161 results about "Glabridin" patented technology

The invention provides glabridin nano-vesicles based on glycyrrhizic acid wrapping, a preparation method of the glabridin nano-vesicles and application of the glabridin nano-vesicles in preparation of whitening and skin care cosmetics, and relates to the technical field of cosmetics. According to the glabridin nano-vesicle based on glycyrrhizic acid wrapping, glabridin is carried by glycyrrhizic acid, glycyrrhizic acid serves as a carrier, the solubility of glabridin can be improved, the skin transmittance of glabridin can be increased, the anti-inflammatory effect of glabridin can be achieved, then the effect of one stone for three birds is achieved, the characteristic and advantage of integration of medicine and auxiliary materials are achieved, and the glabridin nano-vesicle based on glycyrrhizic acid wrapping has good application prospects. The tyrosinase inhibition activity of the glabridin is greatly improved. Meanwhile, the glabridin nano-vesicles wrapped based on glycyrrhizic acid have the advantages of high encapsulation efficiency, large drug loading capacity, good stability and high safety, can effectively promote the whitening factor glabridin to penetrate through the skin cuticle to enter the skin deep tissue, can stay in the skin at a high concentration for a long time, and can continuously play a whitening role.

The invention relates to a glabridin purification process for low-glabridin, which comprises the following steps: removing glabridin in a glabridin product by using a metal organic framework material (MOFs); the purification process comprises the following steps: extracting glycyrrhiza glabra roots with ethanol or methanol, and filtering to remove medicine residues to obtain an extracting solution; concentrating the extracting solution under reduced pressure to a certain volume, and then adsorbing and removing the glabriol through a filler column filled with an MOFs material; or enabling the extract liquor in the purification process of the glabridin to flow through a filler column filled with the MOFs material to adsorb and remove the glabriol; or adding the MOFs material into other fillers in a glabridin column chromatography purification process to adsorb and remove the glabridin, so as to obtain a glabridin product with low glabridin content. According to the method disclosed by the invention, the glabriol in the glabridin is simply and effectively removed, the content of the glabriol in the prepared glabridin product is lower than 0.1%, the safety of the product is improved, and the method has a strong market competitive advantage. The adsorption material can be recycled after being heated and desorbed, and has potential application prospect and wide application value.

The invention relates to the technical field of gel materials, and discloses whitening gel based on biological polysaccharide and a preparation method thereof, the whitening gel comprises the following raw materials: hyaluronic acid, deionized water and thunberg fritillary bulb polysaccharide microcapsules; wherein the bulbus fritillariae thunbergii polysaccharide microcapsule is prepared by taking konjac glucomannan, chitosan and perillaldehyde modified hyaluronic acid as a shell layer and embedding bulbus fritillariae thunbergii polysaccharide and glabridin as a core material; the perillaldehyde modified hyaluronic acid is prepared by reacting alkenyl hyaluronic acid with perillaldehyde under the action of an initiator; the alkenyl hyaluronic acid is prepared by reacting hyaluronic acid with glycidyl methacrylate under the action of a catalyst. The prepared whitening gel has excellent whitening, moisturizing, anti-oxidation and anti-aging effects, effective components are not prone to loss, and the whitening gel can be applied to the skin surface for a long time, plays a whitening role and delays the aging process of the skin.

The invention relates to the field of biological engineering and technology, in particular to an enzyme for synthesizing glabridin, a biological synthesis method of glabridin and a bacterial strain. The invention discloses a series of glabridin synthesizing enzymes (phenylalanine ammonialyase, cinnamic acid-4-hydrogenase, tyrosine ammonialyase, p-coumaric acid coenzyme A ligase, chalcone synthase, chalcone reductase, chalcone isomerase, isoflavone synthase, 2-hydroxyisoflavone dehydratase, 4 '-oxymethyltransferase, 4'-hydroxymethyltransferase and 4 '-hydroxymethyltransferase) derived from glycyrrhiza glabra for the first time. ) can be used in the preparation of a compound (e.g., isoflavone 2 '-hydrogenase, isoflavone reductase, Vissisoketoreductase, isoprenyltransferase, pterocarpin reductase, oxidative cyclase, demethylase, cytochrome P450 reductase, and the like). The de novo synthesis of the glabridin in a microbial cell factory is realized for the first time, and the application prospect of the glabridin biological manufacturing industry is greatly promoted.

