27results about How to "Reduce recurrence" patented technology

The invention relates to the technical field of skin disease health evaluation, in particular to a skin disease health evaluation system integrating multiple clinical evaluation tools. Comprising a patient information management and dynamic risk assessment module, a skin microbiome analysis module, a symptom quantification and assessment module, a physiological index monitoring module, an environmental adaptability monitoring module, an intelligent decision support module and a feedback and optimization module. The method comprises the steps of performing dynamic risk assessment in combination with a machine learning algorithm, performing quantitative assessment on the skin health state of a patient in combination with microbiome analysis and real-time physiological index monitoring, performing quantitative assessment on symptoms through an image analysis technology and a standardized questionnaire, and generating a personalized health assessment report and a treatment scheme by using a deep neural network and an optimization algorithm. Continuously improved closed-loop management is realized through a feedback optimization module; according to the invention, not only is a scientific evaluation basis provided for doctors, but also a patient can obtain customized treatment suggestions.

The invention discloses application of probiotic yeast microcapsules in drugs for targeted regulation of inflammatory macrophage immunity, and belongs to the technical field of biological medicines. As a novel medicine, the yeast microcapsule has the characteristics of engineering, convenience, low cost, high patient compliance, high safety and excellent targeting property, can be used as an oral medicine for treating chronic inflammatory disease rheumatoid arthritis, acts on mitochondria through oxidative stress and oxidative phosphoric acid pathways, inhibits excessive activation of macrophages, and has the effect of treating chronic inflammatory disease rheumatoid arthritis. Release of inflammatory factors is reduced, and inflammatory reaction is relieved; the yeast micro-capsule can promote the phagocytosis and antigen presentation function of macrophages and enhance the immune defense capability of a body, so that the immune function of the macrophages is adjusted, and the yeast micro-capsule shows huge potential in preparation of drugs for targeted adjustment of inflammatory macrophage immunity, and has a broad application prospect in preparation of drugs for targeted adjustment of inflammatory macrophage immunity. And a theoretical basis is provided for developing non-invasive, convenient and safe treatment of chronic inflammatory diseases such as rheumatoid arthritis.

The invention provides core-shell structure nanoparticles with a mediated microenvironment for rheumatoid arthritis treatment and a preparation method thereof.The preparation method comprises the steps that a calcium peroxide precursor is dissolved in absolute ethyl alcohol containing a surfactant, and calcium peroxide nanoparticles are obtained by adding an ammonia water solution and a hydrogen peroxide solution; the preparation method comprises the following steps: carrying out surface treatment on calcium peroxide nanoparticles by using tannic acid to form a tannic acid molecular layer on the surfaces of the calcium peroxide nanoparticles so as to obtain tannic acid modified calcium peroxide nanoparticles; and forming a metal phenolic network shell on the surface of the tannic acid modified calcium peroxide nano-particle by using cerium acetate to obtain the core-shell structure nano-particle.

The invention discloses a user self-management system embedded with a seasonal allergic rhinitis expert database, and belongs to the technical field of big data health management, and the system comprises an expert database construction module which is used for constructing an expert database; the model supervised training module is used for supervising and training the IMB intervention model; the engine connection establishing module is used for establishing engine connection, and the role permission and the index matrix have a corresponding relation; the data formatting module is used for receiving the rhinitis data, identifying and carrying out semantic analysis, and converting and determining formatted data; the guidance information determination module is used for user guidance information; and the user self-management module is used for carrying out terminal visual display on the user guidance information and carrying out user self-management. According to the method, the problem of how to provide targeted guidance according to the seasonal environment variable and the user state to realize effective self-management of the user is solved.

The invention discloses a multi-model collaborative question-answering method and system for the field of hydraulic cylinders. The method comprises the following steps: constructing a knowledge graph of the field of the hydraulic cylinders; receiving a hydraulic cylinder field problem input by a user, calculating a comprehensive score of the hydraulic cylinder field problem, judging whether the problem belongs to a query type problem or not according to the comprehensive score, if so, matching a template from a preset cross-layer query template library according to a semantic vector of the problem, and if not, matching the template; automatically generating a query statement adaptive to the current problem by combining a component parameter-assembly relationship-design specification three-level association path in the hydraulic cylinder domain knowledge graph, submitting the query statement to a database to execute query, and storing a query result; otherwise, judging whether the problem belongs to a calculation type problem according to the comprehensive score, if so, extracting key parameters in the problem, and calling a calculation program library according to the key parameters to complete calculation to obtain a calculation result; otherwise, integrating the query result and / or the calculation result, and generating an answer of the question.

