72 results about "Buccal use" patented technology

A method and composition to help persons reduce or quit smoking is disclosed, employing raw tobacco leaves, or tobacco fluid extract, or food grade tobacco like flavor and aroma, and Antioxidants, with or without and SAMe and caffeine. All ingredients can be in a micro-powdered or liquid form, for buccal administration. The composition can be in a tablet or capsule that is intended to be slowly sucked and dissolved in the mouth, and that delivers the nicotine, caffeine or SAMe, proved to be effective in alleviating smoking withdrawal symptoms. The composition can also be embedded inside a soft squeezable plastic cigarette for simulated smoking, providing additional periodic doses of nicotine, caffeine and SAMe to satisfy cravings for cigarettes.

Drug formulations for systemic drug delivery with improved stability and rapid onset of action are described herein. The formulations may be administered via buccal administration, sublingual administration, pulmonary delivery, nasal administration, subcutaneous administration, rectal administration, vaginal administration, or ocular administration. In the preferred embodiments, the formulations are administered sublingually or via subcutaneous injection. The formulations contain an active agent and one or more excipients, selected to increase the rate of dissolution. In the preferred embodiment, the drug is insulin, and the excipients include a metal chelator such as EDTA and an acid such as citric acid. Following administration, these formulations are rapidly absorbed by the oral mucosa when administered sublingually and are rapidly absorbed into the blood stream when administered by subcutaneous injection. In one embodiment, the composition is in the form of a dry powder. In another embodiment, the composition is in the form of a film, wafer, lozenge, capsule, or tablet. In a third embodiment, a dry powdered insulin is mixed with a diluent containing a pharmaceutically acceptable carrier, such as water or saline, a metal chelator such as EDTA and an acid such as citric acid. Devices for storing and mixing these formulations are also described.

A composition for nasal administration comprising varenicline or its pharmaceutically acceptable salt and at least one excipient. The invention also provides a composition for buccal administration comprising varenicline or its pharmaceutically acceptable salt and at least one excipient to form a solid dosage form, wherein the solid dosage form disintegrates in an oral cavity at body temperature and may adhere to body tissue of the oral cavity; a composition for pulmonary administration comprising varenicline or its pharmaceutically acceptable salt and at least one excipient; and, a method for reducing nicotine addiction, aiding in the cessation of, or lessening of tobacco use in a subject.

The present invention provides a kit comprising, in separate compartments of a container, the following components (a) and (b): (a) a combination of apomorphine or a pharmaceutically acceptable acid addition salt thereof and a pharmaceutically acceptable excipient or carrier; and (b) a solution which comprises a diluent and a pH modifying agent; the components being presented such that they can be combined at the point of use into a formulation which is adjusted to a pH ranging from mildly acidic to alkaline and which is suitable for buccal administration. The formulation is useful in treating Parkinson's disease and in promoting sexual function.

Embodiments of the present invention relate generally to methods and systems for the sublingual and buccal administration of herbal supplements, and more particularly, to the sublingual and buccal administration of Guaraná, which allows for considerably reducing the therapeutic dose, with the additional advantage of increasing the quickness of the beneficial effects.

The present invention provides a pharmaceutical tablet comprising an orally disintegrating tablet core and an excipient coating adhered thereto, wherein the coating comprises gellan gum. The tablet is suitable for oral administration, for example, the drug contained in the core of the tablet is at least partially absorbed through the oral mucosa of the patient and delivered to the patient.

The invention relates to a composition which contains asenapine maleate and is taken by sublingual or buccal administration and a preparation method of the compositionBy using the asenapine maleate as an active ingredient and using an easy-sublimating pore-foaming agent, sublingual tablets which are quickly dispersed and dissolved under the tongue in tens of seconds are prepared, thus the active ingredient can be absorbed quickly through sublingual veins so as to enter blood circulation directly. The composition takes effect quickly and is convenient to take. The invention also discloses a novel in vitro evaluation method.

The invention discloses an oral delivery treatment device which comprises a drug storage bag; the drug storage bag comprises a bag body and an end cover; the bag body is in a hollow semi-annular shape, a drug adding opening is formed in one end of the bag body, the end cover is arranged at the drug adding opening, a plurality of drug outlets are formed in the side face of the bag body, and mouth opening plugs or mouth closing plugs are installed at the corresponding drug outlet. By arranging the drug outlets in the side face of the bag body, the mouth opening plugs or the mouth closing plugs can be flexibly installed according to different treatment positions, the mouth opening plugs are installed at the drug outlet corresponding to the treatment positions, the mouth closing plugs are installed at other positions, and the purpose of accurate drug delivery can be achieved. After liquid medicine is contained or drugs are smeared, the upper teeth or the lower teeth are sleeved with the device, and drug release can be promoted by extruding the oral cavity or manually biting the teeth. The oral delivery treatment device is adopted for delivering drugs to the position where oral mucosa is damaged or ulcerated, the better treatment effect can be achieved with less drug, the drug delivery process is comfortable, and metal burdens and economic burdens of a patient are relieved.