The invention discloses a glabridin-nicotinamide eutectic crystal and a preparation method and application thereof, and belongs to the technical field of eutectic crystals, the eutectic crystal comprises nicotinamide and glabridin molecules, the molecular formula of nicotinamide-glabridin is C26H26N2O5, and the molar ratio of nicotinamide to glabridin is 1: 1. According to the invention, the cocrystal is used as a raw material, complete characterization is carried out on the cocrystal to prove that the cocrystal has certain physical and chemical stability, the stability of nicotinamide is improved after the cocrystal is prepared, and no irritant substance nicotinic acid is generated in cosmetics in a cocrystal stability experiment. And the eutectic crystal is generally neutral, mild, non-irritant, natural and suitable for cosmetics or health care products.

The invention relates to a glabridin self-assembly inclusion with an ultra-small particle size as well as a preparation method and application thereof, and belongs to the technical field of cosmetics. The composition disclosed by the invention is prepared from the following components in parts by weight: 0.5 to 5 parts of glabridin, 10 to 30 parts of polyhydric alcohol, 0.4 to 6.5 parts of liquorice root carrier component, 1.5 to 3 parts of nonionic emulsifier A, 0.45 to 1.8 parts of nonionic emulsifier B and 53.7 to 87.15 parts of water, the liquorice carrier component comprises at least one of glycyrrhizic acid, ammonium glycyrrhizinate and glycyrrhetinic acid; the nonionic emulsifier A is a nonionic emulsifier of which the hydrophilic-lipophilic balance value HLB is greater than 9; and the nonionic emulsifier B is a nonionic emulsifier with a hydrophilic-lipophilic balance value HLB of 2-4. The glabridin self-assembly inclusion disclosed by the invention is smaller in particle size, good in wrapping performance and good in targeting property; the stability is good, glabridin wrapping does not separate out, and the transdermal absorption rate is higher.

The invention relates to the field of biological engineering and technology, in particular to an enzyme for synthesizing glabridin, a biological synthesis method of glabridin and an engineering-modified biological host. The invention discloses a series of glabridin synthesizing enzymes (4 '-O-methyltransferase, isoflavone 2'-hydrogenase, isoflavone reductase, Vissisoketoreductase, isoprenyltransferase, pterocarpin reductase, oxidative cyclase and demethylase) from glycyrrhiza glabra for the first time, and the glabridin synthesizing enzymes have corresponding activities in various biological hosts. The heterologous biosynthesis of the glabridin is realized for the first time, and the yield of the glabridin can reach 60% or above.

The invention discloses a synthetic method of glabridin with optical purity, which comprises the following steps: by taking (R)-3-acetoxyl-2-(2, 4-dimethoxyphenyl) propanol and 2-isopentenyl resorcinol as raw materials, carrying out Mitsunobu reaction to obtain a key intermediate compound I, then carrying out hydrolysis and iodination to obtain an intermediate compound II, and then carrying out cyclization to obtain the glabridin with optical purity. Reducing and removing a protecting group to obtain glabridin. By introducing the isopentene side chain, the reaction activity of an olefin functional group is reserved, a key site is provided for subsequent cyclization conversion, the precise spatial configuration of the product is ensured, and finally glabridin with optical purity is prepared. The method is short in route, low in cost, mild in reaction condition and suitable for industrial production.