The invention discloses an anti-aging water-soluble facial essence block and a preparation, packaging and using method thereof, and relates to the technical field of cosmetics, the anti-aging water-soluble facial essence block is obtained by compounding a filling agent, a humectant, an anti-aging agent, a soothing agent, an anti-allergy agent, a repairing agent, a preservative and a neutralizing agent, and the anti-aging water-soluble facial essence block can improve the anti-aging ability of skin and can also improve the anti-aging effect of the skin. After the traditional Chinese medicine composition is used, the percutaneous water loss rate of the skin of a user can be reduced, the skin barrier can be repaired, and the secondary recurrence of skin problems can be reduced; meanwhile, after the anti-aging water-soluble facial essence block is mixed with water according to a certain proportion, the anti-aging water-soluble facial essence block can be quickly dissolved to form facial essence, the operation is simple, and the use is convenient.

This invention proposes a visual human tissue rotary cutting device and its shell opening and closing control method, belonging to the field of shell medical device technology. The visual human tissue rotary cutting device includes a scalpel sheath, a blade, a ductoscope, an electrocoagulation hemostatic needle, a sampling chamber, and a puncture shell. The scalpel sheath is capable of axial feeding movement. The blade is installed in the scalpel sheath. The ductoscope is fixedly installed on the outer wall of the scalpel sheath. The electrocoagulation hemostatic needle is installed on the outer wall of the scalpel sheath and located on the opposite side of the ductoscope. The sampling chamber is connected to the scalpel sheath and an external vacuum device. The puncture shell includes a first half-shell and a second half-shell, which can be connected at their tail ends and open at their front ends, forming a bullet shape when combined. The lesion tissue is removed by rotating the blade, which completes axial cutting with the axial feeding of the scalpel sheath. The ductoscope provides the surgeon with a surgical field, which improves surgical accuracy and reduces recurrence. The electrocoagulation hemostatic needle is used to handle large-scale active bleeding.

A modified exosome and its preparation method, and an in-situ spray hydrogel of exosomes combined with PD-1 antibody and its application, belong to the field of medical technology, CpG oligodeoxynucleotides and tumor-specific protein OVA are co-loaded on exosomes to obtain modified exosomes. And the in-situ spray hydrogel of exosomes combined with PD-1 antibody is prepared by loading the combined PD-1 antibody (aPD-1) and the above-mentioned modified exosomes into an in-situ spray hydrogel matrix. The in-situ spray hydrogel of the exosome combined with PD-1 antibody can release CpG to stimulate the maturation of dendritic cells at the tumor infiltration site, thereby activating tumor-infiltrating T cells. At the same time, the in-situ spray hydrogel of the exosome combined with PD-1 antibody can home to the tumor-draining lymph nodes, stimulate the maturation of dendritic cells in the lymph nodes, and increase the infiltration of T cells. And it can prolong the survival of mice and reduce the recurrence rate of melanoma after surgery.

The invention belongs to the technical field of traditional Chinese medicines, and particularly relates to a traditional Chinese medicine composition for treating endometrial polyp as well as a preparation method and application thereof. The traditional Chinese medicine composition is prepared from rhizoma smilacis glabrae, platycodon grandiflorum, honeysuckle, salvia miltiorrhiza, corydalis tuber, rhizoma atractylodis, selfheal, szechwan chinaberry fruit, Chinese yam, radix scrophulariae, endothelium The traditional Chinese medicine composition disclosed by the invention has the effects of tonifying spleen and qi, and removing blood stasis and eliminating diseases. A research result shows that the traditional Chinese medicine composition has a remarkable clinical curative effect on spleen deficiency and blood stasis type endometrial polyp, and can improve the menstrual condition of a patient, reduce the traditional Chinese medicine syndrome integral, reduce relapse and improve the detection indexes of the patient including serum VEGF and IL-6.

