158 results about "Natural source" patented technology

The invention discloses a preparation method of artemisia apiacea extracellular vesicles, which comprises the following steps: step 1, pre-treating artemisia apiacea, carrying out primary centrifugal treatment, removing large plant tissues and cell debris, carrying out secondary centrifugal treatment, filtering by a needle filter, and collecting; step 2, transferring the filtered suspension to a sucrose density gradient solution, then carrying out third centrifugal treatment, collecting the solution with the concentration of 30% in the layer, and carrying out fourth centrifugal treatment to obtain artemisia apiacea extracellular vesicles; the invention further discloses an artemisia apiacea extracellular vesicle, a pharmaceutical composition for treating cerebral apoplexy, a medicine and application of the artemisia apiacea extracellular vesicle in preparation of the medicine for treating cerebral apoplexy. The naturally-sourced vesicle delivery system provided by the invention is expected to have higher safety and lower toxic and side effects, and the enrichment concentration of the therapeutic component at the focus part of cerebral apoplexy is improved, so that the bioavailability and the treatment efficiency of the medicine are remarkably improved.

The invention provides a genetically engineered bacterium for producing polydeoxyribonucleotide as well as a construction method and application of the genetically engineered bacterium. The genetically engineered bacterium comprises kluyveromyces marxianus for expressing a salmon DNA polymerase I gene. According to the invention, the edible probiotic Kluyveromyces marxianus is transformed through genetic engineering, efficient, safe and controllable production of PDRN is realized, the biological activity of PDRN is equivalent to that of PDRN from a natural source, and large-scale production and application of PDRN are facilitated.

The invention discloses a natural plant-based antibacterial sanitary napkin and a preparation method thereof, and relates to the technical field of antibacterial sanitary napks.The natural plant-based antibacterial sanitary napkin comprises a surface layer, a bottom layer and an absorption core located between the surface layer and the bottom layer, and the absorption core comprises modified plant antibacterial fibers of a skin-core structure; the modified plant antibacterial fibers are prepared from matrix fibers and modified finishing liquid components through an in-situ mineralization reaction, and the modified plant antibacterial fibers are prepared from the following raw materials in parts by weight: 100 parts of matrix fibers; and 0.06-8 parts of a modified finishing liquid component. A stable metal-polyphenol coordination network is constructed on the surface of the fiber in situ, efficient and lasting antibacterial and odor removal functions are achieved, the problems that a traditional antibacterial agent is prone to loss and poor in odor removal capacity are solved, meanwhile, natural-source raw materials are adopted, excellent biological safety and hydrophilic air permeability are achieved, and the preparation method is suitable for industrial production. And dryness, comfort and safety protection in the using process are guaranteed.

The invention provides a radix asparagi homogeneous acidic polysaccharide. The radix asparagi homogeneous acidic polysaccharide contains pectic polysaccharide which is shown as a formula 1, takes rhamnogalacturonidan I (RG-I) as a core and has a homopolygalacturonic acid (HG) structural domain. The invention further provides a preparation method and application of the radix asparagi homogeneous acidic polysaccharide. The asparagi pectin polysaccharide with a new structure is found for the first time, and the asparagi pectin polysaccharide has the effect on acute lung injury. The acidic polysaccharide disclosed by the invention has the advantage of anti-ALI activity, realizes synergistic protection of intestine-lung double target regions, has anti-inflammatory and anti-oxidation double activities, is natural in source and high in biological safety, and is suitable for long-term adjuvant therapy of acute lung injury.

The invention discloses a natural product composition and application thereof in reducing uric acid and blood sugar. The composition is prepared from luteolin, verbascoside and curcumin according to the weight ratio of 1: 3: 2. According to the invention, when luteolin, verbascoside and curcumin are combined according to a weight ratio of 1: 3: 2, the inhibitory activity on xanthine oxidase (XO) and alpha-glycosidase is the strongest, and the inhibitory activity is obviously superior to the inhibitory activity on xanthine oxidase (XO) and alpha-glycosidase when the luteolin, verbascoside and curcumin are independently used, so that the composition has a synergistic effect on reducing the level of uric acid and regulating blood sugar. The discovery provides a theoretical basis and a formula basis for developing novel natural-source functional products for reducing uric acid and reducing blood sugar, and has important application prospects and development values.