The invention discloses glabridin liposome, a whitening product, a preparation method and application, and relates to the technical field of cosmetics. The glabridin liposome is prepared from the following components in percentage by mass: 0.5%-2.5% of glabridin, 1%-8% of phospholipid, 0%-1% of cholesterol, 10%-15% of liquid grease, 0.5%-1.5% of an emulsifier, 0.5%-1.5% of an antioxidant, 0.2%-1% of trehalose, 10%-30% of glycerol and the balance of water. Through innovation of the process and formula, the problems of instability of glabridin, non-uniformity of lipidosome and the like are solved, the encapsulation efficiency can be improved, the transdermal absorption capacity and stability can be improved, and the inhibitory activity on cell tyrosinase and melanin can be improved.

The invention provides a glabridin flexible liposome, a glabridin flexible liposome mask liquid and a preparation method, and relates to the technical field of cosmetics. The glabridin flexible liposome provided by the invention comprises a flexible nano liposome and glabridin wrapped by the flexible nano liposome, the flexible nano liposome is a liposome modified by dipotassium glycyrrhizinate, and the liposome is formed by phospholipid and cholesterol. According to the invention, the dipotassium glycyrrhizinate is used as an edge active agent, and the glabridin is wrapped in the flexible liposome, so that the problems of poor solubility and poor stability of the glabridin are solved while the transdermal properties of the glabridin and the dipotassium glycyrrhizinate are improved. According to the glabridin flexible lipidosome mask liquid provided by the invention, the glabridin flexible lipidosome is uniformly dispersed in the mask liquid, and the obtained glabridin flexible lipidosome mask liquid has excellent stability and also has good moisturizing, soothing and whitening effects.

The invention relates to a skin care composition with a whitening effect and application of the skin care composition. The skin care composition is prepared from a plant extract, nicotinamide adenine dinucleotide, tetrahydrocurcumin, trehalose, nicotinamide and phenylethyl resorcinol, the plant extract comprises any one or a combination of at least two of a white truffle extract, a perigord truffle extract, a chlorella extract, glabridin or alpha-arbutin. The plant extract, the nicotinamide adenine dinucleotide, the tetrahydrocurcumin, the trehalose, the nicotinamide and the phenethyl resorcinol are creatively combined and matched for use, a synergistic interaction effect is achieved in the whitening aspect, and the composition is mild in performance, free of irritation, safe and free of toxic and side effects and has a good whitening effect after being applied to cosmetic products. The skin whitening effect can be obviously improved, and the good use feeling is achieved.

The present invention provides a melt crystallization method for preparing high-purity glabridin, belonging to the field of chemical purification technology. The method mainly includes steps of melt crystallization, sweating, and material melting. This invention adopts a fractionating melt crystallization method to purify glabridin. The melt crystallization method was utilized in the present invention for purification, and can obtain ultra-high purity products with purity more than 99.9%. This method has the characteristics of simple operation, no need for a large amount of solvent, high product purity, environmental protection, and low energy consumption. It is a green separation and purification process. The technology is suitable for high demand of the market on high-purity glabridin, and has strong market competitive advantages.

The invention discloses a synthetic method of glabridin, which is characterized in that 1, 3-dimethoxybenzene is used as an initial raw material, and the target product glabridin is prepared through a series of reactions. The independently researched and developed glabridin synthesis process has the advantages of cheap and easily available raw materials, simple operation, few side reactions, convenient quality control and the like, and a green organic solvent is adopted in the preparation process, so that post-treatment is simple, recycling can be realized, the emission of three wastes is less, the obtained product is high in yield and purity, and the method is suitable for industrial production and has wide application prospects. And the product has better market competitiveness.

The invention belongs to the technical field of cosmetics, and particularly relates to a glabridin composite glabridin amp. The invention discloses collagen nanoparticles as well as a preparation method and application thereof. The preparation method comprises the following steps: firstly, combining glabridin and glycyrrhizic acid through a non-covalent bond to obtain a glabridin-glycyrrhizic acid eutectic structure capable of overcoming the problem of solubility of glabridin, and then coating the glabridin-glycyrrhizic acid eutectic structure with a glabridin-collagen mixed solution to obtain the glabridin composite glabridin amp. The invention relates to collagen nanoparticles. The glabridin composite glabridin amp obtained by the method disclosed by the invention; the collagen nano-particles and the glabridin are good in water solubility, simple in component, high in stability and free of excessive allergy risks, the skin permeability of the glabridin, the collagen and the glabridin can be improved, the collagen, the glabridin and the glabridin are in synergistic interaction, and the utilization degree is improved.

