101 results about "Intestinal absorption" patented technology

The application provides an extendable digestive tract cannula and application thereof, and relates to the technical field of medical devices. The application comprises a first cannula, a second cannula and a degradable material. Opposite ends of the first cannula are a proximal end and a distal end, respectively. The first cannula is sleeved with the second cannula, and a double-layer structure is formed at the distal end of the first cannula. The double-layer structure is fixed by the degradable material. When the degradable material degrades, the second cannula moves towards the end face of the distal end of the first cannula. By setting the movable second cannula, the second cannula moves backward after the degradable material degrades, so that the length of the digestive tract cannula is extended. Since the length of the digestive tract cannula is increased, the area of intestinal absorption is also increased, the compensatory absorption function of the intestine at the distal end of the digestive tract cannula is weakened, the isolation effect of chyme and the intestine is improved, and the digestion and absorption effect of the intestine can be reduced for a long time.

This invention discloses a strain of *Lactobacillus plantarum* Grx402 with the ability to promote intestinal absorption of short-chain fatty acids. *Lactobacillus plantarum* Grx402 was isolated from the intestines of long-lived individuals in Bama, Guangxi (CGMCC No. 28585). Using a Caco-2 cell model to construct an intestinal absorption model of short-chain fatty acids (SCFAs), it was found that *Lactobacillus plantarum* Grx402 can promote the absorption and transport of acetic acid, propionic acid, and butyric acid by intestinal epithelial cells, exhibiting excellent ability to promote intestinal absorption of short-chain fatty acids. It can be used to prepare dairy products or beverages that promote the intestinal absorption of short-chain fatty acids.

The invention discloses an upatinib emulsifiable paste and a preparation method thereof, the emulsifiable paste is directly smeared on an affected part, administration and use are convenient, diseases are rapidly relieved, the number of treatment times is reduced, the influence of a gastrointestinal tract absorption way on a medicine is reduced, toxic and side effects of gastrointestinal tract administration are reduced, the upatinib emulsifiable paste fills the market blank, administration of a patient is facilitated, and the curative effect of the upatinib emulsifiable paste is improved. And the market prospect is wide.

The invention discloses a perfusion-free parallel double-cell intestine-liver chip system and application thereof in drug uptake evaluation, and belongs to the field of biomedical engineering and organ chips. The chip disclosed by the invention is simple in structure, free of an external pump and a complex pipeline, capable of realizing fluid circulation through swinging, convenient to operate, low in cost and small in pollution risk, and also capable of promoting cell differentiation and optimizing hepatocyte functions. The chip integrates a parallel intestinal cell and a liver cell which are communicated through a shared channel, can continuously simulate intestinal absorption and liver first-pass metabolism, and is closer to an in-vivo physiological state. The device adopts a detachable transparent modular design, can be repeatedly used, supports multi-group parallel operation, can improve experimental flux and result repeatability, and is suitable for in-vitro verification of drug absorption, permeability and metabolism evaluation.

The invention belongs to the technical field of biological medicines, and discloses a fish collagen and rose double-effect anti-aging composition, and the core active ingredients of the fish collagen and rose double-effect anti-aging composition comprise fish collagen peptide, red roses with double petals, dried cranberries, Chinese wolfberry fruits, roxburgh rose puree and saffron. According to the preparation method, specific degradation of intestinal flora is realized by virtue of the targeting effect of the xylooligosaccharide on bifidobacteria through the compound polysaccharide microcapsules, so that collagen peptide and antioxidant components are accurately released in colon, gastric acid damage is effectively avoided, and meanwhile, the piperine nanoparticles inhibit the activity of UGT enzyme, so that the anti-oxidation effect of the collagen peptide on the colon is improved, and the anti-oxidation effect of the collagen peptide on the colon is improved. The bioavailability of crocin is increased to 45% or above from 2%, the absorption rate of rose polyphenol is increased by 3 times, the intestinal absorption efficiency of collagen peptide reaches 95%, a remarkable breakthrough is achieved compared with 60-80% of a traditional process, and an efficient delivery mode of targeted release-absorption enhancement is constructed.

The invention discloses a high-calcium chelating activity collagen peptide prepared based on chicken bones, a peptide calcium chelate and application, an ultrasonic-assisted enzymolysis technology is utilized to destroy a collagen cross-linked structure through an ultrasonic cavitation effect, and three-stage enzymolysis time sequence regulation is combined, so that the hydrolysis rate of the collagen peptide reaches 33.18 + / -0.84%. The collagen peptide provided by the invention has relatively high calcium chelating activity, and the peptide calcium chelate is stable in structure in an intestinal neutral environment and under a weakly alkaline condition and is beneficial to intestinal absorption of calcium.

