16 results about "Bilirubin" patented technology

This invention provides a process for extracting biliverdin hydrochloride through bio-fermentation and a method for synthesizing bilirubin. By studying the complex system of biliverdin obtained through microbial bacterial fermentation, a process for separating and purifying biliverdin was established, and the obtained biliverdin was further used to synthesize bilirubin. This process is simple to operate, uses common resins, employs solvents with low toxicity that are easily recovered and reused, utilizes low-energy membrane separation equipment for concentration, and uses conventional reaction reagents as reducing agents. The process has low operating costs, is environmentally friendly, and yields high-purity and stable-yield biliverdin and bilirubin products, demonstrating excellent prospects for industrial application.

This invention discloses a single-herb bezoar preparation based on an ancient prescription; an enteric-coated bezoar soft capsule and its preparation method. The enteric-coated bezoar soft capsule consists of a bezoar dispersion and an enteric-coated soft capsule shell. A sand mill is used to prepare bezoar powder into micron-sized particles with a particle size ≤100μm. The micron-sized bezoar powder is fully dispersed in a dispersion medium, thereby improving the solubility of bezoar. The single-herb bezoar preparation can improve the problem of inconsistent bezoar content in compound bezoar preparations. The process of preparing the ≤100μm micron-sized bezoar dispersion uses non-metallic grinding equipment, avoiding the catalytic reaction of metal ions during the preparation of micron-sized powder. Low-temperature grinding is also used to avoid denaturation of the heat-sensitive active substances in bezoar, better preserving its biological activity. The enteric-coated formulation prevents the drug from being released in the stomach until it reaches the small intestine, avoiding the precipitation of bilirubin and other bile acids in the acidic environment of the stomach, which would otherwise lead to insoluble solids and poor solubility.

The application belongs to the technical field of medical equipment, and provides a blood treatment system including a blood treatment assembly, an optical detection assembly and a control module. The blood treatment assembly uses a treatment liquid to treat blood of a target object to obtain waste liquid and treated blood, and the treated blood is transfused back to the target object. The optical detection assembly generates irradiation light of at least three wavelengths, wherein the irradiation light of the first wavelength is used for detecting bilirubin or free hemoglobin, the irradiation light of the second wavelength is used for detecting intracellular hemoglobin, and the irradiation light of the third wavelength is used for detecting the waste liquid. The optical detection assembly collects light information of emergent light of the at least three wavelengths. The control module obtains light change information corresponding to the at least three wavelengths according to the light information of the emergent light of the at least three wavelengths and the light information of the irradiation light of the at least three wavelengths. Whether the light change information corresponding to the at least three wavelengths satisfies a preset alarm condition is judged to determine whether to perform a hemolysis alarm or a blood leakage alarm, so that detection is distinguished.

The present application belongs to the technical field of medical apparatus and instruments, and discloses a warm box closed blue light irradiation data management system based on mechanical intelligence, which comprises: a state cluster data module, which collects multi-source heterogeneous data, corrects the clock deviation between the warm box and the preset biological sensor through a space-time alignment protocol, dynamically adjusts the multi-source heterogeneous data sampling rate based on the infant physiological data in the multi-source heterogeneous data after time alignment, and outputs a state cluster data packet with a time stamp; a hierarchical extraction module, which constructs a three-level feature processing pipeline based on the state cluster data packet, including a basic layer that calculates basic statistics through a sliding window; a logic layer that generates a temperature-light effect index and a sealing safety coefficient according to the basic statistics and in combination with the multi-source heterogeneous data; and a decision layer that establishes a treatment efficiency prediction matrix based on the temperature-light effect index and the sealing safety coefficient, and predicts the associated trend of blue light irradiation and bilirubin metabolism; the safety and curative effect stability of infant treatment are improved.

The application discloses a kind of polyether sulfone microspheres, preparation method and application, comprising the following steps: step 1: vinyl imidazole bromide salt, acrylic acid and azobisdimethylvaleronitrile are dissolved in solvent, stirring is carried out under nitrogen protection condition, fully reacts, precipitates, and is filtered to obtain polymer;Step 2: the polymer obtained in step 1 is dissolved in solvent to obtain polymer solution;Step 3: the polymer solution obtained in step 2 and polyether sulfone solution are blended, and polyether sulfone microspheres are obtained by electrospinning;The polyether sulfone microspheres obtained by the application have a diameter of 500-800 μm, have a loose porous structure, have a large specific surface area, and have good bilirubin adsorption effect.

