223 results about "Natural source" patented technology

The invention discloses a method for efficiently separating and purifying plant exosomes and application, and belongs to the technical field of biological nanotechnology. The method comprises the following key steps: (1) performing sterile cleaning on plant raw materials, and then performing peeling or tissue slitting pretreatment; (2) carrying out mechanical crushing treatment by adopting a phosphate buffer solution (PBS), and filtering through a 200-mesh screen to obtain a primary extracting solution; (3) performing gradient centrifugal purification on the extracting solution, collecting supernate, and filtering the supernate through a 0.45 mu m microporous filter membrane; (4) adding 8-12% of polyethylene glycol for low-temperature phase separation and precipitation; (5) purifying by using an electrodialysis technology; and (6) carrying out final concentration by adopting a 100kDa ultrafiltration membrane to obtain the high-purity PELNs preparation. According to the method, the process, equipment and reagents are simple and easy to obtain, the final yield is high, the purity is high, particle size distribution is uniform, and an innovative solution is provided for large-scale industrial production of natural-source nano-drug carriers.

The invention discloses a preparation method of artemisia apiacea extracellular vesicles, which comprises the following steps: step 1, pre-treating artemisia apiacea, carrying out primary centrifugal treatment, removing large plant tissues and cell debris, carrying out secondary centrifugal treatment, filtering by a needle filter, and collecting; step 2, transferring the filtered suspension to a sucrose density gradient solution, then carrying out third centrifugal treatment, collecting the solution with the concentration of 30% in the layer, and carrying out fourth centrifugal treatment to obtain artemisia apiacea extracellular vesicles; the invention further discloses an artemisia apiacea extracellular vesicle, a pharmaceutical composition for treating cerebral apoplexy, a medicine and application of the artemisia apiacea extracellular vesicle in preparation of the medicine for treating cerebral apoplexy. The naturally-sourced vesicle delivery system provided by the invention is expected to have higher safety and lower toxic and side effects, and the enrichment concentration of the therapeutic component at the focus part of cerebral apoplexy is improved, so that the bioavailability and the treatment efficiency of the medicine are remarkably improved.

Provided are hair care formulations that protect the hair follicles and scalp of a subject from negative effects of hair dyeing. The hair care formulations include an antioxidant, a melanin stimulant, an anti-irritation component, a sebum modulator, a scalp repair component, and an anti-inflammatory agent. Several of these components are derived from natural sources, such as extracts from the roots of the Ononis spinosa flower, from mandarin orange fruit, and from seeds of the Schinus terebinthifolia tree. The formulations also include peptides used for melanin stimulation and scalp repair. Also provided are kits containing the scalp protection formulation, along with methods of using the scalp protection formulation. Also provided are formulations supporting hair pigmentation, hair growth, hair length, and hair health.

The invention relates to the technical field of traditional Chinese medicine compositions, in particular to a traditional Chinese medicine composition for relieving acute kidney injury and a preparation method thereof.The traditional Chinese medicine composition comprises honeysuckle-derived exosome-like nano-vesicles (HELNVs), and the particle size distribution of the HELNVs is 68.06-164.20 nm. Firstly, the HELNVs retain various bioactive components of honeysuckle, and the HELNVs retain various bioactive components of the honeysuckle; the components can play a stronger pharmacological role through a synergistic effect; secondly, due to the nanoscale particle size (68.06-164.20 nm), the HELNVs can better penetrate through a biological barrier, and the targeting property and the bioavailability are improved; thirdly, the natural source and exosome-like structure of the HELNVs may endow the HELNVs with unique cell affinity, which is beneficial to the interaction of the HELNVs with target cells; finally, the HELNVs are used as a natural nano-carrier, so that the HELNVs have better safety.

The invention provides a genetically engineered bacterium for producing polydeoxyribonucleotide as well as a construction method and application of the genetically engineered bacterium. The genetically engineered bacterium comprises kluyveromyces marxianus for expressing a salmon DNA polymerase I gene. According to the invention, the edible probiotic Kluyveromyces marxianus is transformed through genetic engineering, efficient, safe and controllable production of PDRN is realized, the biological activity of PDRN is equivalent to that of PDRN from a natural source, and large-scale production and application of PDRN are facilitated.