The invention relates to the technical field of traditional Chinese medicines, in particular to anti-osteoporosis processed isinglass as well as preparation and application thereof. According to the prepared isinglass provided by the invention, the component M is less than or equal to 5kDa, and the proportion is 63.71%, so that the intestinal absorption efficiency and the bioavailability can be remarkably improved. The invention also provides an application of the processed isinglass in preparation of medicines. The medicines can be used for treating and / or preventing osteoporosis caused by estrogen deficiency, intestinal flora imbalance caused by estrogen deficiency or bone diseases caused by estrogen deficiency. Compared with traditional donkey-hide gelatin, the prepared isinglass is better in molecular weight distribution and richer in Maillard reaction products; compared with swim bladder collagen which is not processed by the preparation method disclosed by the invention, the processed swim bladder collagen disclosed by the invention generates active ingredients such as melanoidins through a Maillard reaction, and the active ingredients are cooperated with amino acids, so that the limitation of traditional glues in anti-osteoporosis application is broken through, and a scientific basis is provided for development of functional bone health products.

The invention discloses a lactoferrin gel carrier, a preparation method thereof and application of the lactoferrin gel carrier in an oral delivery system. The preparation method comprises the following steps: mixing a lactoferrin solution with transglutaminase, and reacting under mild conditions to form a gel network. According to the method, gel which is compact in structure and high in stability is formed through enzyme catalytic crosslinking, the mechanical strength and embedding capacity of the gel are remarkably enhanced, and the method is suitable for embedding multiple active ingredients (such as probiotics, polyphenol and vitamins) sensitive to heat, oxygen or shear force. The obtained gel carrier can effectively isolate oxygen, moisture and adverse processing environments, and the stability of embedded components in processing, storage and transportation is remarkably improved. The carrier can be slowly released in a gastrointestinal tract environment, and active ingredients are prevented from being degraded too early in gastric acid, so that the intestinal absorption rate and the bioavailability of the carrier are improved. The materials used in the invention are natural proteins, are safe and non-toxic, and accord with food and health care product application standards.

The present application relates to a kind of bone repair compositions and its preparation method, belong to biological medicine technical field, pharmaceutical composition includes acid anhydride bovine beta-lactoglobulin peptide, casein phosphopeptide, yak bone peptide, loquat leaf extract, pterostilbene, honeysuckle chlorogenic acid and cyperus rotundus extract;Acid anhydride bovine beta-lactoglobulin peptide is prepared using special enzymolysis method.Acid anhydride bovine beta-lactoglobulin peptide, casein phosphopeptide and yak bone peptide are loaded using carboxymethyl chitosan-hydroxyapatite composite microspheres, then using sodium alginate-sodium carboxymethyl cellulose containing loquat leaf extract, pterostilbene, honeysuckle chlorogenic acid and cyperus rotundus extract one coating, then using sodium alginate-sodium carboxymethyl cellulose secondary coating.The present application develops high-efficiency pharmaceutical combination component, using polymer material to coat drug to form sustained-release system, improve bioavailability, using granular carrier to increase the stability and solubility of drug, promote intestinal absorption, improve bone repair process.

The invention discloses a red yeast rice powder-phytosterol ester blood fat reducing formula and an embedding technology, and relates to the technical field of health food, the red yeast rice powder-phytosterol ester blood fat reducing formula comprises, by weight, 30-50 parts of red yeast rice powder, 20-40 parts of phytosterol ester, 10-15 parts of fructo-oligosaccharide, and 1-3 parts of a rosemary extract; through the scientifically verified compounding proportion, the competition of the two components in the intestinal absorption stage is avoided, and the bioavailability is improved. Fructo-oligosaccharide is used as prebiotics, so that intestinal health is promoted, and the absorption capacity of intestinal tracts to active ingredients is improved; the rosemary extract has an anti-oxidation effect, can prolong the oxidation induction period of phytosterol ester to 120 hours, can protect monacolin K and phytosterol ester in the red yeast rice powder from being damaged by external factors such as light and heat, and further improves the stability.

