Looking for breakthrough ideas for innovation challenges? Try Patsnap Eureka!

Integrated human gastrointestinal tract digestive absorption in-vitro substitution model

A gastrointestinal tract digestion and replacement model technology, applied in gastrointestinal cells, biochemical instruments, sterilization methods, etc., can solve the problems of simulating the absorption mechanism, immune mechanism and microbial metabolism mechanism of the digestive tract, etc., and achieve Good stability and reproducible results

Active Publication Date: 2020-12-04
SOUTHERN MEDICAL UNIVERSITY +1
View PDF7 Cites 2 Cited by
  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

The above invention patents have established related in vitro digestion models for simulating human intestinal microorganisms and simulating human gastrointestinal digestion and intestinal microecology, but they also failed to simulate the absorption mechanism, immune mechanism and microbial metabolism mechanism of the digestive tract. simulation of

Method used

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
View more

Image

Smart Image Click on the blue labels to locate them in the text.
Viewing Examples
Smart Image
  • Integrated human gastrointestinal tract digestive absorption in-vitro substitution model
  • Integrated human gastrointestinal tract digestive absorption in-vitro substitution model
  • Integrated human gastrointestinal tract digestive absorption in-vitro substitution model

Examples

Experimental program
Comparison scheme
Effect test

Embodiment Construction

[0042] In order to make the purpose, technical solutions and advantages of the embodiments of the present invention clearer, the technical solutions of the embodiments of the present invention will be clearly and completely described below in conjunction with the accompanying drawings. When the following description refers to the accompanying drawings, unless otherwise indicated, the same reference numerals in different drawings indicate the same or similar elements. It is apparent that the described embodiments are some, not all, of the disclosed embodiments of the invention, which are merely examples consistent with aspects of the invention as recited in the appended claims. Based on the described embodiments of the present invention, all other embodiments obtained by those skilled in the art without creative efforts shall fall within the protection scope of the present invention.

[0043] Unless otherwise defined, the technical terms or scientific terms used in the present ...

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to View More

PUM

No PUM Login to View More

Abstract

The invention provides an integrated human gastrointestinal tract digestive absorption in-vitro substitution model. 12 systems are integrated into an integrated in-vitro simulation digestive model. The systems include a stomach digestion simulation system, a small intestine digestion simulation system, a small intestine absorption simulation system, a large intestine decomposition simulation system, a central intelligent control system, a pH control system, a temperature control system, a stirring rate control system, a conveying system, a central purification system, an automatic cleaning anddisinfection system and an anaerobic system. Through the synergistic effect of the systems, the in-vitro substitution model not only simulates the digestive absorption process of gastrointestinal tracts in vitro, but also simulates the fermentation and decomposition process of intestinal microbial communities at the same time. The model is suitable for accurately quantifying the in-vivo metabolicprocess and toxic effect of nutrients or pollutants in a food matrix to obtain related data such as biological accessibility, biological effectiveness, metabolism trend and microorganism interactionof the nutrients or pollutants, and accurate risk assessment is realized.

Description

technical field [0001] The invention belongs to the technical fields of food safety, in vitro substitution toxicology, microbiology, nutrition, organic chemistry and the like, and in particular relates to an integrated human gastrointestinal digestion and absorption in vitro substitution model. Background technique [0002] After the food enters the gastrointestinal tract of the human body through the mouth, the nutrients or pollutants combined with the food matrix are released into the gastrointestinal juice under the digestion of the gastrointestinal tract, absorbed through the digestive tract, and finally pass through the human body such as blood or lymphatic tissue Circulation reaches the target organ to form a healthy effect. This series of processes is a complex process of digestive juice secretion, enzyme reaction, gastrointestinal motility, and intestinal microbial community. However, the combination form, structure, and physical and chemical properties of nutrients ...

Claims

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to View More

Application Information

Patent Timeline
no application Login to View More
IPC IPC(8): C12M3/00C12M3/06C12M1/38C12M1/36C12M1/34C12M1/24C12M1/12C12M1/04C12M1/02C12M1/00C12N5/09C12N5/071
CPCC12M23/08C12M23/12C12M23/20C12M23/48C12M23/52C12M23/58C12M25/04C12M27/02C12M29/00C12M29/20C12M29/26C12M35/08C12M37/00C12M39/00C12M41/22C12M41/26C12M41/42C12M41/48C12M43/00C12M47/18C12N5/067C12N5/0679C12N5/0693C12N2502/14C12N2502/23C12N2502/30
Inventor 杨杏芬吴炜亮李跃麒范维林李长林徐飞飞
Owner SOUTHERN MEDICAL UNIVERSITY
Who we serve
  • R&D Engineer
  • R&D Manager
  • IP Professional
Why Patsnap Eureka
  • Industry Leading Data Capabilities
  • Powerful AI technology
  • Patent DNA Extraction
Social media
Patsnap Eureka Blog
Learn More
PatSnap group products

Browse by: Latest US Patents, China's latest patents, Technical Efficacy Thesaurus, Application Domain, Technology Topic, Popular Technical Reports.

© 2024 PatSnap. All rights reserved.Legal|Privacy policy|Modern Slavery Act Transparency Statement|Sitemap|About US| Contact US: help@patsnap.com