The invention belongs to the technical field of medicines, and provides application of a natural-source compound monomer medicine composition in preparation of medicines for preventing and / or treating pancreatitis. The pharmaceutical composition comprises baicalin, paeoniflorin, geniposide, wogonin, baicalein, albiflorin, tetrahydropalmatine, rhein, wogonin, aloe-emodin, saikoside A, emodin, benzoyl paeoniflorin, chlorogenic acid, costunolide, or a pharmaceutically acceptable salt thereof. Compared with the prior art, the pharmaceutical composition disclosed by the invention has the advantages that the components of the composition are definite and are all natural sources, the safety is good, the pharmaceutical effect has a remarkable synergistic effect, the administration dosage is reduced by about 200 times under the condition that the treatment effect is better than that of a compound traditional Chinese medicine, the administration mode of the compound medicine for treating pancreatitis is innovated, and the pharmaceutical composition is suitable for clinical application. A new scheme is provided for the treatment of the disease.

The invention discloses a natural plant-based antibacterial sanitary napkin and a preparation method thereof, and relates to the technical field of antibacterial sanitary napks.The natural plant-based antibacterial sanitary napkin comprises a surface layer, a bottom layer and an absorption core located between the surface layer and the bottom layer, and the absorption core comprises modified plant antibacterial fibers of a skin-core structure; the modified plant antibacterial fibers are prepared from matrix fibers and modified finishing liquid components through an in-situ mineralization reaction, and the modified plant antibacterial fibers are prepared from the following raw materials in parts by weight: 100 parts of matrix fibers; and 0.06-8 parts of a modified finishing liquid component. A stable metal-polyphenol coordination network is constructed on the surface of the fiber in situ, efficient and lasting antibacterial and odor removal functions are achieved, the problems that a traditional antibacterial agent is prone to loss and poor in odor removal capacity are solved, meanwhile, natural-source raw materials are adopted, excellent biological safety and hydrophilic air permeability are achieved, and the preparation method is suitable for industrial production. And dryness, comfort and safety protection in the using process are guaranteed.

The invention belongs to the technical field of biological small molecule active peptides, and more specifically relates to a uric acid reducing active peptide, a preparation method and an application thereof. The uric acid reducing activity LQKW has remarkable XOD inhibitory activity, IC50 is 2.70 mg / mL, and the IC50 is superior to that of many known natural source XOD inhibitory peptides; good gastrointestinal digestion stability is shown, and the activity retention rate after in-vitro simulated gastrointestinal digestion is (61.84 + / -0.82)%. According to the invention, a specific binding mechanism of uric acid reduction activity and XOD active sites (Ile648, Phe649 and the like) is clarified through molecular docking, and a basis is provided for rational design based on a structure. According to the invention, the method for efficiently preparing the active peptide fragment from the white spirit vinasse is established, and the high-valued utilization of the wine brewing byproducts is realized. The uric acid reducing activity LQKW provided by the invention can be prepared through solid-phase synthesis, the process is mature, the quality is controllable, and a foundation is laid for industrialization. In addition, as the XOD inhibitor of a natural source, the uric acid reducing activity LQKW has good safety.

The invention provides a radix asparagi homogeneous acidic polysaccharide. The radix asparagi homogeneous acidic polysaccharide contains pectic polysaccharide which is shown as a formula 1, takes rhamnogalacturonidan I (RG-I) as a core and has a homopolygalacturonic acid (HG) structural domain. The invention further provides a preparation method and application of the radix asparagi homogeneous acidic polysaccharide. The asparagi pectin polysaccharide with a new structure is found for the first time, and the asparagi pectin polysaccharide has the effect on acute lung injury. The acidic polysaccharide disclosed by the invention has the advantage of anti-ALI activity, realizes synergistic protection of intestine-lung double target regions, has anti-inflammatory and anti-oxidation double activities, is natural in source and high in biological safety, and is suitable for long-term adjuvant therapy of acute lung injury.

The invention discloses a natural product composition and application thereof in reducing uric acid and blood sugar. The composition is prepared from luteolin, verbascoside and curcumin according to the weight ratio of 1: 3: 2. According to the invention, when luteolin, verbascoside and curcumin are combined according to a weight ratio of 1: 3: 2, the inhibitory activity on xanthine oxidase (XO) and alpha-glycosidase is the strongest, and the inhibitory activity is obviously superior to the inhibitory activity on xanthine oxidase (XO) and alpha-glycosidase when the luteolin, verbascoside and curcumin are independently used, so that the composition has a synergistic effect on reducing the level of uric acid and regulating blood sugar. The discovery provides a theoretical basis and a formula basis for developing novel natural-source functional products for reducing uric acid and reducing blood sugar, and has important application prospects and development values.

Modular multifunctional system, characterized by: a) at least one natural support matrix (module A), b) at least one bioactive component of natural origin (Module B), c) at least one metallic functional element (module C), d) optional synergy-enhancing additions (module D), wherein components b) and c) interact synergistically and together generate functionalities that go beyond the sum of the individual effects.