This invention discloses a pediatric jaundice treatment device and method for pediatric clinicians, relating to the field of medical device technology. The invention includes a base with an outer shell fixedly connected to its top. An opening and closing plate is connected to the inner wall of the outer shell via hinges. An inner light-transmitting shell is located on the top of the base, slightly smaller than the outer shell, and has a gap in between. This invention achieves dynamic tracking of the infant's torso by setting a U-shaped block and a rotating alignment mechanism. When the infant's sleeping position changes from supine to lateral, the pressure-sensing mattress detects the change in torso position in real time. A second controller transmits this signal to a first controller, driving a micro-motor to rotate a second lead screw, causing the U-shaped block to rotate to the corresponding angle. Simultaneously, the first motor drives the first lead screw to lower the mounting shell and rotating block to a position facing the side of the torso, ensuring that the light group is always aligned with the core area of ​​bilirubin accumulation.

The application provides a plasma adsorber for double adsorption of bilirubin and cytokines and an application thereof. The plasma adsorber comprises a column body and a double-function adsorbent. The column body is provided with an interface for connecting an extracorporeal circulation pipeline at each end. The double-function adsorbent is filled in the column body. A filter screen is arranged at the opening of each end of the column body. The volume of the double-function adsorbent in the column body accounts for 60% to 90% of the volume of the column body. The double-function adsorbent is polystyrene-divinylbenzene macroporous resin with a chlorine content less than 1.5% and capable of adsorbing bilirubin and cytokines simultaneously. The pH value of the double-function adsorbent in an initial state is 5.0 to 6.0. After aging, the pH value of the double-function adsorbent is 4.5 to 6.0. The plasma adsorber provided by the application adopts one adsorption column, can adsorb bilirubin and cytokines simultaneously, reduces the difficulty of medical operation, can reduce the probability of sensitization, and is beneficial to improving the safety of blood purification.

The application discloses a kind of heme oxygenase mutant and its multienzyme coupling preparation of application of bilirubin, belong to biological catalysis engineering field.The application obtains the positive mutant of heme oxygenase by directed evolution technology, can efficiently catalyze heme to synthesize chlorophyllin;Further introduce chlorophyllin reductase, coupling cytochrome P450 reductase, formic acid dehydrogenase, and two kinds of core enzyme are coupled with exogenous auxiliary enzyme, constructs recombinant escherichia coli, catalyzes heme to synthesize bilirubin.In the system, without exogenous addition NADPH, reaction time is about 4h, and bilirubin yield is as high as 2.10g / L, and no intermediate accumulation is observed in catalytic process, reaches the highest yield of the synthesis of bilirubin reported at home and abroad, and the shortest reaction time level.Compared with traditional pig bile extraction, the method of the application breaks through the resource limit, and the operation is simple, the yield is high, realizes the efficient, green synthesis of bilirubin.

A standardized phototherapy system for delivering a controlled dose of therapeutic light within a therapeutic optical bandwidth to a patient. The phototherapy system includes a therapeutic light source configured to generate spatially uniform irradiance over is a treatment region. The irradiance generated over the treatment region is controlled by controller via a driver signal and is calibrated using a photonic dosimeter matched to the therapeutic light source. The photonic dosimeter is a photonic dosimeter configured to establish a reference relationship between the driver signal provided to the therapeutic light source and the irradiance generated over the treatment region. The controller can adjust the irradiance of the therapeutic light over the therapy region based on patient data comprising measured concentration of a biological analyte in patient's blood.

The application relates to the field of biological medicine, and discloses a use of indole-3-propionic acid in preparation of a medicine for preventing and treating acute-on-chronic liver failure. Experiments prove that the indole-3-propionic acid can effectively inhibit the formation of neutrophil-related extracellular traps, reduce the levels of alanine aminotransferase, aspartate aminotransferase, total bilirubin and inflammatory factors TNF-alpha, IL-6 and IL-1beta related to acute-on-chronic liver failure, reduce liver tissue necrosis and inflammatory infiltration, and improve the survival rate. Therefore, the indole-3-propionic acid can be used for preparing a medicine for preventing and / or treating acute-on-chronic liver failure, and provides a new small-molecule intervention strategy for acute-on-chronic liver failure.

