5931 results about "Macroporous resin" patented technology

The present invention relates to extraction and purification of functional components in Chinese herbal medicine and aims at provindg extraction and purification process of chlorogenic acid in honeysuckle in relatively high yield and purity. The techonlogical scheme includes twice reflux extraction of honeysuckle cut into sections with dilute alcohol, concentrating the extractive, flocculating for initial purification and final purification through macroporous resin or ethyl acetate extraction. The said process is simple and practical and has less loss of chlorogenic acid and high product yield and purity.

The invention relates to a method for extracting blueberry anthocyanin, which comprises the following steps of: (1) pretreating a raw material; (2) extracting the blueberry anthocyanin, namely adding extracting solution in a volume ratio of the raw material to liquid for leaching to obtain leach liquor, centrifugally collecting and merging clarified supernate which is leached and centrifuged twice, and centrifuging and concentrating under reduced pressure to obtain crude extract of the blueberry anthocyanin; and (3) refining the blueberry anthocyanin, namely adsorbing and eluting the crude extract of the blueberry anthocyanin through macroporous resin, concentrating eluent under reduced pressure, and performing freeze drying or spray drying on concentrated solution of the blueberry anthocyanin to obtain a finished product of the blueberry anthocyanin. The method solves the problems of strong harvesting seasonality and difficult storage of blueberry fruits and huge economic loss due torot caused by the unsalable blueberry fruits, has the advantages of simple process, controlled operation, low cost and no pollution, and is particularly suitable for extracting the blueberry anthocyanin on a large scale.

The invention provides a production method of fructus monordicae extract with over 60% of mogroside V content. In the method, the fresh momordica grosvenori is subjected to the following technique processes: smashing, saccharification, extraction by water, concentration, sedimentation and centrifugation, ion exchange resin refining, macroporous resin refining, concentration, aluminum oxide refining, concentration, spray drying and finishing product. The method can produce high-quality fructus monordicae extract products, reduce material loss, shorten period of production, increase product yield, lower production cost, and is suitable for industrial production. The mogroside V content in the fructus monordicae extract produced by the method is more than or equal to 60%; the fructus monordicae extract has high product purity, single composition, pure white color, good color and taste, fresh and cool sweet taste like that of sugar, simultaneously overcomes the technical problem for industrial production of the high-content and high-quality fructus monordicae extract, and successfully realizes large-scale production.

The present invention relates to process of extracting chlorogenic acid from honeysuckle and belongs to the field of medicinal chemical technology. The process includes the steps of: reflux extraction of honeysuckle with water or ethanol, filtering to collect filtrate, recovering solvent, ethanol deposition to eliminating impurity, letting stand overnight, filtering, decompression recovering solvent, adding water and letting stand overnight, filtering, eluting the filtrate in macroporous resin column, concentrating eluent, collecting chlorogenic acid component, eluting on polyamide column with eluent, collecting chlorogenic acid component, concentration, rectification to obtain chlorogenic acid product with content over 95 %. The present invention is suitable for industrial application.

The invention relates to a chemical industrial waste salt refining process which comprises the following steps: pretreating high salt wastewater generated in the production process of aminobenzene ether and p-nitrophenol so as to adjust the pH value, adsorbing by using activated carbon, kieselguhr or macroporous resin, removing organisms and organic salts in the wastewater, reducing the COD of the wastewater, neutralizing the high salt wastewater, performing multi-effect evaporation or mechanical recompression so as to evaporate and crystallize, and centrifuging a solid salt; performing high-temperature calcination on the centrifuged solid salt in a rotary kiln or a tunnel kiln, thereby decomposing and oxidizing the organisms at a high temperature, further thoroughly combusting the tail gas generated through calcination in a heat accumulation type tail gas combustion furnace, preheating and recycling the tail gas, performing spraying absorption, dissolving the calcinated salt with water so as to prepare a saturated solution, filtering by using a precise filter, directly supplying the filtrate to ionic membrane caustic soda for use, or performing multi-effect evaporation or mechanical recompression on the filtered saturated salt water so as to evaporate, crystallize and purify, and performing centrifugation, thereby obtaining high-quality solid sodium chloride.

