The invention discloses a hydraulic/ultrasonic coupling cavitation device which comprises a hydraulic cavitation mechanism and an ultrasonic functional mechanism, wherein the ultrasonic functional mechanism is arranged on the hydraulic cavitation mechanism; the ultrasonic functional mechanism comprises an ultrasonic transducer, a connecting flange, an amplitude transformer and a functional fixture, wherein the ultrasonic transducer is connected with the amplitude transformer through the connecting flange, the amplitude transformer is connected with the functional fixture, and the hydraulic cavitation mechanism is arranged in the functional fixture and can be a Venturi tube, a pore plate or a liquid nozzle. The invention has the advantages that: an electric ultrasonic cavitation device is combined with the hydraulic cavitation device, and the coupling synergistic effect of the ultrasonic cavitation and the hydraulic cavitation can greatly enhance the cavitation effect to ensure that cavitation energy, sound pressure, sound intensity and efficiency are greatly improved. The hydraulic/ultrasonic coupling cavitation device can be effectively used in industrial production processes of sewage degradation treatment, oil water demulsification treatment, liquid inactivation treatment, Chinese medicine extraction, induced crystallization, wine ageing treatment, material uniform dispersing treatment, and the like.