The invention provides a permeation promoting composition containing PDRN and glabridin and application of the permeation promoting composition in functional skin care products. The composition comprises the following components in percentage by mass: 0.01%-5% of glabridin, 0.1%-10% of glycyrrhizic acid ester stearate, 0.01%-2% of DNA sodium, 0.1%-10% of poloxamer, 0.05%-8% of carbomer, 0.5%-5% of sodium hyaluronate and the balance of one or more of water or solvents such as butanediol, glycerol, 1.3-propylene glycol and the like. In the composition, poloxamer is self-assembled in a system to form micelles, glabridin is wrapped in an inner core, and a PEO chain segment on an outer layer is combined with hyaluronic acid through a hydrogen bond to form a molecular-level wrapping structure, so that the problem of instability of glabridin is effectively solved, meanwhile, the problem of agglomeration of glabridin can be effectively avoided, and the whitening effect of glabridin is effectively promoted. Meanwhile, the glabridin, the glycyrrhizic acid ester stearate, the DNA sodium, the poloxamer, the carbomer and the hyaluronic acid are synergistically matched, so that the composition has good whitening, anti-wrinkle and penetration promoting effects.

The invention belongs to the technical field of cosmetics, and particularly relates to whitening and freckle-removing essence oil and a preparation method thereof. According to the invention, adamantane formyl is introduced into an alpha-arbutin benzene ring to obtain the adamantane formyl modified alpha-arbutin derivative, so that the compatibility of alpha-arbutin and base oil is enhanced; the alpha-arbutin is prevented from being converted into hydroquinone by utilizing the large steric effect of adamantane formyl, so that the safety of the whitening and freckle-removing essence oil is improved; the tranexamic acid is wrapped by the ceramide nano-emulsion, so that the skin allergy risk caused by ingestion of the tranexamic acid is reduced; the ceramide nano-emulsion and tranexamic acid act together to repair skin collagenous fibers, block melanin transfer and inhibit melanin synthesis; trilinolein and glabridin are catalyzed by lipase to form a compound, so that the molecular compatibility and photo-thermal stability of glabridin are enhanced; glycerin promotes transdermal absorption of glabridin and enhances the efficacy of the whitening and freckle-removing essence oil.

The invention relates to a lipidosome based on nonapeptide-1 targeted transdermal delivery as well as a preparation method and application of the lipidosome. The lipidosome comprises a lipidosome carrier, raspberry ketone glucoside, a glabridin clathrate compound, a camellia extract and nonapeptide-1, wherein the raspberry ketone glucoside, the glabridin clathrate compound and the camellia extract are wrapped in the lipidosome carrier, and the nonapeptide-1 is modified on the surface of the lipidosome. Water-soluble raspberry ketone glucoside, a camellia extract and fat-soluble glabridin are compounded and wrapped by using a liposome technology, nonapeptide-1 which can be in targeted combination with skin melanocytes is further added, and the nonapeptide-1 is anchored on the outer side of a liposome carrier through hydrogen bond interaction, so that the liposome based on nonapeptide-1 targeted transdermal delivery is obtained. The composition solves the problem of compatibility of a fat-soluble active matter glabridin, a water-soluble active matter raspberry ketone glucoside and a camellia extract, and enhances permeation of the active matter in skin, so that the active matter directly plays a role at an action target.

