53 results about "Intestinal absorption" patented technology

The application provides an extendable digestive tract cannula and application thereof, and relates to the technical field of medical devices. The application comprises a first cannula, a second cannula and a degradable material. Opposite ends of the first cannula are a proximal end and a distal end, respectively. The first cannula is sleeved with the second cannula, and a double-layer structure is formed at the distal end of the first cannula. The double-layer structure is fixed by the degradable material. When the degradable material degrades, the second cannula moves towards the end face of the distal end of the first cannula. By setting the movable second cannula, the second cannula moves backward after the degradable material degrades, so that the length of the digestive tract cannula is extended. Since the length of the digestive tract cannula is increased, the area of intestinal absorption is also increased, the compensatory absorption function of the intestine at the distal end of the digestive tract cannula is weakened, the isolation effect of chyme and the intestine is improved, and the digestion and absorption effect of the intestine can be reduced for a long time.

The invention discloses a perfusion-free parallel double-cell intestine-liver chip system and application thereof in drug uptake evaluation, and belongs to the field of biomedical engineering and organ chips. The chip disclosed by the invention is simple in structure, free of an external pump and a complex pipeline, capable of realizing fluid circulation through swinging, convenient to operate, low in cost and small in pollution risk, and also capable of promoting cell differentiation and optimizing hepatocyte functions. The chip integrates a parallel intestinal cell and a liver cell which are communicated through a shared channel, can continuously simulate intestinal absorption and liver first-pass metabolism, and is closer to an in-vivo physiological state. The device adopts a detachable transparent modular design, can be repeatedly used, supports multi-group parallel operation, can improve experimental flux and result repeatability, and is suitable for in-vitro verification of drug absorption, permeability and metabolism evaluation.

The invention discloses a high-calcium chelating activity collagen peptide prepared based on chicken bones, a peptide calcium chelate and application, an ultrasonic-assisted enzymolysis technology is utilized to destroy a collagen cross-linked structure through an ultrasonic cavitation effect, and three-stage enzymolysis time sequence regulation is combined, so that the hydrolysis rate of the collagen peptide reaches 33.18 + / -0.84%. The collagen peptide provided by the invention has relatively high calcium chelating activity, and the peptide calcium chelate is stable in structure in an intestinal neutral environment and under a weakly alkaline condition and is beneficial to intestinal absorption of calcium.

The invention discloses a lactoferrin gel carrier, a preparation method thereof and application of the lactoferrin gel carrier in an oral delivery system. The preparation method comprises the following steps: mixing a lactoferrin solution with transglutaminase, and reacting under mild conditions to form a gel network. According to the method, gel which is compact in structure and high in stability is formed through enzyme catalytic crosslinking, the mechanical strength and embedding capacity of the gel are remarkably enhanced, and the method is suitable for embedding multiple active ingredients (such as probiotics, polyphenol and vitamins) sensitive to heat, oxygen or shear force. The obtained gel carrier can effectively isolate oxygen, moisture and adverse processing environments, and the stability of embedded components in processing, storage and transportation is remarkably improved. The carrier can be slowly released in a gastrointestinal tract environment, and active ingredients are prevented from being degraded too early in gastric acid, so that the intestinal absorption rate and the bioavailability of the carrier are improved. The materials used in the invention are natural proteins, are safe and non-toxic, and accord with food and health care product application standards.

The present application relates to a kind of bone repair compositions and its preparation method, belong to biological medicine technical field, pharmaceutical composition includes acid anhydride bovine beta-lactoglobulin peptide, casein phosphopeptide, yak bone peptide, loquat leaf extract, pterostilbene, honeysuckle chlorogenic acid and cyperus rotundus extract;Acid anhydride bovine beta-lactoglobulin peptide is prepared using special enzymolysis method.Acid anhydride bovine beta-lactoglobulin peptide, casein phosphopeptide and yak bone peptide are loaded using carboxymethyl chitosan-hydroxyapatite composite microspheres, then using sodium alginate-sodium carboxymethyl cellulose containing loquat leaf extract, pterostilbene, honeysuckle chlorogenic acid and cyperus rotundus extract one coating, then using sodium alginate-sodium carboxymethyl cellulose secondary coating.The present application develops high-efficiency pharmaceutical combination component, using polymer material to coat drug to form sustained-release system, improve bioavailability, using granular carrier to increase the stability and solubility of drug, promote intestinal absorption, improve bone repair process.

