66 results about "Glabridin" patented technology

The invention discloses an anti-oxidation, whitening and brightening composition as well as a preparation method and application thereof. The anti-oxidation, whitening and brightening composition is prepared from the following components in parts by weight: 2 to 6 parts of nicotinamide, 0.5 to 5 parts of tranexamic acid, 1 to 5 parts of nonapeptide-1 solution, 0.5 to 1 part of tetrahydromethylpyrimidine carboxylic acid, 0.5 to 2 parts of pink red plum compound essence, 0.01 to 0.5 part of hydroxyethyl piperazine ethanesulfonic acid, 0.01 to 0.5 part of glabridin and 0.0001 to 0.2 part of glutathione. According to the invention, the composition prepared from nicotinamide, tranexamic acid, nonapeptide-1, tetrahydromethylpyrimidine carboxylic acid, pink-red plum composite essence, hydroxyethyl piperazine ethanesulfonic acid, glabridin and glutathione is prepared into the essence, and the clearance rate of the essence to ABTS free radicals reaches 58% or above, which shows that the essence has very good antioxidant ability; the cell tyrosinase activity inhibition rate of the composition under the concentration of 1.2% (v / v) reaches 51% or above, which shows that the composition has very good whitening and brightening effects.

The invention discloses an anti-aging and anti-allergy spray suitable for pregnant women based on micro-ecology-barrier-immune synergistic repair and a preparation method of the anti-aging and anti-allergy spray. The spray is prepared from 2.00 percent to 4.00 percent of hydrolyzed quinoa protein, 1.00 percent to 5.00 percent of lactobacillus / soybean milk fermentation filtrate, 0.30 percent to 1.00 percent of radix stellariae extract, 0.20 percent to 1.50 percent of perilla leaf extract, 0.01 percent to 0.50 percent of three-layer liposome tetrahydrocurcumin, 1.00 percent to 10.00 percent of Tibetan plateau freeze-dried tricholoma matsutake extracting solution, an active peptide combination and a ceramide compound. According to a quadruple synergistic mechanism, (1) the pH value of the fermentation filtrate is adjusted to 5.3, and the fermentation filtrate and the hydrolyzed quinoa extract synergistically construct a micro-ecological foundation; (2) repairing the barrier by ceramide NP, cholesterol, phytosphingosine and the like; (3) multiple anti-allergy effects of radices stellariae dichotomae, purple perilla, asiaticoside and dipotassium glycyrrhizinate; and (4) liposome curcumin, glabridin liposome and active peptide cooperate to resist aging, and a'micro-ecological balance-barrier reconstruction-immunosuppression-targeted anti-aging 'quadruple synergistic effect system is constructed. The preparation method comprises the steps of A-phase / B-phase preparation, emulsification, active addition and sterile filling, and the skin requirements in the pregnancy period and the lactation period are met.

This invention discloses a mild and stable temperature-responsive microemulsion composition, its preparation method, and its applications, belonging to the fields of cosmetics and pharmaceutical technology. This invention uses a nonionic decyl glucoside and anionic sodium lauroyl glutamate, introducing tocopherol polyethylene glycol succinate and disodium EDTA, forming a dual stabilizing mechanism of "antioxidant + metal ion chelation," effectively protecting unstable active ingredients such as glycyrrhizin. Experiments show that in an accelerated test at 60℃, the retention rate of glycyrrhizin increased by more than 20%. The microemulsion composition prepared by this invention exhibits high stability, low irritation, and skin-targeted sustained-release properties.

The application discloses a glabridin-nicotinamide co-crystal as well as a preparation method and application thereof, belongs to the technical field of co-crystals, and comprises nicotinamide and glabridin molecules. 26 H 26 N2O5, and the molar ratio of the nicotinamide and the glabridin is 1:1.The application prepares a glabridin-nicotinamide co-crystal, and the co-crystal is completely characterized, and it is proved that the co-crystal has certain physical and chemical stability, the stability of the nicotinamide is improved after being made into the co-crystal, and no stimulating substance nicotinic acid is found in the co-crystal stability experiment. The co-crystal is generally neutral, mild and non-irritating, and is naturally suitable for cosmetics or health products.

