% (w / w) based on the total protein level; the fat content is in the range of 10% to 50% (w / w) based on total solids; the fat droplets are coated with an average protein load of 2 to 10 mg / m2, and wherein the weight ratio of casein: (aLacc + bLac) on the fat droplets is at least 4 times the weight ratio of casein: (aLacc + bLac) in the total composition; the level of sphingomyelin per 100 g of the composition is between 70 mg and 200 mg; the level of phospholipids per 100 g of the composition is between 280 mg and 950 mg.

The invention relates to the technical field of aquaculture and feed engineering, and discloses a bionic fish digestion simulation system based on heat pump temperature control and software driving, which comprises an environment simulation subsystem, a bionic stomach digestion subsystem, a bionic pylorus subsystem, a bionic intestinal tract subsystem and an intelligent control and detection subsystem. The whole bionic digestive organ is immersed in an extremely stable water body environment, and accurate and stable control of the water temperature of + / -0.1 DEG C of the experimental water tank is realized. The problems that a traditional method is poor in temperature uniformity and large in fluctuation are fundamentally solved, the body temperature requirements of various fishes such as cold water fishes and warm water fishes can be accurately met, a reliable temperature basis is provided for digestive enzyme activity simulation, and the scientificity and repeatability of experimental data are remarkably improved.

This invention discloses a method for evaluating the bioavailability of soybean oil based on an in vitro digestion / cell co-culture model. Soybean oil is emulsified using WPI emulsifier and then digested sequentially through simulated gastric and intestinal fluids to obtain the gastric digestion products of soybean oil. Fatty acids are extracted from the intestinal digestion products of soybean oil, dissolved in dimethyl sulfoxide, and linked to fatty acid-free bovine serum albumin to obtain in vitro digestion products of soybean oil that can be absorbed by the intestines. These are then added to a cell co-culture model for cell incubation and transport. HepG2 cells from the cell co-culture model are collected, and Oil Red O staining and total triglyceride content are measured to obtain lipid deposition, thereby evaluating the bioavailability of soybean oil. The in vitro digestion / cell co-culture model of this invention is specifically designed for soybean oil digestion. This method objectively and scientifically evaluates the bioavailability of soybean oil at different metabolic stages, providing a standard basis for the scientific and healthy consumption of soybean oil and possessing significant practical value.

The invention discloses a silage data processing device, method and computer program for predicting rumen digestion gas production. Based on silage properties (13 input variables) and rumen gas production and digestion results (14 output variables at different moments), a model for predicting the gas production and digestion results of the silage in the rumen is constructed by using five tree models such as CatBoost and the like. R2 of the total gas production rate prediction model and R2 of the methane yield prediction model can be higher than 0.83, and the highest R2 can reach 0.96; the R2 of the digestibility model is more than 0.79, except for the IVDMD24h model (0.58), the data processing device and method can be applied to precise feeding and green breeding of ruminants.

The invention belongs to the technical field of carrier delivery, and provides a W / O / W emulsion for efficiently delivering active substances to intestinal tracts and a preparation method of the W / O / W emulsion. The W / O / W emulsion provided by the invention is prepared by constructing an outer water phase through hydrated whey protein isolate and cellulose nanocrystals, taking a glycerol-trehalose aqueous solution as an inner water phase, compounding an emulsifier oil phase and performing high-speed dispersion twice. According to the preparation method, the storage stability (TSilt, 5, Zeta potential absolute value gt, 30mV for storage in 5d) and digestion tolerance of the emulsion can be remarkably improved through the synergistic effect of the protein-cellulose nanocrystals, and internal-phase bioactive substances are prevented from being inactivated through dual protection; the external water-phase cellulose nanocrystals form a physical barrier, so that the digestion rate of whey protein is delayed (the digestion rate at the gastric digestion stage is reduced by more than 40%), the controlled release of functional components is realized, and a structural guarantee is provided for an oral delivery system.