The application discloses a 100% natural source reverse micelle essential oil and a preparation method thereof, and the preparation raw materials comprise 0.6-13 parts of emulsifiers and 20-100 parts of natural source oils in terms of mass fraction. The combination of PCA glyceryl oleate and polyglycerol nonionic surfactants has a mass ratio of (0.5-0.8):(2-2.5), and the combination of polyglyceryl-2 isostearate and polyglyceryl-4 oleate has a mass ratio of (1-1.5):(0.8-1), so that the reverse micelle essential oil can be constructed, the essential oil has the advantages that the essential oil is skin-friendly and non-greasy, can be compatible with hydrophilic active ingredients and oleophilic active ingredients, and can effectively moisturize and nourish the skin.

The invention discloses a natural-source instant wrinkle-removing composition and application thereof, a cosmetic and a preparation method of the cosmetic. The natural-source instant wrinkle-removing composition is prepared from the following components in parts by weight: 0.1 to 6 parts of apple extract, 1 to 5 parts of peach resin extract and 0.01 to 0.5 part of hydroxyproline. The components in the composition are all natural products, and the composition with a good instant wrinkle removing effect can be obtained by matching the components. Meanwhile, compared with an existing wrinkle removing mode, when the natural-source instant wrinkle removing composition is used, the burden of skin can be effectively reduced on the basis that a good wrinkle removing effect is achieved, and the natural-source instant wrinkle removing composition is more friendly to the skin.

The invention relates to a skin moistening composition for a mask and a preparation method thereof, and belongs to the technical field of skin care products, the skin moistening composition is composed of sodium polyglutamate, saccharide isomeride, prunus amygdalus dulcis oil, cajeput leaf oil, an auxiliary natural extract, a permeation enhancing component, a dispersing component, a thickening component, an antiseptic component and deionized water, the auxiliary natural extract comprises a dracocephalum dracocephalum extract and a roselle extract, the permeation enhancing component is at least one of laurocapram and isopropyl myristate, the dispersing component comprises polyglycerol-10 myristate and polyglycerol-6 octoate, the thickening component comprises carbomer and hydroxyethyl cellulose, and the stabilizing component comprises a stabilizing component and a stabilizing component. According to the skin moistening composition, the preservative components comprise sodium ethylparaben and sodium methyl paraben, although the active components of the skin moistening composition are all natural source components, the skin moistening performance is still excellent, the skin moistening and moistening effects are excellent, and the skin care advantages of mildness and strong effect are shown.

The invention relates to a process for preparing a mixture of linear alkanes of natural origin, preferably of plant origin, comprising the steps of: Metathesis of at least one terminal linear olefin, comprising between 5 and 24 carbon atoms, derived from at least one fatty acid or fatty acid ester of natural origin, preferably of plant origin, in the presence of a non-isomerizing olefin metathesis catalyst, whereby a first mixture of internal olefins (I) is obtained; Isomerizing metathesis of the mixture of internal olefins (I) obtained in step i) in the presence of a catalyst or a mixture of catalysts, whereby a second mixture of internal olefins (II) is obtained, and Hydrogenation of the mixture of internal olefins (II) in the presence of a catalyst, whereby a mixture (III) of linear alkanes of natural origin is obtained.

This invention relates to a bioactivator based on L-proline structural modification, its synthesis method, and its application, belonging to the field of agricultural chemistry. The activator employs a biomimetic molecular design strategy, prepared through the splicing of active structural units. L-proline's unique natural source advantage and the important active unit fragment N,N-diethylethanolamine from DA-6 undergo an esterification reaction to yield 2-(diethylamino)ethyl-L-proline ester. Bioactivity experiments were conducted on wheat and soybean, respectively. The results showed that this compound can promote plant growth at low concentrations, exhibiting significantly better growth effects than the blank control in terms of germination rate, root length, and stem length. Furthermore, the preparation process of this invention is simple, low-cost, and easily scalable for industrial production, and it possesses good environmental compatibility. Its unique natural source advantage provides a new option for activator development and has significant potential for agricultural development.

A packaging material comprising a base layer and a film layer extending along the base layer. The film layer comprises at least a biopolymer and one or more naturally sourced additives.

Disclosed herein are compositions for use in a variety of agricultural methods, the compositions comprising a plurality of naturally derived lipid particles comprising a phospholipid, a non-polar lipid, and a surface modifier, and further comprising a biologically active substance.