This invention relates to the field of traditional Chinese medicine (TCM) composition technology. It discloses a TCM formula for treating gout using a warming and dampness-eliminating approach. The TCM composition is made from the following raw materials: kudzu root, yam, cinnamon twig, dioscorea hypoglauca, corydalis rhizome, poria cocos, atractylodes macrocephala, cistanche deserticola, morinda officinalis, and licorice root. Cistanche deserticola and morinda officinalis are the principal herbs to warm and tonify kidney yang, while poria cocos and atractylodes macrocephala are the assistant herbs to strengthen the spleen and eliminate dampness. This warming and dampness-eliminating TCM formula for gout breaks through the limitations of traditional heat-clearing and dampness-eliminating methods, focusing on the pathogenesis of spleen and kidney yang deficiency and internal dampness, treating both the root cause and symptoms, and significantly reducing the recurrence of gout attacks. The entire formula is warming without being drying, does not harm spleen and kidney yang, has high safety, and is suitable for long-term use. The formula is carefully formulated, quickly relieving pain and lowering uric acid, while improving yang deficiency symptoms, with side effects far lower than Western medicine. It has various dosage forms, simple processing, and is easy to produce and promote, providing a safe and effective new solution for gout treatment.

The application relates to the technical field of skin bacteriostatic liquid, and discloses a skin bacteriostatic liquid containing plant extracts and a preparation method thereof, which comprises the following raw materials in parts by mass: composite plant extracts containing nanocrystalline particles 15-20 parts, glycerol 3-4 parts, sodium hyaluronate 0.1-0.2 parts and purified water 75-85 parts. The composite plant extracts containing nanocrystalline particles, glycerol, sodium hyaluronate and purified water are mixed to obtain the skin bacteriostatic liquid, which has the advantages of strong bacteriostasis, long-acting bacteriostasis, mildness and no irritation, and can repair the skin barrier, realize long-acting skin bacteriostasis, reduce the repeated occurrence of skin inflammation, and relieve inflammatory skin aging.

The invention discloses a compound external application gel combining traditional Chinese medicine and western medicine, which is specially designed for treating acne. The medicine integrates traditional Chinese medicine wisdom and modern western medicine efficacy, and aims to quickly relieve acne, regulate body balance, reduce relapse and reduce side effects. Western medicine components comprise malechlorpheniramine, oryzanol, dexamethasone acetate and vitamin B12, and cooperate with traditional Chinese medicine extracts such as artificial musk and pearl to achieve the comprehensive curative effects of resisting inflammation and allergy, improving endocrine and promoting skin repair. The unique preparation process ensures high purity and low toxicity of the medicine, and is suitable for patients of wide age groups. Clinical verifications show that Xinjiaoqing shows debridement speed and user satisfaction superior to those of a conventional therapy in patients of different age groups, especially in young patient groups, the Xinjiaoqing remarkably improves acne symptoms, reduces treatment cycle, improves life quality and treatment compliance, and marks an innovative breakthrough in the field of acne treatment.

The present invention relates to activated dendritic cells and their use in the treatment of cancer. In particular, the present invention relates to a placental derived heat shock protein gp96-antigen complex, dendritic cells activated by said complex, and pharmaceutical compositions, vaccine adjuvants, immunomodulators and vaccine formulations containing said complex or dendritic cells and their use in anti-tumor.

The present invention discloses a comprehensive cardiovascular counseling therapeutic instrument, including a support table, the bottom of the support table is symmetrically fixed with four universal wheels, and an L-shaped fixing frame is fixedly installed on one side of the upper part of the support table, an electric cylinder is fixedly installed in the center of the upper part of the L-shaped fixing frame, and a red light treatment unit is fixedly installed at the telescopic end of the electric cylinder, and the upper part of the support table is located directly below the red light treatment unit and symmetrically provided with two groups of magnetic therapy units. The present invention has good therapeutic effect, is safe and reliable, and can reduce the burden of patients during treatment, especially for elderly patients who are over 70 years old and are slightly fat, who can lie and sleep on the upper part of the support table using the therapeutic instrument, which can effectively reduce their burden during treatment and increase the therapeutic effect. The relatively relaxed treatment environment is conducive to patients' adherence to long-term treatment and their rehabilitation, and can also reduce the recurrence of cardiovascular diseases in patients, ultimately achieving the purpose of curing patients.

