4results about How to "Improve anti-aging effect" patented technology

This invention discloses a fusion protein targeting the urokinase-type plasminogen activator receptor and its application in the field of anti-aging. The fusion protein is composed of a hepatocyte growth factor active domain and a humanized anti-uPAR single-domain antibody linked by a flexible linker peptide, and its specific amino acid sequence is SEQ ID NO:3. This fusion protein can specifically bind to uPAR, which is highly expressed on the surface of senescent cells, with intramolar affinity, achieving targeted delivery of the hepatocyte growth factor active domain. In vitro experiments have demonstrated that this protein can significantly reverse the aging phenotype of human fibroblasts, effectively reduce aging-related β-galactosidase activity, p16INK4a protein expression, and interleukin-6 secretion, and promote cell proliferation. In a rapidly aging mouse model, this protein can systematically improve age-related physiological functional decline. The fusion protein of this invention achieves specific targeting and efficient treatment of senescent cells, providing a new solution for the development of anti-aging drugs.

The application relates to a preparation method of MMP-13 response nanoparticles loaded with PDRN, and belongs to the technical field of biological medicines. In order to solve the problems of low transdermal efficiency of polydeoxyribonucleotide, poor stability under conventional storage conditions, and the fact that a traditional delivery system cannot distinguish between aging and normal tissues, leading to insufficient concentration at a target site and low bioavailability, the application provides MMP-13 response nanoparticles loaded with PDRN. By introducing a natural and safe response unit and a cross-linking strategy, an innovative full-chain solution and solid data support are provided for the development of the next generation of intelligent anti-aging cosmetics which are precise in targeting, efficient in anti-aging, and excellent in stability.

The present application relates to a kind of lycopene and resveratrol microbead and preparation method thereof, to provide a kind of lycopene and resveratrol microbead capable of stable package, not only improve the solubility of two, and have significant antioxidant effect, can make active ingredient stable storage before use, belong to the skin care product technical field.