The invention discloses a red yeast rice powder-phytosterol ester blood fat reducing formula and an embedding technology, and relates to the technical field of health food, the red yeast rice powder-phytosterol ester blood fat reducing formula comprises, by weight, 30-50 parts of red yeast rice powder, 20-40 parts of phytosterol ester, 10-15 parts of fructo-oligosaccharide, and 1-3 parts of a rosemary extract; through the scientifically verified compounding proportion, the competition of the two components in the intestinal absorption stage is avoided, and the bioavailability is improved. Fructo-oligosaccharide is used as prebiotics, so that intestinal health is promoted, and the absorption capacity of intestinal tracts to active ingredients is improved; the rosemary extract has an anti-oxidation effect, can prolong the oxidation induction period of phytosterol ester to 120 hours, can protect monacolin K and phytosterol ester in the red yeast rice powder from being damaged by external factors such as light and heat, and further improves the stability.

The invention belongs to the field of medicines, and particularly relates to a hepatic targeting self-assembly liver protection peptide and application thereof in preparation of a medicine for treating alcoholic liver injury. According to the present invention, the prepared liver targeting self-assembly liver protection peptide FFGGHKDYNDLLDR can be formed through the formation of nanoparticles; the nanoparticles can be orally administered, maintain a stable sequence and structure in a gastric acid environment with a pH value of 2, prevent the influence of a complex enzyme environment in intestinal tracts, are released in a body fluid system after being absorbed by the intestinal tracts, and are enriched in the liver under the action of a liver targeting module in the liver targeting self-assembly liver protection peptide, so that the alcoholic liver injury is effectively inhibited.

The application belongs to the field of feed additives, and particularly discloses application of sodium butyrate in preparation of a feed additive against chicken white dysentery Salmonella, and sodium butyrate is added in chicken basic feed as the feed additive against chicken white dysentery Salmonella; the addition of sodium butyrate in chicken basic feed can significantly reduce the bacterial load of chicken white dysentery Salmonella infection in chicken liver and spleen, significantly increase the ratio of villus length to crypt depth of the cecum of chicken infected with chicken white dysentery Salmonella, and improve the intestinal absorption capacity; the content of CD3+ T cells, TCR+ T cells, macrophages and B cells in the liver of chicken infected with chicken white dysentery Salmonella can be significantly reduced; and then the body weight of chicken infected with chicken white dysentery Salmonella is significantly increased, and the survival rate of chicken infected with chicken white dysentery Salmonella is increased. In summary, the addition of sodium butyrate in chicken basic feed can enhance the resistance to chicken white dysentery Salmonella infection.

The application discloses a pirfenidone nanosuspension inhalation solution for treating interstitial pneumonia and a preparation method thereof, and belongs to the technical field of pharmaceutical preparations. The pirfenidone nanosuspension inhalation solution is composed of the following components in 1000ml: 8-12g of pirfenidone hydrochloride, 4-6g of polyethylene glycol-poly-L-histidine block copolymer, 45-55g of mannitol, 0.4-0.6g of antioxidant, 0.05mol / L of citric acid-sodium citrate buffer, and water for injection, wherein the amount of the citric acid-sodium citrate buffer is appropriate, and the water for injection is added to 1000ml. The application adopts a pulmonary targeted inhalation administration path of non-gastrointestinal absorption, so that the drug directly acts on the lung interstitial lesion part by bypassing the intestinal absorption link.

The invention provides radix astragali homogeneous polysaccharide as well as a preparation method and application thereof, and belongs to the field of separation and purification of natural products. The radix astragali homogeneous polysaccharide is composed of glucose and galactose, and the molecular weight of the radix astragali homogeneous polysaccharide is 1900-2200 Da. The preparation method comprises the following steps: performing water extraction and alcohol precipitation on astragalus membranaceus to obtain astragalus membranaceus crude polysaccharide, and performing column chromatography elution on the astragalus membranaceus crude polysaccharide to obtain the homogeneous astragalus membranaceus polysaccharide with the molecular weight of 1900-2200Da. The radix astragali homogeneous polysaccharide has excellent effects of resisting inflammation, regulating intestinal flora, regulating intestinal absorption function, scavenging free radicals, regulating immunity, improving prebiotic activity and resisting pulmonary fibrosis.

