48 results about "Monascus anka" patented technology

The invention provides application of a monascus composition in preparation of a medicine for preventing and / or treating coronary microcirculation disturbance. The monascus composition comprises one or more of cortex mori, ramulus mori and folium mori, monascus and radix puerariae. When the composition containing the red yeast rice is applied to preparation of the medicine for preventing and / or controlling coronary microcirculation disturbance, the abnormal microvascular structure can be improved (myocardial microvascular density MVD is increased, edema around microvessels is relieved, the lumen stenosis phenomenon is improved, and the endothelial cell condition is good); 2) microvascular occlusion is improved (pathologic results show that microvascular contents are reduced); (3) the abnormal vasodilatation and contraction function of the microvessels is improved (NO is increased); 4) improving blood lipid metabolism disorder; and (5) the heart function is improved (the left ventricular ejection fraction LVEF and the left ventricular short axis shortening rate LVFS are improved, and the left ventricular pressure maximum rising rate LV + dp / dtmax and the left ventricular pressure maximum falling rate LV-dp / dtmax are increased).

A gel for treating hemorrhoids and a preparation method thereof, related to the field of medical technologies, are provided. The gel includes Taraxacum mongolicum, Gerbera jamesonii bolus, Panax notoginseng, Monascus purpureus went, Sanguisorba officinalis, chitosan, Camellia oleifera abel, glycerine, Ginkgo biloba, Swertia manshurica and Sophora japonica. The gel can exert significant synergistic effects, have good therapeutic effects, and high safety, which is of great significance for the prevention and treatment of hemorrhoids.

The invention relates to the technical field of microbial fermentation engineering, and particularly discloses natto red yeast rice herb bean flour and a preparation method thereof. The preparation method comprises the following steps: respectively activating specifically preserved bacillus natto and monascus to obtain secondary seed solutions; inoculating the two seed solutions into a solid-state fermentation culture medium for co-fermentation; and inactivating, drying and crushing the fermentation product to obtain a finished product. The solid-state fermentation culture medium is prepared by compounding a bean matrix (soybeans, black beans or chickpeas) and herb tea components (roses, lotus leaves, chrysanthemums, mulberry leaves, haws, cassia seeds and the like). Through the synergistic effect of the bacillus natto and the monascus, nattokinase and monacolin K are efficiently enriched in a single fermentation system at the same time, conversion of soy isoflavone to a high-bioavailability aglycone type is remarkably promoted, and the obtained product has multiple health-care functions of thrombolysis, lipid reduction, efficient absorption and the like.

The invention discloses a fungal preparation for improving the fermentation performance of monascus purpureus and application of the fungal preparation. The fungus preparation is prepared by compounding Aspergillus niger MQM20136, Monascus purpureus 40269 and Saccharomyces cerevisiae JH301 direct vat set fungicide, the Aspergillus niger MQM20136 is preserved in the China Center for Type Culture Collection in Wuhan, the preservation time is September 25, 2025, and the preservation number is CCTCC (China Center for Type Culture Collection) NO: M 20252120. According to the invention, a fungus preparation taking the aspergillus niger MQM20136 as a main body is constructed, a mutualism and synergistic interaction microbial system is formed in the fungus preparation, and when the fungus preparation is used for pure compound preparation of the monascus purpureus, the quality stability, the esterification capacity, the wine yield and other fermentation properties of the monascus purpureus can be improved.

This invention application provides compositions containing red yeast rice pigment and their applications, compositions with α-glucosidase inhibitory activity and their applications, and further, their application in α-glucosidase inhibitors, belonging to the technical field of natural active compounds inhibiting α-glucosidase. The compositions of this invention comprise one or both of red yeast rice pigment and red yeast rice pigment: wherein the molar ratio of acarbose to red yeast rice pigment is 400:400-600:300; the molar ratio of acarbose to red yeast rice pigment is 400:200-600:150; and the molar ratio of red yeast rice pigment to red yeast rice pigment is 150:400-200:300. The compositions involved in this invention have a significant synergistic inhibitory effect on α-glucosidase, superior to using the above compounds alone, and can achieve reduced drug dosage and reduced drug side effects.

