737results about How to "Improve clearance" patented technology

Systems and methods for the performance of kidney replacement therapy having or using a dialyzer, control components, sorbent cartridge and fluid reservoirs configured to be of a weight and size suitable to be worn or carried by an individual requiring treatment are disclosed. The system for performing kidney replacement therapy has a controlled compliance dialysis circuit, where a control pump controls the bi-directional movement of fluid across a dialysis membrane. The dialysis circuit and an extracorporeal circuit for circulating blood are in fluid communication through the dialysis membrane. The flux of fluid moving between the extracorporeal circuit and the dialysis circuit is modified by the rate at which the control pump is operating such that a rate of ultrafiltration and convective clearance can be controlled. The system provides for the monitoring of an inlet and outlet conductivity of the sorbent cartridge to provide a facility to quantify or monitor the removal of urea by the sorbent cartridge.

The present invention concerns methods for treating and preventing renal / kidney disease, insulin resistance / diabetes, fatty liver disease, and / or endothelial dysfunction / cardiovascular disease using synthetic triterpenoids, optionally in combination with a second treatment or prophylaxis.

The invention features compositions, methods, and kits for the treatment of metabolic disorders such as diabetes and obesity.

In accordance with the present invention, there are provided various methods for modulating the expression of an exogenous gene in an isolated cell and in a mammalian subject employing modified ecdysone receptors. Also provided are modified ecdysone receptors, as well as homomeric and heterodimeric receptors containing same, nucleic acids encoding invention modified ecdysone receptors, modified hormone response elements, gene transfer vectors, recombinant cells, and transgenic animals containing nucleic acids encoding invention modified ecdysone receptor.

Novel humanized monoclonal antibodies, fragments or derivatives thereof which specifically bind carcinoembryonic antigen (CEA) are provided as well as methods for their manufacture. These humanized antibodies are useful in the treatment of cancers which express CEA as well as for diagnostic purposes, e.g., for in vivo imaging of tumors or cancer cells which express CEA.

The invention provides sustained-release chlorine dioxide gel comprising the following components by weight percent: 0.1% to 5.0% of chlorine dioxide precursor, 1.0% to 10.0% of gel, 0.01% to 2.0% of chelating agent, 0.1% to 10.0% of inclusion agent, 30% to 70% of activating agent, 0.1% to 5.0% of sustained-release agent, 0.1% to 5.0% of stabilizing agent and deionized water in balancing amount. The sustained-release chlorine dioxide gel of the invention is capable of conducting the stable sustained-release process at a certain rate for 3 to 6 months, so the sustained-release chlorine dioxidegel has the advantages of long release period, uniform and stable release rate and lasting effect; the sustained-release chlorine dioxide gel is capable of not only removing formaldehyde from indoor air in an effective, safe and lasting way and ensuring the high removal rate of formaldehyde, but also disinfecting and sterilizing the indoor air continuously and thoroughly purifying the indoor air;moreover, the invention dispenses with high-purity chlorine dioxide gas and further has the advantages of simple preparation method and convenient operation.

Methods and devices for treating excess mucus accumulation in mammals by administering gaseous inhaled nitric oxide or nitric oxide releasing compounds as a mucolytic agent or expectorant are provided. Delivery of gaseous nitric oxide can be made nasally or orally and is preferably substantially coincident with inhalation of the mammal or based on a synchronous parameter of the mammal's respiratory cycle. Varying therapeutic profiles may be used for the delivery of gaseous nitric oxide depending on the severity of the excess mucus accumulation. Parameters for the therapeutic profiles may include flow rate of nitric oxide containing gas, duration of administration of nitric oxide containing gas, number of breaths for which nitric oxide containing gas is to be administered, and concentrations of therapeutic NO delivered to the airways.

Methods, compounds, pharmaceutical compositions and kits are described for treating or preventing amyloid-related disease.

The present invention concerns methods and compositions for the treatment of cancer and cancer cells using altered poxviruses, including a vaccinia virus that has been altered to generate a more effective therapeutic agent. Such poxviruses are engineered to be attenuated or weakened in their ability to affect normal cells. In some embodiments, methods and compositions involve poxviruses that possess mutations that result in poxviruses with diminished or eliminated capability to implement an antiviral response in a host. Poxviruses with these mutations in combination with other mutations can be employed for more effective treatment of cancer.

One nonexclusive aspect provides molecules further improved from antibodies that can bind to antigens in an ion concentration-dependent manner. An alternative nonexclusive aspect provides safe and more advantageous Fc region variants that have decreased binding to pre-existing ADA. An alternative nonexclusive aspect provides novel IL-8 antibodies that are superior as pharmaceuticals.