Modular multifunctional system, characterized by: a) at least one natural support matrix (module A), b) at least one bioactive component of natural origin (Module B), c) at least one metallic functional element (module C), d) optional synergy-enhancing additions (module D), wherein components b) and c) interact synergistically and together generate functionalities that go beyond the sum of the individual effects.

The application discloses a 100% natural source reverse micelle essential oil and a preparation method thereof, and the preparation raw materials comprise 0.6-13 parts of emulsifiers and 20-100 parts of natural source oils in terms of mass fraction. The combination of PCA glyceryl oleate and polyglycerol nonionic surfactants has a mass ratio of (0.5-0.8):(2-2.5), and the combination of polyglyceryl-2 isostearate and polyglyceryl-4 oleate has a mass ratio of (1-1.5):(0.8-1), so that the reverse micelle essential oil can be constructed, the essential oil has the advantages that the essential oil is skin-friendly and non-greasy, can be compatible with hydrophilic active ingredients and oleophilic active ingredients, and can effectively moisturize and nourish the skin.

The invention relates to a skin moistening composition for a mask and a preparation method thereof, and belongs to the technical field of skin care products, the skin moistening composition is composed of sodium polyglutamate, saccharide isomeride, prunus amygdalus dulcis oil, cajeput leaf oil, an auxiliary natural extract, a permeation enhancing component, a dispersing component, a thickening component, an antiseptic component and deionized water, the auxiliary natural extract comprises a dracocephalum dracocephalum extract and a roselle extract, the permeation enhancing component is at least one of laurocapram and isopropyl myristate, the dispersing component comprises polyglycerol-10 myristate and polyglycerol-6 octoate, the thickening component comprises carbomer and hydroxyethyl cellulose, and the stabilizing component comprises a stabilizing component and a stabilizing component. According to the skin moistening composition, the preservative components comprise sodium ethylparaben and sodium methyl paraben, although the active components of the skin moistening composition are all natural source components, the skin moistening performance is still excellent, the skin moistening and moistening effects are excellent, and the skin care advantages of mildness and strong effect are shown.

This invention relates to a bioactivator based on L-proline structural modification, its synthesis method, and its application, belonging to the field of agricultural chemistry. The activator employs a biomimetic molecular design strategy, prepared through the splicing of active structural units. L-proline's unique natural source advantage and the important active unit fragment N,N-diethylethanolamine from DA-6 undergo an esterification reaction to yield 2-(diethylamino)ethyl-L-proline ester. Bioactivity experiments were conducted on wheat and soybean, respectively. The results showed that this compound can promote plant growth at low concentrations, exhibiting significantly better growth effects than the blank control in terms of germination rate, root length, and stem length. Furthermore, the preparation process of this invention is simple, low-cost, and easily scalable for industrial production, and it possesses good environmental compatibility. Its unique natural source advantage provides a new option for activator development and has significant potential for agricultural development.

Disclosed herein are compositions for use in a variety of agricultural methods, the compositions comprising a plurality of naturally derived lipid particles comprising a phospholipid, a non-polar lipid, and a surface modifier, and further comprising a biologically active substance.

The invention provides an application of cudrania tricuspidata polysaccharide in preparation of a medicine for treating or preventing HCMV infection, the cudrania tricuspidata polysaccharide ZGs-1 shows a remarkable inhibition effect on expression of immediate early protein IE1 / 2 and early protein p52 and copy numbers of virus genes UL123, UL44 and UL32 in a plurality of key links of HCMV infection, and has definite antiviral activity. Due to the natural source characteristic of the cudrania tricuspidata polysaccharide ZGs-1, the cudrania tricuspidata polysaccharide ZGs-1 is high in safety and low in cytotoxicity, and the cudrania tricuspidata raw material is easy to obtain, so that a candidate drug or functional component with remarkable potential is provided for preventing and treating the HCMV, and the cudrania tricuspidata polysaccharide ZGs-1 has a good development prospect and application value.