The invention discloses a method for producing burdock functional red yeast rice through solid state fermentation. The monascus ruber NCPS2020003 (the preservation number is CCTCC NO: M 20242830) is provided for the first time, the monascus ruber NCPS2020003 is high in Monacolin K yield, no toxin substance citrinin is generated in the fermentation process, and the monascus ruber NCPS2020003 is stable in performance, high in growth speed and high in MK production capacity through fermentation. On the basis, burdock and purple sweet potato powder are used as main matrixes, the burdock functional red yeast rice is prepared through bag type fermentation, space is saved, the burdock functional red yeast rice is scattered once only when high-temperature fermentation is finished, then stirring and water supplementing are not needed in the whole low-temperature fermentation process, the fermentation time of the burdock functional red yeast rice prepared through the technology ranges from 15 days to 30 days, the Monacolin K content in the product reaches 0.5% or above, and the content of the monacolin K in the product reaches 0.5% or above. And the content of open-loop Monacolin K reaches 75% or above.

The invention discloses a red yeast rice fingerprint spectrum detection method. The fingerprint detection method is developed for the monacolin compound in the monascus, whether the to-be-detected sample contains the monascus meeting the quality requirement or not can be directly judged by comparing the similarity of the to-be-detected sample and the contrast fingerprint, the detection efficiency is improved, and the detection cost is reduced.

The invention relates to the field of food preparation, in particular to a quality control method of fried monascus, which comprises the following steps: estimating the growth situation of monascus according to character data of monascus in a culture medium so as to adjust activation culture conditions; obtaining biological characteristics of monascus in the culture medium, and carrying out subregion calibration on the culture medium, so as to extract monascus and prepare a monascus strain solution; curing the pretreated rice raw material to obtain an inactivated raw material, and adjusting the inoculation operation of the inactivated raw material according to the internal structure of the inactivated raw material; predicting the fermentation trend according to the fermentation actual condition data of the inactivated raw material so as to adjust the fermentation condition, and screening the fermentation product to obtain a monascus product; and performing adjustable stir-frying operation on the red yeast rice product to obtain the processed red yeast rice. According to the method, the whole process from monascus culture to monascus extraction and strain liquid preparation is optimized, the purity of the monascus strain liquid is improved, the monascus production period is shortened, and a raw material with reliable and stable quality is provided for improving the monascus production quality.

The main purpose of the present invention is to provide a Monascus pilosus and a composition for reducing weight and improving intestinal flora, the composition comprising the Monascus pilosus and / or a monascus fermentation product thereof, or a functional component comprising the monascus fermentation product. The invention also aims to provide application of the monascus in preparation of the composition for reducing weight and improving intestinal flora. The composition disclosed by the invention has the capabilities of reducing body weight and improving intestinal flora, such as reducing the ratio of the phylum firmicutes to the phylum Bacteroides.

The main purpose of the present invention is to provide monascus and a composition for preventing or treating non-alcoholic fatty liver disease, the composition comprising the monascus and / or a monascus fermentation product thereof, or a functional component comprising the monascus fermentation product. The invention also aims to provide application of the monascus in preparation of the composition for preventing or treating the non-alcoholic fatty liver disease. The composition not only has the efficacy of reducing accumulation of total cholesterol (TC) and triglyceride (TG) in the non-alcoholic fatty liver disease caused by obesity, but also has the efficacy of reducing serum liver function indexes of asparaginic acid transaminase (AST) and alanine transaminase (ALT), so that the composition has the efficacy of preventing or treating the non-alcoholic fatty liver disease and related metabolic diseases thereof. , for example hyperlipidemia.

The utility model relates to oral liquid processing technical field especially relates to a kind of deployment device of red yeast oral liquid, it includes red yeast oral liquid deployment cylinder, and red yeast oral liquid deployment cylinder inside is provided with mixing mechanism, and red yeast oral liquid deployment cylinder side is provided with circulating mechanism;Mixing mechanism includes rotating lever, and rotating lever is rotatably installed at red yeast oral liquid deployment cylinder bottom, and several lower folding rods and upper folding rods are evenly installed on the lateral wall of rotating lever, and the lateral wall of lower folding rod and upper folding rod is fixedly connected with web plate, and the lateral wall of web plate is evenly provided with through-hole, and the inside of rotating lever is fixedly installed with electric telescopic rod, and the output end of electric telescopic rod is slidably passed to the upper side of rotating lever and the upper end of electric telescopic rod is fixedly installed with top disc piece.The utility model is provided with mixing mechanism, can strengthen stirring mixing action, and part of solution will pass through from the through-hole in web plate while stirring, realizes the convection effect of part of solution while stirring, and improves the mixing effect of solution.