The invention relates to the technical field of animal husbandry, and discloses a temperature-sensitive sustained-release gel for treating cow mastitis and a preparation method thereof.The temperature-sensitive sustained-release gel is prepared from, by mass, 15%-24% of a triblock copolymer PLGA-PEG-PLGA solution, 3-7 parts of eucommia ulmoides powder, 2-5 parts of nisin, 1-3 parts of a stabilizer, 1-3 parts of a pH regulator and the balance water. One-time perfusion can be completed under the condition of a small administration volume, a stable sustained-release drug library is formed in the local part of the mammary gland, and the drug is continuously and slowly released through the diffusion effect of the gel layer, so that a lasting inhibition effect is generated on pathogenic bacteria on the surface and in the mammary gland tissue. Due to the fact that the medicine mainly plays a role in the local part of the breast, the high local medicine concentration can be maintained in the breast tissue, diffusion of the medicine to the whole body tissue is reduced, and therefore the risk that the medicine has adverse effects on non-lesion organs or tissues is reduced.

The invention provides a traditional Chinese medicine composition for treating non-erosive gastroesophageal reflux as well as a preparation method and application thereof, and belongs to the technical field of traditional Chinese medicines. On one hand, the invention provides a traditional Chinese medicine composition formula for treating non-erosive gastroesophageal reflux; secondly, the invention provides a traditional Chinese medicine composition for treating non-erosive gastroesophageal reflux. Thirdly, the invention provides a preparation method of the traditional Chinese medicine composition for treating non-erosive gastroesophageal reflux. In the fourth aspect, the invention further provides application of the traditional Chinese medicine composition in preparation of medicine for treating non-erosive gastroesophageal reflux.

The invention relates to the technical field of traditional Chinese medicines, and provides a traditional Chinese medicine composition for treating gynecological diseases, which is prepared from the following components in parts by weight: 300 to 350 grams of cortex phellodendri, 300 to 350 grams of radix scutellariae, 300 to 350 grams of fructus schizandrae, 300 to 350 grams of cuttle bone, 200 to 250 grams of rhizoma coptidis, 110 to 150 grams of radix sophorae flavescentis, 100 to 150 grams of borax, 100 to 120 grams of ha powder, 100 to 120 grams of borneol, 150 to 180 grams of indigo naturalis and 5 to 10 grams of musk. The traditional Chinese medicine composition powder prepared from the traditional Chinese medicine composition through the steps of raw material preparation, crushing, screening and sterilization treatment has the remarkable activity of inhibiting pathogenic microorganisms such as candida albicans, gardnerella and trichomonas vaginalis, and meanwhile, the proliferation activity of human vaginal epithelial cells is remarkably promoted; the traditional Chinese medicine composition has a remarkable treatment effect on mice with qi stagnation and blood stasis type vaginitis.

The invention discloses multifunctional injectable composite hydrogel loaded with active oxygen response polymeric micelles and a preparation method and application of the multifunctional injectable composite hydrogel, and belongs to the technical field of biomedical hydrogels, oxidized hyaluronic acid, modified chitosan and active oxygen sensitive micelles are fused in the hydrogel, and intelligent regulation and control over the rheumatoid arthritis microenvironment are achieved. Through a dual crosslinking technology, the hydrogel not only has improved mechanical strength, but also has shape adaptation and self-repairing capabilities. Due to introduction of the active oxygen response micelle, drug release is intelligent, the release rate is adjusted according to the level of active oxygen in joints, and the curative effect is enhanced; the hydrogel can accurately locate an inflamed joint, intelligently release drugs, reduce side effects, induce polarization of M2 macrophages, improve an inflammatory microenvironment and realize collaborative treatment, intelligent controlled release and long-term stability of the hydrogel provide a new strategy for precision medicine, and the hydrogel is expected to show huge potential in treatment of rheumatoid arthritis and has broad application prospects. Important clinical application values and market prospects are realized.