This invention belongs to the field of cosmetic technology, specifically a glycyrrhizin-based composite nanoparticle containing sclerotherapy, BPOXY, and collagen, along with its preparation method and applications. The invention first combines glycyrrhizin and glycyrrhizic acid via non-covalent bonds to obtain a glycyrrhizin-glycyrrhizic acid eutectic structure that overcomes the solubility problem of glycyrrhizin. Then, a BPOXY-collagen mixture is used to coat the glycyrrhizin-glycyrrhizic acid eutectic structure, yielding glycyrrhizin-based composite nanoparticles containing sclerotherapy, BPOXY, and collagen. The glycyrrhizin-based composite nanoparticles containing sclerotherapy, BPOXY, and collagen obtained using this method exhibit good water solubility of glycyrrhizin, a simple composition, high stability, and minimal risk of allergic reactions. Furthermore, it enhances the skin permeability of glycyrrhizin, collagen, and BPOXY, resulting in a synergistic effect and improved bioavailability.

The invention discloses an anti-oxidation, whitening and brightening composition as well as a preparation method and application thereof. The anti-oxidation, whitening and brightening composition is prepared from the following components in parts by weight: 2 to 6 parts of nicotinamide, 0.5 to 5 parts of tranexamic acid, 1 to 5 parts of nonapeptide-1 solution, 0.5 to 1 part of tetrahydromethylpyrimidine carboxylic acid, 0.5 to 2 parts of pink red plum compound essence, 0.01 to 0.5 part of hydroxyethyl piperazine ethanesulfonic acid, 0.01 to 0.5 part of glabridin and 0.0001 to 0.2 part of glutathione. According to the invention, the composition prepared from nicotinamide, tranexamic acid, nonapeptide-1, tetrahydromethylpyrimidine carboxylic acid, pink-red plum composite essence, hydroxyethyl piperazine ethanesulfonic acid, glabridin and glutathione is prepared into the essence, and the clearance rate of the essence to ABTS free radicals reaches 58% or above, which shows that the essence has very good antioxidant ability; the cell tyrosinase activity inhibition rate of the composition under the concentration of 1.2% (v / v) reaches 51% or above, which shows that the composition has very good whitening and brightening effects.

The present invention relates to a composite growth regulator and its application in tissue culture seedlings, belonging to the technical field of plant growth regulators. The composite growth regulator of the present invention comprises the following components by weight: 10-12 parts of Jerusalem artichoke stem and leaf extract, 10-15 parts of Brevibacillus laterosporus fermentation product, 3-5 parts of glabridin, 8-12 parts of α-lipoic acid, 6-10 parts of indolebutyric acid, 4-8 parts of taurine, and 20-25 parts of sodium alginate. Adding the composite growth regulator in the process of plant tissue culture can significantly improve the rooting rate of tissue culture seedlings, and high-quality regenerated adventitious roots can be obtained, which can improve the survival rate of tissue culture seedlings and prevent the vitrification phenomenon of tissue culture seedlings.

The invention discloses an anti-aging and anti-allergy spray suitable for pregnant women based on micro-ecology-barrier-immune synergistic repair and a preparation method of the anti-aging and anti-allergy spray. The spray is prepared from 2.00 percent to 4.00 percent of hydrolyzed quinoa protein, 1.00 percent to 5.00 percent of lactobacillus / soybean milk fermentation filtrate, 0.30 percent to 1.00 percent of radix stellariae extract, 0.20 percent to 1.50 percent of perilla leaf extract, 0.01 percent to 0.50 percent of three-layer liposome tetrahydrocurcumin, 1.00 percent to 10.00 percent of Tibetan plateau freeze-dried tricholoma matsutake extracting solution, an active peptide combination and a ceramide compound. According to a quadruple synergistic mechanism, (1) the pH value of the fermentation filtrate is adjusted to 5.3, and the fermentation filtrate and the hydrolyzed quinoa extract synergistically construct a micro-ecological foundation; (2) repairing the barrier by ceramide NP, cholesterol, phytosphingosine and the like; (3) multiple anti-allergy effects of radices stellariae dichotomae, purple perilla, asiaticoside and dipotassium glycyrrhizinate; and (4) liposome curcumin, glabridin liposome and active peptide cooperate to resist aging, and a'micro-ecological balance-barrier reconstruction-immunosuppression-targeted anti-aging 'quadruple synergistic effect system is constructed. The preparation method comprises the steps of A-phase / B-phase preparation, emulsification, active addition and sterile filling, and the skin requirements in the pregnancy period and the lactation period are met.