The invention discloses an artemisia selengensis leaf extract self-microemulsifying drug delivery system and a preparation method thereof, and belongs to the technical field of pharmaceutical preparations. The system is composed of artemisia selengensis leaf extract and a self-microemulsion drug delivery system composed of an oil phase, a surfactant and a cosurfactant, and the mass ratio of the oil phase to the surfactant to the cosurfactant is (10-20): (60-80): (10-30). According to the invention, the liquid system is solidified into powder through an adsorption carrier, and the powder is further prepared into enteric-coated tablets. The drug delivery system can significantly improve the solubility, stability and intestinal absorption efficiency of caffeoylquinic acid compounds (CQAs) in the artemisia selengensis leaves, effectively inhibits degradation of the caffeoylquinic acid compounds in gastric juice, shows excellent xanthine oxidase inhibitory activity, can be used for preparing functional foods or drugs for reducing uric acid, and realizes high-valued utilization of artemisia selengensis leaf resources.

The invention belongs to the field of medicines, and particularly relates to a hepatic targeting self-assembly liver protection peptide and application thereof in preparation of a medicine for treating alcoholic liver injury. According to the present invention, the prepared liver targeting self-assembly liver protection peptide FFGGHKDYNDLLDR can be formed through the formation of nanoparticles; the nanoparticles can be orally administered, maintain a stable sequence and structure in a gastric acid environment with a pH value of 2, prevent the influence of a complex enzyme environment in intestinal tracts, are released in a body fluid system after being absorbed by the intestinal tracts, and are enriched in the liver under the action of a liver targeting module in the liver targeting self-assembly liver protection peptide, so that the alcoholic liver injury is effectively inhibited.

The invention belongs to the field of functional food processing, and particularly relates to a preparation method and application of high-dispersity fried millet. By treating millet, millet starch can be pre-gelatinized, and a porous structure is formed, so that on one hand, the bioavailability can be improved, and on the other hand, the loading of functional components can be increased, and the functional components are slowly released through the porous structure, so that the intestinal absorption efficiency is improved; maillard reaction products generated in the frying process can have a synergistic effect with components in the compound spleen-tonifying nutrient solution through segmented frying of the millet, so that the effects of tonifying the spleen and nourishing the stomach are improved, and the intestinal health is improved; and the treated millet can reduce particle aggregation, and can be dispersed more uniformly during subsequent application, so that the stability and the taste are improved.

The application belongs to the field of feed additives, and particularly discloses application of sodium butyrate in preparation of a feed additive against chicken white dysentery Salmonella, and sodium butyrate is added in chicken basic feed as the feed additive against chicken white dysentery Salmonella; the addition of sodium butyrate in chicken basic feed can significantly reduce the bacterial load of chicken white dysentery Salmonella infection in chicken liver and spleen, significantly increase the ratio of villus length to crypt depth of the cecum of chicken infected with chicken white dysentery Salmonella, and improve the intestinal absorption capacity; the content of CD3+ T cells, TCR+ T cells, macrophages and B cells in the liver of chicken infected with chicken white dysentery Salmonella can be significantly reduced; and then the body weight of chicken infected with chicken white dysentery Salmonella is significantly increased, and the survival rate of chicken infected with chicken white dysentery Salmonella is increased. In summary, the addition of sodium butyrate in chicken basic feed can enhance the resistance to chicken white dysentery Salmonella infection.

The application discloses a pirfenidone nanosuspension inhalation solution for treating interstitial pneumonia and a preparation method thereof, and belongs to the technical field of pharmaceutical preparations. The pirfenidone nanosuspension inhalation solution is composed of the following components in 1000ml: 8-12g of pirfenidone hydrochloride, 4-6g of polyethylene glycol-poly-L-histidine block copolymer, 45-55g of mannitol, 0.4-0.6g of antioxidant, 0.05mol / L of citric acid-sodium citrate buffer, and water for injection, wherein the amount of the citric acid-sodium citrate buffer is appropriate, and the water for injection is added to 1000ml. The application adopts a pulmonary targeted inhalation administration path of non-gastrointestinal absorption, so that the drug directly acts on the lung interstitial lesion part by bypassing the intestinal absorption link.

