The invention discloses an iron and steel enterprise high-salinity wastewater treatment process, and belongs to the technical field of industrial wastewater treatment. According to the technical scheme, the process comprises the steps: treating high-salinity wastewater through an adjusting tank, a chemical softening tank, a multi-medium filter, an ozone catalytic oxidation tower, a membrane bioreactor (MBR), primary ultrafiltration, two-stage low-pressure reverse osmosis, activated carbon adsorption, secondary ultrafiltration, weak acid resin, nanofiltration, high-pressure reverse osmosis, adsorption defluorination, electrodialysis (ED), and treatment with chelating resin and a bipolar membrane in sequence; the quality of recycled water is better than that of industrial new water, the recycled water can be used as desalted water, and the produced by-products hydrochloric acid and sodium hydroxide can be recycled for the process system, other water treatment systems of iron and steel enterprises and the like, so that the outsourcing cost is saved, and resource utilization is realized. The process is low in energy consumption, low in cost, simple in equipment, easy to operate, stablein treatment effect and beneficial to water optimization and sustainable development of iron and steel enterprises.