This invention discloses a mild and stable temperature-responsive microemulsion composition, its preparation method, and its applications, belonging to the fields of cosmetics and pharmaceutical technology. This invention uses a nonionic decyl glucoside and anionic sodium lauroyl glutamate, introducing tocopherol polyethylene glycol succinate and disodium EDTA, forming a dual stabilizing mechanism of "antioxidant + metal ion chelation," effectively protecting unstable active ingredients such as glycyrrhizin. Experiments show that in an accelerated test at 60℃, the retention rate of glycyrrhizin increased by more than 20%. The microemulsion composition prepared by this invention exhibits high stability, low irritation, and skin-targeted sustained-release properties.

The present invention relates to the technical field of skin care products, and specifically to an anti-aging composition and its application in the field of skin care. The present invention provides an anti-aging composition, which comprises the following components by mass: 0.01 to 2 parts of ergothioneine, 5 to 30 parts of plant extracts and 2 to 5 parts of a second antioxidant component, wherein the second antioxidant component is any one of asiaticoside, resveratrol, glabridin, glutathione and bosaicin, and the plant extract is any one or more of licorice (GLYCYRRHIZA URALENSIS) extract, forsythia (FORSYTHIA SUSPENSA) extract, viola mandshurica (VIOLA MANDSHURICA) flower extract, chuanxiong (LIGUSTICUM CHUANXIONG) extract and cynanchum atratum (CYNANCHUM ATRATUM) extract. The anti-aging composition is compounded with ergothioneine and a second antioxidant, and then an effective plant extract is added, so that the components of the anti-aging composition can reduce the overall raw material cost of the skin care product through good synergy and maintain a good anti-aging effect.

The invention provides a whitening and spot-fading skin care composition and a preparation method thereof, and belongs to the technical field of whitening and skincare, and the composition comprises modified glabridin, a nicotinamide-tranexamic acid co-coating, an alhagi sparsifolia flower extract and an artemisia desertorum seed extract. The modified glabridin is obtained by modifying glabridin with tocopherol succinate, polyethylene glycol and artemisia desertorum seed gum. The nicotinamide-tranexamic acid co-coating is obtained by coating a mixture of nicotinamide and tranexamic acid with sodium alginate and chitosan hydrochloride. The alhagi sparsifolia extract is obtained by carrying out common enzymolysis on alhagi sparsifolia dry powder through compound enzyme and glucosidase and purifying through a mixed filler adsorption column, and the artemisia desertorum seed extract is obtained by fermenting artemisia desertorum seed powder through aspergillus oryzae, removing impurities through ADS-7 resin and purifying through a polyamide resin column. The effective components are prepared by adopting a special preparation and purification method and are matched according to a specific ratio for use, and the whitening effects of inhibiting tyrosinase, blocking melanin generation, scavenging free radicals and the like are achieved through multi-effect synergism.

The invention provides a glabridin micro-emulsion, a glabridin micro-emulsion mask liquid and a preparation method, and relates to the technical field of cosmetics. The glabridin microemulsion provided by the invention is prepared from the following raw materials: glabridin, tween-80, 1, 2-hexanediol, ethyl oleate and water, and the mass ratio of the glabridin to the tween-80 to the 1, 2-hexanediol to the ethyl oleate to the water is (0.25 to 2.5) to (12.5 to 25) to (12.5 to 50) to (5 to 12.5) to 19. According to the glabridin microemulsion, 1, 2-hexanediol is used as a surfactant, tween-80 is used as a cosurfactant, ethyl oleate is used as an oil phase, glabridin is wrapped in the microemulsion, the solubility and skin permeability of glabridin can be improved, and cosmetics can efficiently play skin care functions such as whitening and relieving. The invention provides a glabridin micro-emulsion mask liquid which has good whitening, moisturizing and soothing effects.