Cosmetic composition for cosmetic use comprising one or more linear or branched polyurethanes with a high natural origin index (NOI) A cosmetic composition for cosmetics with a high degree of naturalness contains at least one linear or branched polyurethane with a natural origin index (NOI) of greater than 0.85, a polyester polyol formed entirely from natural or naturally derived ingredients with an NOI of 1, and an aliphatic diisocyanate and / or triisocyanate, and further contains at least one cosmetic oil that functions as a solvent for polyurethane synthesis. The polyurethane is capable of forming a film on the skin and preferably has a glossy finish.

The invention provides an application of cudrania tricuspidata polysaccharide in preparation of a medicine for treating or preventing HCMV infection, the cudrania tricuspidata polysaccharide ZGs-1 shows a remarkable inhibition effect on expression of immediate early protein IE1 / 2 and early protein p52 and copy numbers of virus genes UL123, UL44 and UL32 in a plurality of key links of HCMV infection, and has definite antiviral activity. Due to the natural source characteristic of the cudrania tricuspidata polysaccharide ZGs-1, the cudrania tricuspidata polysaccharide ZGs-1 is high in safety and low in cytotoxicity, and the cudrania tricuspidata raw material is easy to obtain, so that a candidate drug or functional component with remarkable potential is provided for preventing and treating the HCMV, and the cudrania tricuspidata polysaccharide ZGs-1 has a good development prospect and application value.

The present application relates to the technical field of microbial pesticides, in particular to a deep-sea streptomyces with antifeedant function and antibacterial effect and application thereof. The streptomyces from the South China Sea deep sea is Streptomyces sp. NA13, which was preserved in China Center for Type Culture Collection on August 29, 2022, and the preservation number is CCTCC M 20221343. The strain has the ability to prepare antibiotics such as Antimycin, Candicidin, Naringenin, Surugamide, Fredericamycin, SAL-2242, Albaflavenone, Hopene, SGR PTMs, etc. In particular, the fermentation is used to prepare antimycin or cyclic octapeptide surugamide compounds, including novel antimycin compounds antimycin Q (1). The prepared antimycin compounds are used as insect pest antifeedants or antifungal drug lead compounds, and have application prospects of developing into natural source antibacterial and insecticidal pesticides.

The invention belongs to the technical field of medicines, discloses application of mucuna sempervirens or extracts in preparation of anti-cancer drugs, and provides the anti-tumor effect of the natural plant extracts of the mucuna sempervirens. In-vitro experiment results show that the ethanol extract of mucuna sempervirens can effectively inhibit the activity of liver cancer cells, colon cancer cells, melanoma cells and lung cancer cells, and IC50 is 49.5 [mu] g / mL, 51.4 [mu] g / mL, 103.4 [mu] g / mL and 221.7 [mu] g / mL in sequence. In-vivo experiment results show that the ethanol extract of mucuna sempervirens can significantly inhibit the size, volume and weight of transplanted tumors of mouse colon cancer, and has no obvious influence on each organ of a mouse. Compared with traditional drugs (such as paclitaxel), the pharmaceutical composition has lower toxic and side effects. Meanwhile, various anti-tumor effects can be achieved, the anti-cancer range is wide, the application dosage is low, and wide development prospects are achieved.

A hydrogel dressing with bacteriostatic repairing effect comprises the following components in parts by weight: honeysuckle hydrolat 18-22 parts, sanghuang polysaccharide extract 6-8 parts, gelatin 1-3 parts, humectant 2-4 parts and nutrient agent 1-3 parts. The polysaccharide in sanghuang powder is extracted by ultrasonic synergistic cellulase method, cellulase can effectively degrade cellulose in plants, and then effectively break the plant cell wall, so that the plant cell polysaccharide is effectively dissolved, thereby improving the extraction amount of sanghuang polysaccharide. The process is simple, low in price, mild in conditions, and pollution-free to the environment, and is conducive to green industrial production. The sanghuang polysaccharide prepared by the application has strong antibacterial ability and good antioxidant capacity, and is easier to deeply nourish the skin. The weak acid honeysuckle hydrolat with strong anti-inflammatory and antibacterial ability and natural source is used instead of deionized water to prepare cosmetics. The weak acid honeysuckle hydrolat is more suitable for the skin due to its weak acidity, and the special plant fragrance emitted by the weak acid honeysuckle hydrolat can also cheer the body and mind.

The invention relates to a plant-based titanium dioxide liquid substitute and application of the plant-based titanium dioxide liquid substitute in a compound seasoning, and belongs to the technical field of compound seasonings. Aiming at the problems of food safety dispute of existing titanium dioxide and insufficient optical performance and poor stability of plant-based substitutes, the plant-based whitening stabilizer with a natural source is prepared by taking a banana extract as a matrix and compounding with nano cellulose, whey protein microspheres, locust bean gum and a color fixative. The product is natural in component source, excellent in optical performance and high in suspension stability, and can effectively replace titanium dioxide in the compound seasoning for whitening.