The invention discloses an application of a betaine-lactic acid deep eutectic solvent in promotion of protein intestinal absorption and an application in preparation of a protein intestinal absorption promoting agent. In the betaine-lactic acid eutectic solvent, the molar ratio of betaine to lactic acid is 1: (0.5-1.5). The invention further discloses a protein intestinal tract promoting absorbent which is composed of insulin, betaine and lactic acid, the concentration of the insulin is 2-5 mg / ml, and the molar ratio of the betaine to the lactic acid is 1: (0.5-1.5). According to the invention, model protein insulin is loaded by BL-DES, so that the intestinal absorption efficiency of insulin can be improved. The BL-DES stabilizes the insulin structure through the interaction of hydrogen bonds, Van der Waals' force and static electricity, reduces the viscosity of intestinal mucus, promotes model protein insulin bypass transport by reversibly opening epithelium tight connection, and significantly improves the transmembrane transport efficiency and oral bioavailability of protein. The research of the invention is of great significance to oral protein treatment.

This invention discloses a compound probiotic solid beverage formula that assists in weight control and oil adsorption. The invention designs a beverage formula suitable for human consumption. The compound Chinese herbal medicines and fruit and vegetable powders work together to adsorb oil in the stomach and intestines through physical encapsulation. Hydrolyzed white kidney bean protein blocks starch absorption, and probiotics promote intestinal absorption. Together, they can improve the body's metabolic function and solve health problems such as weight gain caused by greasy diet.

The invention relates to the field of pharmaceutical preparations and pharmaceutical chemistry, belongs to the technical field of oral delivery of antitumor drugs, and particularly relates to an abiraterone lipophilic prodrug and application thereof. The prodrug meets the following general formula: AB-O-C (= O)-(CH2) m-S-S-(CH2) m-C (= O)-O-R, the prodrug significantly improves the fat solubility and intestinal absorption capacity of abiraterone, can be absorbed through a chylomicron-mediated lymph transport pathway, and releases a parent drug in a tumor cell high-reducibility environment. The SNEDDS preparation containing the prodrug can form a particle size of 1t in vivo; the O / W type nano emulsion droplet with the size of 100 nm can significantly improve the oral bioavailability of abiraterone and inhibit the growth of prostatic cancer tumors, and has a good application prospect.

The application discloses a swallowable drug device combination device for promoting intestinal absorption of macromolecular drugs, and belongs to the technical field of drug delivery and medical devices, and the structure comprises an intestinal built-in vibration component and an external alternating magnetic field driving component; the intestinal built-in vibration component comprises a soft magnetic layer and an adhesive hydrogel layer, the soft magnetic layer is prepared by magnetizing after curing of an elastomer material doped with magnetic particles, and the adhesive hydrogel layer is a sodium alginate-acrylamide double-network hydrogel loaded with macromolecular drugs; the external alternating magnetic field driving component comprises a power module, a current driving module, an electromagnetic module, a control module and an interactive terminal; in the working state, the alternating magnetic field generated by the external alternating magnetic field driving component penetrates the body surface tissue and acts on the soft magnetic layer of the intestinal built-in vibration component, so that mechanical vibration is generated to exert physical stimulation on the local tissue in the intestine. The device can accelerate the release rate of macromolecular drugs and enhance the absorption efficiency of the macromolecular drugs in the intestine.

The present application relates to a kind of water product phagostimulant composition and its preparation method, belong to feed technology field, the composition includes the following raw materials: grain powder, inorganic powder, river snail meat powder, vegetable oil, gluten, egg yolk oil, yeast nucleotide;The grain powder includes puffed glutinous rice powder, puffed pea powder and barley malt powder, the inorganic powder includes tricalcium phosphate and titanium dioxide, and the vegetable oil includes perilla seed oil.This application selects puffed glutinous rice powder, puffed pea powder, tricalcium phosphate and titanium dioxide as visual phagostimulant component effectively accelerates the speed of fish positioning feed;At the same time, river snail meat powder, egg yolk oil, perilla seed oil and barley malt powder can promote water production animals sustained feeding from the different dimensions of stimulating olfaction, increasing palatability, stimulating taste and promoting intestinal absorption;In addition, the egg yolk oil selected in this application also has adhesion, and the addition of gluten in this application can reduce the dispersion rate of the composition in water, so that the composition has water production special performance.