The application discloses a glabridin-nicotinamide co-crystal as well as a preparation method and application thereof, belongs to the technical field of co-crystals, and comprises nicotinamide and glabridin molecules. 26 H 26 N2O5, and the molar ratio of the nicotinamide and the glabridin is 1:1.The application prepares a glabridin-nicotinamide co-crystal, and the co-crystal is completely characterized, and it is proved that the co-crystal has certain physical and chemical stability, the stability of the nicotinamide is improved after being made into the co-crystal, and no stimulating substance nicotinic acid is found in the co-crystal stability experiment. The co-crystal is generally neutral, mild and non-irritating, and is naturally suitable for cosmetics or health products.

The present invention relates to a self-assembled inclusion of glabridin with an ultra-small particle size, a preparation method, and an application thereof, and belongs to the field of cosmetic technology. The composition of the present invention comprises the following components in parts by weight: 0.5-5 parts of glabridin, 10-30 parts of polyol, 0.4-6.5 parts of a licorice carrier component, 1.5-3 parts of a nonionic emulsifier A, 0.45-1.8 parts of a nonionic emulsifier B, and 53.7-87.15 parts of water; the licorice carrier component comprises at least one of glycyrrhizic acid, ammonium glycyrrhizate, and glycyrrhetinic acid; the nonionic emulsifier A is a nonionic emulsifier with a hydrophilic-lipophilic balance value (HLB) greater than 9; the nonionic emulsifier B is a nonionic emulsifier with a hydrophilic-lipophilic balance value (HLB) of 2-4. The self-assembled inclusion of glabridin of the present invention has a smaller particle size, good encapsulation performance, and good targeting; it has good stability, the glabridin encapsulation does not precipitate, and the transdermal absorption rate is higher.

The application belongs to the technical field of glabridin preparation, and particularly relates to a preparation method of R-glabridin, which comprises the following steps: S1, under a protective gas atmosphere, dissolving a glabridin racemate in an organic solvent A, and reacting with a halogenated reagent through a substitution reaction, and after purification, preparing a halogenated intermediate I; S2, under the protective gas atmosphere, dissolving the halogenated intermediate I prepared in S1 in an organic solvent B, and under alkaline conditions, preparing an intermediate II through a dehalogen olefination reaction, and after purification; S3, under a hydrogen atmosphere, dissolving the intermediate II prepared in S2 in an organic solvent C, and under the action of a catalyst, preparing R-glabridin through an asymmetric hydrogenation reaction, and after purification. The method has the advantages of multiple raw material sources, obvious cost advantage, convenient preparation method, high total yield, less waste and high purity, and is beneficial to industrialization.

The present application relates to a kind of moisturizing whitening anti-aging cosmetic composition containing hyaluronic acid derivative and glabridin and its application, belong to the field of cosmetics.The cosmetic composition includes glabridin and hyaluronic acid derivative;Wherein, the hyaluronic acid derivative includes hydrolyzed hyaluronic acid or its salt, acetylated hyaluronic acid or its salt and silanized hyaluronic acid or its salt.The present application simultaneously uses hydrolyzed hyaluronic acid or its salt, acetylated hyaluronic acid or its salt and silanized hyaluronic acid or its salt as hyaluronic acid derivative, greatly improve the stability and moisturizing, whitening, anti-aging efficacy of the cosmetic composition provided by the present application, with unexpected synergistic effect.

This invention belongs to the field of pesticide and fertilizer technology, specifically a pesticide and fertilizer for controlling papaya gall disease. It includes a synergistic bactericidal composition, the active ingredient of which is a combination of glycyrrhizin and fluoxastrobin. This pesticide and fertilizer for controlling papaya gall disease contains both bactericidal and boron fertilizer. The bactericidal component enhances the control effect against papaya anthracnose, while the boron fertilizer supplements the boron element needed for papaya growth, thus effectively preventing papaya gall disease. This single application can control both anthracnose and papaya gall disease, promoting the normal and healthy growth of papaya.