The application discloses application of an alcohol extract of white wood of Aquilaria sinensis in preparation of anti-inflammatory products. The white wood of Aquilaria sinensis extract is obtained by using white wood of Aquilaria sinensis as raw material, first extracting and degreasing with petroleum ether, then extracting with ethyl acetate, and then extracting with ethanol or ethanol aqueous solution. The application provides a new high-value utilization way for the white wood of Aquilaria sinensis which is a rich but underutilized natural resource. The extract Fr3 as a natural source of anti-inflammatory active substance has a wide application prospect in preparation of anti-inflammatory drugs, health products and functional foods and other products.

The invention discloses application of a Kunlun chrysanthemum aqueous extract in preparation of drugs for improving autism core symptoms, and belongs to the technical field of biological medicines. In order to solve the problem that the prior art lacks a medicine which is small in side effect, natural in source and capable of improving the autism core symptom, the invention provides application of a coreopsis tinctoria aqueous extract in preparation of the medicine for improving the autism core symptom, and the coreopsis tinctoria aqueous extract has a multi-dimensional synergistic effect of adjusting synaptic plasticity, inhibiting neuroinflammation, improving behavioral phenotype and the like. The concept of treating complex nervous system diseases by traditional Chinese medicine is met, and the autism core symptom is fundamentally improved; the medicine containing the coreopsis tinctoria aqueous extract provided by the invention has the advantages of high safety and small side effect.

The invention discloses a preparation method of torreya grandis gel candies with an effect of reducing total cholesterol. The invention belongs to the technical field of functional food, the Chinese torreya oil and the flaxseed oil have a synergistic effect, and after the Chinese torreya oil and the flaxseed oil are compounded, the blood fat metabolism can be effectively regulated, the total cholesterol level can be reduced, and the content of high-density lipoprotein cholesterol can be increased; the Chinese torreya oil is extracted through a low-temperature pressing process, the linseed oil is prepared through a cold pressing process, active components in the raw materials are reserved to the maximum extent, and meanwhile, the stability and uniformity of functional components in the product are ensured by combining a feeding pump filtering process and a rolling die shaping process; by optimizing the formula and the preparation process of the gel matrix, the product has good elasticity and chewing feeling, is convenient to carry and take and is suitable for daily use. The health-care food does not contain artificially synthesized additives, all the raw materials are natural sources, and the health-care food is suitable for patients with hypercholesterolemia and crowds needing to regulate blood fat, and has relatively high safety and market promotion value.

The invention relates to the field of genetic engineering, in particular to a non-methanol-induced chitin deacetylase pichia pastoris expression vector and engineering bacteria as well as a construction method and application of the non-methanol-induced chitin deacetylase pichia pastoris expression vector and engineering bacteria. According to the invention, a carrier containing a constitutive strong promoter is adopted as a skeleton, a chitin deacetylase gene coding sequence is inserted into the carrier, methanol is not required to be used as an inducer when the obtained recombinant plasmid is applied, and the produced chitin deacetylase is efficient, green and environment-friendly, and can be applied to the fields of beauty industry, agriculture, biomedicine and the like. The invention establishes a non-methanol-induced chitin deacetylase pichia pastoris expression vector and engineering bacteria, which are used for high-efficiency expression of chitin deacetylase, and solves the problem of low enzyme yield of chitin deacetylase from natural sources.

The active oligopeptide TDGLTSLD and the astragalus polysaccharide which can improve the resistance or the immunity or the growth capacity of animals are separated from the astragalus seedlings serving as a natural source, the feed containing the oligopeptide and the polysaccharide can effectively improve the immunity of the animals, the growth capacity such as the feed conversion ratio of the animals can be improved, and the feed has a wide application prospect.

The invention relates to the technical field of biology, and discloses application of ascaroside in anti-aging, and the ascaroside can be widely applied to the fields of anti-aging foods, nutritional supplements and medicines. The invention reveals that ascaroside asc-C9 can play a cross-species conservative anti-aging effect from insects to mammals to a fermentation system for the first time, and the mechanism of ascaroside asc-C9 comprises promotion of mitochondrial function, enhancement of fat browning, improvement of antioxidant level and maintenance of cell energy steady state; the invention provides an anti-aging active molecule which is natural in source and clear in effect and a fermentation preparation approach thereof.