The present application relates to a kind of intestinal absorption hemin, belong to biological medicine technical field, the intestinal absorption hemin, including hemin and gamma-cyclodextrin;The molar ratio of hemin and cyclodextrin is 1:2;The preparation method of the intestinal absorption hemin, comprising the following steps: (1) hemin is mixed with ammonia water, to obtain hemin solution;Cyclodextrin is mixed with water, to obtain cyclodextrin aqueous solution;(2) the hemin solution is mixed with the cyclodextrin aqueous solution, to obtain mixed solution;(3) the mixed solution is stirred, and dried for 5h, to obtain intestinal absorption hemin.The intestinal absorption hemin prepared in the present application has the advantages of water solubility and stability, high bioavailability after gastrointestinal digestion, and can be used as a raw material for preparing nutritional fortifier for iron supplementation.

The invention relates to the technical field of biological medicines, and particularly discloses a method and a composition for promoting intestinal absorption of dihydroquercetin by using quercetin and application of the method and the composition, and the method comprises the following steps: jointly applying an effective amount of dihydroquercetin and an effective amount of quercetin serving as a synergist to an intestinal environment; wherein the quercetin plays a role through at least one of the following mechanisms: inhibiting the function or expression of P-glycoprotein in intestinal epithelial cells; the tight connection of intestinal epithelial cells is regulated. It is found that quercetin not only can effectively inhibit the excretion function of P-glycoprotein in intestinal epithelial cells, but also can enhance the integrity of intestinal barriers by down-regulating the expression level of the protein and up-regulating the expression of tight junction protein, so that intestinal absorption of dihydroquercetin is synergistically promoted from the multi-mechanism level; in addition, the composition can still maintain a good absorption promoting effect in an inflammatory environment, and shows a synergistic anti-inflammatory effect.

The present invention discloses a heme iron – glycine chelated iron supplement preparation, belonging to the technical field of nutritional and pharmaceutical preparations. The preparation employs a four-source composite of heme iron, glycine chelated iron, ferrous gluconate, and ferrous lactate, enabling iron supplementation via heme receptor absorption, amino acid chelation pathways, and ionic diffusion. This design overcomes the limitations of single iron sources, including gastrointestinal irritation and low absorption of inorganic iron, dietary inhibition of conventional organic iron, and the high cost or slow onset of novel iron sources. The four iron sources act synergistically to reduce free iron ions and integrate multiple absorption pathways. As a result, gastrointestinal irritation is minimized, and the inhibitory effects of phytic acid, oxalic acid, and tannins are reduced, enabling stable and efficient intestinal absorption. The preparation achieves non-irritating, highly bioavailable, and sustained iron supplementation.

This invention discloses a method for preparing microencapsulated glycoside compound nutritional supplements, belonging to the field of food nutritional supplement preparation technology. The invention first involves enzymatic hydrolysis-ultrasonic co-extraction of glycoside raw materials followed by purification with modified macroporous resin. Then, the purified glycoside solution is grafted onto a composite encapsulation material to prepare a modified composite encapsulation material emulsion. A core-shell microcapsule precursor emulsion is constructed using microfluidic homogenization, followed by low-temperature vacuum spray granulation to achieve microcapsule formation. Finally, crystal stabilization treatment is performed to obtain the finished product. The microencapsulated glycoside compound nutritional supplements prepared by this invention achieve a glycoside encapsulation rate of over 95%, an in vitro sustained-release period of over 8 hours, and an activity retention rate of over 92% after 6 months of storage. Furthermore, water solubility and intestinal absorption are improved by over 40%, solving the problems of easy inactivation, poor absorption, and lack of sustained-release properties in traditional glycoside nutritional supplements.