The utility model provides a monascus solid-state fermentation device, which belongs to the technical field of fermentation devices and comprises a fermentation tank, a feeding gate plate is mounted on one side of the fermentation tank through a slide rail, a discharging chute is welded on the other side of the fermentation tank, one end of the discharging chute is connected with a sealing door through a rotating shaft, a top plate is clamped at the top of the fermentation tank, and an aeration disc is arranged below the top plate. The top plate is provided with a ventilation pipe and an atomization nozzle, a stirring rod is arranged between the aeration disc and the top plate, and through the arrangement of the stirring rod, the ventilation pipe and the atomization nozzle, a user can stir, ventilate and humidify materials after knowing the environment condition in the fermentation tank, so that the temperature and humidity stability of the fermentation tank is ensured, and the reliability of the device is improved; meanwhile, after the materials are stirred, a user can convey oxygen to the materials in the fermentation tank through the aeration disc, so that the contact area between the red yeast rice and the oxygen is increased, and the fermentation efficiency of the device is improved.

The invention relates to the technical field of strain fermentation, in particular to an incubator for monascus purpureus strain fermentation of monascus purpureus monascus as well as a fermentation process and application of the monascus purpureus strain fermentation of monascus purpureus monascus monascus monascus monascus monascus monascus monascus monascus monascus monascus monascus monascus monascus monascus monascus monascus monascus monascus monascus monascus. A plurality of transverse ropes and longitudinal ropes are distributed on the inner side of the oscillation table in the horizontal direction, when culture bottles are placed in gaps between the transverse ropes and the longitudinal ropes, if the culture bottles do not need to be sealed strictly, the transverse ropes and the longitudinal ropes elastically abut against the outer sides of the culture bottles to be used for limiting and fixing the culture bottles, and if the requirement for sealing in the fermentation culture process is high, the transverse ropes and the longitudinal ropes can be tightly pressed against the outer sides of the culture bottles. The bottom end of the sealing cover is buckled on the opening in the top end of the culture bottle in a covering mode by pulling the sealing cover downwards, at least one of the transverse rope and the longitudinal rope is arranged in the strip-shaped groove in a penetrating mode by pulling the sealing cover manually, the sealing cover is tightly buckled on the culture bottle in a covering mode, and efficient ventilation is achieved through the ventilation pipe.

The utility model discloses a fermentation room stirring device for preparing red yeast rice, which comprises a sliding frame, a height adjusting device, a right stirring device, a left stirring device, a pulling steel rope and a fermentation frame, the sliding frame is connected to the fermentation frame in a sliding mode, and the right stirring device and the left stirring device are symmetrically connected to the sliding frame. The height adjusting device is connected to the sliding frame in a sliding mode and matched with the right stirring device and the left stirring device, and the two pulling steel cables are connected to the two ends of the height adjusting device correspondingly; each of the right stirring device and the left stirring device comprises a stirring device and an adjusting device, and the stirring devices and the adjusting devices are connected to the sliding frame and are matched with each other; the height adjusting device comprises a sliding rail, a pressing frame and a pressing roller. The sliding rail is connected to the sliding frame. The fermentation room stirring device for preparing the red yeast rice is simple in structure, convenient and practical, the red yeast rice is repeatedly stirred and turned over through the right stirring device and the left stirring device, and the red yeast rice is turned over more uniformly while the red yeast rice is rapidly stirred.

The present invention relates to a pharmaceutical composition for treating hyperlipidemia. In particular, the present invention relates to a pharmaceutical combination of probucol with a statin drug / monascus, a pharmaceutical composition or kit containing probucol and a statin drug / monascus, and use of the pharmaceutical combination or the pharmaceutical composition or kit in preparing a medicament for treating hyperlipidemia, especially severe hypertriglyceridemia, severe hypercholesterolemia, and statin-refractory or statin-resistant hypercholesterolemia. The present invention is characterized in that the pharmaceutical combination or the pharmaceutical composition or kit containing probucol and the statin drug contain reduced doses of probucol and the statin drug / monascus, and the probucol and the statin / monascus are configured for simultaneous administration.