The invention discloses a plant acne-removing composition and a preparation method thereof. The composition is prepared by compounding salvia miltiorrhiza, common leafflower herb, aloe, green tea, gentiana macrophylla, snail mucus and the like. The active ingredients of the plant acne-removing composition are compatible by adopting extracts of natural plants, the combination of the radix salviae miltiorrhizae extract, the common leafflower herb extract, the aloe extract, the green tea extract, the large-leaved gentian extract and the snail mucus is natural and non-toxic, the acne-removing effect is good, the effect taking speed is high, acne marks are not left, all the extracts have a synergistic effect, and the plant acne-removing composition is free of toxic and side effects. The effect of treating acne caused by various reasons is excellent. The plant acne-removing composition is good in stability, high in safety, simple in preparation method, wide in raw material source and suitable for large-scale industrial production.

The invention belongs to the technical field of skin analysis and nursing, and discloses a pustular acne sampling, culturing and analyzing method and application thereof. Comprising the steps that volunteer face pustular acne and normal skin photographing is conducted, volunteer face pustular acne and normal skin part microorganism sampling is conducted, microorganism samples are cultured, and treatment is conducted through image J and a pH meter. Based on skin surface pH value regulation and control and zymophyte characteristic analysis, the composition has the biological activity effects of resisting acnes, repairing skin barriers and regulating skin micro-ecology.

The invention relates to the technical field of medicines, and discloses a medicine for treating periodic psychosis, which comprises the following components: pinellia ternate, pericarpium citri reticulatae, poria cocos, immature bitter orange, bamboo shavings, liquorice, ginger, Chinese date, theanine and a cortex albiziae extract. Through the rapid sedation effect of the theanine and the long-acting emotion regulation effect of the cortex albiziae extract, the multi-target synergistic effect is achieved, and the anxiety, depression, emotion fluctuation and sleep disorder symptoms of a patient are effectively improved; according to the composition, a modern extraction and processing technology is adopted, the bioavailability of the medicine is improved, multiple dosage forms such as granules, capsules and tablets are developed, and the compliance of patients is improved. The traditional Chinese medicine composition has the advantages of high efficiency, safety, low side effect and the like, not only can be used for treating periodic psychosis such as bipolar affective disorder and periodic depression, but also is suitable for adjuvant therapy of other affective disorders, and the dependence of patients on traditional western medicines is reduced.

The invention relates to the technical field of medicines, and discloses a traditional Chinese medicine composition for treating acute and chronic bronchitis in children, which is prepared by processing the following raw materials: 3 parts of ephedra, 3 parts of almond, 15 parts of honeysuckle, 15 parts of lysimachia christinae hance, 5 parts of gastrodia elata, 5 parts of tendril-leaved fritillary bulb, 5 parts of pericarpium citri reticulatae, 5 parts of uncaria, 10 parts of poria cocos and 6 parts of liquorice. The composition is prepared according to the following steps: S1, decocting: weighing the medicinal materials according to a prescription proportion, putting the medicinal materials into a container, adding water for soaking, decocting the soaked medicinal materials twice, combining the two decoctions, standing and filtering to obtain a medicine juice; s2, concentration: concentrating the medicine juice to obtain medicine liquid; s3, sub-packaging: sub-packaging the liquid medicine by using a clean and dry glass bottle, and sealing the glass bottle; and S4, sterilization: putting the subpackaged liquid medicine into a high-pressure steam sterilizer for sterilization treatment. The traditional Chinese medicine composition not only can quickly relieve symptoms such as cough and expectoration, but also can regulate lung functions and reduce repeated attack of inflammation.

This disclosure provides a Yao medicine composition, preparation, preparation method, and application for treating vertigo, belonging to the field of ethnic medicine technology. The composition comprises the following components in parts by weight: 5-20 parts of Bidens pilosa, 5-20 parts of Apocynum venetum leaf, 5-50 parts of Achyranthes bidentata, 5-50 parts of Achyranthes bidentata, 5-50 parts of Prunus persica kernel, 5-20 parts of Carthamus tinctorius, 5-20 parts of Paeonia lactiflora, 5-20 parts of Ligusticum chuanxiong, 5-20 parts of Achyranthes bidentata, 5-20 parts of Zanthoxylum bungeanum, 5-20 parts of Pueraria lobata, and 5-20 parts of Angelica sinensis. The composition and preparation of this invention can effectively treat vertigo caused by hypertension, cervical spondylosis, etc., and have high safety, providing a new and effective solution for the treatment of related diseases.