The application discloses a probiotic directional embedding freeze-dried milk tea powder and a preparation process thereof, and relates to the food processing technical field. The probiotic directional embedding freeze-dried milk tea powder comprises freeze-dried milk tea powder and probiotic microcapsule powder, and the mass ratio of the freeze-dried milk tea powder to the probiotic microcapsule powder is (90-95):(5-10). The probiotic microcapsule powder comprises probiotics and an embedding layer wrapped outside the probiotics, and the embedding layer comprises, from inside to outside, a sodium alginate-calcium ion gel layer, a chitosan-pectin composite film layer and an inulin layer. The probiotic directional embedding freeze-dried milk tea powder can maintain the milk tea flavor, does not need to be prepared with hot water, can effectively protect the probiotic activity and improve the survival rate of the probiotics in the stomach digestive tract.

The invention provides a bionic stomach micro-fluidic chip based on liquid drop micro-fluidic control and mechanical force stimulation and application of the bionic stomach micro-fluidic chip. The bionic stomach micro-fluidic chip comprises a liquid drop generation module and a mechanical force stimulation module. The liquid drop generation module is used for dispersing artificial stomach digestive juice and a to-be-digested Newtonian fluid sample in an oil phase by utilizing a micro-fluidic chip structure to form monodispersed water-in-oil liquid drops to simulate a discrete chyme group; and the mechanical force stimulation module is provided with a micro-channel with a periodically variable cross section. When liquid drops flow through the flow channel, the liquid drops are extruded and deformed periodically, a complex flow field is generated in the liquid drops, and the mechanical kneading effect of stomach wall wriggling on chyme balls is simulated. By limiting biochemical reaction in micro-droplets and applying controllable physical shear force, collaborative high-fidelity simulation of chemical and mechanical effects in the gastric digestion process is realized, and the problems that a traditional static model is low in simulation degree and large dynamic equipment is low in flux and high in cost are solved. And a brand new high-throughput research platform is provided for the fields of food and medicine.

The application provides an evaluation method of pesticide residue bioavailability of aquatic products, which comprises the following steps: simulating oral mastication, simulating gastric digestion and simulating intestinal digestion of aquatic product samples to obtain digested chyme; detecting pesticide residues in the digested chyme and the aquatic product samples by gas chromatography respectively, and calculating the bioavailability of pesticides in the aquatic products after gastrointestinal digestion; and further evaluating the bioavailability of pesticides across the cell membrane in the aquatic products by performing cell absorption and transport experiments. The method is simple, convenient and operable, and can be used to evaluate the bioavailability of pesticide residues in aquatic products in human body, and provides a reference for further evaluating the bioavailability of pesticide residues in aquatic products.

The utility model relates to a bionic stomach mechanism with a pressure feedback function and a bionic digestive system, the bionic stomach mechanism comprises a flexible bionic stomach, a flexible sensor and a driving mechanism, the flexible sensor is arranged in the stomach wall of the flexible bionic stomach; the two sets of driving mechanisms are symmetrically arranged on the two sides of the flexible bionic stomach, each driving mechanism comprises a rotary driving source, the output end of each rotary driving source is provided with a telescopic driving source, the output end of each telescopic driving source is connected with a mounting base, a connecting shaft is arranged on each mounting base, and a plurality of rolling wheels are rotationally arranged on each connecting shaft. According to the bionic stomach mechanism, the magnitude of the acting force of the flexible bionic stomach can be adjusted under the condition that the driving mechanism does not need to be shifted, assembled and disassembled, the flexible sensor is integrated in the stomach wall, and the magnitude and distribution of the stress of the stomach wall can be monitored in real time through the flexible sensor; meanwhile, the acting force of the driving mechanism on the stomach wall can be adjusted according to feedback pressure data, so that an experiment closer to the real stomach digestion process of a human body is simulated.