The invention belongs to the field of health-care foods, and in particular relates to sea cucumber stewed food buccal tablets and a preparation method thereof. The invention aims to solve the technical problem of providing sea cucumber stewed food buccal tablets which can not only preserve the original unique flavour of the stewed food to a certain extent but also maintain the nutrient content for a long term and contribute to the effective absorption. The technical scheme for solving the technical problem is to provide a method for preparing the buccal tablets from sea cucumber stewed food. The method comprises the following steps of: a, mixing the prepared sea cucumber and ingredients, and then stewing or boiling to obtain a cooked product containing solid matter and cooking liquor; b, drying and dehydrating the cooked product and grinding; and c, granulating and tabletting the ground cooked product. The sea cucumber stewed food buccal tablets prepared by the method are easy to carry and convenient to take, create the manner of buccal administration and mucous membrane absorption of the sea cucumber stewed food, accord with the traditional eating habits, goes out of the mistakenarea that only extraction and administration is focused to increase the intake of part of the effective ingredients in the field, and has good market prospect.

The invention relates to a medicament for treating pharyngitis, which is prepared from the following medicaments in part by weight: 1 to 3 parts of dregea sinensis, 1 to 2 parts of baical skullcap root, 1 to 2 parts of common alstonia leaf and 0.5 to 1 part of liquoric root. The medicament has reasonable compatibility, acute toxicity tests prove that the medicament has no toxic response, safe and reliable curative effects, good formulations and mouthfeel, and effects of improving local curative effect because of buccal administration, clearing heat and detoxifying, relieving sore throat and downbearing counterflow, and relieving cough and reducing sputum. The clinical curative effect observation and acute toxicity research prove that the medicament has the advantages of no toxic or side responses, and safe and reliable curative effects and is suitable for preventing and treating diseases such as acute and chronic pharyngitis, stomatitis, gingivitis, toothache due to wind-fire evil and allergic cough.

Provided are compositions of cladribine and cyclodextrin which are especially suited for the oral and buccal administration of cladribine.

The invention belongs to the technical field of small medical machinery, in particular to an oral cavity drug delivery device for the periodontal mucosa. The device comprises a drug bottle, wherein the upper end of the drug bottle is in threaded connection with a bottle cover, the bottle cover is in sealed connection with a catheter, one end of the catheter is connected with a connecting tube, theend, away from the catheter, of the connecting tube is connected with liquid release cotton, the side, close to the inner side of the connecting tube, of the catheter is fixedly connected with an aircompression device, the inner side, close to one side of the air compression device, of the connecting tube is rotationally connected with a pressing handrail, the inner portion of the drug bottle isin sealed connection with a liquid extracting tube, the liquid release cotton can adapt to the structural particularity in the oral cavity and can fit the wounded part, so that drug delivery is moreuniform and sufficient, since more bacteria exist in the oral cavity, the used liquid release cotton is not suitable for being used again, and the disposable product not only ensures the sanitary safety but also reduces the cleaning strength of medical workers.

The present invention relates to an aerosol spray device (10, 20, 30, 40) for administration of a substance, specifically a substance having a disagreeable taste, such as nicotine, to the oral cavity of a subject; to an actuator (16, 26, 36, 46) included in said spray device and to methods for delivering the substance.

The invention discloses a bagged tea for buccal administration, which comprises Camellia sinensis leaf, Flos Lonicerae and Dendrobium nobile. The bagged tea is kept between the teeth and the cheek to allow the active components to dissolve in the saliva. The tea contains fluorides and helps to increase the hardness and acid-resistant ability of teeth, prevent dental caries. Flos Lonicerae can clear hear and toxic materials, inhibit bacterial growth, and relieve inflammation. Dendrobium nobile can promote salivation. Therefore the bagged tea can help to eliminate bad breath and refresh breath.

The invention relates to a Chinese brake herb preparation for treating gastrointestinal tract and urinary tract infections and cardiovascular and cerebrovascular diseases and a preparation method thereof. A Chinese brake herb extract is dissolved in a proper solvent by a solvent dispersion method and a solid-liquid phase dispersion melting and dissolving method to prepare Chinese brake herb extract solution; the solution is dispersed and sprayed into an auxiliary material, or is prepared into a uniformly dispersed solid dispersion mixture; and the mixture is crushed, mixed and stirred uniformly, added with a lubricant and tabletted directly, or added with an adhesive, granulated and dried, and added with a lubricant and tabletted. The dispersively mixed particles of the Chinese brake herb extract also can be added with a proper amount of the lubricant and filled into capsules. The preparation is used for treating various symptoms of the gastrointestinal tract and urinary tract infections, also has the effect of treating the cardiovascular and cerebrovascular diseases, and has the advantages of long acting time of the medicament, convenient oral/buccal administration and the like. The Chinese brake herb preparation has the advantages of high content, stable quality, high bioavailability and improvement of the medication compliance of a patient.