A chlorogenic acid extraction process of the present invention includes crushing honeysuckle, water extraction of chlorogenic acid and macroporous resin adsorption to separate high content chlorogenic acid. It features that in the last technological step, the chlorogenic acid extracting liquid is saturated and adsorbed with macroporous resin, the chlorogenic acid in resin is washed and dissolved with low concentration alcohol to obtain chlorogenic acid eluting liquid, the eluting liquid is concentrated while recovering alcohol and the concentrated chlorogenic acid condensate is spray-dried to obtain chlorogenic acid powder product with chlorogenic acid content over 40%. The isochlorogenic acid in the resin column is produced into powder product through methanol washing and dissolving, concentrating and spray drying, after recovering method.

The present invention provides a new water purification method and system using reverse osmosis. In particular, the present invention provides methods and water purification systems using an ion exchange resin and absorbent media for pretreatment of water being fed to a reverse osmosis treatment system, where the pretreatment reduces fouling of, or deposits or chemical attack on the membrane surfaces and passageways. Particularly, a macroporous resin having an average pore diameter in the range of 1,000 to 500,000 Angstroms and a crush strength or Chatillon value of at least 24 g / bead (710 μm bead diameter) is used.

The invention is concerned with a kind of extract of total ketone of salviae miltiorrhizae and total phenolic acid and its produce method form radix Salviae Miltiorrhizae. The extract of total ketone of salviae miltiorrhizae has cryptotanshinone, tanshinone I, tanshinone IIA, methyl Tanshinon, dihydrotanshinon I and ramification. The extract of total phenolic acid has salvianolic acid A, salvianolic acid B, protocatechuic aldehyde and ramification. The extract can be got form one or arbitrary compound of extraction with solvent method, macroporous resin method, column chromatography and liquid-liquid counter-current chromatography. The summation of the content to each total ketone of salviae miltiorrhizae is 20 to 100 percnte (w / w) of the extract of total ketone of salviae miltiorrhizae, the contene of cryptotanshinone, tanshinone I and tanshinone IIA is 5 to 100 percent (w / w) of whole content of total ketone of salviae miltiorrhizae. The summation of the content to each total phenolic acid is 5 to 100 percent (w / w) of the extract of the radix salviae miltiorrhizae total phenolic acid. The content of salvianolic acid B is the 5 to 100 percent (w / w) of the whole salvianolic acid.

The invention provides a production method for extracting sweet tea glucoside from sweet tea leaves. The method comprises the following process flows of: smashing a sweet tea crude drug; extracting a solvent; concentrating; precipitating with alcohol; purifying with macroporous resin; concentrating; carrying out chromatography with polyamide resin; concentrating; crystallizing and recrystallizing; drying; and obtaining a finished product. By using the method, a high-quality sweet tea glucoside product can be produced, and the method also has the advantages of reducing the material loss, shortening the production period, improving the product yield and reducing the production cost and is suitable for the industrial production; the purity of the sweet tea glucoside produced by utilizing the method is higher than 98 percent, so that the product purity is high, and the component is single; the color of the sweet tea glucoside is white and good; and meanwhile, the technical difficulty of industrially producing a high-content and high-quality sweet tea glucoside extractive is overcome, so that large-scale production is smoothly produced.

The invention discloses a method for preparing gardenia pigments from Gardenia jasminoides Ellis, and belongs to the technical field of natural pigment preparation methods. The method comprises the following steps: carrying out crushing peeling, extraction, filtration, macroporous resin purification, eluting, concentrating, drying and the like on Gardenia jasminoides Ellis which is a raw material to obtain a gardenia yellow pigment and geniposide, and processing the geniposide through a biological engineering technology and a membrane filtration and acid precipitation process to prepare a gardenia blue or red pigment. The method allows the production cost of the gardenia yellow pigment to be reduced and the comprehensive utilization level of the raw material to be simultaneously improved; and the prepared series pigments can be applied to fields of foods, health products, cosmetics, medicines and the like.