The invention provides a preparation method for improving storage stability and intestinal absorption efficiency of plant saponin, flavone and polysaccharide. The preparation method comprises the following steps: mixing plant powder obtained by pretreatment with an ethanol solution; activated calcium bentonite is added into the crude extracting solution, stirring is conducted after pH is adjusted, and clinoptilolite is added; adding wooden activated carbon and filter-aid diatomite into the supernate, filtering and drying to obtain low-water-content plant extract powder, preparing a suspension from the plant extract powder and deionized water, shearing, emulsifying, performing high-pressure circulating homogenization, sequentially pre-freezing, and performing vacuum freeze-drying to obtain a nanoscale plant extract product. Efficient extraction and purification of saponin, flavone and polysaccharide are achieved through plant raw material pretreatment, ethanol multiple extraction, double-adsorbent impurity removal, activated carbon purification, vacuum belt type drying and nanocrystallization freeze-drying treatment, the intestinal absorption efficiency is improved through nanocrystallization synchronously, and component activity and storage stability are guaranteed through low-temperature drying; and finally, a nanoscale plant extract product with high purity and high activity is obtained.

The invention designs a preparation method of an active medicinal and edible composite nutrient, and the method comprises the following steps: carrying out initial culture on a ganoderma lucidum monoclonal isolate through a potato dextrose agar plate, and then transferring the ganoderma lucidum monoclonal isolate to a specific liquid culture medium for shake culture; after detecting that the activity of beta-glucosidase reaches 100 mU / mL, centrifuging to take supernatant, and adding rhizoma polygonati, lucid ganoderma and mulberry leaf powder for biotransformation; and inoculating lactobacillus plantarum, adding a freeze-drying protective additive, freeze-drying, and sieving to obtain the active medicinal and edible composite nutrient. According to the method, macromolecular active components of lucid ganoderma, rhizoma polygonati and folium mori are decomposed into small molecules through biotransformation, the problem that a traditional material is poor in intestinal absorption is solved, the prepared active medicinal and edible composite nutrient can restore the number of neutrophils, macrophages and T cells, meanwhile, tnf-alpha, il-12a and ifn-gamma proinflammatory gene expression is up-regulated, and the effect of improving the intestinal absorption rate is achieved. In addition, the natural source is high in safety, and can be used for an immune function regulation scene.

The invention belongs to the field of natural product extraction and medicine preparation, and particularly relates to a preparation method for improving active ingredients of medicinal and edible plants based on a composite carrier. The invention aims to solve the technical problems of poor water solubility, chemical instability, low oral bioavailability and the like of active ingredients of medicinal and edible plants. The deep eutectic solvent is used for extracting the medicinal and edible plant materials, so that the extraction efficiency and stability of active ingredients are improved; constructing a composite carrier protective layer consisting of a polysaccharide-metal organic framework, and loading the extracted active ingredients in the composite carrier protective layer; according to the invention, the outer layer of the composite carrier is coated with a layer of pH-sensitive chitosan derivative outer membrane, so that intelligent-response drug release control is realized, active ingredients are protected from being released or decomposed too early, the active ingredients are effectively released, and the absorption of intestinal tracts is improved; the active component composite carrier prepared by the method disclosed by the invention is of a core-double-layer shell structure and has good chemical stability and environmental response performance.

The invention belongs to the technical field of pet food processing, and particularly relates to a staple food soup pot for kittens and a preparation method thereof.The staple food soup pot for kittens comprises a fiberized meat base and a soup base; the fiberized meat base is in a sheet shape or a block shape, and the fiberized meat base has a three-dimensional cross-linked network structure; the soup base contains nutritional supplements. Through synergistic pretreatment of pancreatic lipase and flavourzyme, macromolecular protein and fat are decomposed into small molecular peptide, amino acid and free fatty acid which are more easily absorbed by intestinal tracts of kittens, and the nutrition titer and bioavailability of the product are remarkably improved.

The present invention provides a composition for intestinal absorption that allows a medicine containing a poorly soluble compound to be orally administered; an agent for treating diabetes that contains the composition for intestinal absorption; a method for producing the composition for intestinal absorption; and a method for producing the agent for treating diabetes. This composition for intestinal absorption comprises first fine bubbles, a poorly soluble compound, and a physiological solution, wherein the concentration of the first fine bubbles is two billion per mL or more, and at least a part of the poorly soluble compound covers at least a part of the first fine bubbles.