The invention discloses a method for synthesizing a natural peptide zinc / calcium chelate based on a microwave catalysis technology, and the method comprises the following steps: S1, preparing a natural peptide into an aqueous solution, adding a zinc salt or a calcium salt into the aqueous solution, adjusting the pH value of the system, and transferring the system into a microwave reactor for reaction; and S2, after the reaction, continuously adding absolute ethyl alcohol into the reaction system, and then carrying out ice bath and centrifugation to obtain the natural peptide zinc chelate or natural peptide calcium chelate with the chelation rate not lower than 60%. According to the method disclosed by the invention, the conformation of the natural peptide is opened and changed into an open chain structure by innovatively using a microwave technology, so that the zinc / calcium ions are favorably combined with chelation sites on a peptide chain, and after a chelation reaction is finished, the conformation is recovered by utilizing ice-bath cooling, so that the zinc / calcium ions are wrapped in the middle of the peptide chain, and the zinc / calcium peptide is obtained. Competitive antagonism of metal (zinc / calcium) ions during intestinal absorption is avoided, a plurality of biochemical processes are reduced, and the zinc / calcium absorption rate of a human body is improved.

The invention provides radix astragali homogeneous polysaccharide as well as a preparation method and application thereof, and belongs to the field of separation and purification of natural products. The radix astragali homogeneous polysaccharide is composed of glucose and galactose, and the molecular weight of the radix astragali homogeneous polysaccharide is 1900-2200 Da. The preparation method comprises the following steps: performing water extraction and alcohol precipitation on astragalus membranaceus to obtain astragalus membranaceus crude polysaccharide, and performing column chromatography elution on the astragalus membranaceus crude polysaccharide to obtain the homogeneous astragalus membranaceus polysaccharide with the molecular weight of 1900-2200Da. The radix astragali homogeneous polysaccharide has excellent effects of resisting inflammation, regulating intestinal flora, regulating intestinal absorption function, scavenging free radicals, regulating immunity, improving prebiotic activity and resisting pulmonary fibrosis.

The invention discloses an echinacoside self-microemulsifying drug delivery system and a preparation method thereof, and belongs to the technical field of pharmaceutical preparations, the echinacoside self-microemulsifying drug delivery system comprises the following components by weight: 0.5%-5% of echinacoside, 10%-50% of an oil phase, 30%-70% of a compound emulsifier and 10%-40% of a co-emulsifier. According to the echinacoside self-microemulsifying drug delivery system and the preparation method thereof, the defects of incomplete in-vivo absorption and low bioavailability of echinacoside caused by the problems of unstable chemical structure, poor water solubility, low passive diffusion absorption efficiency in intestinal tracts and the like of the echinacoside are overcome, the preparation process is simple, and the preparation method is suitable for industrial production. The oral intestinal absorption characteristic of echinacoside is obviously improved.

The invention relates to a composition for improving food calling of aquatic products and a preparation method thereof, and belongs to the technical field of feeds, the composition comprises the following raw materials: cereal powder, inorganic powder, field snail meat powder, vegetable oil, vital gluten, egg oil and yeast nucleotide; the cereal powder comprises puffed glutinous rice flour, puffed pea flour and barley malt flour, the inorganic powder comprises tricalcium phosphate and titanium dioxide, and the vegetable oil comprises purple perilla seed oil. The puffed glutinous rice flour, the puffed pea meal, the tricalcium phosphate and the titanium dioxide are selected as visual food calling components, so that the speed of the fish school positioning feed is effectively increased; meanwhile, the field snail meat powder, the egg yolk oil, the purple perilla seed oil and the barley malt flour can synergistically promote continuous ingestion of the aquatic animals from different dimensions of stimulating smell, increasing palatability, stimulating taste and promoting intestinal absorption; in addition, the selected egg yolk oil also has adhesive force, and the gluten powder is added and compounded with the egg yolk oil, so that the dissolution rate of the composition in water can be reduced, and the composition has the special performance for aquatic products.

The invention discloses an application of a betaine-lactic acid deep eutectic solvent in promotion of protein intestinal absorption and an application in preparation of a protein intestinal absorption promoting agent. In the betaine-lactic acid eutectic solvent, the molar ratio of betaine to lactic acid is 1: (0.5-1.5). The invention further discloses a protein intestinal tract promoting absorbent which is composed of insulin, betaine and lactic acid, the concentration of the insulin is 2-5 mg / ml, and the molar ratio of the betaine to the lactic acid is 1: (0.5-1.5). According to the invention, model protein insulin is loaded by BL-DES, so that the intestinal absorption efficiency of insulin can be improved. The BL-DES stabilizes the insulin structure through the interaction of hydrogen bonds, Van der Waals' force and static electricity, reduces the viscosity of intestinal mucus, promotes model protein insulin bypass transport by reversibly opening epithelium tight connection, and significantly improves the transmembrane transport efficiency and oral bioavailability of protein. The research of the invention is of great significance to oral protein treatment.