The invention is applicable to the technical field of functional tea drink processing, and provides a preparation method of monascus summer tea, which comprises the following steps: carrying out synergistic pretreatment of pulsed electric field and compound enzymolysis on summer tea; inoculating a compound microbial agent composed of monascus, aspergillus niger and lactobacillus plantarum for fermentation; the synthesis of different metabolites is accurately regulated and controlled by adopting a four-stage dynamic temperature change process; a targeted activator system composed of L-arabinose, vitamin C and betaine is added in a key metabolism window stage; an in-situ enzymatic glycosylation system composed of cyclodextrin glycosyl transferase and sucrose synthase is introduced, and monacolin K and tea polyphenol are modified. According to the invention, pH / temperature dual-response targeted activation, fructo-oligosaccharide synergistic in-situ glycosylation and stable network construction are fused with multi-strain synergistic fermentation and dynamic metabolism regulation for the first time, so that the yield, bioavailability, flavor quality and storage stability of monacolin K in a final product are remarkably improved.

The invention relates to the technical field of monascus culture media, and discloses a functional monascus solid-state fermentation culture medium for highly producing acid monacolin K and application of the functional monascus solid-state fermentation culture medium. In order to solve the problem that the content of acid monacolin K in red yeast rice is low, 12-28 parts of soybean cake powder and 3-20 parts of tapioca flour are simultaneously added into a solid culture medium with sticky rice as a main substrate, so that the synthesis efficiency of the acid monacolin K can be greatly improved, and the proportion reaches 50% or above; in addition, the total content of monacolin K is also increased and reaches 13-21 mg / g. Besides, the fermentation method is improved, the monascus ruber is inoculated into the solid-state fermentation culture medium, and stepped cooling is performed in the fermentation process, so that the total content of monacolin K in the monascus ruber product and the content of acid monacolin K in the monascus ruber product are further increased.

The invention is applicable to the technical field of monascus fermentation, and provides a preparation method and application of monascus mother koji, and the preparation method of the monascus mother koji comprises the following steps: carrying out composite stress adaptability pretreatment on monascus production strains; thermosensitive hydrogel is compounded with grains to form an intelligent carrier, and metabolism-induced nutrients are added; in the fermentation process, temperature switching is triggered by monitoring the CO2 release rate in real time, and when the temperature rises to be higher than the phase transformation point of the hydrogel, the carrier shrinks to apply physical stress to hyphae and release nutrients in a pulse mode, so that secondary metabolism is strongly activated. Through multi-level cooperation of strain pretreatment, intelligent carrier, time sequence nutrition and dynamic process, accurate and active regulation and control on growth and metabolism of monascus are realized, the prepared mother yeast is high in activity and short in fermentation period, the yield of monacolin K is remarkably increased, and the method is suitable for efficiently producing high-value monascus products.

The preparation method comprises the following steps: soaking rice grains and lucid ganoderma in water, and cutting the lucid ganoderma into small blocks of which the size is equal to that of rice grains after soaking is completed, so as to prepare treated rice grains and lucid ganoderma; mixing the treated grain and lucid ganoderma, and steaming; cooling the steamed grains and lucid ganoderma to room temperature, inoculating a monascus seed solution, and performing fermentation culture under the conditions of constant temperature and constant humidity to obtain a fermentation mixture; and drying the fermentation mixture to obtain the ganoderma lucidum grain red yeast rice tea. According to the invention, the cereal raw material and the lucid ganoderma are used as a monascus fermentation substrate at the same time, and starch, protein and other substances in the cereal can be converted and utilized by monascus in the fermentation process so as to generate more active substances; in addition, the product produced by the method simultaneously has the effects of monascus and lucid ganoderma.