The invention relates to a method for extracting cyaniding and belongs to the technical field of extracting natural medicaments. The method adopts the process of ultrasonic-assisted enzyme method extraction, flocculation, ultrafiltration, macroporous resin adsorption, nanofiltration condensation, spray drying and high-purity cyaniding. Compared with the traditional processes, the method has the advantages of overcoming the defects in the traditional processes, effectively improving the yield and the quality of the product, greatly lowering the consumption and the loss of the organic solvents,reducing energy consumption, lowering production cost, having practicability and progress and reaching the domestic leading level.

The invention provides a method for extracting new chamaejasmine B from stellera chamaejasme. L, which comprises the process steps of: reflux-extraction after pulverization of stellera chamaejasme. L, alkali extraction and acid precipitation, separation with macroporous resins and crystallization. The method has the advantages of simple operation, low carbon, economy and high purity of product.

The invention discloses a production process of high-purity sweet tea glycosides. The production process comprises the steps of extracting, condensing, flocculating, clarifying, centrifugally separating, refining macroporous resin, ion exchange resin decolorizing, using desalting resin for desalting, conducting composite decolorizing and condensing, and then conducting spray-drying on thick paste to obtain powder with color of milk white to white, namely, high-purity sweet tea glycosides with content of not less than 98%. The production process has the advantages that the high-purity debitterized sweet tea glycosides with content of not less than 98% and color of milk white to white can be produced in batch, so that the problem that the product can not be produced in batch on the market; the product can occupy the sweetener market; a feasible production process path is found to produce sweet tea glycosides in batch. According to chemical component characteristic of Guangxi sweet tea, key production links such as flocculating, clarifying, macroporous resin refining, ion exchange resin decolorizing and debitterizing, desalting resin for desalting and debitterizing, composite decolorizing and on the like are combined effectively.

The invention pertains to the field of medical technology and provides triterpenoid saponin in camellia seeds, and a preparation method and medical application thereof. The triterpenoid saponin is shown in a general formula (1), wherein, R1 is hydrogen or oxhydryl or acyloxy; R2 is the hydrogen or the acyloxy; R3 is the hydrogen or the acyloxy; R4 is the hydrogen or the acyloxy; R5 is methyl or methylol or aldehyde group or carboxyl or metheyl carboxyl; R6 is the hydrogen or orglycosyl; the preparation method comprises the following steps: macroporous resins are degreased, extracted by ethanol, decocted in water, desugared and decolored to obtain crude total saponins and then go though an opened ODS chromatographic column and repeated HPLC method to obtain the total saponins of camellia seeds and monomer theasaponin. The triterpenoid saponin compounds in the camellia seeds have the functions of protecting gastric mucosa, being antineoplastic, reducing blood sugar and blood fat and thelike and are used for preparing medicaments or health-care foods having the functions of protecting gastric mucosa, being antineoplastic and reducing blood sugar and blood fat.

The invention relates to a method for extracting anthocyanin from lycium ruthenicum fruit. The method comprises the following steps of: (1) leaching raw material lycium ruthenicum fruit for 1-30h with an ethanol solution with a pH value of 1-4, and then filtering to obtain leach liquor; (2) carrying out vacuum concentration on the leach liquor obtained in the step (1) to obtain a concentrated solution of which the concentration of the solid is >= 40%; (3) adsorbing the concentrated solution obtained in the step (2) by utilizing macroporous resin, then eluting with an ethanol water solution, and beginning to collect when color of an eluant darkens to obtain a purified anthocyanin extracting solution of the lycium ruthenicum fruit; and (4) carrying out vacuum concentration on the anthocyanin extracting solution of the lycium ruthenicum fruit. Which is obtained in the step (3), to obtain a concentrated solution of which the concentration of the solid is >= 60%, and refrigerating and drying the concentrated solution to finally obtain the lycium ruthenicum fruit anthocyanin. The method for extracting the anthocyanin from the lycium ruthenicum fruit is simple in process, and the prepared anthocyanin has less impurities, excellent quality and favorable stability.

