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Composite lipid adjustment medicine

A drug and lipid-regulating technology, applied in the direction of drug combination, pharmaceutical formula, plant raw materials, etc., can solve the problems of renal structure and function damage, dysfunction, influence, and reduction of calcium ion absorption, so as to reduce adverse reactions and yield. High, increasing efficacy of the drug

Inactive Publication Date: 2009-07-29
王法平
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0004] Although compared with simple Lovastatin, red yeast rice with the same dose of lovastatin reduces the possible toxic and side effects of long-term use of statin lipid-lowering drugs, and the potency is in line with my country's national conditions. However, clinical use in recent years has shown that red yeast rice can cause All adverse reactions caused by statins. At the same time, because red yeast rice contains Citrinin, its target organ is the kidney, also known as nephrotoxin, which can inhibit the removal of α-ketoglutaric acid and pyruvate in renal cortex and liver mitochondria. Hydrogenase activity, thereby reducing the absorption of calcium ions by mitochondria, affecting membrane transfer and redox system, causing damage to kidney structure and function, sexual dysfunction, etc., and also has teratogenicity, toxicity to other organs and cells and its mechanism. Under further study, but potentially dangerous

Method used

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  • Composite lipid adjustment medicine

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0051] Embodiment one: preparation of sugarcane extract

[0052] Take an appropriate amount of sugarcane wax, melt it in advance, saponify it with 10 to 20% concentrated sodium hydroxide, calcium hydroxide or potassium hydroxide solution accounting for the wax weight in the homogeneous phase for 3 to 10 hours, and then use organic solvents such as n-hexane, acetone, methanol Base, ethyl ketone, methanol, ethanol or isopropanol, chloroform, dichloromethane, 1,2-dichloroethane, benzene, toluene or their mixtures selectively extract alcohol mixtures in a solid-liquid extraction system, A total of 15 to 20 hours of extraction, and then recrystallized in the above solvents or their mixtures to obtain sugarcane extract, which is a kind of off-white or light yellow powder crystal, which is policosanol with 24 to 34 carbon atoms, Accounting for more than 90% of the total extract weight, among which the content of octacosanol is the highest, which is 60%-70%; tetracosanol is about 2%, ...

example 2

[0053] Example 2: Cane Red Capsules

[0054] 1. Specification: 300mg

[0055] 2. Prescription:

[0056] Red yeast rice 290.0g

[0057] Sugarcane extract (which contains not less than 90% policosanol) 10.0g

[0058] Lactose 60.0g

[0059] Sodium bicarbonate 12.0g

[0060] Croscarmellose Sodium 1.5g

[0061] 2% hypromellose 30% ethanol solution appropriate amount

[0062] Silica 1.5g

[0063] Magnesium stearate 0.4g

[0064] Makes 1000 capsules

[0065] 3. Preparation process

[0066] (1) Preparation of adhesive: take hypromellose by weighing and dissolve in purified water, add appropriate amount of ethanol, dilute into 2% hypromellose 30% ethanol solution, set aside;

[0067] (2) Processing of excipients: Pass lactose, croscarmellose sodium, and sodium bicarbonate through a 100-mesh sieve respectively, and weigh the prescription amount for subsequent use;

[0068] (3) Mixing: After the red yeast rice and policosanol pass through a 120-mesh sieve, weigh the prescripti...

example 3

[0078] Example Three: Cane Red Tablets

[0079] 1. Specification: 300mg

[0080] 2. Tablet core prescription:

[0081] Red yeast rice 290.0g

[0082] Sugarcane extract (which contains not less than 90% policosanol) 10.0g

[0083] Lactose 73.6g

[0084] Croscarmellose Sodium 3.2g

[0085] Sodium bicarbonate 8.5g

[0086] Silica 1.6g

[0087] Talc powder 1.6g

[0088] Magnesium stearate 0.5g

[0089] 2% hypromellose appropriate amount

[0090] 50% ethanol solution appropriate amount

[0091] Makes 1000 pieces

[0092] 3. Preparation process

[0093] (1) Preparation of adhesive: take hypromellose by weighing and dissolve in purified water, add appropriate amount of ethanol, dilute into 2% hypromellose 50% ethanol solution, set aside;

[0094] (2) Processing of excipients: Pass lactose, 1 / 2 croscarmellose sodium, and sodium bicarbonate through a 100-mesh sieve respectively, and weigh the prescription amount for later use;

[0095] (3) Mixing: After the red yeast rice ...

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Abstract

The invention relates to a compound lipid-regulating medicine, and in particular provides a compound medicine with pure naturally sourced active components for treating hyperlipidemia or atherosclerosis. The compound medicine is characterized by taking monascus and sugar-cane extract as main medicines. The compound lipid-regulating medicine has the advantages of reducing monascus dosage and then toxic-side effects and improving efficacy.

Description

technical field [0001] The invention relates to a compound lipid-lowering medicine, in particular to a compound medicine with pure natural source active ingredients for treating hyperlipidemia or atherosclerosis. It belongs to the field of medicine. Background technique [0002] Red yeast rice is commonly known as "Danqu", which is a traditional medicinal material. It is fermented by inoculating Monascus purpureus Went on rice. The fermentation product contains red yeast glucoamylase, amylase, red yeast pigment, A variety of amino acids, organic acids and other substances are very beneficial to the human body and have multiple uses. It was first recorded in "Qing Yi Lu" written by Tao Gu in the late Tang Dynasty. It has been mainly used as fermented food and food coloring for a long time. In the Ming Dynasty, Li Shizhen conducted research on the medicinal value of red yeast rice. With the development of modern science and technology, the medicinal value of red yeast rice ha...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K36/899A61P3/06A61P9/10
Inventor 杨迎暴王法平
Owner 王法平
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