Provided herein are compositions and methods for non-parenteral delivery of conjugated oligomeric compounds. In certain embodiments, compositions and methods are provided for oral delivery of conjugated oligomeric compounds. In certain embodiments, the oligomeric compounds are conjugated to one or more N-acetylgalactosamines or N-acetylgalactosamine analogues.

The invention relates to an anti-stress feed additive containing gamma-aminobutyric acid. The anti-stress feed additive is mainly prepared from the following raw materials in percentage by weight: 3-5% of radix astragali crude extract, 15-20% of stearic acid, 20-25% of palmitic acid, 8-10% of glycerol monolaurate, 5-10% of phospholipid and the balance of gamma-aminobutyric acid. According to the anti-stress feed additive, the gamma-aminobutyric acid and the astragalus membranaceus are combined for use, and through the synergistic effect of the astragalus membranaceus and the GABA, after a double-layer coating process, the rumen protection rate and the intestinal absorption rate are improved, the anti-stress capacity of ruminants is enhanced, and animal growth is promoted.

The present invention relates to: a pharmaceutical composition for preventing or treating necrotic enteritis, the pharmaceutical composition containing TGF-β1 and FGF2 genes or proteins as active ingredients; and a pharmaceutical preparation and a health functional food that contain the pharmaceutical composition. According to the present invention, TGF-β1 and FGF2, which are known to increase the expression of the CFTR gene, can be used as novel agents for inducing intestinal maturation in premature infants, and various digestive complications such as necrotic enteritis and intestinal absorption disorders, which are intractable diseases, can be treated through the same.

The invention relates to preparation of a spore-containing enteric targeted release microsphere and application of the spore-containing enteric targeted release microsphere in nicotine degradation. A probiotic bacillus subtilis 168 strain is subjected to engineering modification, so that a nicotine degrading enzyme is displayed on the surface of a spore of the probiotic bacillus subtilis 168 strain. In order to realize targeted release of intestinal tracts and reduce loss of recombinant spores in a gastric acid environment, the recombinant spores are wrapped by natural polymeric materials sodium hyaluronate and sodium alginate with pH responsiveness, and the spore microspheres with enteric targeted release are prepared. The microspheres greatly protect recombinant spores, effectively realize'interception type degradation 'of nicotine before nicotine is absorbed into blood by intestinal tracts, and continuously degrade nicotine diffused from blood by a'metabolic siphon' effect, so that the concentration of nicotine combined with a central nicotine receptor is remarkably reduced; brain dopamine reward effect induced by smoking is weakened fundamentally, positive feedback circulation of smoking-pleasant sensation is broken effectively, and visceral organs are protected from toxic and side injury of nicotine.

This invention provides a polypeptide and hydrolyzed casein with neuroprotective effects. The polypeptide AWPQ of this invention can be absorbed by the intestines after ingestion and crosses the blood-brain barrier to enter the central nervous system, thereby promoting the growth, development, and differentiation of nerve cells and ultimately exerting its neuroprotective effect. It has good development prospects in the fields of functional foods or bioactive peptides related to brain health, neuroprotection, and nerve development.

The invention relates to the technical field of food processing, and provides a dark plum flavored radix puerariae powder beverage which innovatively organically combines a dark plum extracting solution with radix puerariae powder, realizes the instant drinking characteristic through a specific preparation process, and thoroughly solves the problems that traditional radix puerariae powder needs to be brewed complexly and is inconvenient to drink after being cooled. And the convenience and palatability of the product are greatly improved. Meanwhile, on one hand, the smoked plums and the kudzuvine roots are both medicinal and edible traditional Chinese medicinal materials, and due to scientific compatibility of the smoked plums and the kudzuvine root powder, organic acids contained in the smoked plums can be utilized to improve the solubility of puerarin and improve the intestinal absorption rate of the puerarin; on the other hand, due to the synergistic effect of active ingredients contained in the smoked plums and the radix puerariae powder, the product has a more excellent mucous membrane protection effect, antioxidant activity and anti-inflammatory activity, and has a better gastrointestinal tract health-care effect after being eaten for a long time. The preparation process is simple and controllable, and the product is stable in character, uniform in color, sour, sweet and palatable in taste and convenient to popularize and apply.