The invention discloses a starch-based gel carrier for collaborative delivery of vitamin D-calcium and a preparation method thereof. According to the invention, calcium ions and vitamin D nutrients are delivered by preparing a starch-based gel carrier, and the release of the carrier in a simulated in-vitro stomach and intestine digestion stage is determined. The starch-based gel carrier prepared by the invention can realize targeted release of calcium ions and vitamin D in an intestinal digestion stage, and is relatively low in cost and simple in process. By taking common corn starch and sodium laurate as examples, after a starch-sodium laurate compound and a starch-vitamin D compound suspension are added into nano calcium carbonate, formation of gel is induced in situ, and slow release of calcium ions and vitamin D in a gastric digestion stage and rapid release of calcium ions and vitamin D in an intestinal digestion stage are realized. The gel carrier can realize protection of vitamin D in a stomach digestion stage and targeted release of vitamin D in an intestinal digestion part, and can effectively improve absorption of vitamin D by a human body so as to assist absorption of calcium ions by the human body.

The present application belongs to the technical field of medicine, and especially relates to a kind of appetizing and digesting tablets. The problem caused by dyspepsia is solved to solve dyspepsia. The technical scheme is as follows: the main use is to relieve dyspepsia.

The invention discloses a method for preparing alpha-linolenic acid-chlorogenic acid co-delivery particles based on complex coacervation and electrostatic spray drying technologies, which comprises the following steps: carrying out enzymatic reaction on 1, 2-dilinolenic acid diglyceride and chlorogenic acid to prepare 1, 2-dilinolenic acid-3-chlorogenic glyceride; the alpha-linolenic acid-chlorogenic acid co-delivery particles are prepared by covalently grafting 1, 2-dilinolenic acid-3-chlorogenic glyceride and soybean protein isolate, carrying out complex coacervation with chitosan, and carrying out electrostatic spray drying on the covalently grafted 1, 2-dilinolenic acid-3-chlorogenic glyceride and the chitosan. Water-soluble chlorogenic acid and fat-soluble linolenic acid can be combined together, and the solubility, physical stability, oxidation stability and environmental stability of the chlorogenic acid and the fat-soluble linolenic acid are improved at the same time, so that the chlorogenic acid and the fat-soluble linolenic acid can be prevented from being degraded due to extreme pH, a high-concentration ion environment and the action of enzyme in the stomach digestion process; the biocompatibility of the co-delivery particles and the bioavailability of the alpha-linolenic acid and the chlorogenic acid are improved.

This invention belongs to the field of probiotic screening and application technology, specifically relating to a strain of *Lactobacillus rhamnosus* and its application in the prevention and treatment of colon polyps and colon cancer. The *Lactobacillus rhamnosus* is named *Lactobacillus rhamnosus* (…). Lacticaseibacillus rhamnosus S28, deposited on January 15, 2026, at the China Center for Type Culture Collection (CCTCC), Wuhan University, Wuhan, China, with accession number CCTCC NO: M2026129, exhibits strong inhibitory activity against *Streptococcus bovis* and demonstrates a strong agglutination effect with it. It can be used to prevent or treat colonic polyps and colon cancer caused by *Streptococcus bovis*. This invention also provides probiotic pellets containing *Lactobacillus rhamnosus* S28, which exhibit strong resistance, effectively protecting the probiotics from gastric digestion, ensuring their smooth arrival in the intestines, and achieving rapid disintegration within the intestines, showing broad market prospects.

This application discloses a method for preparing water-saving surimi gel based on polyphenol-enzyme synergistic crosslinking and its application. The method includes: rinsing surimi raw materials no more than twice; sequentially adding EGCG and TGase to the rinsed surimi, utilizing their synergistic effect to induce protein crosslinking; and then filling and undergoing two-stage heating gelation to obtain the surimi gel. This application significantly improves the breaking strength, elasticity, water-holding capacity, and other textural properties of the surimi gel by introducing synergistic crosslinking of EGCG and TGase into the water-saving rinsing process, successfully overcoming the quality degradation problem caused by reduced rinsing. Simultaneously, the gel exhibits unique digestive-resistant and slow-release properties, delaying protein hydrolysis in the early stages of gastric digestion and ensuring the full release of essential amino acids, thus preserving its nutritional value. This application provides an effective solution for developing high-quality, high-nutrition, and environmentally friendly novel surimi products.