This utility model relates to the technical field of red yeast rice extract processing equipment, and discloses a high-efficiency concentration and separation device for red yeast rice extract, including a processing mechanism with a support mechanism at the bottom; the processing mechanism includes a base plate, a mixing tank fixedly connected to the top left side of the base plate, a rotating rod rotatably connected inside the mixing tank, a spiral stirring blade fixedly connected to the surface of the rotating rod, a motor fixedly connected to the top of the rotating rod, a heater installed inside the mixing tank, and a feed pipe fixedly connected to the top of the mixing tank. This high-efficiency concentration and separation device for red yeast rice extract, driven by the motor, enables the spiral stirring blades to form a three-dimensional circulating stirring effect within the mixing tank. This stirring method can fully disperse the raw materials, allowing the extract to have comprehensive and multi-layered contact and reaction with the raw materials, greatly increasing the chances of dissolution and precipitation of the effective components, thereby significantly improving the extraction rate of the effective components.

The invention relates to the technical field of biology, and discloses application of a polysaccharide monascus extract in preparation of a nerve cell antioxidant drug, and the nerve cell antioxidant drug is used for reducing cell death caused by oxidation and reducing cell active oxygen. The polysaccharide monascus extract has a protection effect on nerve cells in an oxidative stress state. The polysaccharide monascus extract provided by the invention can reduce cell viability reduction, cell death and the level of cell reactive oxygen species (ROS) caused by oxidative stress.

This invention proposes an analytical method for evaluating the quality of red yeast rice based on HPLC fingerprinting and multi-component quantitative analysis, belonging to the field of quality control technology for red yeast rice and related products. The method includes: taking a red yeast rice sample, ultrasonically extracting it with 50% methanol, centrifuging, and filtering to prepare a test solution; performing detection using high-performance liquid chromatography; constructing a red yeast rice fingerprint chromatogram based on the detection results, and simultaneously determining the content of six active ingredients: ankaflavin, citrinin, lactone-type mevastatin, lactone-type lovastatin, acid mevastatin, and acid lovastatin; and combining chemical pattern recognition methods to perform discriminant analysis on red yeast rice samples from different sources to evaluate the quality of the red yeast rice. This invention achieves an organic combination of simultaneous quantitative analysis of multiple components in red yeast rice and overall quality evaluation based on fingerprint chromatograms. Methodological validation shows that this method has good precision, repeatability, and stability, and is accurate and reliable, suitable for the quality control of red yeast rice raw materials and health foods and pharmaceuticals containing red yeast rice.

The utility model relates to the technical field of monascus extract storage, and disclose a kind of anti-deposition stirring device for monascus extract storage, comprising: support plate, its top is equipped with accommodating groove, the accommodating groove is fixedly connected with the storage container for storing monascus extract in;Vertically arranged stirring shaft.The anti-deposition stirring device for monascus extract storage, driving motor drives stirring shaft rotation, so that three groups of stirring vane and the conical anti-deposition head of bottom rotate, and the rotational direction of adjacent two groups of stirring vane is opposite and is arranged to enhance fluid axial mixing ability, form up and down convection, break down sedimentation stratification, bottom sharp cone structure reduces sedimentation adhesion, spoiler further disturbs fluid boundary layer, spoiler is made of stainless steel sheet, with certain strength and corrosion resistance, while circulating pump extracts container bottom liquid by first circulating pipe, is transported to top by second circulating pipe, forms forced circulation flow, makes up partiality of mechanical stirring, realizes full container uniform mixing.

The invention provides monascus purpureus, a high-yield lovastatin and low-citrinin culture medium and a method, and belongs to the technical field of microbial fermentation. The method comprises the following steps: performing streak inoculation on Monascus purpureus HBSDYX-026 to a seed culture medium, and culturing to obtain a seed solution; and inoculating the seed solution to a high-yield lovastatin culture medium for fermentation. According to the invention, by optimizing the components of the culture medium, adjusting the variety and proportion of key nutrient substances, namely a carbon source and a nitrogen source, and screening and adding traditional Chinese medicines and an accelerant, a more suitable environment is provided for the growth of monascus and the synthesis of lovastatin; a monascus strain which is stable in heredity, vigorous in growth, high in lovastatin yield and low in citrinin yield is obtained, a culture medium which can efficiently synthesize lovastatin and is low in citrinin is successfully constructed, and the yield of lovastatin in red yeast rice is remarkably increased.