The application belongs to the technical field of glabridin preparation, and particularly relates to a preparation method of R-glabridin, which comprises the following steps: S1, under a protective gas atmosphere, dissolving a glabridin racemate in an organic solvent A, and reacting with a halogenated reagent through a substitution reaction, and after purification, preparing a halogenated intermediate I; S2, under the protective gas atmosphere, dissolving the halogenated intermediate I prepared in S1 in an organic solvent B, and under alkaline conditions, preparing an intermediate II through a dehalogen olefination reaction, and after purification; S3, under a hydrogen atmosphere, dissolving the intermediate II prepared in S2 in an organic solvent C, and under the action of a catalyst, preparing R-glabridin through an asymmetric hydrogenation reaction, and after purification. The method has the advantages of multiple raw material sources, obvious cost advantage, convenient preparation method, high total yield, less waste and high purity, and is beneficial to industrialization.

The present application relates to a kind of moisturizing whitening anti-aging cosmetic composition containing hyaluronic acid derivative and glabridin and its application, belong to the field of cosmetics.The cosmetic composition includes glabridin and hyaluronic acid derivative;Wherein, the hyaluronic acid derivative includes hydrolyzed hyaluronic acid or its salt, acetylated hyaluronic acid or its salt and silanized hyaluronic acid or its salt.The present application simultaneously uses hydrolyzed hyaluronic acid or its salt, acetylated hyaluronic acid or its salt and silanized hyaluronic acid or its salt as hyaluronic acid derivative, greatly improve the stability and moisturizing, whitening, anti-aging efficacy of the cosmetic composition provided by the present application, with unexpected synergistic effect.

This invention belongs to the field of pesticide and fertilizer technology, specifically a pesticide and fertilizer for controlling papaya gall disease. It includes a synergistic bactericidal composition, the active ingredient of which is a combination of glycyrrhizin and fluoxastrobin. This pesticide and fertilizer for controlling papaya gall disease contains both bactericidal and boron fertilizer. The bactericidal component enhances the control effect against papaya anthracnose, while the boron fertilizer supplements the boron element needed for papaya growth, thus effectively preventing papaya gall disease. This single application can control both anthracnose and papaya gall disease, promoting the normal and healthy growth of papaya.

The present application relates to the field of skin care products, and discloses a whitening and anti-aging composition for skin care products and application thereof, and an essence oil and a preparation method thereof. The whitening and anti-aging composition for skin care products contains an active substance combination and a compound essential oil and plant oil combination; the active substance combination contains glabridin, 4-butyl resorcinol, undecylenoyl phenylalanine, natural bisabalol, ascorbic acid tetraisopalmitate and teprenone; the compound essential oil and plant oil combination contains Damascus rose essential oil, magnolia essential oil, frankincense essential oil, Roman chamomile essential oil, carrot seed essential oil, passion fruit seed oil, red wolfberry seed oil, rose fruit oil and sea buckthorn fruit oil. The skin care product prepared from the whitening and anti-aging composition has a more moderate and efficient transdermal absorption rate, and has excellent anti-photoaging effect and whitening and freckle-removing effect.

The present disclosure relates to the technical field of pharmaceutical preparation, and particularly relates to a preparation method of glabriden; the preparation method comprises the following steps: providing licorice raw materials, crushing and sieving, and then performing a solid state fermentation process to obtain licorice powder after solid state fermentation; then adding into a first mixed organic solution for soaking, and then adding into a first mixed aqueous solution for soaking, and then adding a second mixed organic solution for extraction, collecting the organic phase, and then adding the solid product into the second mixed organic solution for extraction after enzyme inactivation and impurity removal; combining the organic phases and performing dialysis, purification and concentration to obtain a licorice flavone extract; and then performing extraction of the licorice flavone extract by a third mixed organic solution containing imidazolyl sulfonate to obtain a product containing a higher proportion of glabriden.