The invention discloses a method for measuring metabolic energy of shelduck feed raw materials by using an in-vitro digestion method. The method comprises the steps of preparing a buffer solution and a digestive juice, simulating stomach digestion, simulating duodenum digestion, simulating empty ileum digestion, calculating metabolic energy and the like. The method is simple and convenient, low in price, wide in application scene and capable of meeting the requirement for rapid detection of metabolic energy of a large number of samples; the digestion integrating degree with the real in-vivo digestion of ducks is higher, and the metabolic energy measurement is more stable and accurate.

The invention discloses salidroside nano-stabilized particles and a preparation method thereof, and belongs to the technical field of medical biology. The salidroside nano-stabilized particle disclosed by the invention is prepared from WPI, MD and SA, the salidroside nano-stabilized particles are WPI-MD-SA (White Petroleum Institute-Methyl Diisocyanate-Sulfonic Acid The WPI-MD-SA composite carrier is of a ternary composite nanostructure formed by self-assembly of WPI, MD and SA through hydrogen bonds, electrostatic interaction or hydrophobic interaction; the protein content of the WPI is not less than 85%; the polymerization degree of the MD is 6 to 9; the molecular weight of the SA is 3 * g / mol to 5 * g / mol. After the prepared salidroside nano-stabilized particles are redissolved, the particle size is 200-500 nm, the encapsulation efficiency is not less than 80%, the in-vitro stomach digestion retention rate is not less than 80%, the intestinal tract release rate is not less than 80%, the problems that salidroside is low in bioavailability and poor in environmental stability are solved, and a new way is provided for nanocrystallization application of natural active ingredients.

A fully automatic intelligent modular biomimetic human digestive apparatus, and a method. A modular biomimetic complete human digestive system accurately simulates the human digestive process, and comprises key organs such as the oral cavity, the stomach, and the small intestine. Each module has real-time measurement, precise control, and sample collection functions, ensuring that the digestive process is highly controllable and observable. An intelligent control system utilizes sensor technology and microprocessor algorithms to automatically regulate and optimize module operations. The modular structure makes the system easy to assemble and maintain, enables customized configuration as required, and provides flexible, tailored solutions for digestive physiology research. The system comprises modules such as an oral digestion module, a gastric digestion module, a small intestine digestion module, a digesta recovery module, a sample testing module, a power supply module, and a digestive fluid supply module. Each module performs a specific function to collectively ensure the accuracy and controllability of the simulated digestive process.

The application relates to the technical field of simulation of sorghum polyphenols, in particular to a simulation system for in-vitro digestion space-time evolution of sorghum polyphenols based on a kinetic model. The system comprises the following steps: obtaining an in-vitro digestion environment parameter set, constructing a kinetic model for in-vitro digestion based on the in-vitro digestion environment parameter set, the kinetic model comprising a model for pH value in the stomach changing with time and a model for simulating chyme mixing and transportation of peristalsis; obtaining an initial material information set of a target sorghum material, inputting the initial material information set into the kinetic model, setting the initial material information set as an initial state of simulation, and taking time as a horizontal axis to simulate space-time evolution of the form, content and spatial distribution state of polyphenols in the sorghum material in the process of gastric digestion, and obtain evolution data; and generating and outputting a space-time evolution simulation log representing the in-vitro digestion process of sorghum polyphenols according to the evolution data. The application improves the bioavailability of sorghum polyphenols and promotes the innovative development of the functional food industry.