A method of evaluating disposition and / or effect of a candidate compound in an in vitro culture and / or suspension to predict in vivo disposition and / or effect of the candidate compound, which can include the steps of providing a cell culture and / or suspension; exposing a candidate compound to the culture and / or suspension; exposing the culture and / or suspension to a media providing an in vivo relevant extracellular environment, such as a media comprising a component (such as a protein and / or other component, such as lipoproteins, bile acids, and endogenous compounds such as bilirubin) at a physiologic concentration or a concentration having characteristics, such as binding characteristics, similar to the physiological concentration; wherein any combination of any of the exposing steps can occur in any order or simultaneously; and evaluating in vitro disposition and / or effect of the compound to predict in vivo disposition and / or effect of the candidate compound.

The application belongs to the technical field of biological medicine, and particularly relates to POFUT1 The application discloses an application of a gene function inhibitor in preparation of a drug for treating cholestatic liver disease. POFUT1 It is found for the first time that inhibition of the function of the gene can significantly reduce the degree of liver lesion of cholestatic liver disease. POFUT1 The deletion of the gene can significantly reduce serum liver enzyme, bile acid and bilirubin levels, reduce liver inflammatory cell infiltration and collagen deposition. Further verification by AAV8-mediated RNA interference technology shows that targeted silencing of the gene in liver cells can effectively alleviate liver injury and liver fibrosis. POFUT1 The application provides a novel treatment target and strategy for cholestatic liver disease, and has a wide clinical application prospect.

The application discloses an image processing method and device for judging hemolysis of suspended red blood cells, and the method comprises the following steps: acquiring a blood image set; the blood image set comprises a plurality of blood images and corresponding label information; acquiring a blood parameter information set; the blood parameter information set comprises a plurality of blood parameters and corresponding label information; the blood parameters comprise hemoglobin concentration, reticulocyte concentration, indirect bilirubin concentration, lactate dehydrogenase concentration and globin concentration; a blood hemolysis composite detection model is constructed by using the blood image set and the blood parameter information set; the collected blood image and blood parameter are processed based on the blood hemolysis composite detection model, and hemolysis detection result information is obtained; the hemolysis detection result information is used for representing the red blood cell hemolysis information of the corresponding blood of the collected blood image and blood parameter.

The utility model discloses a multistage centrifugal separation device for bilirubin extraction belongs to bilirubin extraction technical field, including separation box body, detachable setting the box cover of separation box body top, rotatory setting rotatory board of box cover bottom wall, detachable setting the filter vat of multiple coaxial settings of rotatory board bottom wall, hollow rotating shaft vertically through setting between box cover with rotatory board, the feed pipe of movable setting in hollow rotating shaft and bottom end extension to the inside filter vat of most, and drive hollow rotating shaft rotates the drive assembly of, multiple filter vat same bottom wall, the filter hole aperture of multiple filter vat reduces gradually from inside to outside, the filter hole aperture of each filter vat bottom wall and the filter hole aperture of outermost layer are same. The device can realize multistage centrifugal separation, improve centrifugal efficiency, and can dismantle filter vat after centrifugation to clean and wash filter vat.

This invention discloses a method for simultaneous detection of bilirubin and hemoglobin concentrations based on a single-frame image of the eye, comprising: acquiring an image containing a color chart and the eye under a standard light source; performing manual white balance and color correction matrix transformation based on the color chart; extracting the sclera and lower eyelid regions using a YOLOv8 segmentation network; inputting the left and right eye regions into a twin-Swin-Transformer network with shared weights; obtaining predicted values ​​through multi-scale feature fusion and a regression head; and introducing a feature consistency loss optimization model. This invention achieves high-precision simultaneous non-invasive detection of bilirubin and hemoglobin, with advantages such as good color constancy, strong anti-interference ability, and high clinical application value.

The present invention relates to a pharmaceutical composition for preventing or treating inflammatory diseases comprising a compound of chemical formula 1, and to a cosmetic composition comprising the compound. By comprising the compound of chemical formula 1, the present invention can protect cells and reduce inflammation by removing reactive oxygen species and suppressing inflammatory cytokines in a non-toxic manner.