The invention belongs to the technical field of traditional Chinese medicines, and particularly relates to a method for simultaneously extracting and purifying glabridin, glycyrrhizic acid and isoliquiritigenin. The method comprises the following steps: (1) adding ethanol into glycyrrhiza glabra, and extracting to obtain an extracting solution; (2) extracting the extracting solution with ethyl acetate to obtain an organic phase and a water phase; and (3) purifying the organic phase by using a rapid preparative liquid chromatograph, carrying out gradient elution by using 30%-70% of ethyl acetate-cyclohexane as a mobile phase, and collecting the eluent, thereby obtaining the glabridin. (4) carrying out acidification and centrifugal precipitation on the water phase to obtain a glycyrrhizic acid crude product and a supernatant, adding absolute ethyl alcohol into the glycyrrhizic acid crude product, and carrying out ultrasonic extraction and centrifugation to obtain a glycyrrhizic acid ethanol solution; and (5) extracting and purifying the supernate to obtain the isoliquiritigenin.

The application discloses a recombinant engineering strain for biosynthesis of glabridin and a construction method and application thereof, and belongs to the technical field of synthetic biology and enzyme engineering. The recombinant engineering strain comprises a recombinant plasmid pRSFDuet-SiDR-SiTR-PmGDH; wherein the nucleotide sequence of SiTR is shown as SEQ ID NO:1, the nucleotide sequence of SiDR is shown as SEQ ID NO:2, and the nucleotide sequence of PmGDH is shown as SEQ ID NO:3. Through technical means such as optimization of gene sequences, construction of expression vectors and in-vivo directed evolution, the application successfully constructs the recombinant functional strain pTDG- E. coli BL21(DE3) and its evolution strain pTDGm258- E. coli BL21(DE3). The strains can efficiently catalyze the conversion of a substrate into glabridin, and have important industrial application value.

The invention belongs to the technical field of traditional Chinese medicines, and particularly relates to a method for simultaneously extracting and purifying glabridin, glycyrrhizic acid and isoliquiritigenin by a column chromatography extraction method. The method comprises the following steps: adding an ethanol solution into glycyrrhiza glabra, extracting by adopting a column chromatography extraction method, extracting an extracting solution by using dichloroethane, enabling an organic phase to pass through a silica gel column, and crystallizing an eluent to obtain glabridin. Acidifying and centrifuging the extracted water phase, and dissolving the precipitate with acetone to obtain glycyrrhizic acid; and extracting and purifying the filtrate to obtain the isoliquiritigenin. The invention provides a simple and efficient new extraction technology which is low in energy consumption, small in solvent dosage and high in extraction rate compared with traditional ultrasonic extraction and the like, and aims to extract glycyrrhizic acid and glabridin in glycyrrhiza glabra at the same time, separate glycyrrhizic acid and glabridin, separate isoliquiritigenin from the remaining part through simple conversion, and improve the purity of glycyrrhizic acid and glabridin in glycyrrhiza glabra. The comprehensive development and utilization of the glycyrrhiza glabra are achieved.

The invention belongs to the technical field of functional compositions, and particularly relates to a composition containing glabridin and application and a product thereof. The composition disclosed by the invention consists of glabridin and procyanidine, wherein the mass ratio of the glabridin to the procyanidine in the composition is 1: (1-100). The composition disclosed by the invention can effectively reduce the MDA level and has an anti-oxidation effect; the melanogenesis and tyrosinase activity can be effectively inhibited, and the melanin index can be reduced. The composition disclosed by the invention is relatively good in safety, can be applied to preparation of cosmetics, health-care products or foods and medicines with antioxidant or whitening effects, and has a wide industrial application prospect.

The utility model discloses a chromatographic device for glabridin production, which relates to the technical field of chromatography, and comprises a chromatographic column, the bottom of the chromatographic column is fixedly connected with a base, the top of the chromatographic column is provided with a screening mechanism, and the outer wall of the chromatographic column is provided with an extraction mechanism. In the chromatography process, a filler is needed to help separation of a glabridin mixture, firstly, the filler is placed above a sieve plate, then a motor is started to drive a rotating shaft to rotate, when the rotating shaft rotates, a convex block can be driven to rotate, when the convex block makes contact with the sieve plate, the sieve plate can be driven to slide in a sliding groove, and the filter screen can be separated. And when the contact between the convex block and the sieve plate is finished, the sieve plate can be extruded due to the counter-acting force of the spring, so that the mechanism can enable the small-particle filler to smoothly enter the chromatographic column, the contact between the filler and a mobile phase is increased, and finer separation can be realized.