The present application relates to the technical field of microbial pesticides, in particular to a deep-sea streptomyces with antifeedant function and antibacterial effect and application thereof. The streptomyces from the South China Sea deep sea is Streptomyces sp. NA13, which was preserved in China Center for Type Culture Collection on August 29, 2022, and the preservation number is CCTCC M 20221343. The strain has the ability to prepare antibiotics such as Antimycin, Candicidin, Naringenin, Surugamide, Fredericamycin, SAL-2242, Albaflavenone, Hopene, SGR PTMs, etc. In particular, the fermentation is used to prepare antimycin or cyclic octapeptide surugamide compounds, including novel antimycin compounds antimycin Q (1). The prepared antimycin compounds are used as insect pest antifeedants or antifungal drug lead compounds, and have application prospects of developing into natural source antibacterial and insecticidal pesticides.

A hydrogel dressing with bacteriostatic repairing effect comprises the following components in parts by weight: honeysuckle hydrolat 18-22 parts, sanghuang polysaccharide extract 6-8 parts, gelatin 1-3 parts, humectant 2-4 parts and nutrient agent 1-3 parts. The polysaccharide in sanghuang powder is extracted by ultrasonic synergistic cellulase method, cellulase can effectively degrade cellulose in plants, and then effectively break the plant cell wall, so that the plant cell polysaccharide is effectively dissolved, thereby improving the extraction amount of sanghuang polysaccharide. The process is simple, low in price, mild in conditions, and pollution-free to the environment, and is conducive to green industrial production. The sanghuang polysaccharide prepared by the application has strong antibacterial ability and good antioxidant capacity, and is easier to deeply nourish the skin. The weak acid honeysuckle hydrolat with strong anti-inflammatory and antibacterial ability and natural source is used instead of deionized water to prepare cosmetics. The weak acid honeysuckle hydrolat is more suitable for the skin due to its weak acidity, and the special plant fragrance emitted by the weak acid honeysuckle hydrolat can also cheer the body and mind.

The application discloses application of an alcohol extract of white wood of Aquilaria sinensis in preparation of anti-inflammatory products. The white wood of Aquilaria sinensis extract is obtained by using white wood of Aquilaria sinensis as raw material, first extracting and degreasing with petroleum ether, then extracting with ethyl acetate, and then extracting with ethanol or ethanol aqueous solution. The application provides a new high-value utilization way for the white wood of Aquilaria sinensis which is a rich but underutilized natural resource. The extract Fr3 as a natural source of anti-inflammatory active substance has a wide application prospect in preparation of anti-inflammatory drugs, health products and functional foods and other products.

The invention discloses application of a Kunlun chrysanthemum aqueous extract in preparation of drugs for improving autism core symptoms, and belongs to the technical field of biological medicines. In order to solve the problem that the prior art lacks a medicine which is small in side effect, natural in source and capable of improving the autism core symptom, the invention provides application of a coreopsis tinctoria aqueous extract in preparation of the medicine for improving the autism core symptom, and the coreopsis tinctoria aqueous extract has a multi-dimensional synergistic effect of adjusting synaptic plasticity, inhibiting neuroinflammation, improving behavioral phenotype and the like. The concept of treating complex nervous system diseases by traditional Chinese medicine is met, and the autism core symptom is fundamentally improved; the medicine containing the coreopsis tinctoria aqueous extract provided by the invention has the advantages of high safety and small side effect.