The invention belongs to the field of biological medicines, and relates to application of a monascus extract or a pharmaceutical composition thereof in preparation of antitumor drugs. Specifically, the invention relates to application of the monascus extract in preparation of antitumor drugs, and the monascus extract is prepared by a method comprising the following steps: (1) extracting monascus with an ethanol solution for one time or multiple times to obtain an ethanol extracting solution; (2) loading the ethanol extracting solution on a silica gel column, and eluting with a petroleum ether and ethyl acetate mixed solution to obtain a petroleum ether and ethyl acetate elution part; or eluting with a petroleum ether and ethyl acetate mixed solution and ethyl acetate in sequence to obtain an ethyl acetate elution part. The red yeast rice can effectively inhibit proliferation of liver cancer cells, breast cancer cells or lung cancer cells, and has the potential of treating or preventing liver cancer, breast cancer or lung cancer.

The invention relates to a Chinese and western medicine composition for treating hyperlipemia. The invention relates to a probucol and red yeast rice medicinal composition, in particular to a probucol and red yeast rice medicinal composition or a medicine box containing probucol and red yeast rice, and application of the medicinal composition, the medicinal composition or the medicine box in preparation of medicines for treating hyperlipidemia, in particular severe hypertriglyceridemia and severe hypercholesteremia. The pharmaceutical composition, the pharmaceutical composition containing probucol and red yeast rice or the kit containing probucol and red yeast rice contains a small dose of probucol and red yeast rice, and the probucol and red yeast rice are configured in a form of simultaneous administration.

The invention belongs to the technical field of degradable packaging materials, and relates to a monascus polysaccharide-based fully biodegradable packaging material, which is prepared from the following raw materials in parts by weight: 60 to 70 parts of modified monascus polysaccharide; 10 to 20 parts of a composite modifier; 5-10 parts of a plasticizer; 3-5 parts of a filling agent; 0.3 to 0.5 part of vitamin E; the mechanical property, the water resistance and the forming stability of the monascus polysaccharide-based material are improved through a composite modification system, and finally the degradable packaging material which is low in cost, high in degradation efficiency and excellent in use performance is prepared.

1. Name of the product in this design: Packaging Box (Red Yeast Rice Tablet). 2. Purpose of this design: For use in packaging boxes. 3. The key design features of this product are the combination of shape and pattern. 4. The image or photograph that best illustrates the design's key features: the front view.

This invention provides a red yeast rice fermentation product for eliminating nodules. A group of important compositions for eliminating nodules were screened and obtained, including dihydroquercetin, Tian Shan snow lotus culture, chicken gizzard lining, dandelion, prunella vulgaris, platycodon grandiflorus, and black buckwheat. The culture medium was prepared using the traditional Chinese medicine composition, and red yeast rice was inoculated for fermentation. This process transformed the large active molecules in the traditional Chinese medicine composition that eliminate nodules into small active molecules such as aglycones, thereby enhancing the efficacy of eliminating nodules and significantly improving the therapeutic effect of the traditional Chinese medicine composition in eliminating nodules, thus meeting clinical needs.

The invention provides a buckwheat monascus culture method. The buckwheat monascus culture method comprises the following steps: monascus purification: inoculating a cleaned and activated monascus raw material into a solid culture medium, and culturing to obtain a single monascus colony; propagating and culturing the monascus: inoculating the single monascus bacterial colony into a seed culture solution for culturing, and finishing propagating and culturing when a monascus bacterial colony grows in the seed culture solution; and preparing the buckwheat monascus: inoculating the seed culture solution containing the monascus masses into a prefabricated buckwheat solid culture medium, culturing to obtain a buckwheat monascus fermentation product, and heating and drying the buckwheat monascus fermentation product to constant weight to obtain the buckwheat monascus. Buckwheat is used as a main raw material to produce buckwheat red yeast rice, the production cost is reduced, buckwheat seed coats are reserved in the production process, then functional components in buckwheat are reserved, effective components of buckwheat are promoted to be converted into substances which are easy to grow and develop of monascus through a buckwheat germination process, the fermentation time is shortened, and the production efficiency is improved. The growth of aflatoxin and the like can be effectively avoided.