The present application relates to a kind of organosilicon alcohol compositions and its preparation method and application, belong to medical instrument field, medical or dressing preparation field, the specific therapeutic activity of pharmaceutical preparation, the specific use or preparation manufacturing technology field of cosmetic or similar dressing preparation technical field.The organosilicon alcohol composition includes organosilicon alcohol, active ingredient and solvent;The active ingredient includes at least one of ergothioneine, retinol, glutathione, 4-butyl resorcinol, hexyl resorcinol, phenylethyl resorcinol and glabridin.The organosilicon alcohol composition provided by the present application forms complex by using organosilicon alcohol and active ingredient, constructs stable supramolecular system, greatly improves the stability of the obtained composition, and improves skin permeability, and has excellent whitening effect.

The invention provides a recombinant collagen patch for treating facial dermatitis and eczema and fading pigmentation and a preparation method of the recombinant collagen patch. The application comprises a base material layer and a functional composition loaded on the base material layer, wherein the functional composition comprises recombinant human collagen III, an anti-inflammatory active component and a whitening active component. Wherein the anti-inflammatory active component is a compound of ganoderma sinensis spore powder zymolyte, dipotassium glycyrrhizinate and asiaticoside in a specific mass ratio, and the whitening active component is an alpha-arbutin-ferulic acid condensate and a compound of tranexamic acid and glabridin in a specific mass ratio. And the base material layer is alginate-sodium carboxymethyl cellulose composite hydrogel which is modified by gamma-ray irradiation. Through the synergistic effect of all the active ingredients and the optimized preparation process, the multiple effects of resisting inflammation, repairing a barrier and fading hyperpigmentation are achieved, and the product is good in biocompatibility and remarkable in effect.

The invention relates to the technical field of cosmetics and external preparations, in particular to a phenethyl resorcinol-containing composition as well as a preparation method and application thereof. The composition containing phenylethyl resorcinol is prepared from the following raw materials in parts by mass: 0.5 to 3 parts of recombinant collagen, 0.1 to 1 part of sodium hyaluronate, 0.1 to 1 part of phenylethyl resorcinol, 0.01 to 0.1 part of glabridin, 0.2 to 1 part of beta-glucan wrapped by lipidosome, 1 to 3 parts of composite antioxidant, 0.1 to 1 part of chitosan, 0.5 to 2 parts of emulsifier, 3 to 8 parts of humectant and the balance of water, totaling 100 parts by mass. The composite antioxidant contains 40 wt% or more of shea butter modified by polyhydric alcohol, and the number-average molecular weight of the polyhydric alcohol is 50-200. Through the synergistic effect of beta-glucan and PEG modified shea butter, the transdermal absorption effect of the composition is remarkably enhanced, the blackening phenomenon of the skin is effectively improved, and the moisture content of the skin is increased.

The invention relates to the field of extraction, separation and purification of natural products, in particular to a method for purifying glabridin from glycyrrhiza glabra waste residues. According to the method, the glycyrrhiza glabra waste residues are taken as raw materials, and efficient purification is realized through a three-step core process: firstly, heating reflux extraction is performed by adopting a specific small-polarity organic solvent; secondly, carrying out primary purification by utilizing polyamide resin column chromatography; finally, specific ultra-pure microsphere polymer adsorption resin or two types of C18 reverse-phase silica gel fillers are innovatively selected for refining chromatography. Through optimized combination of a filler system, the key problems of low purification efficiency, high solvent consumption, difficulty in large-scale production and the like in a traditional process are solved, the process flow is simple and stable, the solvent can be recycled, a high-purity product with the glabridin content not lower than 92% can be efficiently prepared from the waste residues, high-value utilization of waste resources is achieved, and the method is suitable for industrial production. And the method has remarkable economic and environmental benefits.

This invention provides a traditional Chinese medicine (TCM) whitening and freckle-removing composition and its application in the preparation of skincare products. The TCM whitening and freckle-removing composition comprises the following raw material components by weight percentage: Dendrobium nobile extract (principal ingredient) 0.1-5.0%; Astragalus membranaceus extract (assistant ingredient) 0.5-8.0%; Papaya extract 0.1-3.0%; Polygonum multiflorum extract 0.1-3.0%; Ginseng extract 0.05-2.0%; Ligusticum chuanxiong extract 0.05-2.0%; oil-soluble licorice extract (Glycyrrhiza glabra, containing glycyrrhizin) 0.01-1.0%; Carthamus tinctorius (Saffron) extract 0.01-0.5%; and Angelica sinensis extract 0.05-1.0%. Based on TCM principles, this invention uses authentic Chinese medicinal materials and modern extraction and formulation techniques to create various formulations of skincare products that offer both external whitening effects and gentle repair, thus solving the technical problem of long-term, safe, and effective whitening and freckle-removing treatment.