The invention discloses a preparation method of high pure crocin and geniposide. The preparation method comprises following main steps: selecting raw materials of gardenia ellis plants, extracting with water or an alcohol-water mixed solution, merging the extracting solutions, condensing, filtering, subjecting the obtained extracting solution to an adsorption treatment by macroporous resin, then performing gradient elution with a ethanol-water mixed solution, obtaining geniposide and gardenia yellow refined extracts; subjecting the geniposide refined extract to a recrystallization treatment with ethyl acetate so as to obtain the geniposide product; subjecting the gardenia yellow refined extract to go through column chromatography, which has been pressurized and stuffed with modified silica gel, to separate, and obtaining the high pure crocin product (color value larger than 600) and a chlorogenic acid component. The products have the advantages of high purity, simple technology, strong operability and convenience for automation, comprehensive utilization of the plant resources is achieved, the solvent is convenient to recycle and reuse, and the preparation method is easy to apply to the industrial amplification.

The invention discloses a method for simultaneously preparing chlorogenic acid and luteoloside from honeysuckle flower, which comprises the following steps of: extracting by using ethanol, enriching by using D101 macroporous resin, separating and purifying by using a silicagel column and a polyamide column, recrystallizing and the like. In the method, the chlorogenic acid and the luteoloside are extracted from the honeysuckle flower by a hot ethanol solvent extraction method; the aims of enriching the chlorogenic acid and the luteoloside and separating the chlorogenic acid from the luteoloside are fulfilled by regulating the concentration and pH value of eluent used by the macroporous resin; and the chlorogenic acid and the luteoloside are subjected to silicagel column chromatography, polyamide column chromatography and recrystallization respectively to form the chlorogenic acid and the luteoloside with the purity of over 95 percent.

The present invention relates to the preparation process of high-purity momordica glycoside V. The preparation process includes: crushing grosvenor momordica, heated ethanol reflux extracting, separating the extract in D101 macroporous resin, deionized water and ethanol eluting to no color and collecting the eluate, decompression concentrating to obtain paste, separating in positive phase silica gel column with chloroform, methanol and water as eluent and collecting the eluate, decompression concentrating, separating in negative phase silica gel C-18 column, detecting the eluate with HPLC, merging momordica glycoside V components with the same retention time and purity of 90-98 % and over 98 % separately, decompression concentrating to obtain momordica glycoside V component with purity of 90-98 % and momordica glycoside V component with purity over 98 %. The present invention has raised momordica glycoside V purity and low cost.

The invention relates to a process for extracting anthocyanin from blueberries. The process uses the blueberries as a raw material and comprises the following steps of: pulverizing the raw material and adding acid water with a pH of 1-3 for soaking and extracting; clarifying an obtained extract by using a precipitator; adsorbing by using macroporous resin; eluting by using a 70 percent alcohol solution; ultrafiltering an obtained eluent by using an ultrafiltration membrane and then concentrating by using a nanofiltration membrane; and spraying and drying an obtained concentrated solution to obtain a finished product. By adopting the process to produce the blueberry anthocyanin, the product yield has high cost value ratio, and the energy consumption is less. The process is easy for industrialization.

The invention discloses a method for preparing low-caffeine high-tea polyphenol tea powder, which comprises the following steps of: extracting and roughly filtering tea leaves, centrifuging filtrate subjected to rough filtration at an ultrahigh speed, adsorbing centrifugate by using macroporous resin, performing graded elution by using aqueous solution of ethanol to separate caffeine from tea polyphenols, concentrating tea polyphenol eluent and drying concentrate. The tea polyphenol content of the low-caffeine high-tea polyphenol tea powder prepared by the method is more than or equal to 85 percent, wherein the catechin content is more than or equal to 60 percent, the EGCG content is more than or equal to 35 percent and the caffeine content is less than or equal to 1 percent. The method has the advantages of simple process, high extraction ratio, low cost and high product quality and safety; and the low-caffeine high-tea polyphenol tea powder prepared by the method can be used for preparing health-care food or cosmetic.

