The invention discloses a health-care food for improving the moisture of skin and removing wrinkles, which is prepared by the following raw materials in parts by weight; 10-15 parts of collagen powder, 6-8 parts of soybean isoflavone, 3-5 parts of pearl powder, 3-5 parts of aloe extract, 3-5 parts of American ginseng extract, 3-5 parts of poria cocos extract, 3-5 parts of amur corktree bark extract, 2-3 parts of Chinese date, 1-2 parts of vitamin C powder, 3-5 parts of fructo-oligosaccharide, 3-8 parts of sodium carboxymethylcellulose, 1-5 parts of citric acid, 1-5 parts of malic acid and 5-20 parts of sucralose. The invention has the functions of internally expelling the toxin, tonifying the qi and nourishing the yin and replenishing the collagen lacked in human bodies by reasonably blending with the collagen powder, the soybean isoflavone, the pearl powder, the aloe extract, the poria cocos extract, the American ginseng extract, the amur corktree bark extract, the Chinese date and the vitamin C powder, thereby achieving the effects of water replenishing and wrinkle removal from inside to outside; and in addition, the raw materials of the fructo-oligosaccharide and the like are added, thereby the invention has the effects of adjusting tastes and promoting intestinal absorption.