A parking brake having an actuator, wherein the actuator is driven with a direct current motor which can be operated in two directions and which moves a piston of the actuator and, via a self-locking gear mechanism of the actuator, at least one brake shoe for applying or releasing the parking brake. A control unit for performing open-loop or closed-loop control of the movement of the direct current motor is also provided. During open-loop or closed-loop control of the movement of the direct current motor for applying and / or releasing the parking brake, the control unit takes into account a hydraulic admission pressure which is currently present at the piston if the brake is applied or was present at the piston if the brake has been released when it had previously been applied. A corresponding method for operating such a parking brake is also disclosed.

This invention features betulinic acid derivatives having the formula: wherein the variables are defined herein. The invention also provides related compounds and intermediates thereof, as well as pharmaceutical compositions, kits, and articles of manufacture comprising such compounds. Treatment methods and methods of manufacture are also provided.

A vest for a human body has a bladder coupled to a pulsator operable to subject the vest to repeated pulses of air which applies and releases pressure to the body. The vest has a cover having a pocket accommodating the bladder, shoulder straps, and end flaps. The bladder is permanently connected to the cover. Releasable hook and loop fasteners connect the straps to chest portions of the vest and end flaps to each other. A releasable retainer secured to the end flaps prevent the end flaps and releasable fasteners from disengaging when air pressure pulses are applied to the vest. The bladder has an air chamber and a sleeve having an air receiving passage and openings to allow air to flow from the air receiving passage into the air chamber. An oval-shaped coil spring within the sleeve maintains the air receiving passage open.

A family of new bicycle shifting systems incorporate improved derailleur designs that are controlled by sealed hydraulic actuators. The shifting systems (i) a hydraulically-actuated, manually-powered front and rear derailleur shifting system, (ii) a hydraulically-actuated, power-assisted front and rear derailleur shifting system with manual control, and (iii) a hydraulically-actuated, power-assisted front and rear derailleur shifting system in which the shifting sequence for the rear derailleur is controlled automatically by pedal speed. Each of these shifting systems utilize a totally sealed, inclined linear shifting path. Environmental contaminants are prevented from entering any of the critical derailleur or control elements. The linear, inclined shifting path provides precise chain shifting, more uniform chain wrap on the rear bicycle drive sprockets, and lower chain and sprocket wear. Several different shifting control units are disclosed. An integrated shifting and braking module is also disclosed.

In accordance with the present invention, there are provided various methods for modulating the expression of an exogenous gene in a mammalian subject employing modified ecdysone receptors. Also provided are modified ecdysone receptors, as well as homomeric and heterodimeric receptors containing sane, nucleic acids encoding invention modified ecdysone receptors, modified ecdysone response elements, gene transfer vectors, recombinant cells, and transgenic animals containing nucleic acids encoding invention modified ecdysone receptor.

Methods and devices for treating excess mucus accumulation in mammals by administering gaseous inhaled nitric oxide or nitric oxide releasing compounds as a mucolytic agent or expectorant are provided. Delivery of gaseous nitric oxide can be made nasally or orally and is preferably substantially coincident with inhalation of the mammal or based on a synchronous parameter of the mammal's respiratory cycle. Varying therapeutic profiles may be used for the delivery of gaseous nitric oxide depending on the severity of the excess mucus accumulation. Parameters for the therapeutic profiles may include flow rate of nitric oxide containing gas, duration of administration of nitric oxide containing gas, number of breaths for which nitric oxide containing gas is to be administered, and concentrations of therapeutic NO delivered to the airways.

A vest for a human body has a bladder coupled to a pulsator operable to subject the vest to repeated pulses of air which applies and releases pressure to the body. The vest has a cover having a pocket accommodating the bladder, shoulder straps, and end flaps. The bladder is permanently connected to the cover. Releasable hook and loop fasteners connect the straps to chest portions of the vest and end flaps to each other. A releasable retainer secured to the end flaps prevent the end flaps and releasable fasteners from disengaging when air pressure pulses are applied to the vest. The bladder has an air chamber and a sleeve having an air receiving passage and openings to allow air to flow from the air receiving passage into the air chamber. An oval-shaped coil spring within the sleeve maintains the air receiving passage open.