The invention provides high-solubility and high-stability glabridin whitening oil as well as a preparation method and application thereof, and belongs to the technical field of cosmetics. By introducing the specific natural glycolipid, the solubility and long-term stability of glabridin in various common oils and fats can be remarkably improved, and a uniform oil phase system which is clear and transparent in appearance and light in texture is formed. The composition avoids turbid feeling, sticky skin feeling and safety worries caused by traditional chemical solubilizers or emulsifiers, conforms to the development trend of natural, safe and efficient cosmetics, and provides a core solution for developing high-quality and transparent-appearance skin-nourishing-with-oil whitening effect products. The requirements of the market on high-end skin care oil with excellent efficacy and pleasant sensory experience are met.

Provided are a skin care composition, a method for preparing same, and a system for skin care. The skin care composition comprises an active ingredient and a carrier. The active ingredient comprises a whitening ingredient, an anti-inflammatory ingredient, and a soothing ingredient. The carrier comprises a phospholipid ingredient, an emulsifier, a non-aqueous solvent, and water. The whitening ingredient comprises glabridin, nicotinamide, and nonapeptide-1. The anti-inflammatory ingredient comprises palmitoyl tripeptide-8. The soothing ingredient comprises acetyl dipeptide-1 cetyl ester. The carrier comprises a liposome particle. The liposome particle at least partially encapsulates the active ingredient and has an average particle size of less than or equal to 500 nm. The skin care composition can achieve a significant whitening effect.

The application discloses a strong whitening essence liquid and a preparation method thereof. The strong whitening essence liquid comprises the following components in mass percentage: 4-6% of tranexamic acid, 0.2-0.5% of 4-butyl resorcinol, 1.5-2.5% of nano glabridin and 2.5-3.5% of DMI penetration enhancer, and the balance is deionized water. The strong whitening essence liquid is prepared through the selection of the components and a specific preparation process, and each component is wrapped in a nano-liposome, so that the effects of strong whitening, rapid lightening, mild low stimulation, long-term stability and uniform component dispersion are achieved.

The invention discloses a preparation method of a licorice extract and application of the licorice extract in an oral whitening agent, and belongs to the technical field of foods and medicines. According to the method, the corresponding extract is prepared through extraction, refining and inclusion processes of liquorice, the core component glabridin can directly inhibit the activity of tyrosinase, release of proinflammatory factors is reduced, and the extract has the triple effects of whitening, resisting inflammation and resisting oxidation. Through a water-soluble dietary fiber and metal ion inclusion technology, the licorice extract and the resistant dextrin are compatible according to a specific ratio to prepare the oral whitening agent, and the oral whitening agent can effectively protect glabridin from being degraded in stomach and intestinal environments, realizes targeted release of intestinal tracts, and improves the stability and bioavailability of active ingredients. The process is simple and convenient, large-scale production is easy, and the product is safe and effective and has a good commercial prospect.

The invention relates to the technical field of medicine, in particular to application of glabridin in preparation of a medicine for treating depression, glabridin serves as an active component, and depressive symptoms are relieved by adjusting the balance of neurotransmission substances or improving the neuroinflammation state.

The invention belongs to the field of separation and purification, and discloses an extraction method and application of high-purity glabridin, and the extraction method specifically comprises the following steps: a glycyrrhiza glabra raw material and a pH response type DES reagent are mixed, stirred and extracted for 1-2 hours, centrifugation is carried out, a supernatant is collected, and the pH response type DES reagent is composed of hydrogen bond receptor choline chloride and hydrogen bond donor malonic acid; and adding an alkali solution into the supernate to adjust the pH value to 7.0-8.0 for phase separation, separating into an upper-layer solution phase and a lower-layer precipitation phase, collecting the lower-layer precipitation phase, centrifuging, washing and drying to obtain the glabridin. According to the invention, the integration of extraction and primary separation is realized, the extraction and primary enrichment are combined into one in the process of'alkali addition, namely precipitation ', and meanwhile, the DES component can be almost quantitatively recovered, so that the production cost and the environmental burden are greatly reduced, the purity of the obtained product is higher, and the load of the subsequent refining process is reduced.