The invention discloses a yak skin oligopeptide, a preparation method and application thereof, and a functional food or medicine, and belongs to the technical field of bioactive peptides, the yak skin oligopeptide comprises at least one of RDIFL, FRVP, RDILF and FDLRF oligopeptide, compared with other hypoglycemic peptides, the molecular weight is smaller, the yak skin oligopeptide can be directly absorbed by intestinal tracts, and the effect of delaying blood sugar rise is achieved. The oligopeptide RDIFL, the oligopeptide FRVP, the oligopeptide RDILF and the oligopeptide FDLRF have excellent inhibitory activity on alpha-glucosidase, the semi-inhibitory concentrations of the oligopeptide RDIFL, the oligopeptide FRVP, the oligopeptide RDILF and the oligopeptide FDLRF can reach 10.107 mmol / L, 13.063 mmol / L, 8.653 mmol / L and 12.369 mmol / L respectively, digestion and absorption of carbohydrates can be effectively delayed,

This invention discloses a compound probiotic solid beverage formula that assists in weight control and oil adsorption. The invention designs a beverage formula suitable for human consumption. The compound Chinese herbal medicines and fruit and vegetable powders work together to adsorb oil in the stomach and intestines through physical encapsulation. Hydrolyzed white kidney bean protein blocks starch absorption, and probiotics promote intestinal absorption. Together, they can improve the body's metabolic function and solve health problems such as weight gain caused by greasy diet.

The invention relates to the field of pharmaceutical preparations and pharmaceutical chemistry, belongs to the technical field of oral delivery of antitumor drugs, and particularly relates to an abiraterone lipophilic prodrug and application thereof. The prodrug meets the following general formula: AB-O-C (= O)-(CH2) m-S-S-(CH2) m-C (= O)-O-R, the prodrug significantly improves the fat solubility and intestinal absorption capacity of abiraterone, can be absorbed through a chylomicron-mediated lymph transport pathway, and releases a parent drug in a tumor cell high-reducibility environment. The SNEDDS preparation containing the prodrug can form a particle size of 1t in vivo; the O / W type nano emulsion droplet with the size of 100 nm can significantly improve the oral bioavailability of abiraterone and inhibit the growth of prostatic cancer tumors, and has a good application prospect.

The application discloses a swallowable drug device combination device for promoting intestinal absorption of macromolecular drugs, and belongs to the technical field of drug delivery and medical devices, and the structure comprises an intestinal built-in vibration component and an external alternating magnetic field driving component; the intestinal built-in vibration component comprises a soft magnetic layer and an adhesive hydrogel layer, the soft magnetic layer is prepared by magnetizing after curing of an elastomer material doped with magnetic particles, and the adhesive hydrogel layer is a sodium alginate-acrylamide double-network hydrogel loaded with macromolecular drugs; the external alternating magnetic field driving component comprises a power module, a current driving module, an electromagnetic module, a control module and an interactive terminal; in the working state, the alternating magnetic field generated by the external alternating magnetic field driving component penetrates the body surface tissue and acts on the soft magnetic layer of the intestinal built-in vibration component, so that mechanical vibration is generated to exert physical stimulation on the local tissue in the intestine. The device can accelerate the release rate of macromolecular drugs and enhance the absorption efficiency of the macromolecular drugs in the intestine.

The invention provides a soda water beverage added with nattokinase and a preparation method and application thereof, the soda water beverage added with nattokinase has a pH value of 7.8-8.2 and a carbonation degree of 0.8-1.2 g / L, and contains nattokinase, and the activity of the nattokinase is greater than or equal to 10,000 FU / L. The soda water beverage added with the nattokinase is applied to preparation of products for regulating PCSK9 activity, reducing the low density lipoprotein cholesterol LDL-C level in blood or preventing / assisting in managing obesity and related metabolic syndromes. The product is a beverage, a health food or a dietary supplement. The nattokinase can be used for specifically hydrolyzing the Ser153-Gly154 site of the PCSK9 protein, and the Ser153-Gly154 site of the PCSK9 protein can be specifically hydrolyzed. According to the beverage, the activity of nattokinase is protected by optimizing pH and a carbonation system, the intestinal absorption rate of the nattokinase is improved, and the function of PCSK9 is inhibited in a targeted manner so as to regulate blood lipid metabolism. Compared with an existing oral enzyme preparation, the oral enzyme preparation has high efficiency, stability and consumption convenience, and an innovative diet intervention scheme is provided for obesity and related metabolic diseases.