Systems and methods for the performance of kidney replacement therapy having or using a dialyzer, control components, sorbent cartridge and fluid reservoirs configured to be of a weight and size suitable to be worn or carried by an individual requiring treatment are disclosed. The system for performing kidney replacement therapy has a controlled compliance dialysis circuit, where a control pump controls the bi-directional movement of fluid across a dialysis membrane. The dialysis circuit and an extracorporeal circuit for circulating blood are in fluid communication through the dialysis membrane. The flux of fluid moving between the extracorporeal circuit and the dialysis circuit is modified by the rate at which the control pump is operating such that a rate of ultrafiltration and convective clearance can be controlled. The system provides for the monitoring of an inlet and outlet conductivity of the sorbent cartridge to provide a facility to quantify or monitor the removal of urea by the sorbent cartridge.

This invention provides a novel surgical device well suited to use in laparoscopic or other (e.g. open surgical) procedures. In certain embodiments, the device comprises a surgical probe, including a handle comprising at least one channel passing through the handle; and at least one conduit passing through the handle, where wherein at least one effector element is inserted into or through the channel, which effector element effects one or more surgical functions; and where the conduit comprises a distal conduit port that directs gas out of the conduit to substantially remove debris and / or fluid from a surface disposed proximal to the effector and / or from the effector element.

A preferred embodiment of a self-locking door assembly includes a door whose hinged-side connects to one side of a door frame by at least one hinge having two pivot joints. One of the pivot joints is mounted to the door frame and the other is mounted to the inside of the door. The free end of the door carries a latch member which engages an underside of the opposite side of the door frame when the door is partially or fully closed. After the latch engages the frame, forcing the hinged side of the door closed causes the hinge to toggle, holding the door closed under force and takes up play in the pivot joints and / or latch. For security, the pivot joints and latch are concealed when the door assembly is closed.

Methods and compositions for the treatment of Alzheimer's Disease are described. More specifically, the invention demonstrates that administration of cardiovascular agents to a mammal suffering from the symptoms of Alzheimer's Disease causes an amelioration of those symptoms. The finding of the present invention can be used in treatment regimens designed to attenuate or prevent Alzheimer's Disease.

A parking brake having an actuator, wherein the actuator is driven with a direct current motor which can be operated in two directions and which moves a piston of the actuator and, via a self-locking gear mechanism of the actuator, at least one brake shoe for applying or releasing the parking brake. A control unit for performing open-loop or closed-loop control of the movement of the direct current motor is also provided. During open-loop or closed-loop control of the movement of the direct current motor for applying and / or releasing the parking brake, the control unit takes into account a hydraulic admission pressure which is currently present at the piston if the brake is applied or was present at the piston if the brake has been released when it had previously been applied. A corresponding method for operating such a parking brake is also disclosed.

The invention discloses a preparation method for a chlorella anti-oxidative peptide. The preparation method is as follows: by taking chlorella as material, carrying out wall-breaking treatment on the chlorella to obtain soluble protein by utilizing a dilute alkali swelling-combined ultrasonic-wave process; and hydrolyzing the chlorella protein by a biological enzyme method to obtain the chlorella anti-oxidative peptide with remarkable anti-oxidative effect. The invention further discloses a treatment process combining ultralow temperature treatment, high pressure treatment with dilute alkali swelling and ultrasonic waves, which can improve yield of the water-soluble protein and can further improve anti-oxidative ability of hydrolysate. A product obtained by virtue of the preparation method disclosed by the invention is high in purity and strong in anti-oxidative activity.

The invention provides a method for preparing a traditional Chinese medicine fruit and vegetable enzyme beverage, and relates to the food field. The method comprises the steps: mixing a fruit and vegetable mixture with rock candy according to the mass ratio of 3:(0.5-1.5), placing the mixture in a fermentation tank, and in a sealed state and under a condition of the temperature of 2-30 DEG C, fermenting for 160-200 days, to obtain a fruit and vegetable fermented liquid; mixing the fruit and vegetable fermented liquid with a traditional Chinese medicine decoction liquid, inoculating with one or two or more of lactobacillus delbrueckii subsp.bulgaricus, lactobacillus plantarum subsp.plantarum, yeast and bifidobacterium animalis, and in a sealed state and at the temperature of 35-40 DEG C, fermenting for 3-8 days, to obtain the traditional Chinese medicine fruit and vegetable enzyme beverage. The medicine and food homology and mutual harmony and complementation effects are achieved; the obtained traditional Chinese medicine fruit and vegetable enzyme beverage has the advantages of high total phenol content, high DPPH(.) scavenging rate and high SOD enzyme activity, shows strong antioxidant capacity, can improve the human body gastrointestinal health-care functions, and can be used as a daily drinking health drink.