A whitening and spot-fading composition based on molecular docking technology and a preparation method therefor. The composition comprises atractylenolide I, pachymic acid, paeoniflorin and glabridin, wherein the mass ratio of the atractylenolide I, pachymic acid, paeoniflorin and glabridin is 50-600:100-700:600-2000:10-200. On the basis of the docking binding energy of active ingredients in four plants Atractylodes macrocephala, Paeonia lactiflora, poria cocos and licorice to a key target molecule of a disease, it is found by screening that compounding the atractylenolide I, pachymic acid, paeoniflorin and glabridin as active ingredients can obtain the composition having a remarkable whitening and spot-fading effect, the melanin synthesis inhibition rate of the composition reaches 69.4%-83.6%, and the tyrosinase activity inhibition rate of the composition reaches 76.8%-91.3%.

The invention discloses a synthetic method of (R)-glabridin with high optical purity, and belongs to the technical field of organic synthesis. The synthesis method provided by the invention comprises the following steps: dissolving methyl-protected isoflavone in a solvent, and adding boron tribromide to carry out a protecting group removal reaction; then carrying out asymmetric hydrogen transfer reaction on a reaction product in an acid-base mixed solution under the action of a chiral ruthenium catalyst; and finally, in the presence of acid, carrying out dehydroxylation reaction on the reaction product and a silane reagent in a solvent to obtain the (R)-glabridin. The (R)-glabridin is efficiently synthesized with high selectivity through a simple three-step reaction, the total yield is high, the optical purity is excellent, the conditions are mild, the post-treatment method is simple, and the method is suitable for large-scale production.

The invention relates to a method for preparing total flavonoids rich in glabridin from glycyrrhiza glabra residues at low temperature. The method comprises the following specific steps: adding an ethanol-water solution into glycyrrhiza glabra residues for extraction, concentrating an extracting solution, and sequentially carrying out resin enrichment, decoloration, purification, concentration and low-temperature drying on a concentrated solution to obtain the high-purity total flavonoids (the content of the total flavonoids is greater than or equal to 92%, and the content of glabridin is greater than or equal to 40%). The process flow provided by the invention is simple, convenient, controllable, green and environment-friendly; only ethanol is used as an organic solvent in the extraction and purification process, the solvent can be recycled, meanwhile, a separation material can be repeatedly used, and the production cost of a unit product is remarkably reduced; according to the process, the product transfer rate is high, and large-scale preparation and industrial production are stably and efficiently realized.

The application discloses a whitening composition and a skin care product, the whitening composition is prepared by mixing 4-butyl resorcinol, glabridin and glycyrrhizol according to a molar ratio of (3-5):1:1, and the skin care product contains the whitening composition; the three active components of the whitening composition synergistically act on different pathways to inhibit the activity of tyrosinase and reduce the content of melanin, multiple whitening synergies are realized, the glabridin and the glycyrrhizol can reduce the irritability of the 4-butyl resorcinol, and can be used as raw materials of the whitening skin care product.

The utility model discloses a chromatography liquid concentration kettle for glabridin production, which comprises a lower kettle body and an upper kettle body, the lower kettle body and the upper kettle body are fixedly connected through a connecting frame, a plurality of supporting legs are arranged on the lower kettle body, a rotating ring is arranged between the lower kettle body and the upper kettle body, a sealing ring is arranged on the rotating ring, and the lower kettle body and the upper kettle body are fixedly connected through the connecting frame. The lower kettle body and the upper kettle body are respectively provided with an annular sealing groove, each sealing ring is provided with a reinforcing mechanism playing a reinforcing role, and the lower kettle body is provided with a driving motor through a supporting plate. Due to the design that the rotating ring is matched with the driving motor, the gear and the gear ring, the direction of the feeding pipe can be freely adjusted, and production flexibility and applicability are improved.