36 results about "Enterosorption" patented technology

The invention belongs to the field of pharmaceutical preparations, and relates to a recombinant protein vaccine alpha 1,3-fucosyltransferase nanoparticle and a preparation method thereof. The recombinant protein vaccine alpha 1,3-fucosyltransferase nanoparticles prepared by the invention not only can improve the absorption of alpha 1,3-fucosyltransferase in body intestines, but also can improve the ability of macrophages to take in alpha 1,3-fucosyltransferase, and can be used for preventing and treating infection caused by helicobacter pylori.

The invention provides an integrated human gastrointestinal digestion and absorption in vitro substitution model, which is integrated by 12 systems into an integrated in vitro simulation digestion model, including a gastric digestion simulation system, a small intestine digestion simulation system, a small intestine absorption simulation system, a large intestine Decomposition simulation system, central intelligent control system, pH control system, temperature control system, stirring rate control system, conveying system, central purification system, automatic cleaning and disinfection system and anaerobic system. Through the synergy of various systems, this in vitro surrogate model not only simulates the digestion and absorption process of the gastrointestinal tract in vitro, but also simulates the fermentation and decomposition process of the intestinal microbial community. This model is suitable for accurately quantifying the metabolic process and toxic effect of nutrients or pollutants in the food matrix in the body, and obtaining relevant data such as bioaccessibility, bioavailability, metabolic fate and interaction with microorganisms of nutrients or pollutants. Realize precise risk assessment.

An object of the present invention is to provide a pharmaceutical composition that improves intestinal absorption of a compound having a structure represented by the general formula [1]. The composition containing a compound represented by the general formula [1] or a salt thereof and (b) a lipophilic substance improves intestinal absorption of the compound. In the formula, A represents —(NR4)—, —(CR5R6)— or the like; B represents an alkylene group or an alkenylene group; R1 represents an alkyl group, an alkenyl group or the like; R2 represents an adamantylalkyl group or the like; R3 represents an unsaturated heterocyclic ring; R4, R5 and R6 each represent a hydrogen atom or the like; and X represents an oxygen atom or the like.

The invention provides an intestinal-kidney system based on a microfluidic chip for simulating the absorption process of drugs in vivo. The microfluidic chip is mainly composed of a top chip, a porous filter membrane and a bottom chip. The top chip is seeded with intestinal cells, which can simulate the absorption process of drugs in the body; the bottom chip is mainly connected by the left main channel and the right main channel through collagen channels. Inoculate glomerular microtissues in the left main channel, grow glomerular microtissues at the hemispherical interface between the left main channel and the collagen channel by side culture, and form a cell barrier. The right main channel is used as a collection area, which can be observed The glomerular filtration function, and the nephrotoxicity caused by the chemical composition of the drug after intestinal absorption affect the glomerular filtration function. Toxic effects due to the effect of different drug combinations on absorption can be observed. The construction of a drug toxicity evaluation system that simulates the absorption process in vivo, and its application in the evaluation of nephrotoxicity after drug absorption.

The invention pertains to the traditional Chinese medicine field, which provides a medicine used for curing anorexia and limosis and is produced by the following raw medicines with portions by weight: 9-10 portions of corn, 9-10 portions of yam, 3-4 portions of corium stomachichum galli, 3-4 portions of atractylodes macrocephala, 2-3 portions of monascus, 0.5-1 portions of rhubarb and 2-3 portions of black soybeans. The medicine of the invention integrates with the health preserving, treatment and rehabilitation, promotes stomach reception, splenic normal functioning and intestinal absorption, and can achieve the aims of effectively curing the anorexia and the limosis through opsonizing human intestinal flora.

The present invention relates to a Laoxianghuang paste. The raw materials include 100 parts of Laoxianghuang, 2-7 parts of ginseng, 2-7 parts of poria cocos, 6-10 parts of tangerine peel, 6-10 parts of almond and perilla stalk in parts by weight. 8‑15 parts, 8‑15 parts of chrysanthemum, 2000‑2300 parts of water, 60‑184 parts of rock sugar, 3‑4.6 parts of sodium carboxymethylcellulose and 1.5‑2.3 parts of xanthan gum. The preparation method of Laoxianghuang paste of the present invention is simple, the medicinal materials are all of the same origin, the taste is prepared independently, the brewing is convenient, the time is short, and there is no impurity particle insoluble matter, and the medicine enters the intestine quickly, the absorption efficiency is high and the concentration is maintained at a high level And quickly play a role.