The invention relates to the technical field of intestinal tract treatment, and discloses an edged capsule movement complete ileum hovering device and method, which comprises a peristaltic shell, a driving mechanism is arranged at the tail end of the peristaltic shell, a hovering mechanism is arranged in the peristaltic shell, an administration mechanism is arranged at the head end of the peristaltic shell, and a linkage mechanism is further arranged at the position, close to the administration mechanism, of the peristaltic shell; the driving mechanism is arranged in the wriggling shell, the driving mechanism drives an opposite lantern ring of the hovering mechanism to move oppositely, so that a connecting rod assembly drives a movable assembly to form an opening state, the device hovers at the ileum section, and a linkage mechanism drives the dosing mechanism to form a wriggling state along with the intestinal tract and a hovering continuous dosing state; a patient with the ileitis disease can obtain more accurate and effective treatment, the medicine directly acts on a focus area, and the risk of systemic absorption and adverse reaction is reduced; meanwhile, the continuous administration mode ensures that the effective drug concentration is maintained at the focus part for a long time, and inflammation fading and tissue repairing are facilitated.

The invention relates to the technical field of clinical drug balloons, in particular to a novel drug balloon device and a using method. The balloon catheter comprises a balloon, a catheter body and a connecting base, the balloon is installed at the front end of the catheter body and intervenes in a blood vessel for treatment, the balloon comprises an outer balloon body and an inner balloon body, the outer balloon body wraps the inner balloon body, a gap is formed between the outer balloon body and the inner balloon body, and medicine is stored in the gap formed between the outer balloon body and the inner balloon body. The balloon is used for puncturing into a blood vessel to perform expansion support treatment on a narrow part of the blood vessel, and is also used for conveying medicine to a blood vessel wall and treating the narrow part of the blood vessel and vascular hyperplasia, and the catheter is used for operating and controlling the balloon to move in the blood vessel, so that an operation doctor can perform an interventional operation conveniently; the outer balloon and the inner balloon are used for making contact with the blood vessel wall and controlling expansion respectively, operation is convenient, the expansion size is limited, operation errors are reduced, and the medicine can be stored conveniently through the gap interlayer between the outer balloon and the inner balloon and can be directly fed into the diseased position.

The present invention relates to the field of medical care technology, and specifically discloses a personalized endocrine therapy management system for thyroid cancer after radiotherapy, comprising: an information collection unit, a data analysis unit, a feature screening unit, an SVR model analysis unit, a classification supervision unit, and a feedback push unit. The information collection unit is used to obtain patient endocrine therapy data, the data analysis unit is used to preprocess and analyze the obtained data, the feature screening unit is used to analyze the data and select special items therefrom, and the SVR model analysis unit is used to analyze and predict the processed data. The present invention uses an SVR model to take important features of a patient's condition as input, and can predict the target dose of levothyroxine after radioactive iodine treatment for thyroid cancer patients. Compared with the empirical method that is currently more clinically used, the method is more objective and accurate, and can shorten the TSH target time of the target patient population, reduce the risk of recurrence or metastasis of the patient, and improve the quality of life of the patient.

The present invention discloses a cervical cancer excision device, comprising: a holding cup and a cutting device, wherein the holding cup has a holding cavity for holding biological tissue, and the holding cup is provided with a suture needle area made of soft material and a knife through hole arranged below the suture needle area; the cutting device comprises a cutting knife arranged in the holding cup, and a cutting drive device for driving the front end of the cutting knife to extend or retract from the knife through hole. The present invention provides a suture needle area made of soft material on the holding cup, so that during the operation, the suture needle can fix the vaginal stump to be removed on the outer wall of the holding cup by suturing in the suture needle area to form a closed space, and then drive the cutting knife to extend from the knife through hole below the suture needle area to cut the vagina. The present invention can prevent tumor cells on the cervix from falling into the abdominal cavity, causing local dissemination and implantation, and reduce the recurrence of tumors after surgery.