The invention discloses a preparation method of torreya grandis gel candies with an effect of reducing total cholesterol. The invention belongs to the technical field of functional food, the Chinese torreya oil and the flaxseed oil have a synergistic effect, and after the Chinese torreya oil and the flaxseed oil are compounded, the blood fat metabolism can be effectively regulated, the total cholesterol level can be reduced, and the content of high-density lipoprotein cholesterol can be increased; the Chinese torreya oil is extracted through a low-temperature pressing process, the linseed oil is prepared through a cold pressing process, active components in the raw materials are reserved to the maximum extent, and meanwhile, the stability and uniformity of functional components in the product are ensured by combining a feeding pump filtering process and a rolling die shaping process; by optimizing the formula and the preparation process of the gel matrix, the product has good elasticity and chewing feeling, is convenient to carry and take and is suitable for daily use. The health-care food does not contain artificially synthesized additives, all the raw materials are natural sources, and the health-care food is suitable for patients with hypercholesterolemia and crowds needing to regulate blood fat, and has relatively high safety and market promotion value.

The invention relates to the field of genetic engineering, in particular to a non-methanol-induced chitin deacetylase pichia pastoris expression vector and engineering bacteria as well as a construction method and application of the non-methanol-induced chitin deacetylase pichia pastoris expression vector and engineering bacteria. According to the invention, a carrier containing a constitutive strong promoter is adopted as a skeleton, a chitin deacetylase gene coding sequence is inserted into the carrier, methanol is not required to be used as an inducer when the obtained recombinant plasmid is applied, and the produced chitin deacetylase is efficient, green and environment-friendly, and can be applied to the fields of beauty industry, agriculture, biomedicine and the like. The invention establishes a non-methanol-induced chitin deacetylase pichia pastoris expression vector and engineering bacteria, which are used for high-efficiency expression of chitin deacetylase, and solves the problem of low enzyme yield of chitin deacetylase from natural sources.

The active oligopeptide TDGLTSLD and the astragalus polysaccharide which can improve the resistance or the immunity or the growth capacity of animals are separated from the astragalus seedlings serving as a natural source, the feed containing the oligopeptide and the polysaccharide can effectively improve the immunity of the animals, the growth capacity such as the feed conversion ratio of the animals can be improved, and the feed has a wide application prospect.

The invention relates to the technical field of biology, and discloses application of ascaroside in anti-aging, and the ascaroside can be widely applied to the fields of anti-aging foods, nutritional supplements and medicines. The invention reveals that ascaroside asc-C9 can play a cross-species conservative anti-aging effect from insects to mammals to a fermentation system for the first time, and the mechanism of ascaroside asc-C9 comprises promotion of mitochondrial function, enhancement of fat browning, improvement of antioxidant level and maintenance of cell energy steady state; the invention provides an anti-aging active molecule which is natural in source and clear in effect and a fermentation preparation approach thereof.

The invention discloses a feed additive containing an edible fungus fermentation product as well as a preparation method and application of the feed additive. The feed additive comprises the following components in percentage by mass: 20%-60% of fermentation product powder, 40%-80% of a carrier, 0.01%-0.05% of an antioxidant and 1%-5% of prebiotics. The carrier is used for diluting and stabilizing the active components and improving the fluidity, the antioxidant can effectively prevent the oxidation of the grease and the active components, and the prebiotics and the active components in the fermentation product have a synergistic effect to regulate the intestinal flora. The composition integrates antibacterial, anti-inflammatory and immunoregulation functions, has comprehensive effects, and has better effects than those of a single-component antibody replacement product. All the components are natural sources or GRAS substances, no residues exist, no drug resistance risk exists, and the production performance and the health state of animals can be remarkably improved.

A blue pigment for cosmetic applications is provided, which exhibits excellent color and stability characteristics, while being fully plant-based, edible and of natural origin.

The invention belongs to the technical field of prebiotics, and particularly relates to plant extract composite prebiotics as well as a preparation method and application thereof. The invention provides a plant extract composite prebiotics, which is prepared by compounding a purslane ethanol extract and a common turnip ethanol extract in equal mass ratio, and the purslane ethanol extract and the common turnip ethanol extract are prepared by soaking purslane and common turnip in an ethanol solution with the volume concentration of 94-96%, performing ultrasonic extraction, concentrating and freeze-drying. The plant extract composite prebiotics provided by the invention can remarkably promote the growth of probiotics such as lactobacillus plantarum, lactobacillus paracasei and pediococcus pentosaceus, have the effects of regulating intestinal flora balance and promoting intestinal colonization of the probiotics, and also have antioxidant activity, thereby providing a new choice for development of prebiotics with natural sources.