The invention provides a method for extracting mogroside V. According to the method, fresh fructus momordicae serves as a raw material and is washed, smashed and extracted according to the following steps that (1) the fresh fructus momordicae is saccharifed; (2) aqueous extraction and concentration are conducted; (3) sedimentation and centrifugation are conducted; (4) adsorption and separation are conducted through macroporous resin, wherein multiple resin column groups are used for adsorption, resolution liquid is collected in sections, and according to different contents, combination is conducted in batches; (5) ion exchange resin is refined; (6) ethyl alcohol is concentrated and recycled; (7) silica gel is refined; (8) concentration and spray drying are conducted, so that mogroside V extract serving as a final product is obtained. According to the technology of refinement, various types of aglucone of fructose of the fructus momordicae are gathered in a bed layer in sections and the extracted mogroside V is high in purity, good in color and pure in taste.

The invention provides a method for separating high-purity anthocyanin monomers from black rice. The method comprises the following steps of: grinding 5 to 8 percent of episperm on the outer layer of black rice and brown rice to obtain black rice pericarp, leaching anthocyanin in the black rice pericarp by acidized ethanol, and extracting and defatting petroleum ether; performing primary purification of ethanol extracts of the black rice pericarp by using macroporous resin; separating the anthocyanin in coarse extracts of the anthocyanin of the black rice pericarp by the medium pressure preparation liquid phase chromatographic technique, collecting two leading anthocyanin components, which are cyanidin-3-glucoside and paeonidin-3-glucoside, in the black rice pericarp respectively according to the obtained chromatogram, and performing rotary evaporation of eluent at a temperature of below 45 DEG C until all methanol is gone, and performing freeze-drying to obtain powder of the anthocyanin monomers.

The invention relates to a method for extracting chlorogenic acid, which belongs to the technical field of pharmaceutical chemicals. The method combines macroporous resin enrichment, ethyl acetate extraction and a mixed solvent split-phase method to achieve multi-step gradient purification of the chlorogenic acid so as to obtain a chlorogenic acid product with high purity. The method comprises the processes of water extraction, column passing, extraction, phase splitting and recrystallization. The macroporous resin adopted by the column passing process is 306 type or XAD series resin; and the split-phase agent adopted by the split-phase method is petroleum ether, chloroform or the mixture of the petroleum ether and the chloroform. The method is applicable to the process of extracting and preparing the chlorogenic acid from honeysuckles, cortex eucommiae leaves and cortex eucommiae barks.

The invention relates to spina date seed reference extract and a preparation method and application thereof and belongs to the technical field of traditional Chinese medicine quality control. The preparation method of the spina date seed reference extract includes the following steps of smashing, degreasing, extracting, macroporous resin purifying, silica gel purifying and acquiring of the spina date seed reference extract finally. Spina date seed medicinal materials are degreased, extracted and purified through a specific method, finally the spina date seed reference extract with specific constituents is acquired, and the reference extract includes jujuboside A, jujuboside B and other saponin constituents and further includes spinosin, 6'''-ferula asafetida spinosin and other flavonoid constituents. The spina date seed reference extract serves as a reference to be used in quality control over a traditional Chinese medicine preparation containing spina date seed medicine flavor and has the advantage that constituent information is comprehensively fed back; when the spina date seed reference extract is used, the complex pretreatment step is not needed, inspection can be directly conducted after dissolution, and the advantages of being easy and convenient to operate and low in detection cost are achieved.

The process of preparing high purity chlorogenic acid and flavonid with eucommia leaf includes the following steps: crushing eucommia leaf and extracting with pH 3-6 alcohol solution of 45 %-55 % concentration; saturation adsorbing the extracted solution with medium polarity JD-1 macroporous resin, and eluting successively with water, 20 %-45 % concentration alcohol solution and 60 %-75 % concentration alcohol solution to obtain crude chlorogenic acid product and flavonid-containing powder separately; eluting the crude chlorogenic acid product in silica gel column with ethyl acetate, acetone, methanol or ethanol, collecting the eluted solution, decompression concentrating, and re-crystallizing the concentrate in acetone or water to obtain refined chlorogenic acid product. The present invention has simple technological process, convenient operation, reuse of the macroporous resin, low comprehensive cost and excellent industrial application foreground.