The invention discloses an upatinib gel plaster and a preparation method thereof, the gel plaster can improve the skin transmittance, absorptivity and stability of an upatinib gel composition through the combination of sorbitol and propylene glycol and the compounding of other components such as a penetration enhancer. The traditional Chinese medicine composition is used for treating psoriasis and arthritis, can be directly adhered to an affected part for administration, is convenient to use, reduces the influence of a gastrointestinal tract absorption way on the medicine, reduces toxic and side effects of gastrointestinal tract administration, is large in medicine loading capacity and long in acting time, and does not pollute clothes. The developed Upatinib gel plaster fills up the market blank, is convenient for patients to take, and has a wide market prospect.

The invention discloses a traditional Chinese medicine composition, belongs to the technical field of traditional Chinese medicines, and aims to solve the problems of dyslipidemia and liver lipid deposition caused by chronic high fat diet. The composition comprises two formulas, wherein the formula A consists of astragalus membranaceus, lucid ganoderma and schisandra chinensis according to the weight ratio of 1: 1: 1; the formula B is composed of schisandra chinensis and liquorice according to the weight ratio of 3: 1, and can significantly activate an NRF2 / ARE pathway, up-regulate expression of antioxidant genes such as NQO1 and HO-1, inhibit H2O2-induced ROS generation and cell apoptosis, and improve related symptoms from the molecular level; meanwhile, the provided preparation method can improve the solubility of active ingredients and the intestinal absorption efficiency, avoids ingredient degradation caused by high-temperature extraction, ensures long-acting stable release of the medicine in vivo, and is mainly used for improving dyslipidemia and liver lipid deposition caused by chronic high-fat diet.

The invention provides iron binding peptides based on tuna blood combined meat. The amino acid sequences of some polypeptides are SEQ ID NO: 1-6. The polypeptide provided by the invention can be used for preparing a product for treating iron-deficiency anemia. According to the tuna red meat hematopoietin provided by the invention, an organic iron compound with high bioavailability is formed through the chelation of specific polypeptide iron ions in preparation of a blood replenishing product, so that the absorption efficiency of intestinal tracts on iron is remarkably improved. A carrier formed by the polypeptide can protect iron ions from being damaged by gastric acid, and the iron ions are delivered to an absorption part in a targeted mode, so that the hemoglobin synthesis efficiency is improved by 40% or above. The natural polypeptide ligand disclosed by the invention avoids gastrointestinal irritation of a traditional iron supplementing agent, and is not interfered by absorption of dietary factors such as phytic acid and tannin. The tuna processing by-product is used as the raw material to prepare the functional blood-enriching peptide, so that high-value utilization of fishery resources is realized, and an eco-friendly new iron-enriching source is provided.

The present disclosure relates to a novel (Lactococcus lactis subsp. cremoris HEM 20103 strain useful for promoting intestinal absorption of calcium, and uses thereof. The novel Lactococcus lactis HEM 20103 strain of the present invention was confirmed to exhibit acid resistance, bile resistance, and intestinal cell adhesion ability and to have an excellent effect of promoting intestinal absorption of calcium. In addition, by increasing bone mineral content, the strain was confirmed to increase calcium metabolism, bone density, bone volume per unit volume, and cortical bone thickness and to significantly improve trabecular bone thickness, trabecular number per unit area, and trabecular spacing in osteoporosis model mice. Therefore, the strain of the present invention is expected to be widely used as a health functional food composition, a feed composition, a feed additive, and the like for promoting intestinal absorption of calcium and to have an excellent effect of preventing or treating intestinal absorption-related diseases of calcium such as osteoporosis or osteopenia.

The invention discloses a micromolecular non-anticoagulant heparin soft capsule, which is an oral preparation using micromolecular non-anticoagulant heparin as an active pharmaceutical ingredient and a soft capsule as a carrier, and is prepared by the following steps: preparing a capsule skin and a core material, preparing the capsule skin containing an enteric-coated material and the core material containing the micromolecular non-anticoagulant heparin active pharmaceutical ingredient into a suspension by using matrix oil; and then pelleting and drying. The soft capsule can reduce the damage of gastric acid to small-molecule non-anticoagulant heparin active substances, increase the absorption of intestinal tracts and improve the bioavailability, so that a medicinal preparation is safe and stable and is suitable for being applied as a medicine.