The invention discloses a rodgersia sambucifolia hemsl medicinal composition with good stability and high bioavailability as well as a preparation method and an application of the medicinal composition. The composition provided by the invention comprises 1.5 to 5.0% by weight of rodgersia sambucifolia hemsl extract, 5.0 to 24.0% by weight of flavoring agent and the balance of bentonite. The method provided by the invention comprises the processes of active component extracting, ingredient processing and mixing; the active component extracting means grinding the rodgersia sambucifolia hemsl into coarse powder, extracting with ethanol, concentrating to obtain a paste, adjusting the pH value, filtrating and concentrating to obtain a thick paste, diluting, decoloring, filtrating and concentrating to obtain a concentrated thick paste, standing, filtrating the precipitate, and drying to obtain a rodgersia sambucifolia hemsl active component extract; crushing and screening the bentonite; and mixing a main material and the adjuvants to obtain a target composition. According to the invention, the rodgersia sambucifolia hemsl extract is taken as an active component of the medicinal composition, and the formula is reasonably arranged to completely give full play to the effect of the adjuvants on improving the physical and chemical property of a medicinal preparation and the gastrointestinal absorption capacity of the human bodies, so that the stability and the bioavailability of the preparation are improved, the taste is improved, and the crowds with fear of sugars suitable for the composition can be expanded.

The invention relates to the use of human lysozyme in biological medicines targeting drug resisting bacterium and viruses, the invention also discloses its preparation and use thereof. The human lysozyme film agent contains active 300U - 3 million U / ml of human lysozyme, the suppository prepared thereby can be administered directly through rectal intestine, thus can prevent the gastric mucosa from being stimulated, it can facilitate administration to infant and children by using this method.

The present invention relates to the technical field of genetic recombination, and specifically discloses a liposome-encapsulated recombinant veterinary growth-promoting protein and its preparation method and application. The nucleotide sequence of the gene encoding the recombinant veterinary growth-promoting protein is shown as SEQ ID NO Shown in: 1, it is the fusion protein of porcine somatotropin and chicken somatotropin, which can act on the growth promotion of pigs and chickens simultaneously; the molecular weight of this protein is relatively large, and can better solve the problem of short half-life; adopt liposome Encapsulating the recombinant fusion protein in it can avoid the decomposition of protease in the gastrointestinal tract, and more importantly, the liposome has the function of promoting absorption and can guide the intestinal absorption of the protein. The invention uses recombination to produce animal growth-stimulating hormone, which is simpler and lower in cost than the extraction method, and can be widely used in feed additives.

The invention provides a special feed compound additive for squid, which belongs to the technical field of squid breeding, including (I) oligosaccharide composition; and / or (II) carboxylic acid ester; and (III) protease complex; the (III) protease The complex is a protease complex comprising a potent protease mixture obtained by culturing Myces lanuginosa. The invention also provides a special feed for squid containing the basic feed and compound additives for the special feed for squid. The beneficial effects are: the special feed compound additive for squid can improve the intestinal flora of squid and can promote the regeneration of intestinal villi, improve the efficiency of intestinal absorption, maintain the health of gastrointestinal tract and / or reduce the demand for antibiotics, and reduce the Abuse of antibiotics has significantly reduced the morbidity and mortality of goblins.

A composition comprising, as an active principle, a pharmaceutically acceptable salt of elafibranor, characterised in that the pharmaceutically acceptable salt of elafibranor is chosen from at least a salt of choline, of ethanolamine, or of diethanolamine, or of L-lysine, or of piperazine, or of calcium, or of tromethamine. More particularly, one or more embodiments relate to the use of elafibranor salts with a view to improving stability and solubility compared with elafibranor in the basic form thereof. These salts make it possible to establish pharmaceutical formulations in various advantageous forms as intravenous injections or formulations by enteral route having quicker and less variable absorption and consequently better bioavailability.

The invention belongs to the technical field of medicine, and relates to a pegylated phenol red and its preparation method and application. The polymer is a small molecule drug, phenol red, which is covalently linked to one end of polyethylene glycol (PEG), wherein the phenolic hydroxyl group on the phenol red is covalently linked to the long chain of polyethylene glycol derivatives through an ether bond. The structures under different pH conditions are as follows, wherein, n and R are as described in the claims and description. The invention also provides a preparation method of PEGylated phenol red. The present invention also includes the application of the polyethylene glycolated phenol red to have accurate moisture correction in the body intestinal absorption test. The method of the invention has easy-to-obtain raw materials, simple operation, wide application range and green reaction.

The invention discloses a directional active peptide preparation method based on a Caco-2 cell model, and belongs to the technical fields of deep processing of agricultural products and comprehensiveutilization of byproducts of agricultural products. Rice protein is used as a raw material, after protease treatment, by simulation of gastrointestinal digestion in vitro and simulation of a small intestine absorption process by the Caco-2 cell absorption model, an antioxidant peptide component resistant to digestion and easy to absorb is directionally and efficiently screened out, and then, gel chromatography and high performance liquid chromatography separation and purification are carried out to obtain a high-activity antioxidant peptide which has a clear amino acid sequence and is easy toabsorb and utilize by a human body. An efficient active peptide screening system is constructed based on simulation of gastrointestinal digestion in vitro and simulation of the small intestine absorption by the Caco-2 cell absorption model, the bioavailability of the antioxidant peptide of the rice protein is improved from the source, the problem of low bioavailability of the active peptide in vivo is solved to a certain extent, and the method has wide application prospects.