A bone regeneration material containing a solid first phase of hydroxyapatite of natural origin which is macroporous, having pores of diameters greater than or equal to 50 pm, and a solid synthetic second phase of calcium phosphate intended to enrich the first phase and having a Ca / P molar ratio of between 0.2 and 2 is provided. The bone regeneration material has a defined weight ratio of the solid first phase of hydroxyapatite of natural origin to the solid synthetic second phase of calcium phosphate of between 99 / 1 and 1 / 99.

The invention provides a polyarylether polymer as well as a preparation method and application thereof, and belongs to the technical field of ultrafiltration membrane preparation. The polyarylether polymer provided by the invention has a structure as shown in a formula I which is described in the specification. Uniformly mixing the polyarylether polymer, a pore-foaming agent and an organic solvent 1, and carrying out vacuum defoaming to obtain a membrane casting solution; and coating the surface of a base material with the membrane casting solution, and then immersing the base material in water for phase inversion to obtain the ultrafiltration membrane. According to the preparation method, the hydroxyl-containing functional natural-source nano material is grafted with amino acid, finally, the modified polymer is prepared through nucleophilic reaction, and the ultrafiltration membrane prepared from the polymer solves the problems of particle loss and environmental pollution in traditional blending modification. The ultrafiltration membrane prepared by modifying the polymer body has relatively high pure water flux and flux recovery rate.

This invention provides a composition containing a naturally derived active ingredient that can suppress apoptosis of NK cells. [Solution] This is a composition for inhibiting apoptosis of natural killer cells, in which tea catechins are used as an active ingredient.

The invention provides degradable piezoelectric water bionic hydrogel as well as a preparation method and application thereof and a preparation method of a piezoelectric bionic hydrogel scaffold. The preparation method comprises the following steps: adjusting hydrogen bond acting force by using urea and polyhexamethylene biguanide hydrochloride so as to change the pore size and the adhesion property of the hydrogel; and the hydrogel has excellent piezoelectric property by introducing a degradable piezoelectric material of a natural source. According to the present invention, the good biocompatibility is represented, and the great potential is provided in the biomedical material aspect.

The invention belongs to the technical field of bioengineering and application thereof, and particularly relates to fucoidanase based on ancestor sequence reconstruction and application of the fucoidanase. An assumed artificial protein with endo-1, 3-fucosan activity is constructed through an ancestor sequence reconstruction strategy, so that the artificial endo-1, 3-fucosan enzyme which is completely different from a fucosan enzyme sequence of a natural source is obtained, and the amino acid sequence of the artificial endo-1, 3-fucosan enzyme is SEQ ID NO. 1. The fucoidanase can be used for degrading fucoidan from various sources in an incision manner, and under the condition of controlling the enzyme addition amount or the reaction time, the fucoidan can be quickly degraded within 10 minutes to generate fucoidan oligosaccharide with a specific structure.

The invention discloses a method for preparing tea polysaccharide through fungal fermentation and application of the tea polysaccharide in oxidation resistance and HCMV resistance. The fermented tea polysaccharide FTP is an acidic polysaccharide, can significantly inhibit expression of immediate early-stage protein IE1 / 2 and early-stage protein p52 of HCMV, and reduces DNA copy numbers of immediate early-stage gene UL123, early-stage gene UL44 and late-stage gene UL32, so that the fermented tea polysaccharide FTP shows clear prevention and treatment effects on HCMV infection; meanwhile, the polysaccharide also shows excellent antioxidant activity, and has relatively high scavenging capacity on DPPH free radicals and ABTS cation free radicals. The fermented tea polysaccharide has antiviral and antioxidant dual biological activities, is high in safety and low in toxic and side effects, provides a new natural source candidate component for developing anti-HCMV medicines, and has a good application prospect.