The invention relates to an anthocyanidin made from Vaccinium uliginosum L. and separation and purification methods thereof, which belong to the technology field of active component extraction and purification and functional food development. The content of anthocyanidin in Vaccinium uliginosum L. is 29.8-40%, wherein the content of malvidin accounts for 4.68-5.48% of the anthocyanidin; and antioxidant activity of the anthocyanidin is as 7.8-15 times as that of Vc. The preparation method includes pre-treating raw material, cold soaking and concentrating, purifying and concentrating, and freeze dying. The ultrasonic and microwave-assisted cold soaking method is employed for separation, and an AB-8 macroporous resin static-dynamic combined absorption purification method is employed. The invention provides an environmental friendly, high-efficiency and low-cost separation and purification technology of anthocyanidin made from Vaccinium uliginosum L., which maintains product bioactivity such as antioxidant property of product and ideal separation effect, establishes the basis for wide utilization of abundant resource of Vaccinium uliginosum L. and industrialized development promotion of a series of Vaccinium uliginosum L. health food, and embodies great economic benefit and social benefit in deep processing of the Vaccinium uliginosum L.

The invention discloses an effective component containing cyanidin 3-O-glucoside, a preparation method and an application. The preparation method comprises (1) extraction: using black soybean hull as raw material, adding water, extracting at normal temperature, screening and obtaining extract, (2) absorbing the extract via a macroporous resin, eluting via water and alcohol water solution gradiently, checking the eluent, collecting the component rich in cyanidin 3-O-glucoside, depressurizing and concentrating to obtain concentrate, (3) absorbing the concentrate via polyamide resin, gradiently eluting via water and alcohol water solution, checking, collecting the component rich in cyanidin 3-O-glucoside, depressurizing and concentrating the eluent, and drying, to obtain the effective component whose cyanidin 3-O-glucoside content is higher than 50%. Tests prove that the effective component of cyanidin 3-O-glucoside is effective and non-toxic, with better analgesic, anti-acute inflammatory and anti-adjuvant rheumatoid arthritis functions.

The invention discloses the preparation of a compound polysaccharide humectant and application of the compound polysaccharide humectant to cigarettes. The preparation method comprises the following steps of: (1) crushing compound Chinese medicines such as Adenophora elata, dwarf lilyturf tuber, and platycodon grandiflorus, adding water, slightly boiling, performing reflux extraction, mixing extracting solution, and filtering; (2) adding protamex and high-temperature amylase into the extracting solution, and performing enzymolysis; (3) absorbing naturally cooled enzymolysis extracting solution by using a macroporous resin column, and collecting flow-through liquid; (4) concentrating the flow-through liquid in a rotary evaporator until the moisture is not evaporated to obtain the polysaccharide humectant; and (5) dissolving the polysaccharide humectant in water and adding into cut tobacco, wherein the humidification effect of cigarettes is remarkably improved, and the dry sensation of the cigarettes is reduced and the sweet degree of the cigarettes is strengthened when the cigarettes are smoked. The invention has the outstanding advantages that: the compound polysaccharide humectant can improve the aesthetic quality of the cigarettes, reduce the dry sensation of smoke, improve the sweet degree and comfort degree, and has remarkable effects of promoting the secretion of saliva or body fluid and humidifying; and the application of the technology cannot change the conventional cigarette processing technology, and the technology has actual application value.

The present invention provides a method of reducing the concentration of an iodide compound using an ion exchange resin. The ion exchange resin is a macroporous resin having sulfur functional groups exchanged with silver, a dry weight capacity of at least 5.0 eq / kg, a mean pore diameter (D50) of about 400-800 Å, a pore volume of about 0.4-0.6 ml / g, and a surface area of about 20-40 m2 / g.