Described are methods of preventing, treating and diagnosing of a subject having a condition, such as, an inflammation or infection of the respiratory tract. Methods of treatment and prevention include administration of effective amounts of calcium salt formulations to a subject. Methods of diagnosing include the use of biomarkers and optionally the use of kits that can detect biomarkers. Further described are methods for modulating an immune response that include the modulation of Toll-like receptors.

The invention provides a method and a device for online detection of foreign fiber in cotton. The device comprises a cotton opener, channels, windows, a CCD (Charge Coupled Device) camera, an illumination light source, a background plate, a nozzle array, a foreign fiber channel, a foreign fiber collecting unit, a computer, an electrical equipment cabinet, operating buttons, a frequency conversionfan and a cotton conveyance pipe. The method comprises the following steps: opening lint cotton; feeding the lint cotton into the detection area of the CCD camera through the channels; performing theillumination and CCD camera sampling in three steps, and further collecting the detection results of the three steps for identifying the foreign fiber; calculating the time for nozzles in the corresponding positions to the foreign fiber to open and close by combining the action delay time of each nozzle; controlling the corresponding nozzles to operate, so as to remove the foreign fiber; and meanwhile, outputting clean cotton with the foreign fiber being removed from the clean cotton output channel, wherein, by combining the performance parameters of the CCD camera, the cotton flow rate in the corresponding area of each nozzle can be calculated from the data obtained through infrared LED illumination and sampling, and the average cotton flow rate can be further calculated; and then, the cotton flow rate in the channels can be stabilized within a per-determined range by controlling the frequency conversion fan.

The invention discloses a quinolizinones compound which comprises an optical isomer, a raceme and a cis-trans-isomer and a random combination or pharmaceutical salt thereof. A structure of the quinolizinones compound is as shown in a formula I: (with reference to the specification), wherein one of V and Y is O, and the other one of V and Y is CR8R9; R8 and R9 respectively independently are hydrogen or C1-6 alkyl. The invention further discloses a preparation method and application of the compound in the formula I. The compound in the formula I can obviously reduce a HBsAg (Hepatitis B surface antigen) level in vivo and meanwhile, inhibit replication of a HBV (Hepatitis B Virus), wherein when V or Y is O, solubility of the compound is obviously improved, the compound has excellent medicinal attributes and meanwhile, is also low in toxicity, pharmacokinetics and pharmacodynamics functions are improved, efficiency of combining with the HBV can be greatly improved, and a clearance ratio of the HBV in vivo can also be further improved.

The invention discloses a remote-control submerged underwater desilting vehicle, which comprises a vehicle frame and a walking mechanism; a mud cleaning working mechanism is arranged at the front end of the vehicle frame, and a sealed cabin is arranged at the rear end of the vehicle frame; the mud cleaning working mechanism comprises a mud pump with an output port connected with a mud discharging pipe; a driving motor, a transmission device and a power take-off device are arranged in the sealed cabin; the driving motor is used for driving the walking mechanism through the transmission device and the power take-off device; the desilting vehicle further comprises a main controller which comprises a radio signal transmitting device which is communicated with a remote control device, the remote-control submerged underwater desilting vehicle further comprises a float which is fixed relatively to the vehicle frame; the float is connected with an air pump through a gas piping; the gas pipe is provided with a three-position steering valve which is used for feeding the water and discharging the gas for the float, or feeding the gas and discharging the water or neither feeding the gas nor feeding the water; the mud pump, the driving motor and the air pump are respectively connected with the main controller and are controlled by the main controller. The desilting vehicle is simple in structure, convenient to use, high in desilting efficiency and low in construction cost; the working depth is greater than 5m. The desilting vehicle is suitable for the complex underwater environment, and is applicable to the industrial circulating cooling water settling pond, the channel, the conduit and the like.

A macerating apparatus for a toilet in which the problem of jamming the macerator at startup is solved by rapidly detecting the flushing of the toilet and accelerating the macerator before motion-jamming solid objects in the effluent from the toilet can reach the macerator. The macerating apparatus may be comprised of a macerating cutter operatively connected to a motor, and a sensor in communication with the motor. The sensor may detect the flow of effluent from the toilet toward the macerator, the flow of makeup water from the supply tank into the toilet, or the mechanical action of the mechanism used to flush the toilet. The apparatus may include an intake basket having an asymmetric inlet tube and containing the macerating cutter, wherein the asymmetry of the inlet tube provides additional operating clearance between a cutting blade of the macerating cutter and the intake basket.